This volume is the eleventh published from a conference sponsored by the World Organization for Specialized Studies on Diseases of the Esophagus (OESO) and the second to be published in Annals. As with the preceding publications, the present one follows a world conference of OESO; in this case, a conference entitled Reflux disease, from LES to UES, and beyond, held in Como, Italy. Collectively, the papers present the wealth of ideas and knowledge covered by the four-day OESO conference on esophagology, with each paper showcasing the responses provided by top experts to precise questions during the sessions of the conference. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.