With the thorough understanding of stem cell biology and the advent of targeted therapeutics for cancer, stem cell-based therapeutic strategies are being increasingly explored for the treatment of various cancer types."Mesenchymal Stem Cells in Cancer Therapy" sheds light on current stem cell based targeted therapies for cancer, by focusing on the application of mesenchymal stem cells (MSC) in various cancers with emphasis on a number of aspects that are critical to the success of future stem cell based therapies for cancer. Sections of this publicationare devoted to developing stem cell based therapies for cancer with the main focus on tumoritrophic properties of stem cells, engineering targeted therapeutics, utilization of imaging techniques and the recent combination studies utilizing currently employed therapeutics with stem cells."Mesenchymal Stem Cells in Cancer Therapy"informs readers about critical and cutting edge stem cell therapies for cancer and also enables them to appreciate the vast plain of unresolved questions in stem cell research for cancer therapeutics.
Includes biological foundation on key sources of mesenchymal stem cells and the various ways they can be utilized to treat cancer.Provides examples of current MSC based cancer therapies and prospects for the future with insights from the leading lab on cancer cell therapies.Technically advanced topic written for widespread understanding for clinical and research audiences."

How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.

Cardiovascular disease has evolved into an epidemic health concern. During the past decades, considerable effort has been made to develop novel and safer therapeutic options. Gene therapy has offered much renewed hope and instigated the present book. For the treatment of cardiovascular disease gene therapy has risen to an interesting and important point of view of curing disease. Although most of the studies are still experimental beneath a well defined number of clinical studies, more and more studies are designed to be carried out in humans. Based on a rich compilation of scientific as well as clinical studies around the world, this book gives insights into the general principles of gene transfer as well as therapeutic strategies including stem cell therapy as an alternative approach to gene therapy.

Stem cells are the building blocks of the body and can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer's and Parkinson's disease and many others. This book provides an overview and in-depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that went through a peer-review process.

This book presents and discusses current research in the study of stem cell therapy. Topics discussed include stem cell-based therapies; current therapies for multiple sclerosis; stem cell transplantation modulates mRNA gene expression profile in doxorubicin-induced cardiomyopathy; human somatic cell nuclear transfer and parthenogenesis; human cord blood stem cell applications in cell therapy; cancer stem cells and neurotrophin in obstetrics and gynaecology.

Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This book offers important research from around the globe dedicated to this dynamic subject.

The creation of the science on stem cells and development of its theoretical bases is a prevalent topic today, taking into account comparative evolutionary cell biology and the cardinal problem of the developmental biology. This allows revealing correlations and studying correlative dependencies of various structures at different levels of biohierarchy. The creation of every science is impossible without the application of methodology. This book examines the system of non-traditional ideas about the nature and role of stem cells in ontogenesis, reproduction and evolution of plants. The main properties of plant stem cells have been developed, which has shown the integrity of morphogenous and reproductive processes at all stages of plant's life cycle.

Even as classic cytogenetics has given way to molecular karyotyping, and as new deletion and duplication syndromes are identified almost every day, the fundamental role of the genetics clinic remains mostly unchanged. Genetic counselors and medical geneticists explain the "unexplainable," helping families understand why abnormalities occur and whether they're likely to occur again. Chromosome Abnormalities and Genetic Counseling is the genetics professional's definitive guide to navigating both chromosome disorders and the clinical questions of the families they impact. Combining a primer on these disorders with the most current approach to their best clinical approaches, this classic text is more than just a reference; it is a guide to how to think about these disorders, even as our technical understanding of them continues to evolve. Completely updated and still infused with the warmth and voice that have made it essential reading for professionals across medical genetics, this edition of Chromosome Abnormalities and Genetic Counseling represents a leap forward in clinical understanding and communication. It is, as ever, essential reading for the field.

"The Forever Fix" is the first book to tell the fascinating story of gene therapy: how it works, the science behind it, how patients (mostly children) have been helped and harmed, and how scientists learned from each trial to get one step closer to its immense promise, the promise of a "forever fix," - a cure that, by fixing problems at their genetic root, eliminates the need for further surgery or medication.

Gene therapy has been regarded as a great potential for specific treatment of gene-related human diseases, such as cancer, genetic and epidemic diseases. Gene therapy refers to the biomedical technology that inserts normal or therapeutic exogenous genes into target cells to repair or replace defective genes in target cells, so as to achieve the purpose of treating diseases. Efficient gene delivery systems are the crucial roles for successful implementation of gene therapy. This book provides a platform for young scholars and students to systematically understand the preparation and characterization of the existing non-viral gene delivery systems, as well as providing a technology platform for clinical gene therapy

Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.