Synthetic Glycomes (Hardcover)

Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in understanding the functions of glycans. However, limited accessibility of glycans is a major obstacle to the functional glycomics study. Although isolation from biology samples provided some structures, the low abundance of glycans obtained and the difficulty in complete structural assignment restricted the subsequent assay. To circumvent this limitation, many synthetic strategies, including chemical, enzymatic and chemo-enzymatic ones have been developed to make libraries of structurally defined complex glycans available. The glycans provided by these techniques combined with high-throughput glycoarray techniques have broadened and deepened our understanding about functional glycomics. The aim of this book is to provide a comprehensive review of the current state of the synthetic glycome and a brief introduction of the application of the synthetic glycome in glycoarray assay. Accordingly, synthetic strategies toward generating glycans with comprehensive structures as well as the glycoarrays to unveil the glycan functions are described in this book.

General

Imprint:	Royal Society of Chemistry
Country of origin:	United Kingdom
Series:	Chemical Biology, Volume 11
Release date:	April 2019
First published:	2019
Editors:	Wanyi Guan • Lei Li • Peng George Wang
Dimensions:	234 x 156 x 38mm (L x W x T)
Format:	Hardcover - Unsewn / adhesive bound
Pages:	469
ISBN-13:	978-1-78801-164-8
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins Books > Science & Mathematics > Biology, life sciences > Biochemistry > Carbohydrates Books > Science & Mathematics > Biology, life sciences > Biochemistry > Enzymology Books > Professional & Technical > Biochemical engineering > Biotechnology > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > General Promotions
LSN:	1-78801-164-3
Barcode:	9781788011648

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