A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.

This book is a comprehensive guide to occupational factors of malignant diseases. It discusses potentially work-related malignancies, in the context of exposure assessment, specific clinical and pathological features of occupational cancer and biomarkers of exposure and disease. Epidemiological data about risk ratios of the cancer in question are reviewed for various occupations and with exposure to specific carcinogens, carcinogenic mechanisms, host susceptibility factors (genetic and other) and other environmental and life-style risk factors. Aspects such as surveillance of workers exposed to carcinogens and strategies for prevention of occupational cancer are also discussed. Occupational Cancers is aimed at oncologists, pathologists, residents in training, clinical researchers, clinicians in occupational health, epidemiologists, pulmonologists, lawyers and public health officials.

This book provides salient information on all aspects of influenza/flu viruses affecting animals and humans. It specifically reviews the properties and replication of influenza viruses; their evolution and emergence; epidemiology; role of migratory birds in disease transmission; clinical signs in humans, animals and poultry; pathogenesis and pathogenicity; public health importance and potential threats; diagnosis; prevention and control measures; and pandemic preparedness. Influenza/flu viruses evolve continuously and jump species causing epidemics as well as pandemics in both human and animals. During the past 150 years, various strains of influenza virus like the Spanish flu, Asian flu, Hong Kong flu, bird flu and swine flu were responsible for high mortality in humans as well as birds. High mutation rates, antigenic shifts, drifts, reassortment phenomena, and the development of antiviral drug resistance all contribute to ineffective chemotherapy and vaccines against influenza viruses. Due to their devastating nature, high zoonotic implications and high mortality in humans and poultry, they have a severe impact on the socioeconomic status of countries. Disease awareness, rapid and accurate diagnosis, surveillance, strict biosecurity, timely adoption of appropriate preventive and control measures and pandemic preparedness are crucial to help reduce virus transmission, thus reducing clinical cases, deaths and pandemic threats.

This book examines the issue of ethics in the context of the provision of military health care in an epidemic. Outbreaks of epidemics like Ebola trigger difficult ethical challenges for civilian and military health care personnel. This book offers theoretical reflections combined with reports from recent military and NGO missions in the field. The authors of this volume focus on military medical ethics adding a distinct voice to the topic of epidemics and infectious diseases. While military health care personnel are always crucially involved during disaster relief operations and large-scale public health emergencies, most of the current literature treats ethical issues during epidemics from a more general perspective without taking into account the specifics of the military context. The contributions in this volume provide first-hand insights into some of the ethical issues encountered by military health care personnel in missions during the Ebola outbreak in 2014/2015. This practical perspective is complimented by academic analyses and theoretical reflections on ethical issues associated with epidemics. This book will be of much interest to students of military studies, ethics and African politics.

Written by a team of international experts, this third edition designed to guide public health personnel or teams in any country that investigates reports of alleged waterborne illnesses. The manual is based on epidemiologic principles and investigative techniques that have been found effective in determining causal factors of disease incidence. The guidelines are presented in the sequence usually followed during investigations and are organized so that an investigator can easily find the information needed in any phase of an investigation. The book services as a guide to: * Develop a waterborne disease surveillance and emergency operations program * Handle illness alerts and water-related complaints that may be related to illness * Interview ill persons, those at risk, and controls * Develop a case definition * Transport water specimens and clinical specimens * Trace sources of contamination * Identify factors responsible for contamination, survival of pathogenic microorganisms or toxic substances, and/or propagation of pathogens * Collate and interpret collected data * Report information about the outbreak This edition has been extensively updated. A section has been added on water not intended for drinking as a source of illness. The chapter on "collection and analysis of data" has been significantly expanded to explain how data is collected and used to suggest possible vehicles, routes, and agents. The book is designed to improve the quality of investigation of outbreaks and disease surveillance. The International Association for Food Protection is a non-profit association of food safety professionals. Dedicated to the life-long educational needs of its Members, IAFP provides Members with an information network through its two scientific journals (Food Protection Trends and Journal of Food Protection), its educational Annual Meeting, international meetings and symposia along with international interaction between food safety professionals.

Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest. The structure of the analysis is such that it excludes studies of, for instance, nutrition, alcohol or street drug use and many other lifestyle factors where prospective information or independent register information is difficult or impossible to obtain. Epidemiology of Human Congenital Malformations culminates with a discussion on how the presence of malformations can be explained and various possibilities for the prevention of birth defects. Moreover, it will include a series of instructions on how to read epidemiological literature in this field making it an essential resource both for those currently working in the field of reproductive epidemiology or those intending to enter it. It will additionally be useful for doctors working with malformations, either as obstetricians, neonatologists or pediatricians.

This book is dedicated to Dr. Philip A. Schwartzkroin. The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written by leaders in the field who have years of experience and individuals with diverse expertise, articles are likely to have a long-lasting impact and be relevant for both epileptologists and neuroscientists. Authors address topics that are important, unresolved questions in the field of epilepsy research, drawing on available data from both the bench and the clinic to support their points. A given topic is addressed by one or more authors, each writing from his/her own unique perspective. For all of the individuals who have been trained or worked with Philip Schwartzkroin in the past and/or have appreciated his contributions to the epilepsy field, this volume is an excellent way to celebrate his achievements and look to the ways they have moved the field forward and continue to stimulate its growth.

After graduating from Tripoli, Libya in 1990, Dr Benamer came to the United Kingdom in 1991 to further his training in medicine. He obtained the MRCP in 1994 and trained in neurology in Glasgow. He obtained a PhD and CCST in 2000 and was appointed a consultant neurologist in Wolverhampton and Birmingham the same year. He has been the lead neurologist in New Cross Hospital in Wolverhampton since 2006. Dr Benamer is a general neurologist with special interest in movement disorders. Dr Benamer is honorary clinical senior lecturer in Birmingham University and has an interest in medical education, in which he obtained a postgraduate certificate from Keele University in 2007. He has published more than 35 papers and two books. He is currently a senior editor of the Libyan Journal of Medicine. He was also an examiner of the MRCP Diploma from 2005 to 2009. Dr Benamer's publications relevant to the subject of the book: 1. Benamer HT. 2007. Neurological disorders in Libya: an overview. Neuroepidemiology 29:143-9 2. Benamer HT. 2008. The ancestry of LRRK2 Gly2019Ser parkinsonism. Lancet neurology 7:769-70; author reply 70-1 3. Benamer HT, de Silva R, Siddiqui KA, Grosset DG. 2008. Parkinson's disease in Arabs: a systematic review. Movement disorders: official journal of the Movement Disorder Society 23:1205-10 4. Benamer HT, Ahmed ES, Al-Din AS, Grosset DG. 2009. Frequency and clinical patterns of multiple sclerosis in Arab countries: a systematic review. Journal of the neurological sciences 278:1-4 5. Benamer HT, Grosset D. 2009. Stroke in Arab countries: a systematic literature review. Journal of the neurological sciences 284:18-23 6. Benamer HT, Grosset DG. 2009. A systematic review of the epidemiology of epilepsy in Arab countries. Epilepsia 50:2301-4 7. Benamer HT, Shakir RA. 2009. The neurology map of the Arab world. Journal of the neurological sciences 285:10-2 8. Benamer HT. 2010. Neurology expertise and postgraduate training programmes in the Arab world: a survey. European neurology 64:313-8 9. Benamer HT, de Silva R. 2010. LRRK2 G2019S in the North African population: a review. European neurology 63:321-5 10. Benamer HT, Deleu D, Grosset D. 2010. Epidemiology of headache in Arab countries. The journal of headache and pain 11:1-3 11. Benamer HT. 2011. More epidemiological studies of neurological disorders are needed in the Arab countries. Neuroepidemiology 36:70.

This is a text in methods of applied statistics for researchers who design and conduct experiments, perform statistical inference, and write technical reports. These research activities rely on an adequate knowledge of applied statistics. The reader both builds on basic statistics skills and learns to apply it to applicable scenarios without over-emphasis on the technical aspects. Demonstrations are a very important part of this text. Mathematical expressions are exhibited only if they are defined or intuitively comprehensible. This text may be used as a self review guidebook for applied researchers or as an introductory statistical methods textbook for students not majoring in statistics.​ Discussion includes essential probability models, inference of means, proportions, correlations and regressions, methods for censored survival time data analysis, and sample size determination. The author has over twenty years of experience on applying statistical methods to study design and data analysis in collaborative medical research setting as well as on teaching. He received his PhD from University of Southern California Department of Preventive Medicine, received a post-doctoral training at Harvard Department of Biostatistics, has held faculty appointments at UCLA School of Medicine and Harvard Medical School, and currently a biostatistics faculty member at Massachusetts General Hospital and Harvard Medical School in Boston, Massachusetts, USA. 

This volume presents a systems approach to understanding and managing the AIDS crisis - an approach that addresses the needs not only of HIV- infected individuals, but also of families and communities at risk from AIDS. Discussions are included on HIV epidemiology and risk reduction, medical management of the AIDS patient, and neuropsychiatric aspects of HIV infection. Strategies for psychotherapeutic intervention, from individual through group to extended family system, are described in detail. The authors examine spiritual, religious and cultural factors in communities and offer guidelines for building a community network for AIDS prevention and intervention. Full consideration is also given to ethical and policy issues, and to the risks faced by health care providers. First published in 1993. Routledge is an imprint of Taylor & Francis, an informa company.

Custom-designed for clinicians on the frontline of treatment and prevention of the human papillomavirus (HPV), this stand-alone handbook provides the scientific background needed to understand and administer the new HPV vaccines. Written by some of the discoverers of these vaccines, this accessible text explores the biology and epidemiology of HPV, its diagnosis, screening, prevention, and treatment, and the types of diseases linked to the virus. The Guide to Genital HPV Diseases and Prevention: * aids clinicians in addressing patient questions and concerns * discusses the basic virology and pathogenesis of HPV * explores the relationship between HPV and cancer, especially cancer of the cervix * covers the various treatment methods, including both chemical and physical methods * details prevention strategies, such as condoms and microbicides, and vaccines (Gardasil, Cervarix, Silgard, and those in development) * is an essential reference for an array of clinicians, including family practice physicians, internal medicine specialists, pediatricians, dermatologists, gynecologists, and oncologists

This concise volume analyzes the potential for the workplace environment-where so many people spend so much of their day-to improve workers' capacity for health and wellness. It pinpoints the link between sedentary lifestyles and poor health, and explores the role of office spatial design in encouraging physical activity to promote physical activity, health and prevent disease. The featured research study tracks workers' movement in a variety of office layouts, addressing possible ways movement-friendly design can co-exist with wireless communication, paperless offices, and new corporate concepts of productivity. From these findings, the author's conclusions extend public health concepts to recognize that influencing population-wide levels of activity through office architectural design alone may be possible. This SpringerBrief is comprised of chapters on : Physical activity and disease: Theory and practice Space-use and the history of the office building Identifying factors of the office architectural design that influence movement, Interdisciplinary research methods in studying worker physical activity, decision-making and office design characteristics The KINESIS model for simulating physical activity in office environments The questions and potential for solutions in Workplace Environmental Design in Architecture for Public Health will interest and inform researchers in interdisciplinary topics of public health and architecture as well as graduate and post-graduate students, architects, economists, managers, businesses as well as health-conscious readers.

Diet is a major factor in health and disease. Controlled, long-term studies in humans are impractical, and investigators have utilized long-term epidemiological investigations to study the contributions of diet to the human condition. Such studies, while valuable, have often been limited by contradictory findings; a limitation secondary to systematic errors in traditional self-reported dietary assessment tools that limit the percentage of variances in diseases explained by diet. New approaches are available to help overcome these limitations, and Advances in the Assessment of Dietary Intake is focused on these advances in an effort to provide more accurate dietary data to understand human health. Chapters cover the benefits and limitations of traditional self-report tools; strategies for improving the validity of dietary recall and food recording methods; objective methods to assess food and nutrient intake; assessment of timing and meal patterns using glucose sensors; and physical activity patterns using validated accelerometers. Advances in the Assessment of Dietary Intake describes new avenues to investigate the role of diet in human health and serves as the most up-to-date reference and teaching tool for these methods that will improve the accuracy of dietary assessment and lay the ground work for future studies.

This book will be of interest to readers active in the fields of survival analysis, genetics, ecology, biology, demography, reliability and quality control. Since Sir David Cox's pioneering work in 1972, the proportional hazards model has become the most important model in survival analysis. The success of the Cox model stimulated further studies in semiparametric and nonparametric theories, counting process models, study designs in epidemiology, and the development of many other regression models that could offer more flexible or more suitable approaches in data analysis. Flexible semiparametric regression models are increasingly being used to relate lifetime distributions to time-dependent explanatory variables. Throughout the book, various recent statistical models are developed in close connection with specific data from experimental studies in clinical trials or from observational studies.

It is now forty years since the discovery of AIDS, but its origins continue to puzzle doctors, scientists and patients. Inspired by his own experiences working as a physician in a bush hospital in Zaire, Jacques Pepin looks back to the early twentieth-century events in central Africa that triggered the emergence of HIV/AIDS and traces its subsequent development into the most dramatic and destructive epidemic of modern times. He shows how the disease was first transmitted from chimpanzees to man and then how military campaigns, urbanisation, prostitution and large-scale colonial medical interventions intended to eradicate tropical diseases combined to disastrous effect to fuel the spread of the virus from its origins in Leopoldville to the rest of Africa, the Caribbean and ultimately worldwide. This is an essential perspective on HIV/AIDS and on the lessons that must be learned as the world faces another pandemic.

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses. Book Sections Classical designs and causal inference, measurement error, power, and small-sample inference Designs that use full-cohort information Time-to-event data Genetic epidemiology About the Editors Ornulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic. Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology. Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies. Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology. Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data. Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.

Global Health continues to provide readers with a comprehensive, up-to-date and thought-provoking outline and understanding of the constantly evolving global health landscape. In this new edition the authors have maintained the successful structure and organisation of the previous edition to examine and explain recent health changes and consider likely future patterns. New or expanded topics covered include: emerging and re-emerging infectious disease threats increasing awareness of, and interest in, antimicrobial resistance and superbugs terrorism, global conflict and health the new UN 2030 Agenda for Sustainable Development the drive for Universal Health Coverage (UHC) the use of information technology in global health substance abuse palliative and end-of-life-care ethical issues in global health. Using clear and original explanations of complex issues, this text makes extensive use of boxed case studies and international examples, with discussion questions posed for readers at the end of each chapter. Readers will also be able to take advantage of the new website that was designed to complement this book. Global Health is essential reading for students and researchers of global health, public health and development studies.

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

This textbook on statistics is written for students in medicine, epidemiology, and public health. It builds on the important role evidence-based medicine now plays in the clinical practice of physicians, physician assistants and allied health practitioners. By bringing research design and statistics to the fore, this book can integrate these skills into the curricula of professional programs. Students, particularly practitioners-in-training, will learn statistical skills that are required of today’s clinicians. Practice problems at the end of each chapter and downloadable data sets provided by the authors ensure readers get practical experience that they can then apply to their own work. 

This book describes the growing body of information on the epidemiology, clinical manifestations, transmission, pathogenesis, diagnosis, and treatment of Kingella kingae infections in young children. In addition, it covers experimental methods that have been developed to study the microbiology, genetics, and virulence factors of K. kingae, information that provides the foundation for new approaches to treatment and prevention of K. kingae disease. With this content in mind, excerpts from the book will be of relevance for clinicians who care for pediatric patients, for clinical microbiologists who are involved in detecting organisms in clinical specimens, and for scientists who are studying K. kingae in an effort to develop novel targets for antimicrobial therapy and new approaches to prevention. First isolated in the 1960s by Elizabeth O. King, a bacteriologist at the CDC, Kingella kingae was largely ignored over the next two decades as a human pathogen because of its uncommon recovery from patients with disease. However, in recent years K. kingae has been increasingly recognized as a clinically important pathogen in young children, and is currently recognized as the leading cause of osteoarticular infections in young children in a growing number of countries. Research into this organism has grown tremendously over the past 15 years, resulting in a better appreciation of the importance of K. kingae in pediatric patients and of the molecular mechanisms of disease.

Comparative effectiveness research (CER) is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care (IOM 2009). CER is conducted to develop evidence that will aid patients, clinicians, purchasers, and health policy makers in making informed decisions at both the individual and population levels. CER encompasses a very broad range of types of studies-experimental, observational, prospective, retrospective, and research synthesis. This volume covers the main areas of quantitative methodology for the design and analysis of CER studies. The volume has four major sections-causal inference; clinical trials; research synthesis; and specialized topics. The audience includes CER methodologists, quantitative-trained researchers interested in CER, and graduate students in statistics, epidemiology, and health services and outcomes research. The book assumes a masters-level course in regression analysis and familiarity with clinical research.

This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed “nutrition and cancer� from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the “omics�) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions.

This is a monograph on the concept of residual life, which is an alternative summary measure of time-to-event data, or survival data. The mean residual life has been used for many years under the name of life expectancy, so it is a natural concept for summarizing survival or reliability data. It is also more interpretable than the popular hazard function, especially for communications between patients and physicians regarding the efficacy of a new drug in the medical field. This book reviews existing statistical methods to infer the residual life distribution. The review and comparison includes existing inference methods for mean and median, or quantile, residual life analysis through medical data examples. The concept of the residual life is also extended to competing risks analysis. The targeted audience includes biostatisticians, graduate students, and PhD (bio)statisticians. Knowledge in survival analysis at an introductory graduate level is advisable prior to reading this book.

With this book, Siegel, an internationally known demographer and gerontologist, has made a unique contribution to the fledgling fields of health demography, and the demography and epidemiology of aging. The book represents a felicitous union of epidemiology, gerontology, and demography, and appears to be the first and only comprehensive text on this subject now available. Drawing on a wide range of sciences in addition to demography, gerontology, and epidemiology, including medical sociology, biostatistics, public policy, bioethics, and molecular biology, the author treats theoretical and applied issues, links methods and findings, covers the material internationally, nationally, and locally, and while focusing on the elderly, treats the entire life course. The methods, materials, and pespectives of demography and epidemiology are brought to bear on such topics as the prospects for future increases in human longevity, the relative contribution of life style, environment, genetics, and chance in human longevity, the measurement of the share of healthy years in total life expectancy, the role of population growth in the rising costs of health care, and the applications of health demography in serving the health needs of local communities. The separate chapters systematically develop the topics of the sources and quality of health data; mortality, life tables, and the measurement of health status; the interrelationships of health, on the one hand, and mortality, fertility, migration, and age structure, on the other; health conditions in the less developed countries; the concepts and theories of aging and projections of the aged population; and local health applications, public health policy, and bioethical issues in health demography. Given its comprehensiveness, clarity, interdisciplinary scope, and authencity, this book appeals to a wide range of users, from students and teachers of medical sociology, the demography of aging, and public health studies to practitioners in these areas, both as a text in health demography and the demography/epidemiology of aging, and as a reference work in these fields.

This textbook provides a coherent introduction to the main concepts and methods of one-parameter statistical inference. Intended for students of Mathematics taking their first course in Statistics, the focus is on Statistics for Mathematicians rather than on Mathematical Statistics. The goal is not to focus on the mathematical/theoretical aspects of the subject, but rather to provide an introduction to the subject tailored to the mindset and tastes of Mathematics students, who are sometimes turned off by the informal nature of Statistics courses. This book can be used as the basis for an elementary semester-long first course on Statistics with a firm sense of direction that does not sacrifice rigor. The deeper goal of the text is to attract the attention of promising Mathematics students.