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Books > Medicine > Clinical & internal medicine > Haematology
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Myeloma Bone Disease (Paperback, 2010 ed.)
Loot Price: R5,814
Discovery Miles 58 140
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Myeloma Bone Disease (Paperback, 2010 ed.)
Series: Current Clinical Oncology
Expected to ship within 10 - 15 working days
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Multiple myeloma is the second most common hematologic malignancy
and c- rently affects approximately 50,000 people in the United
States. Each year about 20,000 people are diagnosed with myeloma.
Although new treatments have been developed, which signi?cantly
prolong the survival of patients, myeloma bone d- ease still
remains a major cause of severe morbidity and increased mortality
in patients with myeloma. Myeloma bone disease is characterized by
"punched out" lytic lesions caused by increased osteoclastic bone
destruction accompanied by suppressed or even absent osteoblast
activity. Advances in our understanding of both the pathophysiology
of myeloma bone disease and the development of novel agents that
target speci?c pathways involved in both the increased osteoclast
f- mation and the suppressed osteoblast activity in myeloma provide
new hope for these patients. The treatment of myeloma bone disease
was revolutionized by cl- ical trials that demonstrated the
signi?cant bene?t of intravenous bisphosphonate therapy in patients
with myeloma bone disease. With the identi?cation of many of the
cytokines and chemokines involved in myeloma bone disease, novel
th- apies such as denosumab that blocks RANKL activity, anti-DKK1,
which targets the inhibition of osteoblast activity by blocking Wnt
signaling inhibition, and the potential anabolic effects of agents
such as bortezomib and activin have greatly improved our potential
to block the progression or reverse myeloma bone disease.
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