The ability of an epithelial cell to adhere to its neighbor and
to the extracellular environment is an essential process that
defines in part a normal multicellular organism. In the
post-genomic era of cancer biology, it is known that epithelial
tumors are multi-clonal and are genetically unstable. In contrast,
during the process of tumor metastasis, which is the major cause of
death from cancer, a restricted set of adhesion molecules are
displayed on the tumor cell surface. The adhesion molecules provide
a selective advantage for migration of the tumor cell to a distant
site. In this volume, the expression of specific adhesion molecules
within human cancer tissues are highlighted. The expression
signatures from published DNA microarray and immunohistochemistry
studies are detailed. The concept that the alteration of specific
adhesion molecules influence the cancer migration ability and
cancer damage responses is detailed in this volume; both features
are essential for the survival of an invading tumor cell. Defining
the minimal adhesion receptors preserved on cancer cells during
tumor progression will define the metastatic adhesion signature.
Understanding the metastatic adhesion signature will reveal
vulnerabilities that could be exploited for the prevention and/or
eradication of the invading cancer cell.
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