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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Enzymology
Proteomics in Biology, Part B, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in proteomics.
Volume 45 of Advances in Enzyme Regulation is the proceedings of
the 45th International Synthesis in Normal and Neoplastic Tissues
held at Indiana University School of Medicine Indianapolis, Indiana
September 27-28, 2004.
A direct spinoff of the Advances in Enzyme Regulation journal this
internationally acclaimed series reports progress at the cutting
edge in the strategic area of regulation at the molecular level. In
an integrated presentation of original papers, leading scientists,
Nobel Prize winners and other outstanding experts from many
countries review the best research produced each year and evaluate
what is newest and what promises to be the most important in
clinical and basic investigations.
Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions Part A & B, are the latest volumes in the Methods in Enzymology series, continuing the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods centered on the use of Electron Paramagnetic Resonance (EPR) techniques to study biological structure and function.
This volume contains papers of 23 outstanding scientists who are working at the leading edge of metabolic regulation studies. Much of the volume focuses on novel aspects of signal transduction with emphasis on the role of phospholipase C in cell control mechanisms.
Volume 42 lives up to its goal of advancing a few steps ahead of the general front of mammalian enzymic and metabolic regulation studies. This volume contains papers of 25 outstanding scientists working at the cutting edge of metabolic regulation. Much of the volume focuses on novel aspects of signal transduction with an emphasis on nuclear expression.
The largest collection of articles on the three major gene
families, this work ranges from enzymology to molecular biology to
physiological implications. The three gene families are related in
that the enzymes catalyse the NAD(P) dependent oxidation or
reduction of carbonyl containing substrates. The substrates are
important in diverse areas such as alcoholism, diabetes and cancer
related problems as well as simple detoxification. The scope of the
chapters, contributed by leading international scientists, is wide
and covers gene regulation to enzyme mechanisms and protein
structure. This is the only publication dealing in such depth with
just three gene families. An important reference for researchers in
toxicology and molecular biology.
Immunoassay techniques have become essential in various fields of
pure and applied research. This volume of the well known
"Laboratory Techniques" series will be of assistance to those who
have plans or are making efforts to develop ultrasensitive enzyme
immunoassays for antigens and antibodies.
Glutathione S-Transferases: Structure and Mechanism of an Archetypical Detoxication Enzyme (R. Armstrong). Regulation of Cholesteryl Ester Hydrolases (D. Hajjar). The New Biology of Adenosine Receptors (T. Palmer & G. Stiles). Microtubule Dynamics: Bioenergetics and Control (D. Purich & J. Angelastro). Expression of the α-Crystallin/Small Heat-Shock Protein/Molecular Chaperone Genes in the Lens and Other Tissues (C. Sax & J. Piatigorsky). Phosphoenolpyruvate Carboxykinase (GTP): The Gene and the Enzyme (R. Hanson & Y. Patel). Indexes.
RNA Modification provides a useful examination of the science and its role in biological regulation, the current frontier of life science research, and includes various RNA modications and their role in gene expression. It represents the most up-to-date knowledge and protocols available today.
The continuation of an annual series, Enzymology and Molecular Biology of Carbonyl Metabolism is the largest collection of articles on the three major gene families. The scope of the chapters, contributed by leading international scientists, is wide and covers gene regulation to enzyme mechanisms and protein structure. This is the only publication dealing in such depth with just three gene families. It is an important reference for researchers in toxicology and molecular biology.
In the past 35 years, the use of commercial enzymes has grown from
an insignificant role in the food industry to an important aspect
of food processing. This Third Edition of Enzymes in Food
Processing explores recent and extensive changes in the use of
enzymes as well as the discovery of new enzymes and their uses.
Included in the book is a history of the role of enzymes in food
processing, enzyme characterization, a discussion of different
classes of enzymes including lipases and proteases, commercial
enzyme production, and the processing of particular foods such as
meat, vegetables, fruit, baked goods, milk products, and beer.
Unlike earlier editions, it provides basic information on enzymes
and their uses not adequately described in the current literature.
Food technologists will find in this edition a description of the
properties of those enzymes that are important in food processing,
as well as a description of the properties of those enzymes that
are important in food processing, as well as a description of the
many applications of enzymes in the foods processing industry. The
book is intended for food technologists, and will be of value to
the microbiologist and enzyme chemist as well. This treatise
provides a comprehensive treatment of enzymes used in food
processing.
Science is on the cusp of a revolutionary breakthrough. We now understand more about ageing - and how to prevent and reverse it - than ever before. In The Telomerase Revolution, Dr Michael Fossel, who has been at the cutting edge of ageing research for decades, describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to intervene in age-related disease, dramatically extend life spans and even reverse human ageing. Telomerase-based treatments are already on offer, and have shown early promise, but much more potent treatments will become available over the next decade. This is the definitive work on the latest science of human ageing, covering both the theory and the clinical implications, taking readers to the forefront of one of the most remarkable advances in human medicine.
In an intriguing series of experiments carried out many years ago, a common scientific belief, feted by no less than three Nobel prizes, was brought into question. The observations were about proteins-the molecules that the genetic code specifies and that are in one way or another central to all of life's activities. The experiments however were not about what proteins do, but how they are moved, in particular how they are moved from where they are made to where they act. The results of these studies conflicted with the standard view of how this happens, and thus became controversial. The standard view, the vesicle theory of protein secretion, envisions proteins being carried within and out of cells en masse in membrane-bound sacs or vesicles. The controversial experiments demonstrated that to the contrary individual protein molecules cross the relevant membranes as a result of their own motion. This was thought to be impossible at the time. Proteins Crossing Membranes is a personal narrative that tells the story of the controversy. Among other things, the author illustrates that scientists, like the rest of us, can rigidly hold onto their beliefs despite evidence that they are misguided. Key Features Reviews the data in support and critical of the vesicle theory of protein secretion Explores the ways scientists respond to evidence that challenges a favored theory Documents the author's personal experiences in this conflict-laden situation
Biological catalysis plays a dominant role both in fermentation and industrial process chemistry. This collection of chapters, written by a well-known biochemist and enzymologist, should serve as an invaluable reference to those investigators seeking to optimize the application of enzymatic catalysis for commercial purposes.
This book comprises a total of fourteen chapters contributed by experts from different countries across the globe. The book is divided into five sections containing two to three chapters each. It is a comprehensive collection of articles that give an overview of microbial catalysts which include enzymes that contribute to many fields and are widely used in industrial products. Microorganisms have served and continue to serve as one of the largest and useful sources of many enzymes used in foods and the food industry. Microbial catalysts are environmentally friendly and consume lower energy. A particular focus of this book is on applied and industrial microbiology, agricultural microbiology, and food microbiology. All of the sections discuss microbial catalysts, enzymes with respect to their function and their benefits to humankind in general, and biotechnology as a subject of which enzymology is an integral part. This book deals also with the structure and function of some microbial enzymes. Microbial catalysts are generally preferred than plants and animals as sources of industrial enzymes because their production cost is low. In addition, their enzyme content is more predictable and controllable, and more so because of the easy availability of raw materials with constant composition for their cultivation.
Alexander Todd, the 1957 Nobel laureate in chemistry is credited with the statement: "where there is life, there is phosphorus". Phosphorus chemical biology underlies most of life's reactions and processes, from the covalent bonds that hold RNA and DNA together, to the making and spending 75 kg of ATP every day, required to run almost all metabolic and mechanical events in cells. Authored by a renowned biochemist, The Chemical Biology of Phosphorus provides an in-depth, unifying chemical approach to the logic and reactivity of inorganic phosphate and its three major derivatives (anhydrides, mono- and diesters) throughout biology to examine why life depends on phosphorus. Covering the breadth of phosphorus chemistry in biology, this book is ideal for biochemistry students, postgraduates and researchers interested in the chemical logic of phosphate metabolites, energy generation, biopolymer accumulation and phosphoproteomics.
Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally 'difficult to target' proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.
This volume aims to provide an in-depth view of the complete biochemistry of sulfur with an emphasis on aspects not covered elsewhere. Given its role in the formation of proteins and presence in the amino acids methionine and cysteine, sulfur is essential to life. Current literature on the biochemistry of sulfur is vast and widely dispersed, as such this volume is intended as a single-source for everything concerning sulfur biochemistry from metabolic roles of inorganic sulfur, to thiol and thioether chemical biology, to the university of cysteine chemistry in proteomes. Authored by a renowned biochemist and experienced writer and educator, this book is ideal for students and researchers in biochemistry, biology and the life sciences with an interest in sulfur and its role in life.
Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in understanding the functions of glycans. However, limited accessibility of glycans is a major obstacle to the functional glycomics study. Although isolation from biology samples provided some structures, the low abundance of glycans obtained and the difficulty in complete structural assignment restricted the subsequent assay. To circumvent this limitation, many synthetic strategies, including chemical, enzymatic and chemo-enzymatic ones have been developed to make libraries of structurally defined complex glycans available. The glycans provided by these techniques combined with high-throughput glycoarray techniques have broadened and deepened our understanding about functional glycomics. The aim of this book is to provide a comprehensive review of the current state of the synthetic glycome and a brief introduction of the application of the synthetic glycome in glycoarray assay. Accordingly, synthetic strategies toward generating glycans with comprehensive structures as well as the glycoarrays to unveil the glycan functions are described in this book.
Ubiquitination and Protein Stability - Part A Volume 618, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapter written by an international board of authors. Topics of note in this new release include the Preparation of ubiquitinated nucleosomes with native and non-hydrolyzable linkages, Methods to measure ubiquitin chain length and linkage, Genetic approaches to study the yeast ubiquitin system, Enzymatic preparation of monoubiquitinated proteins, Methods to distinguish the function of ubiquitin in autophagy and the proteasome pathway, the Purification and characterization of enzyme activity of USPs, and much more.
Chemokines, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in chemokines, and includes sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokines, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies.
Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions Part A & B, are the latest volumes in the Methods in Enzymology series, continuing the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods centered on the use of Electron Paramagnetic Resonance (EPR) techniques to study biological structure and function. |
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