Unique case-based format facilitates understanding of difficult clinical scenarios Focuses on tips and tricks to help prevent common mistakes Key pictures show a range of colorectal pediatric situations

Strain Measurement in Biomechanics will provide a valuable reference source for all research workers in biomechanics and biomaterials as well as orthopaedic manufacturers and orthopaedic surgeons.

are then selected and must meet the general 'biocompatibility' require ments. Prototypes are built and tested to include biocompatibility evalua tions based on ASTM standard procedures. The device is validated for sterility and freedom from pyrogens before it can be tested on animals or humans. Medical devices are classified as class I, II or III depending on their invasiveness. Class I devices can be marketed by submitting notification to the FDA. Class II and III devices require either that they show equivalence to a device marketed prior to 1976 or that they receive pre-marketing approval. The time from device conception to FDA approval can range from months (class I device) to in excess of ten years (class III device). Therefore, much planning is necessary to pick the best regulatory approach. 2. Wound Dressings and Skin Replacement 2.1 Introduction Wounds to the skin are encountered every day. Minor skin wounds cause some pain, but these wounds will heal by themselves in time. Even though many minor wounds heal effectively without scarring in the absence of treatment, they heal more rapidly if they are kept clean and moist. Devices such as Band-Aids are used to assist in wound healing. For deeper wounds, a variety of wound dressings have been developed including cell cultured artificial skin. These materials are intended to promote healing of skin damaged or removed as a result of skin grafting, ulceration, burns, cancer excision or mechanical trauma."

The topicS in this book represent the presentations given at the Fifth Annual Meeting entitled "Cardiac Surgery: Current Issues" held at the Frenchman's Reef Beach Resort. St. Thomas. U.S. Virgin Islands. November 11-14. 1992. This symposium was sponsored by the Division of Cardiothoracic Sur gery. the School of Cardiovascular Perfusion and the Department of Nursing Education and QUality Assurance of Cooper Hospital/University Medical Center. the University of Medicine and Dentistry of New Jersey. Robert Wood Johnson Medical School. Camden. New Jersey. as well as the Academy of Medicine of New Jersey. Chapter authors were charged with the task of writing brief overviews of major issues related to the field of cardiac surgery. The book is specifically tailored to the needs of cardiothoracic surgeons. cardiovascular perfusionists. allied health professionals and nursing personnel involved in all phases of caring for the cardiac surgical patient. Although intended as a reference source with emphasis on up-dated approaches applied in cardiac surgery. it is hoped that the discussion of these topics will compliment other texts and manuscripts. Obviously.';ibook of this length cannot cover the whole multidiSciplinary and complex field of cardiac surgery. However. co-editors are certain that the annual appearance of this text will highlight comprehensive. new and interesting approaches to the field of cardiac surgery."

A thorough review of the operative techniques as well as the indications, pitfalls, strategies and timing, complications, and long term results involved in the surgical treatment of ulcerative colitis and Crohn's Disease. As IBD is characterised by a high incidence of re-operations and complications, independent sections of the text are devoted entirely to surgical treatment of specific complications and the management of recurrent diseases. Exquisitely illustrated with over 200 line drawings, this book contains important information on medical treatment, endoscopic evaluation, pathology, radiology, and aetiology.

The aim of this symposium was to provide basic and clinical investigators with the latest information on the biology of wound healing and tissue repair. Written and edited by eminent experts in the field, the papers cover the general concepts of wound healing; the role of nutrients; endogenous growth factors; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors.

A description of the latest methods of oncological and hematological diagnostics, such as immunological, molecular genetic and histological essays. All methods are described in principle in their different variations and compared with regard to their effectiveness and cost. Written for scientists, clinicians and personnel in research, specialised and routine diagnostic laboratories in hospitals, this book satisfies the increased demand for information on new methods in hematology and oncology.

This reference book is for anyone involved in generating surgical training scenarios, as well as in VR-based training in general. It examines the main components required to define a scenario, in the context of surgical scene generation: Generation of the scene geometry; modelling of organ appearance; definition of biomechanical parameters. The book is the ideal reference for any reader involved in generating training scenarios, as well as in VR-based training in general.

With the introduction of new post-graduate Medical training in the UK, virtually all doctors will be exposed to some form of surgical training prior to specialization. Many of these doctors will have little exposure to surgical emergencies in medical school. Thus, they may unnecessarily refer to a senior doctor when not needed, or catastrophically neglect a patient needing urgent surgical opinion. Surgical Emergencies in Clinical Practice is a compact resource which allows any clinician, without previous surgical knowledge, to be able to make an accurate diagnosis and have a treatment plan for the whole spectrum of surgical emergencies. The essential steps of initial management of all surgical emergencies is outlined in a manner that can be used on a day-to-day basis for clinical management. Written by experts in the field, Surgical Emergencies in Clinical Practice is a valuable tool for all junior doctors and medical students in the UK, Europe, Asia and North America. It will also be of interest to nurse practitioners, general practitioners and allied health professionals managing these patients.

As recently as 20 years ago, ceramics were widely ignored as potential biomaterials. Interest in bioceramics has increased dramatically over the past decade to the point where it is anticipated they will be the materials of choice for many orthopedic, otologic, maxillofacial and dental applications during the decade of the '90s. Alumina ceramics are being used extensively as articulating comJ1onents in total joint prostheses because of Ithe materials low coefficient of friction and excellent wear resistances. Alumina ceramics are also being used in dental and maxillofacial applica tions because of the materials excellent biocompatibility. Because of its ability to chemically bond to bone, hydroxyapatite is rapidly becoming the material of choice for many dental and maxillofacial applications. For the past decade, one of the most widely researched topics in the field of orthopedics has been the clinical evaluation of joint prostheses based upon stabili zation via tissue ingrowth. It appears that the next generation of joint prostheses will be based upon direct chemically bonding to bone using hydroxyapatite, surface-active glass or surface-active glass ceramics coatings. Resorbable bioceramics are limited to temporary bone space fillers, periodontal pockets treatment and resorbable pharma ceutical delivery systems. Bioceramics is a comprehensive reference textbook covering the history of bio ceramics, present status of bioceramics, and prediction for future use of bioceramics. This book will serve as a major reference for students, as well as experienced bio material researchers. The book presents the state-of-the-art of bioceramics as of 1991."

Focuses primarily on aortic and mitral valve disease. Special attention devoted to optimal timing and the role of echocardiography to assess prosthetic valve function and dysfunction. Discusses techniques for aortic valve surgery and choosing valve replacement devices. Part of the series: Developments in Cardiovascular Medicine

Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy.

In the past ten years, full-scale simulation training has become dramatically more evident in undergraduate and graduate medical education. This increase has been due pri marily to two factors: the development of new computer-driven technology and an interest in simulation-specific training techniques. Technologically, simulators have evolved from simple anatomical reproductions to full-scale accurate reproductions of anatomy and physiology powered by multiple computers. High-technology simulation centers run by teams of faculty are emerging as integral tools in fulfilling medical centers' educational missions. In addition, educational techniques specific to simulation, which have been de veloped and used by other industries for over half a century, are being applied to medical training. Aviation and aerospace have used sophisticated simulation since the 1950s to train pilots and astronauts. Extrapolating these methods for use in the medical world has been a natural course of events, particularly in specialties that require some of the same basic thought processes and interactions required of the pilot or astronaut. It is not surprising, then, that anesthesiology would be the medical specialty to take the lead in adding simula tion training to its educational programs. The anesthesiologist's job in the operating room is similar to that of a pilot in a cockpit, not in the specific tasks, but in decision making, technological and human interfaces, and crisis management."

Trauma surgery has increasingly become a specialized field inspired by different principles and philosophy. A good trauma surgeon is a surgeon who knows how to perform abdominal, vascular, thoracic, urologic, gynecologic, and orthopaedic procedures and is able to repair multiple traumatic injuries in the best sequence possible. In this second volume the focus is exclusively on thoracic and abdominal trauma, with coverage of injuries to all regions. The surgical techniques employed in managing such trauma are carefully described with the aid of high-quality illustrations. Exploratory surgery (via either laparotomy or laparoscopy), damage control surgery, and definitive surgery are all fully covered, and attention is drawn to important technical tips and tricks. The volume will be a handy pocket guide for trainee surgeons who are beginning to deal with severe multiple trauma patients, as well as for all general or specialty surgeons and professionals (including scrub nurses and theatre staff) who are involved in trauma care and wish to keep abreast of developments in this complex field. Also available: Trauma Surgery Vol. 1: Trauma Management, Trauma Critical Care, Orthopaedic Trauma and Neuro-Trauma

- Unlike previous atlases that deal with overall surgical techniques, this book goes into greater detail and focuses on individual cases.

- Lavishally illustrated with 534 illustrations, 133 of which are in color.

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****VERKAUFSKATEGORIE*** 0 e

Rehearse for life in clinical practice with this easy-to-use and unique series, which combines cases drawn from real-life experiences with a refreshing approach to presentations as you would see them in day-to-day situations. Get the most from clinical practice, with Clinical Cases Uncovered Packed full with over 120 cases, this comprehensive title on the surgical management of conditions will be your core revision text. Featuring everything you need to know on surgery, Professor Harold Ellis and Christopher Watson have left nothing out. Whether it's a gastric ulcer or an intercranial mass shown up on an MR scan, you can work your way through with Clinical Cases Uncovered. For further information, visit www.clinicalcasesuncovered.com

Lung cancer is the most common cause of cancer-related death in the world. Recently, better understanding of the biology of lung cancer has led to the development of newer targeted therapies for specific subpopulations of lung cancer patients. While this has led to multiple exciting advances that promise to improve outcomes in the future, there has also been a significant increase in the complexity of care of the lung cancer patient. Part of the Oxford American Oncology Library, this concise handbook identifies best-practice guidelines, as well as differences of opinion in the field. It presents the most current procedures for the diagnosis and management of lung cancer in a succinct and easy-to-read manner. Chapters focus on topics such as the biology, pathology, and staging of lung cancer, special populations, and supportive care. Lung Cancer is a must-have tool for busy oncologists.

It gives me particular pleasure to write the foreword to this book; this is largely due to the fact that I have devoted a substantial part of my life to the improve ment of the methods used in ophthalmic research. Rarely has one of my students taken the opportunity of dealing systematically with the possibilities of these methods. Dr. Eisner is, however, one of these exceptions. First, he has substantially improved the indentation contact glass; secondly, he has, with untiring enthusiasm, made a systematic collection of the normal and pathologic findings, which, with the help of the indentation contact glass and the slit lamp, can be observed in the outermost periphery of the fundus and the ciliary body. He has compared them to findings obtained with slight magnification in autopsy eyes and to histological sections. Owing to a fortunate circumstance, W. Hess, who is both an excellent draughts man and a master of the special examination technique, was able to reproduce the visual phenomena faithfully. The reader who tries to interpret these illustrations spatially will discover that this was often not easy. It is a process which requires a certain effort of imagi nation of space, but which is very rewarding. Dr. Eisner's monograph is an introduction to a little-known branch of biomicroscopy which broadens our means of diagnosis and promises further interesting aspects for the future. I wish him well-earned success.

From the foreword: "Microsurgery of Retinal Detachment is an important contribution to the practice of vitreoretinal surgery. In this comprehensive volume, Dr. Bonnet shares her extensive experience in the management of conditions ranging from retinal tears and primary retinal detachment to giant retinal breaks and vitreoretinal surgery. The field of microsurgery has continued to evolve over the last twenty years, both for the anterior segment surgeon and, since 1970, for the vitreoretinal surgeon. Although there have been extensive descriptions of vitrectomy techniques, little has been written about microsurgical techniques for scleral buckling operations. This subject is well covered in the present edition, which consequently will be a valuable resource to the majority of retinal surgeons who do not as a rule employ microsurgery in the repair of retinal detachments."

The papers collected in this volume represent the formal proceedings of the Third European Symposium on Calcified Tissues which was held in Davos, Switzerland from 11th to 16th April 1965 under the sponsorship of the Laboratorium fur experi mentelle Chirurgie, Schweizerisches Forschungsinstitut Davos. This Symposium fol lowed the now established tradition of the previous Symposia held in Oxford in 1963 and in Liege in 1964. Participation was again strictly on a residential basis. This year the Schatz alp Hotel provided a scenic and secluded meeting place high on a mountain side overlooking Davos yet close to the Forschungsinstitut in which the opening session of the Symposium was held. The papers and communications published in the volume are arranged in order of presentation and are grouped under the five main themes selected for discussion by the Symposium, namely, "Cell function in the formation, maintenance and destruc tion of osseous tissue," "Response of calcified tissues to mechanical factors," "Mecha nisms of mineralization and diseases related to mineral deposition," "Hormones and bone" and "Fundamental structure of dental hard tissues." The programme consisted of a number of review lectures given by invited speakers and of short communications in relation to each of the above themes. No attempt was made to record the dis cussions to the papers as, being a residential meeting, the more valuable and interest ing interchanges took place informally in small discussion groups and not within the time schedule of the prearranged programme."

Dermatosurgery cannot readily be therefore be to impart the knowledge assigned to anyone branch of medical that gives the dermatologist this free- science, and as with any borderline dom of choice. This involves the teach- case, this assignation is a matter of con- ing not only of the basic principles of troversy. Since the end of the last cen- dermatosurgery but also of the ability tury, the place of the subject in the field to discriminate according to the most of dermatology has been firmly estab- varied criteria. In this field, technical lished. This is hardly surprising, since knowledge, motivation, and enthusi- a number of specialists in dermatology asm are not enough; talent is also re- spent the first part of their professional quired. C. Moncorps was engaged in work life as surgeons: for example, E. Lang of Vienna, famous for his treatment of on a monograph on dermatosurgery lupus by plastic surgery; and K. Linser (unfortunately nowhere near comple- of Tiibingen, one of the originators of tion) at the time of his death. As a for- varicose-vein stripping. H. T. Schreus mer pupil and long-standing colleague and C. Moncorps were distinguished of his, it is particularly gratifying to me to see colleagues past and present con- members of a later generation of sur- gery-oriented dermatologists; the der- tinuing a tradition in their work.

This monograph is intended to compile the lectures presented at the 4th Annual Symposium "Cardiac Surgery:1992" held at the Frenchman's Reef Beach Resort, St. Thomas, US Virgin Islands, November 7-10, 1991. This symposium was organized by the Division of Cardiothoracic Surgery and the School of Cardiovascular Perfusion, Cooper Hospital/University Medical Center, Camden, New Jersey and sponsored by the University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Philadelphia Academy of Cardiovascular Perfusion and the American Society of Extracorporeal Technology -Region II. The symposium was devoted to cardiothoracic surgeons, cardiologists, cardiovascular perfusionists, and nurses involved in the management of the cardiac surgical patient. Therefore, the context of the book represents the multidisciplinary nature of cardiac surgery at its present level of development. The contributors to this book have critically examined their experience and discussed controversial issues regarding cardiac pathophysiology, surgical indications, operative techniques, and long term care and outcome. The co-editors wish to express their gratitude for the contributors' efforts in the production of this manuscript. We would also like to thank the members of the Organizing Committee, Jane V. Stewart MSN, RN, CCRN, Roger A. Vertrees BA, CCP, Rosemary Volosin, MSN, RN, Rosemary Morrone and Paul R. Cappola BS, CCP, who have greatly contributed to the success of the symposium."

The topics in this book represent the presentations given at the Fifth Annual Meeting entitled "Cardiac Surgery: Current Issues" held at the Frenchman's Reef Beach Resort, St. Thomas, U.S. Virgin Islands, November 18-20, 1993. This symposium was sponsored by the Division of Cardiothoracic Surgery, the School of Cardiovascular Perfusion and the Department of Nursing Education and Quality Assurance of Cooper Hospital/University Medical Center, the University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden, New Jersey, as well as the Academy of Medicine of New Jersey. Chapter authors were charged with the task of writing brief overviews of major issues related to the field of cardiac surgery. The book is specifically tailored to the needs of cardiothoracic surgeons, cardiovascular perfusion ists, allied health professionals and nursing personnel involved in all phases of caring for the cardiac surgical patient. Although intended as a reference source with emphasis on up-dated approaches applied in cardiac surgery, it is hoped that the discussion of these topiCS will compliment other texts and manuscripts. Obviously, a book of this length cannot cover the whole multidisciplinary and complex field of cardiac surgery. However, co-editors are certain that the annual appearance of this text will highlight comprehensive, new and Interesting approaches to the field of cardiac surgery."

The volatile anesthetics continue to be one of the most mysterious yet commonly used class of drugs in medical practice today. A prominent and troublesome side effect of volatile anesthetics is their ability to alter hemodynamics. This arises from two diverse but interrelated phenomena, depression of cardiac contractility and dilation of the vasculature. These effects of volatile anesthetics on cardiac and smooth muscle plus the action of volatile anesthetics on skeletal muscle in the malignant hyperthermic syndrome have led to concern about the interaction of volatile anesthetics (and other anesthetic agents) with calcium metabolism in the muscle cell. Many of the phenomena caused by anesthetics appear to have common mechanisms in all of the muscle types; however, the differences among skeletal, cardiac and smooth muscle also lead to distinct effects of the anesthetics in each. Given the diverse research disciplines which have been brought to hear on the mechanism of anesthetic alteration of contractility, the symposium from which this book originates was convened for the purpose of gathering those with common interests in anesthetic agents and their cellular and subcellular actions in muscle. The recent symposium had its origins in a small but exciting meeting that took place at the University of Texas at Houston in 1984. At that time, Robert Merin and Jacques Chelly convened a group of people who had interest in cardiac muscle and calcium antagonists.