This book contains the proceedings of the ARW NATO conference on Lipid Mediators in Immunology of Burn and Sepsis held in He1singor, Denmark, July 20-25, 1986. This meeting brought together some of the most distinguished re- searchers in the fields of thermal injury, the immune system and lipid mediator biochemistry. It is well known that there is a substantial impairment of the immune response during sepsis, burn, trauma and other kinds of shock. These conditions are characterized by a massive inflammatory process which occurs during the early phase following injury. Among the various mediators released at this time are 1euko- trienes, thromboxane, histamine and platelet-activating factor. This latter autocoid possesses potent proinf1ammatory properties and toge- ther with the other mediators may account for some of the post-injury pathophysi 01 ogi ca 1 phenomena such as extravasati on, hypotensi on, chemotaxis...It is of great interest to note that recently 1euko- tri enes and plate 1 et-acti vati ng factor have been shown to be potent mediators of the immune response. Thus, the purpose of this meeting was to bring together clinicians, immunologists and biochemists in order to examine and hopefully clarify the putative role of various lipid mediators prominent in the early stages after injury. This book is divided into the following six sections. Section 1 provides a general overview of the physiological con- sequences of burn, sepsis and shock.

Developmental Perspectives on Craniofacial Problems presents a developmental approach to psychological research on craniofacial anomalies. Craniofacial anomalies represent one of the most commonly occurring birth defects, and although recent surgical advances have been substantial, little has changed in over forty years with regard to the assumption that facial disfigurement must result in psychological problems. This book advances current understanding of the psychological impact of craniofacial anomalies by reevaluating the prevailing view in light of the most current perspectives and findings in developmental psychology. Distinguished scholars have applied their expertise in social, emotional, and personality development to understanding the psychological development of children with craniofacial anomalies, covering a wide range of topics in developmental psychology.

One of the first applications of lasers was for surgery on the retina of the eye. That, and the evident analogy to the old dreams of powerful heat rays, led many to predict that lasers would quickly be used for all kinds of cutting and welding, including surgical applications. It was soon apparent that laser sur gery could be performed in ways that caused little bleeding. Nevertheless, other surgical applications have been slower to arrive. One difficulty has been the enormous range of possibilities provided by the many different kinds of lasers. Infrared, visible, and ultraviolet light beams each interact very differently with human tissues. Light pulses of enor mously great peak powers became available from lasers, but their effects dif fered in surprising ways from those obtained with continuous beams. That provided both opportunities (i.e., treating or removing a very thin surface layer without affecting the underlying tissue) and problems with undesired side effects. Moreover, techniques were needed to deliver a precisely con trolled amount of energy just where it was desired. Lasers also had to be engineered and manufactured with the desired power levels and a high reliability."

Cyclosporin has had a remarkable effect on clinical organ transplantation. Prior to its introduction, considerable advances had been made in the grafting of vital organs, particularly the kidney, heart and liver. In many developed countries, however, transplantation was not considered wo-rthwhile in terms of gain for the investment of resources. The improved results of kidney grafts following the use of cyclosporin has changed this attitude. For all types of organ transplantation, cyclosporin has resulted in an improvement of functional graft survival and has allowed a reduction in steroid dose and, in some cases, no steroids at all. It has permitted the first successful experimental transplantation of the heart and lungs in primate species by Reitz and colleagues and their results were applied directly to the clinic. It was largely due to the introduction of cyclosporin that the Washington Consensus Meeting on Liver Transplantation came to a favourable recommendation and the result has been the proliferation of units performing liver transplantation, approximately fifty in North America and another fifty in Europe, where previously there had been a handful. Having been involved in cyclosporin for organ grafting from the beginning, I have been able to witness these developments which have far exceeded my expectations once the nephrotoxicity of cyclosporin was demonstrated in man. It is fitting that Dr.

The clinical acceptance of computed anatomic cross-sections. Schematic line tomography (CT) as an integral part of our drawings are also generously used to il diagnostic armamentarium was based on its lustrate particularly complex anatomic re ability to display cross-sectional anatomy gions and help the reader obtain a correct with near anatomic precision. However, perspective on these more difficult regions. the radiologist must first be knowledgeable The book successfully presents a clear per of the complexities of normal anatomy be spective on the anatomy we see daily in fore he can truly make full use of this tech using cross-sectional imaging techniques. nology. This book will prove useful as a learning Michael Farkas has truly made our task guide for the uninitiated, and as a refer as radiologists easier. As noted in the ence for the more experienced. Either preface, the book carefully correlates rep way, it is an important contribution to our resentative CT slices with corresponding literature. Elliot K. Fishman, M.D."

The ability of an epithelial cell to adhere to its neighbor and to the extracellular environment is an essential process that defines in part a normal multicellular organism. In the post-genomic era of cancer biology, it is known that epithelial tumors are multi-clonal and are genetically unstable. In contrast, during the process of tumor metastasis, which is the major cause of death from cancer, a restricted set of adhesion molecules are displayed on the tumor cell surface. The adhesion molecules provide a selective advantage for migration of the tumor cell to a distant site. In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.

Panoramic radiology systems are currently being used in more practices than at other any time in the past. The practitioner now has decisions to make regarding detector technology selection for image acquisition and must remain informed about appropriate usage. This book is applicable to all panoramic dental images and equipment. It approaches panoramic radiology usage in the context of general and specialty applications.

Osteomyelitis of the Jaws is the first textbook of its kind covering exclusively all aspects of this challenging disease. A clear classification of osteomyelitis of the jaws is provided. Clinical presentation and diagnosis are meticulously described and illustrated. Radiological imaging from conventional radiographs to CT, MRI and PET diagnosis are outlined for all types of osteomyelitis of the jaws. Pathology and Pathophysiology of this disease are described in a clear way. All therapeutic modalities from surgery to antibiotic and hyperbaric oxygen therapy are comprehensively outlined and discussed. Each type of Osteomyelitis of the jaws are additionally described and illustrated in case reports giving this book a very practical approach to the subject."

With his keen analytical mind and penchant for organization, Charles Darwin would have made an excellent clinical investigator. Unfortunately for surgery, his early exposure at Edinburgh to the brutality of operations in 1825 convinced him to reject his father's plan for his career and pursue his interest in nature. His subsequent observations of how environmental pressures shaped the development of new species provided the essential mechanism to explain evolution and the disappearance of those species that failed to adapt. Today, surgeons face the same reality as new technology, progressive regulation by government and payers, medico-legal risks, and public demands for proof of performance force changes in behavior that our predecessors never imagined. We know that surgeons have always prided themselves on accurate documentation of their results, including their complications and deaths, but observational studies involving a single surgeon or institution have given way to demands for controlled interventional trials despite the inherent difficulty of studying surgical patients by randomized, blinded techniques. That is why this book is so timely and important. In a logical and comprehensive approach, the authors have assembled a group of experienced clinical scientists who can demonstrate the rich variety of techniques in epidemiology and statistics for reviewing existing publications, structuring a clinical study, and analyzing the resulting data.

The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.

Comprehensively addressing the various aspects of sinus disease in children, this reference describes the entire spectrum of pediatric sinusitis management, surgery, and control-opening with sections on anatomy and pathophysiology; demonstrating approaches in diagnostic work-up and medical therapy; detailing surgical management; and considering topics such as sinusitis complications, comorbidity, tonsillectomy, adenoidectomy, cystic fibrosis, and allergy or immune deficiency; this guide is a stand-alone source for anyone involved in pediatric sinus disease.

A symptom-based version of the critically-acclaimed Norton/Surgery: Basic Science and Clinical Evidence, Learning Surgery provides a ready reference to those in third and fourth year residencies. Essential algorithms and case presentations meet with clerkship learning objectives as outlined by the Association of Surgical Education in their ASE Manual. Two sections include Introduction to Clinical Surgery in the Surgical Clerkship Setting and Management of Surgical Diseases During the Clerkship. Chapters include: Stroke, Hypertension, Abdominal Masses, Head Injuries, and Burns. Written by leading clinicians and educators, both surgery residents and medical students will find LEARNING SURGERY indispensible in their rotations and clerkships. Surgeons who train residents will also find the text a valuable ajunct to their teaching.

The increased complexity of spinal surgical procedures in recent years has required more sophisticated anesthetic management of patients undergoing these procedures. Spine surgery anesthesia is now recognized as a distinct sub-specialty, increasingly undertaken by general anesthesiologists as well as neuroanesthesiologists. Anesthesia for Spine Surgery describes the anesthetic management and surgical procedures at every vertebral level in both adult and pediatric patients. The most important related considerations are covered, including: * Postoperative pain management * One lung ventilation during anterior thoracic spine surgery * Intraoperative neuromonitoring * Fluid management Additional chapters review the radiological features of normal and abnormal spines, common complications of spine surgery and ASA closed claims relating to spine surgery anesthesia. Written by highly experienced neuroanesthesiologists and spine surgeons, Anesthesia for Spine Surgery is essential reading for trainee and practising anesthesiologists, neuroanesthesiologists and spine surgeons.

This practical, engaging book provides concise, real life-tested guidance to healthcare teams concerned with widely reported and incentivized hospital quality and safety metrics, offering both a conceptual approach and specific advice and frameworks for reviewing quality and safety numerator events, from the perspective and experience of clinicians and administrators working within the Ochsner Health System. The text opens with the rationale for closely managing widely (including publicly) reported hospital patient quality and safety measures. Attention is given to the financial implications of quality performance, with respect to both penalties and payment incentives used by payer organizations. It then reviews the major public ratings and their relevant methodologies, including CMS, AHRQ and NSHN. In addition, it addresses ratings by proprietary organizations that have a large member clientele, such as Vizient, USNews, Leapfrog, Healthgrades, CareChex and others. Each metric - for example, the AHRQ Patient Safety Indicators (PSIs), and other metrics such as readmission rate, risk adjusted complications, hospital-acquired conditions and mortality - is addressed in a stand-alone chapter. For each, the importance, approach to review, opportunity for optimization, and engagement of healthcare staff are reviewed and discussed. Overall, this book forefronts the benefits of a collaborative approach within a health system. The concurrent review process, multidisciplinary collaboration among quality improvement, clinical documentation, coding and medical staff personnel are all emphasized. Also described in detail is the approach to and specific opportunities for medical staff education and engagement. Additional key topics include Engagement of the Medical Staff and House Staff (i.e., residents and other trainees), Futile Care, Surgical Quality Improvement (NSQIP), Nursing Provider Partnership, and Translation of Data Review to Successful Performance Improvement. Specialty chapters on pediatric, neurologic and transplant quality metrics are also included.

This book, written by leading experts from many countries, provides a comprehensive and up-to-date description of how to use 2D and 3D processing tools in clinical radiology. The opening section covers a wide range of technical aspects. In the main section, the principal clinical applications are described and discussed in depth. A third section focuses on a variety of special topics. This book will be invaluable to radiologists of any subspecialty.

In 1987, Dr. Benjamin Carson gained worldwide recognition for his part in the first successful separation of Siamese twins joined at the back of the head. Carson pioneered again in a rare procedure known as a hemispherectomy, giving children without hope a second chance at life through a daring operation in which he literally removes one half of their brain. Such breakthroughs aren t unusual for Ben Carson. He s been beating the odds since he was a child. Raised in inner-city Detroit by a mother with a third grade education, Ben lacked motivation. He had terrible grades. And a pathological temper threatened to put him in jail. But Sonya Carson convinced her son he could make something of his life, even though everything around him said otherwise. Trust in God, a relentless belief in his own capabilities, and sheer determination catapulted Ben from failing grades to the directorship of pediatric neurosurgery at Johns Hopkins Hospital in Baltimore, Maryland. Gifted Hands takes you into the operating room to witness surgeries that made headlines around the world---and into the private mind of a compassionate, God-fearing physician who lives to help others."

Since Mondors times in the forties of the last century there was no other book in surgery to be written so easy and witty Boris D. Savchuk, World Journal of Surgery This, the fifth edition of Scheins Common Sense Emergency Abdominal Surgery, builds on the reputation of the four previous editions. Already a worldwide benchmark, translated into half a dozen languages, this book guides surgeons logically through the minefields of assessment and management of acute surgical abdominal conditions. Tyro and experienced surgeons alike will benefit from the distilled wisdom contained in these pages. The direct, no-nonsense style gives clear guidance while at the same time providing amusing (or saddening) insights into our collective surgical psyche. Old chapters were revised or rewritten and new chapters have been added, including a completely new colorectal section with its new co-editor. Finally, in an attempt to rejuvenate the book, Danny took over the helm while the aging Moshe was pushed down the line Selected reviews and comments from readers of the previous edition What to say, perhaps the most appropriate medical book ever written. This is written with short punchy chapters making it a very difficult book to put down. By the end I was a total enthusiast this is a text like no other I read Unreservedly recommended to old and young alike. A Must Have Book. I am about to end my chief year in general surgery residency my copy of the first edition shows the wear of half a dozen total read throughs and probably hundreds of referencings... Simply perfect. The best choice in surgery for trainees! It makes the more difficult surgery areas very easy to understand. I recommend it to all surgeons. One of the best books I have read in my life! Must read for all docs out there. But the moral of the book is that if scientific rigorousness (protocols, guidelines, evidence-based) and common sense are at odds, follow common sense.

A notable surgeon and charismatic teacher himself, Professor Ellis has brought together in Operations that Made History a fascinating collection of renowned surgical procedures, each one illustrating a different aspect of the history of surgery. The first section of the book looks at examples of surgical procedures which have made a major contribution to the history of surgery, such as the first successful gastrectomy, performed in Vienna over a hundred years ago by Theodor Billroth. Some operations, whilst in themselves minor procedures, have nevertheless had a massive impact on the history of surgery. These are grouped together in the second section. In the final part of the book, Professor Ellis focuses on the famous patient, such as Nelson and George IV. In surgery, as in fields of human activity, history is forgotten at our peril. Operations that Made History gives its readers a unique insight into a remarkable speciality, using the lessons of history to instruct as well as amuse.

Written by leading American practitioners, the Oxford American Handbooks of Medicine each offer a pocket-sized overview of an entire specialty, featuring instant access to guidance on the conditions that are most likely to be encountered. Precise and prescriptive, the handbooks offer up-to-date advice on examination, investigations, common procedures, and in-patient care. These books will be invaluable resources for residents and students, as well as a useful reference for practitioners.
Part of the most popular medical handbook series in the world, the Oxford American Handbook of Surgery is a dependable manual geared for ultra-quick reference any time. It is comprehensive enough to serve as a mini-text, yet it is thin and light and uses concise, bulleted text, quick reference tabs, four-color presentation, and bookmark ribbons to help provide fast answers on the ward. Written by an acclaimed author, this Handbook presents information in a succinct, comprehensive, and affordable volume in the proven format of the Oxford Handbook Series.

Why choose the Oxford American Handbook of Clinical Surgery?
The design....
The Handbook uses a unique flexicover design that's durable and practical. Compact, light, and fits in your pocket Also has quick reference tabs, four-color presentation, and bookmark ribbons to help provide fast answers.
The interior layout....
The Handbook is a quick reference in a small, innovative package. With one to two topics per page, it provides easy access and the emergency sections are in red to stand out. Icons throughout aid quick reference.
The information....
The Handbook succinctly covers all the essential topics in a one or two-page spread format with colored headings that break up the text and provide a logical structure for readers of all levels. Common clinical questions are answered clearly and extensively.
The history....
Oxford University Press is known around the world for excellence, tradition, and innovation. These handbooks are among the best selling in the world.
The price....
You get an extremely useful tool at a great value

The Operation Primer provides excellent photographic step-by-step guidance to the surgical procedure. It has been produced to describe the operation in the simplest manner possible without over-symplifying. The core of the Operation Primer is the section on the Nodal Points where the surgical key steps are described in detail. This surgical guide book proves essential reference material to surgeons wishing to update in this specific area.

The Operation Primer Laparoscopic Cholecystectomy provides one means of understanding and learning the now largely standardized procedure of laparoscopic cholecystectomy through a series of clearly defined individual steps (the so-called Nodal Points). Following this systematic procedure is an important step towards the avoidance of complications.

There is increasing recognition of the burden of venous thromboembolism (VTE) in patients with advanced incurable disease and the clinical, ethical, and philosophical challenges they may pose. With a growing elderly population and oncological therapies helping patients live longer with malignant disease, VTE is likely to be an ongoing problem. Whilst presentation, diagnosis, and treatment of VTE in general medicine is well established, its management within the palliative care setting is less clear-cut. Clinical presentation is often masked by other palliative symptoms, and symptoms can be consistent with those of other conditions; diagnosis is therefore underappreciated, and the condition can be difficult to manage.
Bringing together contributions from international experts in the field of VTE and palliative care, this book explores the increasing challenges faced by healthcare professionals when managing VTE in advanced disease. Topics such as the epidemiology and pathogenesis of the condition are discussed. It appraises the current evidence informing the prevention, diagnosis, and treatment of VTE, with particular emphasis on its application to patients with incurable malignancy and non-malignant disease. Chapters are illustrated with key learning points and, where appropriate, case studies are presented to illustrate the decision-making processes that may occur when balancing the evidence with its impact on patient quality of life.
This practical resource is invaluable for healthcare professionals working in all areas of medicine where patients with advanced cancer and non-malignant disease are cared for.

The multi-authored, multi-institutional, and multi-specialty-based text is designed as a valuable resource for surgeons working on the maxillofacial region. Meant to be a clinically based history of the past, the present, and the future of the field, this is a one-of-a-kind text that will cater to a variety of professions: from oral & maxillofacial surgeons, plastic and reconstructive surgeons, otolaryngologists - head and neck surgeons, cosmetic surgeons and the general dental practitioner. The History of Maxillofacial Surgery: An Evidence-Based Journey is divided into three sections for ease of understanding: The first section gives an overview of the early history; the second section provides a discussion of conventional procedures; and the third section gives a history of advanced procedures and techniques. By understanding the fundamental procedures and techniques of the field, practitioners can continue to further the field by building upon the past. Including historic case studies paired with real patient photos, this text details why professionals do what they do today with insight directly from the clinic. To provide a unique perspective the book is edited by three individuals at different stages of their careers. Each chapter is authored by a young surgeon paired with a seasoned surgeon.

A case-focused Otolaryngology primer for trainees and practicing clinicians alike As disorders of the head and neck continue to become more prevalent, otolaryngologic head and neck surgeons are in greater demand than ever before. Many schools of medicine are integrating Problem-Based Learning (PBL) to help students develop the skills necessary for surgical management of head and neck conditions, yet the selection of guidebooks available to trainee otolaryngologic surgeons is limited. Essential Cases in Head and Neck Oncology uses real-life clinical cases to present clear and up-to-date explanations of treatment strategies for a wide range of cutaneous, salivary gland, and upper aerodigestive tract conditions, including benign and malignant tumors. Written and edited by renowned leaders in the field, and endorsed by the American Head & Neck Society, this essential resource contains full-color photographs, illustrations, and diagrams to better support readers in acquiring, synthesizing, and applying essential skills and knowledge in a clinical context. Its chapters provide detailed coverage of the oral cavity, skull base, trachea, thyroid, larynx, paragangliomas, salivary glands, and more. This textbook also includes: Covers the full spectrum of head and neck surgeries, including reconstructive procedures Discusses ethics related to cancer treatments, medical research, and other care issues Promotes multidisciplinary critical thinking, clinical problem-solving, communication, and collaboration Helps medical students and trainees evaluate their learning and contextualize their knowledge Features high-quality images and succinct explanatory text throughout Essential Cases in Head and Neck Oncology is an indispensable study aid for trainee clinicians, residents, and fellows, and an excellent reference guide for oncologists, otolaryngologists, surgeons, and other practitioners working in medical oncology, radiation oncology, and oromaxillofacial surgery.