The manifold problems of shock are still of great importance, diagnostic and therapeutic experience of the "severely ill" being supplied with new information almost every month. In the 5 periodicals which have found their way to my desk during the past few days there are no less than 10 interesting articles on questions concerning shock research see Bibliography 41 b, 53 a, 60 a, 192 a, 242 a, 350 b, 810 a, 941 a, 1069 a, 1082 a]. The most urgent point still is to maintain as complete as possible the objective catalog of the various shock manifestations found in man and in animals - yet at the same time to view interpretations of these phenomena in their relative and temporal "truth." Problems of shock research are not only interesting for their scientific value but also for their clinical implication. In particular, almost every practicing physician is facing problems of blood replacement very frequent ly. The effective or circulating blood volume remains an important theoret ical and therapeutic problem in the shock field. For years, U. F. GRUBER has pursued this question clinically and experimentally. This volume deals with the world literature in an exceptionally thorough manner. This book is made more than a compilation by including a long list of original work done with F. D. MOORE in Boston, in the Surgical Department in Chur, with L. E. GELIN and S. E."

Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day. Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format Includes and illustrates the WHO Classification of Hematologic Malignancies Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology. "Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing" "There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date"

Textbook of Hemophilia, 3rd edition Edited by Christine A. Lee, MA, MD, DSc, FRCP, FRCPath, FRCOG Emeritus Professor of Haemophilia, University of London, London, UK Erik E. Berntorp, MD, PhD Professor of Coagulation Medicine, Lund University Malmo Centre for Thrombosis and Haemostasis, Skane University Hospital, Malmo, Sweden W. Keith Hoots, MD Director, Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute National Institutes of Health, Bethesda, MD; Professor of Pediatrics and Internal Medicine, University of Texas Medical School at Houston, Houston, TX, USA Without doubt, Textbook of Hemophilia, 3rd edition is the definitive reference source on all aspects of haemophilia including diagnosis, management and treatment. Edited by three, world-renowned experts on haemophilia, this completely revised resource features chapters written by over 60 international contributors with international expertise in caring for haemophilia patients. Textbook of Hemophilia, 3rd edition * Features eight new chapters, covering individualised dosing, vCJD and haemophilia, new drugs in the pipeline, and surgery in inhibitor patients * Presents new developments, such as gene therapy * Highlights controversial issues and provides advice for everyday clinical questions * Represents essential reading for all healthcare professionals involved in the care of those with haemophilia Titles of related interest Hemophilia and Hemostasis: A Case-Based Approach to Management, 2nd Edition Ma, ISBN: 9780470659762 Current and Future Issues in Hemophilia Care Rodriguez-Merchan, ISBN: 9780470670576 www.wiley.com/go/hematology

In this issue of Hematology/Oncology Clinics, guest editors Drs. Sophie Lanzkron and Jane Little bring their considerable expertise to the topic of Sickle Cell Syndromes. Top experts in the field cover key topics such as structural racism and impact on sickle cell disease (SCD); pathophysiology and biomarkers of SCD; genetic modifiers of SCD; allogeneic transplant and gene therapy: reproductive health; chronic pain; and more. Contains 16 relevant, practice-oriented topics including innovative therapies, addressing challenging complications, novel science on mechanisms of disease; preventing cognitive decline in people with SCD; quality of life in SCD; and more. Provides in-depth clinical reviews on sickle cell syndromes, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editors Drs. Matthew B. Yurgelun and Douglas A. Rubinson bring their considerable expertise to the topic of Pancreatic Cancer. Top experts in the field cover key topics such as pancreatic adenocarcinoma: trends in epidemiology, risk factors, and outcomes; decision making regarding perioperative therapy in individuals with localized pancreatic adenocarcinoma; the evolving role of radiotherapy in the management of individuals with pancreatic adenocarcinoma; and more. Contains 14 relevant, practice-oriented topics including diabetes, cachexia, sarcopenia, and metabolic factors in individuals with pancreatic adenocarcinoma; PARP inhibitors and other novel therapeutics in pancreatic adenocarcinoma; screening and surveillance for pancreatic adenocarcinoma in high-risk individuals; germline testing for individuals with pancreatic adenocarcinoma and novel genetic risk factors; and more. Provides in-depth clinical reviews on pancreatic cancer, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editors Drs. Sung-Yun Pai and Nirali N. Shah bring their considerable expertise to the topic of Gene-Based Therapies for Pediatric Blood Diseases. Top experts in the field cover key topics such as CAR T-cell therapy: current status; engineered T cells; NK-cell therapy; hemoglobinopathies: beta-thalassemia, sickle cell disease; hemophilia A/B; primary immunodeficiencies; and more. Contains 14 relevant, practice-oriented topics including the evolution of gene therapy; viral vectors in hematopoietic stem cell gene therapy; gene editing in hematopoietic stem cells; nonintegrating vectors and engineered capsids; regulatory aspects of gene therapy; and more. Provides in-depth clinical reviews on gene-based therapies for pediatric blood diseases, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Paravasation von Zytostatika kann zu schwerwiegenden Zwischen- und Notfallen bei der Tumortherapie fuhren. Das uberarbeitete Kompendium hilft die jeweilige Situation rasch und sicher einzuschatzen. Im allgemeinen Teil werden umfassend die Themen Pradisposition, Pravention, Schadigungstyp, allgemeine Massnahmen im Umgang mit Paravasaten, spezifische Antidota und Dokumentation behandelt. In der 2. Auflage wurde die wissenschaftliche Information des allgemeinen Teils und der Substanzen auf den aktuellen Stand gebracht. Der substanzspezifische Teil enthalt detaillierte Handlungsanleitungen fur uber 50 Zytostatika, um gezielt Massnahmen einzuleiten. Vordrucke fur ein Paravasate-Set, UEbersichtstabellen, Dokumentationsboegen und Patientenaufklarungen sowie eine CD-ROM liegen zur Unterstutzung fur die klinische Praxis bei. Das Buch ist aus dem Konsens einer interdisziplinaren Arbeitsgruppe entstanden, die samtliche publizierte Literatur gesammelt und systematisch ausgewertet hat.

In this ground-breaking account of the political economy and cultural meaning of blood in contemporary India, Jacob Copeman and Dwaipayan Banerjee examine how the giving and receiving of blood has shaped social and political life. Hematologies traces how the substance congeals political ideologies, biomedical rationalities, and activist practices. Using examples from anti-colonial appeals to blood sacrifice as a political philosophy to contemporary portraits of political leaders drawn with blood, from the use of the substance by Bhopali children as a material of activism to biomedical anxieties and aporias about the excess and lack of donation, Hematologies broaches how political life in India has been shaped through the use of blood and through contestations about blood. As such, the authors offer new entryways into thinking about politics and economy through a "bloodscape of difference": different sovereignties; different proportionalities; and different temporalities. These entryways allow the authors to explore the relation between blood's utopic flows and political clottings as it moves through time and space, conjuring new kinds of social collectivities while reanimating older forms, and always in a reflexive relation to norms that guide its proper flow.

A-Z of Haematology provides an essential 'quick reference guide' to definitions covering the entire spectrum of haematology, from blood transfusion and coagulation through to recent advances in molecular haematology.

It is the indispensable guide for all those practising or studying haematology including research scientists and biomedical scientists working in diagnostic laboratories. Scientists working in cytogenetics and immunophenotyping will also find it a valuable repository of relevant knowledge.

A-Z of Haematology includes:
Definitions cover the entire spectrum of haematology, from blood transfusion and coagulation through to molecular haematology
Essential "quick reference guide" for all those practising or studying haematology
Over 100 figures to explain and clarify difficult concepts
Inclusion of all CD numbers and oncogenes to be encountered in daily practice
Appendices of laboratory data and normal values included

In this issue of Hematology/Oncology Clinics, guest editors Drs. Alexandra P. Wolanskyj-Spinner and Ronald S. Go bring their considerable expertise to the topic of New Developments in the Understanding and Treatment of Autoimmune Hemolytic Anemia. Top experts in the field cover key topics such as warm AIHA; cold AIHA; drug-induced AIHA; adult Evans syndrome; immunotherapy-associated AIHA; complications of AIHA; and more. Contains 11 relevant, practice-oriented topics including diagnosis and differential diagnosis; red cell antigens and antibodies; traditional and novel tests; DAT neg AIHA; and more. Provides in-depth clinical reviews on new developments in the understanding and treatment of autoimmune hemolytic anemia, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Fully revised and updated for its second edition, Paediatric Haematology and Oncology provides an easily accessible source of information about all of the basic principles of childhood cancer and leukaemia, and detailed specialist knowledge on how to care for children with those conditions. Featuring new chapters on the biology of childhood leukaemia and central nervous system tumours, the book includes a greater focus on the rapidly expanding research in the biology and genetics of childhood malignancy, as well as new clinical treatments and more detail on various tumour types. Logically split into 12 sections on different aspects of haematology and cancer to allow quick and easy reference, the book provides general principles of diagnosis and treatment, short- and long-term care, and oncological emergencies, before moving on to chapters on specific diseases. Normal values and useful websites are also included for reference. Chapters have been expanded to feature more clinical images to aid in diagnosis and interpretation, making this second edition an invaluable companion for the trainee and consultant in paediatric haematology and oncology.

Many experts now consider genetic evaluation to be pivotal for the optimal diagnosis, classification, risk stratification, and therapeutic decision-making for persons diagnosed with blood cancer. This new text specifically focuses on the genetic alterations essential for establishing diagnosis and assesses how they might impact the precision oncology standard of care. Providing an authoritative review of the state of the art, this is essential reading for physicians, hematologists, and oncologists for optimal management of individual patients.

In this issue of Hematology/Oncology Clinics, guest editor David A. Reardon brings his considerable expertise to the topic of Central Nervous System Malignancies. Top experts in the field cover key topics such as CNS Metastases, Leptomeningeal Disease, Neurofibromatoses, Imaging Advances for CNS Tumors, and more. Contains 16 relevant, practice-oriented topics including CNS Tumor Classification: An Update on the Integration of Tumor Genetics; Etiology and Epidemiology of CNS Tumors; The Evolving Role of Neurosurgical Intervention for CNS Tumor ; Update on Radiation Therapy for CNS Tumors; and more. Provides in-depth clinical reviews on CNS Malignancies, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Recognising a need to promote and enhance teaching of clinical endocrinology and diabetes in UK medical schools, the Society for Endocrinology, in collaboration with Diabetes UK and the Association of British Clinical Diabetologists, created a national curriculum that sets out the minimum recommended standards for undergraduate medical education. Clinical Endocrinology and Diabetes at a Glance corresponds to the curriculum and covers all important areas of diabetes and endocrinology in a clinically relevant and concise manner, with complementary figures to ensure principles are explained clearly. It highlights key practical skills for undergraduates in line with the GMC recommendations that medical graduates should be well prepared for their Foundation posts. There is also emphasis on the importance of multidisciplinary teams in the management of endocrine diseases and diabetes. These include sections on structured education programmes, psychosocial aspects, and patient self-management and monitoring. Clinical Endocrinology and Diabetes at a Glance will serve as a valuable resource for medical students and junior doctors treating patients with these conditions.

This book has been highly successful ever since it was first published in 1958. Emphasis throughout is placed on diagnosis and management, with particular stress on clinical problems as they confront the practitioner. The new fifth edition has been completely revised and updated to take account of important recent developments such as AIDS, lymphomas and leukaemias, and in order to contain the length, some sections of the book have been condensed. The "British Medical Journal said of the fourth edition, Although this book is clearly orientated to bedside problems, it never fails to explain the

This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include-but are not limited to- Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.

Blood has long been an object of intrigue for many of the world's philosophers and physicians, and references to it have existed since the earliest studies of human anatomy. Herodotus of Halicarnassus, whose writings 500 years before the birth of Christ drew on stories collected during his widespread travels, was amongst the first to identify the ritualistic and medical significance of blood. However, despite this long established history, haematology as a medical specialty is relatively new. A History of Haematology: From Herodotus to HIV traces the history of haematology from biblical times to the present, discussing the major defining discoveries in the specialty, ranging from war as a catalyst for the development of new techniques in blood transfusion, to the medical response to the HIV/AIDS epidemic. In this beautifully illustrated and passionately rendered history of the field of haematology, Professor Shaun McCann traces the remarkable developments within haematology and the work of the scientists and pioneers central to these advances. This engaging and authoritative history will appeal to a wide audience including haematologists, nurses and other health care workers in haematology, as well as medical students, and general physicians with an interest in haematology.

Myelodysplastic syndrome (MDS) is a family of clonal haematopoietic stem cells disorders characterized by dysplasia, ineffective hematopoiesis and susceptibility to transformation to Acute Myeloblastic Leukaemia (AML) that are shown to be strikingly refractory to current therapeutic modalities. The first chapter of this book provides a detailed review of the risk factors, treatment options and prognosis of MDS. Chapter two studies the inflammatory and autoimmune nature of MDS. Chapter three discusses the pathogenesis of 5q-syndrome. Chapter four examines the genetic mutations identified in MDS and their significance. Chapter five reviews different prognostic factors and stratifications of risk in Argentinean patients with MDS. Chapter six discusses epigenetics and epigenetic therapy. Chapter seven introduces mild oral chemotherapy treatments for elderly patients with a higher-risk myelodyspastic syndrome. Chapter eight discusses lenalidomide treatment in lower risk myelodysplastic syndromes. Chapter nine analyzes the old and new-integrating prognostic models and mutational advances with epigenetic and cellular therapies for MDS. The last chapter studies the entropy evaluation of bone marrow biopsies in MDS.

This issue of Hematology/Oncology Clinics of North America is devoted to Neuroendocrine tumors. Articles in this issue include: Pathology Classification of Neuroendocrine Tumors; Clinical Presentation and Diagnosis of Neuroendocrine Tumors; Surgical Management of Gastrointestinal Carcinoid Tumors; Systemic Therapies for Advanced Gastrointestinal Carcinoid Tumors; Thymic and Bronchial Carcinoid Tumors; Surgical Management of Pancreatic Neuroendocrine Tumors; Systemic Therapies for Advanced Pancreatic Neuroendocrine Tumors; Pheochromocytoma and Paraganglioma; Poorly Differentiated Neuroendocrine Tumors; Role of Somatostatin Analogs in the Treatment of Neuroendocrine Tumors; Peptide Receptor Radiotherapy in the Treatment of Neuiroendocrine Tumors; Hepatic-Directed Therapies in Patients with Neuroendocrine Tumors; and Neuroendocrine Tumor Clinical Trial Interpretation and Design.

Coagulopathy (also called clotting disorder and bleeding disorder) is a condition in which the blood's ability to clot (coagulate) is impaired. Acquired hemophilia is a rare disorder characterized by spontaneous bleeding in a patient with no previous personal or family hemorrhagic history. The first chapter explores the challenges associated with this disease, its unfamiliarity often causing a delay in diagnosis and therapeutic approaches. The second chapter focuses on lower gastrointestinal bleeding (LGIB) in children, describing the epidemiology, etiology and clinical management. The third chapter reviews the pathogenesis, risk factors and treatment strategies of coagulopathy in patients with craniocerebral injury. The next article examines Vitamin B12 with its four cobalamin vitamers, which often play a role in coagulation. The next chapter starts with a description of the methodology of viscoelastic hemostatic assay, followed by a review of literature on the utilization of thrombelastography (TEG) or rotational thromboelastometry (ROTEM). Finally, the role of TEG and ROTEM to monitor or guide prophylaxis/treatment of thromboembolic events and the limitations of using them to detect hypercoagulability and identify patients with increased risks for thromboembolic complications are discussed. The final chapter of this book focuses on the use of fresh frozen plasma (FFP) in patients who are not actively bleeding, critically questions these assumptions in the context of pre-procedural administration of FFP, and also examines why carrying out high quality trails in this area has been so problematic.

Behcet's disease is a chronic relapsing inflammatory disease of unknown etiology involving multiple organs. Along with blindness, other bodily functions are greatly affected by this disease; conditions of the vascular, intestinal and central nervous systems are usually life threatening and require aggressive therapy. Recently, significant progress has been made in several areas of this disease. The introduction of biological agents (such as anti-TNF) have had a positive impact on the effectiveness of treatments. However, there are still a number of unmet needs in various fields of this disease. Despite this, there remains a number of unaddressed issues concerning the treatments of this disease. Several genes have been shown to be associated with this disease, in addition to HLA-B51. Abnormalities in several subsets of T helper cells have been implicated in the pathogenesis of Behcet's disease. Recent advances in the field of innate immunity have shed light on the new aspects of Behcet's disease; that is, this disease has both autoimmunity and autoinflammatory aspects. On the other hand, there are still controversies as to the diagnosis and treatment of recalcitrant manifestations of the disease. This publication highlights the most recent understanding of Behcet's disease and raises several unanswered questions in both basic to clinical treatment of this ailment. The contents of this book are primarily based on the most up-to-date results of research programs sponsored by the Japanese government as well as findings from Korean researchers. In particular, novel classification for neurological involvement (which has been discovered in Japan) led to the establishment of diagnostic criteria and treatment recommendation. Thus, this publication brings forth useful information for a variety of specialists who are involved in the management of this intractable disease.

Arterial blood gas (ABG) analysis is a fundamental skill in modern medicine yet one which many find difficult to grasp. This book provides readers with the core background knowledge required to understand the ABG, explains how it is used in clinical practice and provides a unique system for interpreting results. Over half of the book is devoted to thirty clinical case scenarios involving analysis of arterial blood gases, allowing the reader to gain both proficiency in interpretation and an appreciation of the role of an ABG in guiding clinical diagnosis and management. A practical guide written for all those who use this test and have to interpret the results. Utilises worked examples to allow the reader to gain confidence in interpreting ABGs and appreciate the usefulness of the test in a variety of different clinical settings. Written in a simple style and presents the concepts in a straightforward manner. Additional clinical case scenarios put the ABG into practice. Includes a video detailing how to take a sample.