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Acute Pulmonary Embolism - A Challenge for Hemostasiology (Paperback, Softcover reprint of the original 1st ed. 2000)
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Acute Pulmonary Embolism - A Challenge for Hemostasiology (Paperback, Softcover reprint of the original 1st ed. 2000)
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Inspite of considerable progress in prevention, diagnosis, and
treatment, pulmonary embolism has remained a threat to the patient
and a challenge for the physician both in conservative, as well as
in operative disciplines. Pulmonary embolism is according to
pathology observations still the most frequently overlooked
clinical diagnosis. In 1-5 per 100 autopsies, clinically unexpected
pulmonary emboli are found. In addition, the sequelae of recurrent
pulmonary emboli, the syndrome of pulmonary hypertension with or
without right heart failure, continues to present a therapeutic
dilemma - and no progress is in sight. In intensive care medicine
pulmonary embolism, either acute, massive, and/or recur- rent,
continues to be both a therapeutic as well as a preventive
challenge mobilizing pharmacotherapeutic, catheter-interventional,
and operative resources. Diagnostic, therapeutic, and preventive
strategies are currently in use. Their basis, however, seems
surprisingly thin, as far as our knowledge on the natural course of
this chameleon-like illness with and without fibrinolytic,
anticoagulative, catheter or opera- tive treatment is concerned. A
large European multicenter register has been initiated by
Professors Kasper and Geibel with the help of Boehringer Ingelheim
Pharmaceutics, in order to better describe the natural course of
pulmonary embolism under current treat- ment modalities.
Furthermore, recently the clinical significance of the valve patent
foramen ovale as a source of paradoxical emboli is beginning to be
better understood. Many concepts therefore require revision.
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