In this book, the authors present current research in the study of the sources, environmental concerns and control of dust. Topics discussed in this compilation include the characterisation of heavy metals content in attic dust from copper ore and ferronickel smelter processing plants in Macedonia; dust control in the mining industry of Australia; the health and environmental effects of dust storms in the Arabian Peninsula; dust fallout and its potential hazard on public health in Kuwait; photochemical and climate implications of airborne dust and assessing the quality of the urban environment by the elemental concentrations of foliage dust.

This book presents and discusses current research in the study of soil contaminants. Particular attention is placed on the effect soil contaminants have on crop production and growth. Topics discussed include a risk assessment of arsenic in homegrown vegetables; soil properties and crop performance in the semi-arid subtropics of Australia; pesticides as a threat or boon to fertile agricultural lands; amendment-enhanced phytoextraction of soil contaminants and the ecological significances of secondary metabolites in terrestrial biosystems.

Book & DVD. Biomonitoring is the assessment of human exposure to chemicals by measuring the chemicals of their metabolites in such human specimens as blood and urine. Most chemicals or their metabolites were measured in blood, serum and urine samples from random subsamples of about 2500 participants from the National Health and Nutrition Examination Survey conducted by the Centers for Disease Control (CDC). This book explores the ongoing assessment of the exposure of the U.S. population to environmental chemicals by the use of biomonitoring. It provides unique exposure information to scientists, physicians, and health officials to help prevent exposure to some environmental chemicals.

Formaldehyde, one of the most widely produced chemicals in the world, is used in many products, including disinfectants, pressed wood and clothing and other textiles. Exposure to this chemical, which has been linked to adverse health effects for more than 30 years, typically occurs through inhalation and dermal contact. Formaldehyde can be used to enhance wrinkle resistance in some clothing and textiles, especially those made of cotton. The Consumer Product Safety Commission reviewed formaldehyde in clothing in the 1980s and determined that the levels found did not pose a public health concern. At that time, most clothing sold in the U.S. was made here, but the market has changed such that most U.S. clothing is now made in other countries. This book examines this market change which has raised new questions about the levels and dangers of formaldehyde in apparel, textiles and other consumer products.

Carbon monoxide (CO) is a colourless, odourless, highly toxic, poisonous gas. Exposure to a few hundreds ppm can cause permanent health damages or death. CO can thus be considered as one of the most dangerous environmental pollutants and therefore, its removal and detection is of extreme importance for safe living. This book presents current research in the study of the sources, uses and hazards of carbon monoxide. Topics discussed include the cardiac effects of carbon monoxide intoxication; CO oxidation using gold supported on Ce-Mn-O composite materials; heterogeneous catalysis in carbonylative coupling reactions; and, the evaluation of carboxyhemoglobin (CO-Hb) by oximeter in the forensic practice.

The history of a long-running environmental catastrophe chronicles the harmful effects of lead pipes and their continued use despite evidence that they pose a significant health risk. In The Great Lead Water Pipe Disaster, Werner Troesken looks at a long-running environmental and public health catastrophe: 150 years of lead pipes in local water systems and the associated sickness, premature death, political inaction, and social denial. The harmful effects of lead water pipes became apparent almost as soon as cities the world over began to install them. Doctors and scientists noted cases of acute illness and death attributable to lead in public water beginning in the middle of the nineteenth century, and an editorial in the New York Herald called for the city to study the matter after a bizarre illness made headlines in 1868. But officials took no action for many years. New York City, for example, did not take any steps to reduce lead levels in water until 1992, long after the most serious damage had been done. By then, in any case, much of the old lead pipe had been replaced with safer materials. Troesken examines the health effects of lead exposure, analyzing cases from New York City, Boston, and Glasgow and many smaller towns in Massachusetts, New Hampshire, and England. He draws on period accounts, government reports, court decisions, and economic and demographic analysis to document the widespread nature of the problem, the recognized health effects-particularly for pregnant women and young children-and official intransigence. He presents an accessible overview of the old and new science of lead exposure-explaining, for example, why areas with soft water suffered more harmful effects than areas with hard water. And he gives us compelling and vivid accounts of the people and politics involved. The effects of lead in water continue to be felt; many older houses still have lead service pipes. The Great Lead Water Pipe Disaster is essential reading for understanding this past and ongoing public health problem.

The contents of this volume focuses on the relationship between passive smoking and cardiovascular pathology. Findings concerning the harmful effects of passive smoking, namely isolated or public exposure to someone else's smoking, began in the 1970's. This book reflects the current views on the relationship between cardiovascular pathology and passive smoking providing the main achievements obtained with the findings on the subject. The book presents the factors that influence negatively both a normal and diseased heart and blood vessels of non-smokers exposed to environmental smoking by means of different chapters structured with a sequence that begin from normal patterns until reaching the final step: irreversible damage of the heart and blood vessels.

"Superbly written and researched." —Booklist "Builds a strong case." —Kirkus Lyme disease is spreading rapidly around the globe as ticks move into places they could not survive before. The first epidemic to emerge in the era of climate change, the disease infects half a million people in the US and Europe each year, and untold multitudes in Canada, China, Russia, and Australia. Mary Beth Pfeiffer shows how we have contributed to this growing menace, and how modern medicine has underestimated its danger. She tells the heart-rending stories of families destroyed by a single tick bite, of children disabled, and of one woman’s tragic choice after an exhaustive search for a cure. Pfeiffer also warns of the emergence of other tick-borne illnesses that make Lyme more difficult to treat and pose their own grave risks. Lyme is an impeccably researched account of an enigmatic disease, making a powerful case for action to fight ticks, heal patients, and recognize humanity’s role in a modern scourge.

Palladium is a steel-white, ductile metallic element resembling and occurring with the other platinum group metals and nickel. Palladium and its alloys are used in the (petro) chemical and the automotive industries as catalysts, in dentistry, and in electronics and the, electrical industry.This book evaluates the risks to human health and the environment posed by exposures to palladium. The general population is primarily exposed to palladium through dental alloys or jewellery. There were case reports referring to palladium sensitivity associated with exposure to palladium-containing dental restorations; the, symptoms being contact dermatitis, stomatitis or mucositis and oral lichen planus.Palladium ions are considered to be highly toxic to aquatic organisms. However, due to palladium's high economic value, emissions of palladium from point sources are currently minimal. Increased use of catalytic converters may increase palladium emissions from diffuse sources. It was recommended that these emissions should, be controlled to be as low as possible.

Zinc is a common element in the natural environment. Apart from artificially reduced zinc metal, it exists in the divalent state Zn (II) in the environment and it is an essential element for most organisms. It is well known that zinc deficiency causes numerous effects in humans, including neurosensory changes, growth retardation and delayed wound healing, but most people obtain sufficient amounts of zinc from their diet to avoid these effects. On the other hand, it is reported that high doses of zinc cause gastrointestinal distress, nausea and diarrhoea.This book evaluates the risks to human health and the environment posed by exposures to zinc. Overall evaluation suggests that normal healthy individuals not exposed to zinc in the workplace are at potentially greater risk from the adverse effects associated with zinc deficiency than from those associated with normal environmental exposure to zinc because of its relatively low toxicity in humans and the limited sources of human exposure.

This publication seeks to provide a framework for selecting and validating biomarkers for risk assessment. Initial chapters consider the role of biomarkers in risk assessment and their validity. A biomarker is any substance, structure or process that can be measured in the body or its products, and influence or predict the incidence of outcome or disease. Biomarkers can be classified into markers of exposure, effect and susceptibility. If biomarkers are to contribute to environmental and occupational health risk assessments, they have to be relevant and valid. Relevance refers to the appropriateness of biomarkers to provide information on questions of interest and importance to public and environmental health authorities and other decision-makers. The validity of a biomarker is a function of intrinsic qualities of the biomarker and characteristics of the analytic procedures. Additionally, three broad categories of validity can be distinguished: measurement validity, internal study validity and external validity. Measurement validity is the degree to which a biomarker indicates what it purports to indicate. Internal study validity is the degree to which inferences drawn from a study actually pertain to study subjects and are true. External validity is the extent to which findings of a study can be generalized to apply to other populations. Subsequent chapters examine the validation of specific types of biomarkers and cross-species comparability. Supporting the main text are four extensive appendices covering the following subjects: 1. Biomarkers of exposure and effect for carcinogenicity 2. Biomarkers of exposure and effect for non-carcinogenic end-points 3. Measurement of drug metabolizing enzyme polymorphisms as indicators of susceptibility 4. Validation of biomarkers for environmental health research and risk assessment

Forty years after the publication of Rachel Carson's "Silent Spring," this important study examines the history, industrial uses, and harmful effects of the twelve most commonly used organochloride chemicals. All have been fully or partially banned by the Stockholm Protocol, an international treaty signed by about 120 countries in December 2000. Among the twelve are the dioxins (the active ingredient in Agent Orange) and polychlorinated byphenyls (PCBs), which are toxic in minute quantities. Johansen pays special attention to the Inuit of the Arctic, where these chemicals have been bio-accumulating to dangerous levels, moving up the food chain to a degree of toxicity that some Inuit mothers are no longer able to safely breast-feed their infants.

The polar stratospheric ozone has been devastated by emissions of chlorofluorocarbons (CFCs), and new scientific findings connect global warming near the Earth's surface to significant cooling in the stratosphere. This synergy aggravates ozone depletion because the chemical reactions that destroy the ozone become more energetic as temperatures drop. Synthetic toxins have taken their toll on minority ethnic groups in the United States, and persistent organic pollutants have inflicted physiological damage on humans and other animals. Finally, Johansen explores the estrogenic effects of such chemicals. Sperm counts have declined as much as 50% in 50 years.

Evaluates the risks to human health and the environment posed by exposure to dinitro-"ortho"-cresol, a chemical used for over a century as an acaricide, larvicide, and ovicide to control the dormant forms of many insects in orchards. The chemical is also sprayed on potatoes to prevent virus and disease contamination of the tubers. Although the chemical's use as a pesticide has been banned in many countries, significant volumes of obsolete stocks are still found in several parts of the world, especially in developing countries. Dinitro-"ortho"-cresol continues to be used in the plastics industry as an inhibitor of polymerization in styrene and vinyl aromatic compounds. Concerning environmental behavior studies indicate that the chemical is rapidly biodegraded in soil and has no potential to volatilize when released to water. Evidence further suggests that uptake by treated fruit trees or potatoes leaving residues at harvest time does not occur. Food is therefore not considered an important source of exposure for the general population. Occupational exposures during agricultural spraying and during manufacturing and formulation are regarded as the principal sources of human exposure. The most extensive part evaluates the results of toxicity studies in laboratory mammals and "in vitro "test systems. Short-term dietary administration decreased body-weight gain in some species, usually without significant alteration in food consumption. At high doses, adverse effects on the liver have been observed. Data on embryotoxicity, teratogenicity, mutagenicity, and carcinogenicity were judged inadequate for evaluation. The evaluation of effects on human health draws on data obtained during the limited use of dinitro-"ortho"-cresol in the 1930s as a therapeutic agent for the treatment of obesity and on cases of acute poisoning. Symptoms associated with toxicity include restlessness, flushed skin, sweating, thirst, deep and rapid respiration, severe increase of body temperature, and cyanosis leading to collapse, coma, and death. Concerning adverse effects on occupationally exposed workers, the report cites a dramatic decline over the last 25 years in reported cases of occupational intoxication. The decline is attributed to better education of users, the use of adequate protective equipment, and improvements in application techniques, equipment, and formulations. The report concludes that when used according to registered recommendations, and when measures for personal protection are followed, exposure to dinitro-"ortho"-cresol is reduced to levels that do not cause systemic toxicity.

AN ESSENTIAL CONVERSATION FROM TODAY'S LEADING VOICES ON EFFECTING CHANGE IN HEALTH AND SOCIETY "The Robert Wood Johnson Foundation has changed the conversation about health in the United States." -Jo Ivey Boufford, President, New York Academy of Medicine In a society where a person's zip code is a stronger predictor of health status than their genetic profile, every public health challenge is also a challenge of equity, implementation, and policy. For better or worse, improving health requires societal change, and the scale of today's societal challenges can have a stifling effect on even the most well-intended efforts. Assembled by the Robert Wood Johnson Foundation and featuring today's most prominent voices from diverse sectors, Knowledge to Action is a collection of short conversations focused on the idea of meaningful change - its definition, its impediments, and exploring how we can transition from research to action in health, well-being, and equity. Steeped in honesty and benefiting from the diverse experiences of an extraordinary assembly of academics, journalists, policymakers, public health practitioners, and researchers, this book offers provocative yet actionable perspectives that will benefit anyone who reads it.

This volume studies the risk to the environment and human health posed by nitroPAHS. Data on the in vivo genotoxicity of nitroPAHs are available for 15 nitroPAHs. All nitroPAHs that gave positive results in vivo were also positive in vitro. Four nitroPAHs that were positive in in vitro genotoxicity tests revealed inconsistent or inconclusive genotoxicity (2-nitronaphthalene, 5-nitroacenaphthene and 3-nitrofluoranthene) or negative genotoxicity (2,7-dinitrofluorene; limited validity) results in vivo. There are no reports on the effects of individual nitroPAHs on humans. As would be expected, since nitroPAHs occur in complex mixtures in the atmosphere and exhaust, the exact contribution of nitroPAHs to the adverse health consequences of exposure to polluted atmospheres and to exhaust cannot be elucidated.

This book evaluates the risk to human health and the environment posed by exposures to fluorides. It is widely known that fluoride has both positive and negative effects on human health, and there is a narrow range between intakes that are associated with these effects. Cases of skeletal fluorosis associated with the consumption of drinking water containing elevated levels of fluoride are reported. Fluoride is ubiquitous in the environment and virtually all foodstuffs contain at least trace amounts of fluoride. The amount of fluoride present naturally in non-fluoridated drinking water is highly variable, being dependent upon the individual geological environment. Also, fluorides, especially hydrogen fluoride, are important industrial compounds and they are used in aluminium production, glass manufacturing and so on. This document focuses on environmental exposure to fluoride derived mostly from inorganic sources and its effects on humans, animals and other biota.Data on hydrogen fluoride, calcium fluoride, sodium fluoride, sulfur hexafluoride and silicofluorides are covered, as these compounds are considered to be the most relevant of the inorganic fluorides on the basis of quantities released to the environment, environmental concentrations and toxicological effects on living organisms. A review of studies on the environmental fate and concentration of fluorides is also presented in this document.

This book evaluates the risks to human health and the environment posed by arsenic and arsenic compounds. Arsenic is widely distributed in the earth's crust and is emitted into the atmosphere by coal-fired power generation plants and volcanic activity. Inorganic arsenic of geological origin is found in groundwater, which is used as drinking-water in several parts of the world, e.g. Bangladesh. In these areas, drinking-water is the main source of arsenic intake, but elsewhere food is the principal source.

Evaluates the findings of close to 600 studies aimed at determining whether the health risks associated with tobacco use are enhanced by co-exposure to numerous chemical, biological, and physical agents commonly found in the workplace. Co-exposures in the domestic and general environment, which are especially important in newly industrializing countries, are also considered in this comprehensive review. Although all forms of tobacco use are covered, particular attention is given to risks arising from exposure to mainstream and sidestream smoke from cigarettes. The book has four chapters. The first summarizes what is known about the health risks caused by tobacco use. A brief overview of the history of tobacco use is followed by a detailed explanation of the chemistry of processed tobacco and the many toxic compounds found in tobacco and in mainstream and sidestream smoke. The chapter also includes an overview of all documented acute and chronic adverse effects of tobacco, including smokeless tobacco. The second and most extensive chapter evaluates the evidence on health effects caused by interactions between tobacco smoke and asbestos, non-asbestos fibres, seven inorganic chemicals, five organic chemical agents, including ethanol, four physical agents, and seven biological agents, including two widespread infectious agents. The chapter also includes an explanation of the concept of interaction and how it can be measured, a discussion of vector effects, whereby cigarettes become contaminated with toxic chemicals in the workplace, and a review of data indicating that tobacco smoking can alter the metabolism of therapeutic drugs and other chemicals. Chapter three considers whether adverseeffects following co-exposure to tobacco smoke and other agents are separate effects or possible interactions. The report found evidence for synergism in the production of adverse effects, including cancer, between tobacco smoking and exposure to asbestos, ethanol, silica, and radiation. The report also found evidence that tobacco smoking affects the health risks of exposure in coal mining, pesticide handling, and in the rubber and petroleum industries. In addition, tobacco smoking can increase the risk of byssinosis produced by exposure to cotton dust, and nasal cancer caused by exposure to wood dusts. On the basis of this evaluation, the final chapter concludes that all possible measures should be taken to eliminate tobacco use, particularly smoking. To avoid interaction with occupational exposure and to eliminate hazards arising from exposure to environmental tobacco smoke, the report concludes that smoking in the workplace should be prohibited.

This publication summarizes the scientific knowledge base on which principles and methods involved in neurotoxicity risk assessment are based. It is aimed at providing a framework for public health officials, research and regulatory scientists and risk managers on the use and interpretation of neurotoxicity data from human and animal studies and it discusses emerging methodological approaches to studying neurotoxicity. The introductory chapter examines definitions and critical concepts in neurotoxicity and looks at the criteria for quality of data used in risk assessment. This is followed by a detailed discussion of the structure and function of the nervous system, of the special susceptibilities of the human fetus, children and the elderly and of the types of effects on the nervous system. Recent progress in developing validated methods for detecting neurotoxicity in humans is investigated, as is our understanding of the factors that affect the validity and reliability of human neurotoxicological studies. Sources of human data include accidental and occupational exposures, case-studies, clinical evaluations, epidemiological studies, and field and laboratory studies. Standardized neuropsychological tests, validated computer-assisted test batteries, neurophysiological and biochemical tests, and refined imaging techniques have been improved and become well established. The most extensive section reviews data derived from experimental animal models. Batteries of functional tests have been developed, validated and used extensively in neurotoxicological studies. Many different types of behavioural tests have been used to assess chemical-induced changes in sensory, motor and cognitive function, whereas neurophysiological measures have been standardized to assess chemical-induced sensory and motor function. The final chapter examines the steps involved in neurotoxicity risk assessment: hazard identification, dose-response assessment, exposure assessment and risk characterization. The application of risk assessment principles for neurotoxicants is similar to that of other non-cancer end-points, except that issues of reversibility, compensation and recovery of function in the nervous system require special consideration. This document provides guidance on neurotoxicity risk assessment at a broad international level.

Putting Health into Place draws together original works that collectively argue for a reinvention of medical geography. There is a growing interest worldwide in relationships between human health and the experience of place, an interest driven both by developments in sociocultural theory and observed health concerns. This book is a resource for those wishing to explore or to teach beyond the frontiers of conventional medical geography. As the first word of the book's title suggests, this is an active volume, one that contributes to situating health in the simultaneously tangible, negotiated, and experienced realities of place. Robin A. Kearns and Wilbert M. Gesler argue that medical issues are a necessary but insufficient focus in developing geographies of health and healing. This contention is supported by the authors of the thirteen substantive chapters who convey research findings from the Americas, Britain, and the Pacific. This book represents a collective commitment to exploring links between social and cultural theory, ideas about place, and discourses on health that will be of interest to readers across the social and health sciences.

This book offers an up-to-date guide to the concepts, procedures, statistical methods and models used to assess human exposure to environmental chemicals. Noting that exposure assessment is a comparatively new discipline of the environmental sciences, the book aims to encourage its use as a powerful tool for measuring actual levels of exposure and determining whether interventions are needed to protect public health. With this goal in mind, the book gives researchers expert advice on the design and conduct of studies, the interpretation of findings, and the best methods for ensuring the reliability and reproducibility of results. Throughout, emphasis is placed on the ways in which well-designed exposure assessments can enhance the practical value of findings from traditional epidemiological and toxicological investigations. The book has twelve chapters. The first six cover conceptual and methodological issues. Chapter one introduces basic concepts used in exposure assessment, and describes direct and indirect methods of measuring or estimating actual exposure and determining whether intervention is required. The uses of human exposure data are covered in chapter two, which explains how studies of human exposure can reduce the uncertainty of estimates used in epidemiology, risk assessment and risk management. Chapter three considers several generic study designs and approaches, and compares their advantages and limitations. Chapter four, on statistical methods, discusses selective applications of descriptive and inferential statistics, using data on lead exposure as an example. Subsequent chapters review methods for the collection and application of time-use data and introduce the principles, methods and data requirements of exposure modeling. Against this background, chapters in the second half of the book offer practical advice on the design and conduct of studies aimed at assessing exposure to chemicals in different environmental media. Separate chapters describe sampling methods used to analyze chemical concentrations in air, water, and food, and in soil and settled dust. Environmental allergens that can contribute to disease or alter susceptibility are considered in chapter nine, which concentrates on methods for measuring particles from house dust mites and their feces, allergens from pets and cockroaches, and allergens or toxins from fungi, bacteria and pollen. Subsequent chapters describe the use of biological markers in exposure assessment, and discuss issues surrounding the quality assurance of exposure studies and results. The final chapter presents brief summaries and examples of exposure studies in order to illustrate different study designs for different objectives, target pollutants, and populations. Studies that show how exposure assessment supports epidemiology and risk management, particularly in developing countries, are also included.

Summarizes current understanding of the complex interactions between chemicals, the immune system, and target organs that lead to manifestations of allergic hypersensitivity and autoimmunity. Noting that the incidence of allergic disorders has increased significantly in many countries, the book responds to the urgent need to improve methods for detecting potential allergens and predicting their effects in both individuals and populations. The need for better preventive strategies and therapeutic options is also considered, particularly in view of the high costs of allergic disorders in terms of health care and time lost from work. Addressed to researchers, the book concentrates on what is known about the mechanisms of sensitization and autoimmunity elicited by numerous industrial chemicals, adjuvant environmental factors, such as air pollution, tobacco smoke, and ultraviolet radiation, and food allergens with a proven involvement of the immune system. Although a large number of allergies are covered, particular attention is given to asthma and contact dermatitis as major occupational diseases undergoing intensive investigation. Throughout, a special effort is made to identify lines of investigation that will lead to a better understanding of fundamental mechanisms and thus improve the prospects for treatment and prevention. Over 1000 references to the literature are included. The book opens with a detailed explanation of the structure and functional processes of the immune system, followed by a discussion of the mechanisms by which chemicals can disrupt these functions. Also discussed are fundamental concepts of immunosuppression, immunodeficiency, and immunological tolerance that helpexplain the mechanistic basis of sensitization, allergic responses, and autoimmunity. Chapter two provides an overview of mechanisms involved in four major types of hypersensitivity and in autoimmunity. Mechanisms are illustrated with examples of diseases - from occupational asthma, through myasthenia gravis, to chronic beryllium disease - where exposure to environmental chemicals might play a role. The numerous hypotheses put forward to explain the mechanisms of autoimmune reactions are also critically assessed. Factors influencing allergenicity are covered in chapter three, which concentrates on the many complex endogenous and exogenous factors that govern the induction of allergic responses. Against this background, chapter four discusses clinical aspects of the most important allergic diseases. These include allergic contact dermatitis, atopic eczema, allergic rhinitis and conjunctivitis, allergic asthma caused by contact with chemicals, food allergy, and autoimmune diseases associated with drugs, chemicals, and environmental factors. Each disease is profiled in terms of its epidemiology, clinical manifestations, etiology, pathogenesis, diagnosis, and strategies for treatment and prevention. The remaining chapters review the epidemiology of asthma and allergic disease, including trends over time in different geographical regions, describe procedures for hazard identification through the demonstration of allergenicity, and explain how the principles of risk assessment can be applied to allergy. The book concludes with a glossary of terms, followed by 15 precise recommendations for the protection of human health and a list of priorities for further research.

This book evaluates the risks to human health and the environment posed by exposure to copper, a malleable metal found naturally in a wide variety of mineral salts and organic compounds, and in the metallic form. Copper is an essential element for all biota. It is widely used in cooking utensils and water distribution systems, in fertilizers, bactericides, fungicides, algicides, and antifouling paints, and in animal feed additives and growth promoters. Industrial applications include use as an activator in froth flotation and sulfide ores, in the production of wood preservatives, in electroplating, and in the manufacturing of azo-dyes.

A state-of-the-art review of methods and procedures for assessing the risks to human health posed by environmental chemicals. Addressed to regulatory authorities, risk managers and other decision-makers, the book aims to demystify the principles of risk assessment and thus encourage wider use of this powerful tool for protecting populations. Since the detection of chemical hazards may have socioeconomic and political consequences, the book gives particular attention to methods for the accurate identification of risks and determination of their severity. The book has four chapters covering each logical step in the process of risk assessment. The first, on hazard identification, explains how data on a chemical's toxicity and mode of action can be used to determine whether the chemical will cause adverse effects on health. The strengths and limitations of different types of data are discussed together with criteria commonly used to establish causality. Methods for assessing dose-response relationships are reviewed in chapter two, which explains how to characterize the relationship between the dose administered or received and the incidence of an adverse effect. Exposure assessment is covered in the next chapter, which describes methods for determining the nature and extent of contact with chemical substances and discusses the characteristics of exposure in the general environment, in the workplace, and from consumer products. The final chapter explains the procedure of risk characterization as a decision-making tool that brings together estimates of exposure levels and risks and summarizes sources of uncertainty in the scientific data. Practical options for risk management are presented asa range of regulatory, non-regulatory, economic, and technological measures.