The Tohoku University Graduate School of Dentistry first introduced the concept of "Interface Oral Health Science", designed to establish and maintain healthy oral cavities, which are home to a number of mixed systems. Included in those systems are: (1) host tissues such as teeth, mucosa, muscle and bone, (2) parasites and microorganisms cohabiting the surfaces of the oral cavity and (3) biomaterials that are used for the rehabilitation of oral functions. In addition, (4) these systems are subject to severe and complex mechanical forces. Therefore, it is critical to promote dental studies that integrate a wide range of interdisciplinary research as medicine, agriculture, material science, engineering, and pharmacology. With this incentive, international symposiums for interface oral health science have been held several times in the past. The concept has since refined and expanded, the result being the "Biosis-Abiosis Intelligent Interface," and projects aiming at the creation of highly functional and autonomic intelligent interfaces are ongoing. This book brings together a number of studies on incentives and projects by leading authors. Topics include biosis-abiosis interface of dental implants, biomaterials in interface science, biomedical engineering interface and cell manipulation and tissue regeneration. Readers not only from the field of dentistry but also many related areas will find this book a valuable resource.

Anesthesia and Analgesia in Laboratory Animals focuses on the special anesthetic, analgesic, and postoperative care requirements associated with experimental interventions. Fully revised and updated this new edition provides the reader with agents, methods, and techniques for anesthesia and analgesia that ensure humane, reproducible, and successful procedural outcomes. The content is structured in six sections. The first deals with ethical, regulatory, and scientific considerations. Chapters in this section include US and international regulatory considerations, and optimization of anesthesia and analgesia. Part two is dedicated to the principles of anesthesia and analgesia with chapters covering topics in a non-species-specific way, but with a slant towards laboratory animals, including relevant pharmacology of the agents. Part three covers Anesthetic equipment and monitoring. Section four deals with periprocedural care including dedicated chapters to the assessment and management of pain in laboratory species. Part five provides practical considerations by species, including relevant anatomy, physiology, and behavior of a broad range of lab animal species. Part six closes the book with special topics covering management of chronic pain, fetus and neonate interventions, considerations for in-vivo imaging and the study of pain. Anesthesia and Analgesia in Laboratory Animals is the complete reference for veterinarians involved in lab animal research as well as senior graduate, graduate students, post-docs, and researchers who utilize animals in biomedical research.

are then selected and must meet the general 'biocompatibility' require ments. Prototypes are built and tested to include biocompatibility evalua tions based on ASTM standard procedures. The device is validated for sterility and freedom from pyrogens before it can be tested on animals or humans. Medical devices are classified as class I, II or III depending on their invasiveness. Class I devices can be marketed by submitting notification to the FDA. Class II and III devices require either that they show equivalence to a device marketed prior to 1976 or that they receive pre-marketing approval. The time from device conception to FDA approval can range from months (class I device) to in excess of ten years (class III device). Therefore, much planning is necessary to pick the best regulatory approach. 2. Wound Dressings and Skin Replacement 2.1 Introduction Wounds to the skin are encountered every day. Minor skin wounds cause some pain, but these wounds will heal by themselves in time. Even though many minor wounds heal effectively without scarring in the absence of treatment, they heal more rapidly if they are kept clean and moist. Devices such as Band-Aids are used to assist in wound healing. For deeper wounds, a variety of wound dressings have been developed including cell cultured artificial skin. These materials are intended to promote healing of skin damaged or removed as a result of skin grafting, ulceration, burns, cancer excision or mechanical trauma."

Developments in the field of instrumentation of innovative instrumentation. Although laser applications have permeated nearly every aspect are among the major contributions to human advancement. The history of surgery has seen of surgical therapy, the expectations have fre many revolutionary developments cause quantum quently been unrealistic and the evaluation of leaps in progress. Electrocautery, the anesthesia technological development has always been machine, computed axial tomography, and the painfully slow. The properties of vaporization, surgical microscope are all revolutionary in coagulation, and cutting unified in an invisible struments that have irrevocably changed the shaft of light have enabled the neurosurgeon to direction of neurological surgery. vaporize inaccessible tumors of brain and spinal In the early stages of application, there are cord, harness recalcitrant bleeding sites, and cut always detractors and valid controversy concern through the most formidable calcified tumors. ing the value of a new instrument. Some will The application of this new energy form in remember those who argued that the magnifica tandem with the surgical microscope has, in my tion and illumination provided by the micro opinion, extended the scope of all aspects of scope were not valuable to the skilled surgeon neurosurgery. We have much more work to do. and would prolong the operative time and in lt is necessary to document improved results and crease infection rates. Others may recall that demand technological advances and safe inno Cushing was told to abandon the blood pressure vations."

Principios de fisiopatologia quirurgica Actualmente, en la mayoria de las escuelas de Medicina y durante las residencias medicas, se acostumbra tener para cada materia, un libro de texto unico, el que frecuentemente es traducido de una lengua ajena al castellano. Los autores hemos pensado que el estudio de la Cirugia General, requiere no solo poder repetir algo escrito en una sola fuente de informacion, y menos que sea ajena a nuestro medio, sino que esta especialidad, al igual que las demas quirurgicas, obliga a un proceso ordenado de razonamiento, que dote al cirujano de una vision panoramica, basada en la informacion suficiente, que le permita entender el por que de las enfermedades a las que se enfrenta en su practica cotidiana. Esta obra, precisamente pretende sumarse al arsenal bibliografico del estudioso de la cirugia, para hacerle agradable el aprendizaje, dotarle de suficientes elementos para facilitar su quehacer cotidiano y, sin duda, proporcionarle no solo de principios para simplificar el proceso diagnostico, sino para justificar el tratamiento que le va a ofrecer a su paciente. Nos sentiremos mas que satisfechos si alcanzamos a despertar su curiosidad mas alla del contenido del texto, para verse obligado a complementarlo, con otras fuentes de informacion, asi como im genes, tratamientos, tecnicas quirurgicas etc.; es decir si logramos inquietarlo a seguirse preguntando por que? Pero...habremos, sin duda, superado nuestro proposito si ademas, conseguimos con ello, el que se maraville al descubrir los recovecos del inmenso universo que es la cirugia.

Recent advances in technology have opened up new possibilities in the diagnosis and treatment of cerebrospinal vascular diseases. It is now possible to use magnetic resonance imaging to map brain function and metabolism as an aid to diagnosis. Novel applications of magnetic resonance angiography allow three-dimensional imaging, and the magnetization transfer contrast technique gives us a new window on cerebral vascular function. This volume presents work in all these fields as well as previewing the techniques of endovascular surgery for cerebrospinal vascular diseases. These include modern stereotactic radiosurgery for arteriovenous malformations and for angiographically occult vascular malformations of the brain. This book presents an overview of the latest applications of technology to this rapidly developing and challenging field.

Speed and accuracy are the two most important qualities that candidates for the MRCS Viva are expected to demonstrate. Revision Notes for the MRCS Viva has been written to prepare candidates for this most daunting of exams. The book provides a comprehensive exam preparation tool for intercollegiate MRCS oral examinations. It is organised into two sections, the first devoted to chapters on basic sciences, the second to system specific surgery. Each chapter is broken down into topics most likely to appear in current examinations. For each topic, succinct notes provide candidates with a framework for answering the stem and secondary questions encountered in the exam.

The use oflasers has entered almost every facet of medicine and biology. Therefore, it is to be expected that the reviews contained in this vol urne will reflect this diversity. As dinical acceptance has grown with various diagnostic and therapeutic applications, so has the need for a more thorough understanding of the theoretical background for each. This is especially true where a correlation is to be made between the theoretical background and the experimental data. It is only in this way that we can attain the optimal form of any therapy. The basic coupling ofenergy into biological tissue and its conversion into heat is characterized by many parameters. One ofthe most important is pulse duration. The review by Bimgruber in Chapter 6 shows how our knowledge ofthis parameter has been extended.The need for a more basic understanding of the interaction of electromagnetic energy with various kinds of materials has led to investigations on the nature of plasmas their stability and instability, and how theyexist. Docchio reviews the factors that cause them to occur at a specific locale and then to move away from that site. The availabilityofmany types ofoptical fibers has extended our ability to deliver laser energy from various types oflasers into almost anyselected location. This is particularly useful in medicine, where less invasive ap proaches to surgery and diagnosis are always helpful. However, as Rol and his colleagues explain, the power-handling capabilities ofoptical fibers limit many applications, particularly for short-duration, high-peak-power laser pulses."

For Fear of Pain offers a social history of the operating room in Britain during the final decades of painful surgery. It asks profound questions: how could surgeons operate upon conscious patients? How could patients submit? It presents a revisionist view of surgery, hygiene, nursing, military and naval surgery and the introduction of anaesthesia.

In this issue of Surgical Clinics, guest editor Dr. John D. Horton brings his considerable expertise to the topic of Pediatric Surgery. Top experts in the field cover key topics such as management of anorectal malformations and Hirschsprung's disease; management of abdominal tumors; management of congenital diaphragmatic hernia; management of esophageal atresia and tracheoesophageal fistula; and more. Contains 16 relevant, practice-oriented topics including management of disorders of gut rotation; surgical support of the developmentally delayed/neurologically impaired child; management of intestinal failure and nutritional support; management of biliary atresia and biliary cysts; chest wall malformations and congenital lung lesions; and more. Provides in-depth clinical reviews on pediatric surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Complications of Female Incontinence and Pelvic Reconstructive Surgery reviews the prevention, evaluation and management of complications arising from female pelvic surgery. Potential complications of both routine and specialized female pelvic procedures such as transvaginal slings, cystocele and rectocele repairs, urethral diverticulectomy, and transvaginal mesh repairs are reviewed. The chapters are divided by procedure allowing the reader to easily find what they are looking for. Images and figures of methods of evaluation and repair of these complications are included throughout. The volume is organized based on the specific types of surgeries performed and the user is able to look up the type of surgery performed and immediately find all of the potential complications and their treatments. This text will serve as a comprehensive guide and reference allowing the surgeon quick and ready access to information about the complications of female pelvic surgery.

Principios de fisiopatologia quirurgica Actualmente, en la mayoria de las escuelas de Medicina y durante las residencias medicas, se acostumbra tener para cada materia, un libro de texto unico, el que frecuentemente es traducido de una lengua ajena al castellano. Los autores hemos pensado que el estudio de la Cirugia General, requiere no solo poder repetir algo escrito en una sola fuente de informacion, y menos que sea ajena a nuestro medio, sino que esta especialidad, al igual que las demas quirurgicas, obliga a un proceso ordenado de razonamiento, que dote al cirujano de una vision panoramica, basada en la informacion suficiente, que le permita entender el por que de las enfermedades a las que se enfrenta en su practica cotidiana. Esta obra, precisamente pretende sumarse al arsenal bibliografico del estudioso de la cirugia, para hacerle agradable el aprendizaje, dotarle de suficientes elementos para facilitar su quehacer cotidiano y, sin duda, proporcionarle no solo de principios para simplificar el proceso diagnostico, sino para justificar el tratamiento que le va a ofrecer a su paciente. Nos sentiremos mas que satisfechos si alcanzamos a despertar su curiosidad mas alla del contenido del texto, para verse obligado a complementarlo, con otras fuentes de informacion, asi como imagenes, tratamientos, tecnicas quirurgicas etc.; es decir si logramos inquietarlo a seguirse preguntando por que? Pero...habremos, sin duda, superado nuestro proposito si ademas, conseguimos con ello, el que se maraville al descubrir los recovecos del inmenso universo que es la cirugia.

Recent Advances in Surgery 31 is the latest volume in the successful and well-established Recent Advances series. This title is updated annually, covering the latest trends within surgery and reflecting any changes to the professional examinations for surgeons. Suitable for experienced medical professionals, as well as students and candidates of the MRCS/AFRCS, this edition reviews the latest trends within surgery and forms a useful update of general surgery for candidates of the Intercollegiate examination. Over 30 contributors, who are recognized experts in their particular field, provide in-depth reviews of important topics relevant to the management of all surgical patients and advancing areas in surgical subspecialties.

The Springer Handbook of Auditory Research presents a series of com prehensive and synthetic reviews of the fundamental topics in modem auditory research. It is aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes will introduce new investigators to important aspects of hearing science and will help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume is intended to present a particular topic comprehensively, and each chapter will serve as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The series focuses on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature. Each volume in the series consists of five to eight substantial chapters on a particular topic. In some cases, the topics will be ones of traditional interest for which there is a solid body of data and theory, such as auditory neuroanatomy (Vol. 1) and neurophysiology (Vol. 2). Other volumes in the series will deal with topics which have begun to mature more recently, such as development, plasticity, and computational models of neural processing."

Real-life cases sharpen your critical thinking skills for your clerkship and the shelf exam The 60 cases in Case Files Surgery feature realistic clinical scenarios designed to help you enhance and hone your clinical decision-making skills. Each case includes an easy-to-understand discussion correlated to key concepts, definitions of key terms, clinical pearls, and Board-style review questions to reinforce learning. The format allows you to review a patient vignette and then explore/examine the case in a contextual, application-based manner. The book is ideal for both quick-access and slow and careful study. Realistic cases are accompanied by questions that encourage you to think through the differential diagnosis and treatment options Real-life surgery cases with high-yield discussions aligned to clerkship guidelines USMLE-style review questions and clinical pearls accompany each case Primer on how to approach clinical problems and think like an experienced doctor

With a long practice of organ transplantation, retransplantation has become a major goal in patients with long-term failure of their first transplant (chronic rejection, exhaustion of the transplant, recurrence of the initial disease, etc. ). In addition, retransplantation can be necessary in the initial period, due to severe acute rejection, a non-functioning organ, or surgical complication. Immunological and non-immunological factors affecting the success of a second transplant are described in this volume, together with alternatives to retransplantation. It is hoped that in the future retransplants will be less frequent, as a result of improved prevention of transplant failure. J. L. Torrroine et a/. (ens. ), Retra isplantation, xvii. Q 1997 Kluwer Academic Pirblislters. P . iilted in Great Britain. List of contributors R. ARNOLD Y. W. CHO University of Pittsburgh UCLA School of Medicine Center for Medical Ethics Tissue Typing Laboratory Division of General Internal Medicine 950 Veteran Avenue 200 Lothrop Street - MUH, Suite W-919 Los Angeles, CA 90095-1652 Pittsburgh, PA 15213-2582 USA USA P. COCHAT M. A. BELGER Hopital Edouard Herriot UKTSSA Pavillon S Fox Den Road 5, Place d'Arsonva1 Stoke Gifford F-69437 Lyon Cedex 3 Bristol BS12 5RR France UK B. CUZIN F. BERTHOUX Hopital Edouard Herriot Service de Nephrologie et Pavillon V Transplantation Renale 5, Place d3Arsonval Hopital Nord F-69437 Lyon Cedex 3 F-42055 Saint Etienne Cedex 2 France France J. H. DAUBER C.

In this issue of Dental Clinics, guest editor Dr. Stephanie M. Munz brings her considerable expertise to the topic of Special Care Dentistry. In this issue, top experts in the field focus on the provision of dental care services for people with cognitive, physical, medical, or developmental conditions which can preclude them from receiving routine dental care. Key topics include patients with cleft lip, orofacial pain, and neurosensory disorders, in addition to teledentistry, mentorship, advocacy, and the impact of the COVID pandemic. Contains 11 relevant, practice-oriented topics including dental materials in special care dentistry; the pandemic impact on oral health of patients with special healthcare needs; teledentistry for patient-centered screening and assessment; oral health advocacy over the lifespan for the patient with special healthcare needs; interprofessional collaboration for the patient with special healthcare needs; and more. Provides in-depth clinical reviews on special care dentistry, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.