This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barrier may result in damage to the skin or may alter absorption. With contributions from over 40 international experts in the field of skin biology, the book presents the central role of the skin barrier to health and disease reviewing; The skin's anatomy and physiology, with focus on the stratum corneum as a barrier to foreign substances. Dermal absorption, cutaneous metabolism, and epidermal transporters. Altered barriers, racial skin types, aged skin, photoaged skin, cosmetics and skin sensitization. Modern approaches to drug delivery across the skin barrier, including liposomes, microneedle technology, active and passive transdermal delivery. Examples and case studies of chemical toxicity after topical exposures ranging from arsenic, metal working fluids, bromine, jet fuel, sulfur mustard and including the emerging area of nanomaterial penetration. Toxicology of the Skin is essential reading for drug delivery pharmacologist, formulation scientists, dermatologists, toxicologists, molecular biologists, engineers, surgeons, students and anyone interested in skin irritation and skin absorption.

"Know thyself," a precept as old as Socrates, is still good advice. But is introspection the best path to self-knowledge? What are we trying to discover, anyway? In an eye-opening tour of the unconscious, as contemporary psychological science has redefined it, Timothy D. Wilson introduces us to a hidden mental world of judgments, feelings, and motives that introspection may never show us.

This is not your psychoanalyst's unconscious. The adaptive unconscious that empirical psychology has revealed, and that Wilson describes, is much more than a repository of primitive drives and conflict-ridden memories. It is a set of pervasive, sophisticated mental processes that size up our worlds, set goals, and initiate action, all while we are consciously thinking about something else.

If we don't know ourselves―our potentials, feelings, or motives―it is most often, Wilson tells us, because we have developed a plausible story about ourselves that is out of touch with our adaptive unconscious. Citing evidence that too much introspection can actually do damage, Wilson makes the case for better ways of discovering our unconscious selves. If you want to know who you are or what you feel or what you're like, Wilson advises, pay attention to what you actually do and what other people think about you.

Showing us an unconscious more powerful than Freud's, and even more pervasive in our daily life, Strangers to Ourselves marks a revolution in how we know ourselves.

The brand new novel from the critically-acclaimed author of Snow Foal and Otters' Moon. Perfect for fans of Jacqueline Wilson and Gill Lewis. 'A mesmerising voice' - Joanna Nadin A brand new novel from Susanna Bailey - the bestselling author of Snow Foal and a new star of middle grade contemporary fiction. Ever since Billie's kind and nature-loving dad went to prison, her life has lost its shine. And now, Mum's new boyfriend has moved in and home is full of sharp-glass silences. Billie's never felt more alone. Until one day she discovers an injured young raven and in nursing him back to life, Billie finds friendship, hope and a letter that might bring her one step closer to reuniting with Dad. Raven Winter is the story of friendship, family and the belief in a very special relationship with a young raven set against the beautiful and the wintery backdrop of the Yorkshire Dales.

Pool cover prevents debris ut of the pool when not in use.It also effectively maintains the water's temperature and prevents evaporation as well.

The Admiral Catcher Goalkeeper Gloves are made from PU outer, they have a latex palm, finger savers and an adjustable wrist strap for the perfect fit

In die laaste boek in die gewilde trilogie begin Lehandi se matriekjaar slegter as ’n rugbywedstryd wat uitgereen het. Haar ma is verloof en Prissie die Vissie is saam met haar strooimeisie. En dit terwyl Lehandi alweer single is. Boonop het die nerd Peyton van vakansie af teruggekom met spiere en kontaklense. En alles verander skielik handomkeer, 180 grade in die verkeerde rigting, wanneer haar vorige BFF Reqita weer terugstap in haar lewe in.

Veronique Jephtas verteenwoordig die kraakvars stem van ’n nuwe generasie Afrikaanssprekendes – die born frees, gebore ná 1994 – wat grootgeword het in ’n land met meer geleenthede vir almal maar waar die wonde van die verlede halsstarrig bly sweer.

In Soe rond ommie bos skryf Jephtas protesposie en verbeel ’n gemeenskap wat vry is van gesprekke wat rondom die bos loop.

Like many national curricula around the world, South Africa’s curriculum is rich in environment and sustainability content. Despite this, environmental teaching and learning can be challenging for educators. This comes at a time when Sustainable Development Goal 4 via Target 4.7 requires governments to integrate Education for Sustainable Development into national education systems.

Teaching and Learning for Change is an exploration of how teachers and teacher educators engage environment and sustainability content knowledge, methods, and assessment practices – an exposition of quality education processes in support of ecological and social justice and sustainability. The chapters evolve from a ten-year research programme led out of the DSI/NRF SARChI Chair in Global Change and Social Learning Systems working with national partners in the Fundisa for Change programme and the UNESCO Sustainability Starts with Teachers programme. They show the integration of education for sustainable development in teacher professional development and curricula in schools in South Africa. They reveal how university-based researchers, teachers and teacher educators have made theoretically and contextually reasoned choices about their lives and their teaching in response to calls for a more sustainable world in which education must play a role.

Teaching and Learning for Change will be of interest to education policymakers in government, advisors and educators in educational and environmental departments, NGOs and other institutions. It will also be of interest to teacher educators, teachers and researchers in education more generally, and environment and sustainability education specifically.

I have just killed myself. I meant it to be quick, but when I came to stick the poison arrow into the vein in my arm, I couldn't, and the arrow tip went into the thickest part of my leg instead. Maybe, inside my head, I wanted a little more time. To think. So I am sitting here under the thin shade of a thorn tree and thinking about my life and the things that were me - Be, of the Ju/'hoansi people. Be's story is one of sadness, but it is also a story of love, courage and dignity. It is told masterfully by Lesley Beake, award-winning novelist for young people.

Hoe dans jy as die lied in jou hart stil geraak het?

Bekende musiekster, Zander Breedt, se muses het hom verlaat. Die helder ligte van die verhoog het hul glans verloor, en dit klink asof die suiwer melodieë in sy kop vervang is met ’n droewige klaaglied.

Boonop is daar sy nuwe skoonsus, Anine Vos, ’n joernalis, ’n spesie waarvoor hy nie baie ooghare het nie. Hy moet haar gedoog, al maak sy dit duidelik dat sy nie tyd het vir ’n popster soos hy nie. Tog, om een of ander rede begin die note weer helder deur Zander se
gedagtes klink wanneer sy naby is.

Anine kan nie verstaan hoekom juis sý die opdrag moes kry om ’n in diepte-artikel oor Zander te skryf nie. Sy het mos niks verloor by hierdie mislike musikant nie. Om deur sy lewe te krap is die laaste ding wat sy wil doen terwyl haar eie hart nog gebreek is.

When Emily meets enigmatic and dazzling actress Tamsin, her life changes. Drawn into Tamsin's world of Soho living, boozy dinners, and cocktails at impossibly expensive bars, Emily's life shifts from black and white to technicolour and the two women become inseparable.

Tamsin is the friend Emily has always longed for; beautiful, fun, intelligent and mysterious and soon Emily is neglecting her previous life - her work assisting vulnerable women, her old friend Lucy - to bask in her glow. But when a bombshell news article about a decades-old sexual assault case breaks, Emily realises that Tamsin has been hiding a secret about her own past. A secret that threatens to unravel everything . . .

Young Women is a razor sharp novel that slices to the heart of our most important relationships, and asks how complicit we all are in this world built for men.

From the author of Cold Storage comes a riveting, eerily plausible thriller about a worldwide blackout and the lengths one family go to stay alive.

When the world falls into darkness no one is safe... A nation without power. A society without rules. A race to build a better world...

In Aurora, Illinois, Aubrey Wheeler is just trying to get by after her semi-criminal ex-husband split, leaving behind his unruly teenage son. Then the lights go out - not just in Aurora but across the globe. A solar storm has knocked out power almost everywhere. Suddenly, all problems are local, very local, and Aubrey must assume the mantle of fierce protector of her suburban neighborhood.

Across the country lives Aubrey's estranged brother Thom, a fantastically wealthy, neurotically over-prepared Silicon Valley CEO, plans to ride out the crisis in a gilded desert bunker he built for maximum comfort and security. But the complicated history between the siblings is far from over, and what feels like the end of the world is just the beginning of several long-overdue reckonings which not everyone will survive...

Aurora is suspenseful storytelling - both large scale and small - at its finest.

A luxury house in France. A gathering of wealthy, reckless friends. And a woman on the run.

Deep in the lavender fields of Provence, nine guests arrive at a luxury holiday home. They all know each other well, or at least they think they do. The only stranger is the young woman hired to do the catering. Over the course of their break, loyalties will be tested, secrets revealed, and tensions pushed to the point of no return...

The sensational new novel from the universally acclaimed Sabine Durrant - destined to be the thriller of summer 2022.

The emigration debate is as old as our democracy itself.

When the “new South Africa” dawned in 1994, many people left the country out of fear for what majority rule would hold. More still left in the years that followed to seek a better life elsewhere, and communities of expats can be found all over the world in places such as Canada, England and Australia. Today, 25 years after the dawn of democracy, as optimism about the country's future ebbs and flows, new impetus has been given to the emigration debate. This time around, it is not only being discussed in reactionary circles, but around dinner tables of all creeds as many people leave for better education, job opportunities and safety. With the reality of nine wasted years tugging at our wallets and future prospects, and the allure of a global economy pulling strong, more and more people are asking, “Should I go?”

In Should we go? more than 20 of South Africa's foremost thought leaders such as Jonathan Jansen, Mandy Wiener, Phumzile van Damme and Ferial Haffajee grapple with this question. It is an attempt to find some answers that will give insight to and challenge every person who is thinking of leaving, has already left, or has decided to stay so that they may thrive as South Africans wherever they are.

Alet Law is the newsletter and engagement editor at News24 and former opinions editor. She holds a PhD in political communication from the University of Cape Town.

Computer-animated children's comedy about an arch-criminal who has a change of heart. Trying to outdo his main rival Vector (voice of Jason Segel), serial villain Gru (Steve Carell) hatches a plan to steal the moon, aided by his army of genetically altered corn pops. About to set his dastardly plan in motion, and bristling with his arsenal of freeze-rays and sci-fi gadgetry, all goes according to plan until the arrival at his door of three little orphan girls, Margo (Miranda Cosgrove), Agnes (Elsie Fisher) and Edith (Dana Gaier), in search of a father figure.

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Cooker & Multifunction Oven

Cooker & Multifunction Oven

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The Smeg 9kg Silver Front Loader Washing Machine has an A+++ energy rating, 15 programs and an automatic load balance system, which ensures that your laundry is evenly distributed.

Cooker & Multifunction Oven

Originating in Guastalla, Italy, La Germania combines culinary craft with engineering skill. With roots in the tradition of the Italian family, culture and style, La Germania ovens and hobs are built with passion and precision by people who know about cooking.

Originating in Guastalla, Italy, La Germania combines culinary craft with engineering skill. With roots in the tradition of the Italian family, culture and style, La Germania ovens and hobs are built with passion and precision by people who know about cooking.