Managing patients with thrombotic vascular disease is complex and challenging: Ischemic vascular disease remains a complicated interplay of atherosclerosis and thrombosis--even with the evolution in our understanding of the pathobiology of thrombosis.There has been tremendous growth in therapeutic options which are quickly finding their place in daily practice, including a remarkable expansion in the number of intravenous and oral antithrombotic agents and new antiplatelet agents

Now more than ever, all cardiologists, hematologists, and specialists in vascular medicine, as well as other professionals, such as hospital pharmacists, who deal with prognosis and intervention in preventing thrombosis, need a resource that distills current knowledge of this important subject.

Written and edited by today's leading international, "Therapeutic Advances in Thrombosis, 2e" provides physicians with the very latest in medical and surgical advances in antithrombotic therapies. With this comprehensively updated edition you get: Coverage of virtually all aspects of venous and arterial thrombotic disease and the corresponding therapiesStrategies to manage specific clinical conditions and how to tailor treatment to individual patient needsUpdated chapters covering thrombolysis in ST-elevated myocardial infarctions; thrombosis in patients with diabetes, pregnancy, and renal dysfunctionSpecial emphasis on the pharmacology of novel anticoagulants and their practical use in venous thromboembolism and atrial fibrillation.

Plus, all chapters fully explore clinical trial designs and outcomes for particular treatment therapies, as well as contain the relevant ACC/AHA/ESC guidelines, so you can confidently apply what you learn.

th America th America

Who would have thought that something so commonplace as iron deficiency would lead to prehistoric ochre, Egyptian amulets, Renaissance alchemy, Victorian projections of maidenhood, and the astrophysical end of everything? Whether mild or deadly, anemia affects an essential body fluid: blood. In Pale Faces, Charles L. Bardes probes deeply into this illness as metaphor by exploring the impact of both science and culture on its treatment across the ages. His innovative "life" of this condition ranges widely through history, mythology, literature and clinical practice to examine how our notions of specific medical conditions are often deeply rooted in language, symbolism and culture. Delving into the annals of anemia and its treatment, he takes us on a fascinating journey back through the history of medicine--from the Greeks and ancient practices of bloodletting and magic up to the diagnostic rituals of a modern medical office. A scholar of the literary as well as the medical arts, Bardes gives us a beautifully written, free-ranging text, resonant with poetic associations yet anchored in concrete clinical experience. As a practicing physician, Bardes is also able to draw upon his direct experience with patients to demystify the doctor/patient relationship. Through detailed descriptions of the diagnostic processes involved in blood related conditions, as well as the particular understanding of the inner workings of the human body provided by modern medical science, we are treated to the complex ways in which doctors think. Charles L. Bardes, MD, is a practicing physician who teaches extensively at Weill Cornell Medical College, where he directs the Medicine Clerkship and serves as Associate Dean. He is the author of Essential Skills in Clinical Medicine, a guide for students and interns, and Pale Faces: The Masks of Anemia, the first book in the Bellevue Literary Press Pathographies series. He has been the Bernard DeVoto Fellow in Nonfiction at the Bread Loaf Writers' Conference and his essays have appeared in numerous journals, including Agni. He lives in New York.

This issue of Hematology/Oncology Clinics, Guest Edited by Dr. Raymond L. Comenzo, is devoted to Systemic Amyloidosis due to Monoclonal Immunoglobulins. This issue is one of six selected each year by our series Consulting Editors, George P. Canellos and Edward J. Benz. Topics discussed in this important issue include: The Spectrum of Monoclonal Immunoglobulin Diseases, Systemic Amyloidosis due to Clonal Plasma Cell Diseases, Systemic Amyloidosis due to Low-grade Lymphomas, The Process of Amyloid Formation due to Monoclonal Immunoglobulins, Cardiac Involvement, Renal Involvement, Liver and Gastrointestinal Involvement, Peripheral Nervous System Involvement, Options for Chemotherapy, Stem-cell Mobilization and Autologous Transplant, Monoclonal Antibody Therapies, Solid Organ Transplant, Supportive Care, Patient Voices, and Future Perspectives.

This issue of Hematology/Oncology Clinics, Guest Edited by Dr. John P. Leonard, is devoted to Mantle Cell Lymphoma. This issue is one of six selected each year by our series Consulting Editors, George P. Canellos and Edward J. Benz. Topics discussed in this important issue include: Molecular pathogenesis of Mantle Cell Lymphoma; MCL and cell cycle dysregulation; Heterogeneity in MCL biology and outcomes; Watch and wait in mantle cell lymphoma; Limited stage mantle cell lymphoma; Initial and consolidation therapy for younger patients with MCL; Approach to the initial treatment of older patients with MCL; Current and future approaches to the use of minimal residual disease monitoring in the treatment of patients with MCL; Bruton's Tyrosine Kinase inhibitors for treatment of Mantle Cell Lymphoma; BTKi resistance in MCL; Blastoid MCL; Allogeneic transplant and CAR-T cell therapy in MCL; Quality of life considerations and chronic therapy in management of patients with MCL; and Key clinical and translational research questions.

This issue of Hematology/Oncology Clinics, Guest Edited by Dr. Jonathan W. Friedberg, is devoted to Follicular Lymphoma. This issue is one of six selected each year by our series Consulting Editors, George P. Canellos and Edward J. Benz. Articles in this important issue include: Epidemiology of Follicular Lymphoma, Pathogenesis of Follicular Lymphoma, Circulating tumor DNA and MRD assessment in Follicular Lymphoma, Clinical and biological prognostic factors in Follicular Lymphoma, Vitamin D and Follicular Lymphoma, Initial Treatment of Early Stage and Low Tumor Burden Follicular Lymphoma, Initial Treatment of High Tumor Burden Follicular Lymphoma, Maintenance Antibody Therapy of Follicular Lymphoma, Cellular Therapy in Follicular Lymphoma, Immunomodulatory Agents in Follicular Lymphoma, Phosphoinositide 3-Kinase Inhibition in Follicular Lymphoma, Novel Agents Beyond Immunomodulatory Imide Drugs and Phosphoinositide 3-Kinases for Follicular Lymphoma, Early progression of Follicular Lymphoma, Biological Basis of Histological Transformation, and Treatment of Histological Transformation.

Crash Course - your effective every-day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have the essential information you need in one place to excel on your course and achieve exam success. A winning formula now for over 20 years, each series volume has been fine-tuned and fully updated - with an improved full-colour layout tailored to make your life easier. Especially written by senior students or junior doctors - those who understand what is essential for exam success - with all information thoroughly checked and quality assured by expert Faculty Advisers, the result are books which exactly meet your needs and you know you can trust. Each chapter guides you succinctly through the full range of curriculum topics, integrating clinical considerations with the relevant basic science and avoiding unnecessary or confusing detail. A range of text boxes help you get to the hints, tips and key points you need fast! A fully revised self-assessment section matching the latest exam formats is included to check your understanding and aid exam preparation. The accompanying enhanced, downloadable eBook completes this invaluable learning package. Series volumes have been honed to meet the requirements of today's medical students, although the range of other health students and professionals who need rapid access to the essentials of haematology and immunology will also love the unique approach of Crash Course. Whether you need to get out of a fix or aim for a distinction Crash Course is for you! Provides the exam syllabus in one place - saves valuable revision time Written by senior students and recent graduates - those closest to what is essential for exam success Quality assured by leading Faculty Advisors - ensures complete accuracy of information Features the ever popular 'Hints and Tips' boxes and other useful aide-memoires - distilled wisdom from those in the know Updated self-assessment section matching the latest exam formats - confirm your understanding and improve exam technique fast

Medical Semiology Guide of the Cardiovascular System and the Hematologic System provides a comprehensive understanding of medical semiology in the cardiovascular and hematologic systems. Highly illustrated with many original images from the author's daily medical practice, the book highlights all signs of diseases and important semiological maneuvers in the field. Each chapter incorporates a specific questionnaire with important questions that should be asked to patients in different situations to obtain valuable information that helps identify rare and unusual diseases. This unique feature of the book aims to facilitate the learning process among medical students, while also acting as a quick reference for clinicians.

This issue of Hematology/Oncology Clinics, guest edited by Ravi A. Chandra, Lisa A. Kachnic, and Charles R. Thomas, Jr., is the second volume of Contemporary Topics in Radiation Medicine, with focus on Disease Sites. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. Topics discussed in this issue will include: Breast, Central Nervous System, GI, Genitourinary/Prostate, Gynecologic, Head & Neck, Thoracic, Hematologic cancers (including Leukemias, Lymphomas), Pediatric Cancer, Sarcoma/STS, Skin, Oligometastatic Disease, Palliation & Supportive Care & Inpatient Medicine, Radiation Emergencies, among others.

This issue of Hematology/Oncology Clinics, Guest Edited by Drs. Ravi A. Chandra, Lisa A. Kachnic, Charles R. Thomas, Jr., is part one of a two-part issue focused on Contemporary Topics in Radiation Medicine. Topics include, but are not limited to, Basic Medical Physics, Basic Radiobiology, Modern Radiation Treatment Planning & Delivery, Advanced Imaging Techniques in Diagnosis and Tx, Particle Therapy/Protons, SRS/SBRT, Modern Brachytherapy, Immunotherapy/Abscopal, Nanotechnology, Bioinformatics & Artificial Intelligence, Quality-of-life & Outcomes, Normal Tissue Issues and Toxicity, Radiation Modifiers, and Health Economics/Disparities.

Concise, portable, and user-friendly, The Washington Manual Hematology and Oncology Subspecialty Consult, 4th Edition , provides quick access to the essential information needed to evaluate a patient on a subspecialty consult service. This edition offers state-of-the-art content, including coverage of new anti-cancer drugs and new biomarkers and therapeutic targets. Ideal for fellows, residents, and medical students rotating on hematology and oncology subspecialty services, the manual is also useful as a first-line resource for internists and other primary care providers. Key Features: Thoroughly revised to include new standards in the treatment of malignancies and hematologic disorders, mechanisms of action of new therapeutic agents, and the current use of molecular prognostic factors. A new chapter on immunotherapy reviews approved and potentially approved new therapies that help you improve clinical outcomes for your patients. A reorganized, consistent format throughout ensures that you can find what you need quickly and easily. Comprehensive coverage addresses all areas of hematology and oncology. Symptoms, signs, and problems encountered in daily practice are presented in a quick-reference bulleted format. Updated references are provided for readers who would like additional information on a particular topic. Written by fellows and junior faculty from the Washington University School of Medicine in St. Louis. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use

This issue of Hematology/Oncology Clinics, guest edited by Dr. Caron A. Jacobson, with consulting editors George P. Canellos and H. Franklin Bunn, will focus on Non-Hodgkin's Lymphoma. Topics include, but are not limited to: Ontogeny, Genetics, Molecular Biology and Classification of B and T cell Non-Hodgkin's Lymphoma; Diffuse large B cell lymphoma and high grade B cell lymphoma; Burkitt lymphoma and other highly aggressive B cell lymphomas; CNS lymphoma; Mantle cell lymphoma; Follicular lymphoma; Marginal zone lymphoma and lymphoplasmacytic lymphoma; Non-cutaneous T cell lymphoma; Cutaneous T cell lymphoma; Transplant and other adoptive immune cell therapies for non-Hodgkin lymphoma; Non-cellular immune therapies for non-Hodgkin's lymphoma; and Targeting biology in non-Hodgkin's lymphoma.

The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor Mark H. Yazer MD. * A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms * Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context * Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage * Review of the development of the evidence-base for transfusion medicine * Content on the clinical practice for transfusion and alternatives to transfusion

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers.

The first edition of this manual appeared in 1992 and was entitled ECAT Assay Procedures. It was the result of a unique cooperation between experts brought together by the European Concerted Action on Thrombosis and Disabilities (ECAT). The Concerted Action was at that time under the auspices of the Commission of the European Union. The second edition, like the first edition, deals with diagnostic tests within the field of thrombosis. However, the second edition has a broader scope because it is no longer limited by the frontiers of ECAT. Experts allover the world, in and outside ECAT, have contributed to this edition. The editors are very grateful for their contributions. The need for a new edition is obvious. Since 1992 new assays have been introduced for research, diagnosis, and therapy of thrombosis; for other assays improvements have been suggested, while a few others became redundant. The editors waived the radioimmunoassays of ~-thrombog1obulin and platelet factor 4 due to the fact that the kits required for these assays are rarely, or no longer, available. Also the PAI-1 activity assay was waived as it is liable to many inconsistencies and to large variations. A list of names and addresses of manufacturers marketing the kits and reagents has been compiled, together with a list of the recommended nomenclature of quantities in thrombosis and haemostasis, in order to facilitate the use of the updated version. These lists have been carefully compiled by Johannes J. Sidelmann, PhD, Department of Clinical Biochemistry in Esbjerg, Denmark.

This issue of Clinics in Laboratory Medicine, edited by Drs. Julio Delgado and Eszter Lazar-Molnar, will focus on HLA and Disease. Topics include, but are not limited to, The potential impact of NGS in HLA and disease association studies, HLA typing by NGS, HLA Antibody Testing: Evolution and Challenges, Diversity of killer cell immunoglobulin-like receptors and disease, Technical Aspects of Crossmatching in Transplantation, HLA Markers in Celiac Disease, HLA Associations in Drug Hypersensitivity Reactions, HLA in BMT, Post-transplant monitoring, HLA epitope matching in transplantation, and Molecular Testing in Post-Transplant Monitoring.

For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You'll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. A unique section on haematology in under-resourced laboratories. Ideal as a laboratory reference or as a comprehensive exam study tool. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. diagnosis, molecular testing, blood transfusion- and much more. Complete coverage of the latest advances in the field. An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.

Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis.

Transfusion Medicine for Pathologists: A Comprehensive Review for Board Preparation, Certification, and Clinical Practice is a concise study guide designed to complement standard textbooks in the field of clinical pathology. Pathology residents and fellows of transfusion medicine will find this book useful as a preparation tool for their exams. In addition, the book is a valuable timesaver for busy residents looking for a focused and compact study guide on transfusion medicine that will also be ideal for practicing pathologists who cross-cover transfusion medicine in their clinical practice.

This issue of Clinics in Laboratory Medicine, edited by Dr. Dan Milner, will focus on Global Health and Pathology. Topics include, but are not limited to: Clinical Laboratory Volunteerism, Pathologists Overseas; Anatomic Pathology Volunteerism; Funding Strategies in Research and Global Pathology; Diagnostics for Cancer and Health Systems building through pathology laboratories; Training the next pathologists in global health; Maximizing internet resources for improving pathology/lab medicine in LMICs; Pathology-based research in Africa; HIV and Cancer: Role of Pathology in success; Lymphoma and Pathology in Africa: Current approaches and future diagnostics; Laboratory Capacity as a tool for building health systems; Building Cross Country Networks for Laboratory Capacity and improvement; Lab accreditation; Practical success in Telepathology experiences in Africa; Pathology and WHO vision of the future of LMICs; Breast Cancer in LMICs: Why we need pathology and clinical trial capability to solve this challenge; Cytopathology in LMICs: why and how to integrate to capacitate healthcare; and Biorepositories and Data Cores for Research in Global Health.

This issue of Hematology/Oncology Clinics, edited by Dr. Ali Taher, focuses on Thalassemia. Topics include, but are not limited to, Molecular basis and genetic modifiers; Evolving spectrum of epidemiology; Clinical classification; Ineffective erythropoiesis, anemia and iron overload; Hypercoagulability and vascular disease; Clinical complications and their management; Transfusion and iron chelation therapy; Hematopoietic Stem Cell Transplantation in Thalassemia; Gene therapy and genome editing; Emerging therapies; Quality of life; Advances in understanding pathophysiology and treatment of fertility, pregnancy, and prenatal diagnosis in Thalassemia; and MRI for iron overload.