Decreased platelet counts can be due to a number of disease processes causing decreased platelet production, increased platelet destruction, or can be medication-induced. Health care providers have to differentiate inherited thrombocytopenias, primary immune thrombocytopenias (ITP), secondary immune thrombocytopenias, myelodysplastic syndromes with thrombocytopenia, bone marrow failure syndromes and non-immune thrombocytopenias. ITP is the most common cause of isolated thrombocytopenia. This book focuses on discussing ITP in adults; new treatment for ITP; thrombocytopenia during pregnancy; the different diagnosis of thrombocytopenia; heparin-induced thrombocytopenia; and thrombocytopenia in dengue.

Anaemia is defined as the decrease in haemoglobin from normal values either by loss of red blood cells or deficit in production or both. Haemoglobin is the major transporter of oxygen. The variation in haemoglobin is therefore a factor in determining the cardiac output. This book begins by discussing the effects anaemia has on heart diseases. The book then continues to discuss the influence of iron deficiency anaemia and recovery on oxidative/antioxidant status; influence of iron deficiency anaemia on bone metabolism; sickle cell anaemia; anaemia in myelodysplastic syndromes; transfusion in chronic anaemia; the prevalence, risk factors and management with a focus on chronic kidney disease; strategy for treating anaemia in chronic kidney disease patients from the standpoint of iron utility; and parasitic anaemia.

"Hematology in Traditional Chinese Medicine Cardiology" instructs readers on the blood, complement and immune system from the western and Chinese medicine perspectives. The book focuses on the cardiovascular issues concerning blood and the immune system, provides laboratory values concerning blood and the cardiovascular system, and covers cardiovascular diseases from the Chinese medicine and western medicine perspectives. It compares the eight principles in traditional Chinese medicine with basic science perspectives in western medicine, analyzes laboratory blood testing for heart diseases, and discusses the use of blood results for diagnosing and monitoring.
Balances basic theories in Chinese medicine with basic medical sciences on blood, immune system and cardiovascular diseasesProvides laboratory tests and values necessary for the monitoring of blood quality, and other tests for monitoring cardiovascular diseases in integrative Chinese medicinePrepares the practitioner to sit for the Niambi Wellness Integrative anatomy and patho-physiology in cardiology final online exam

Thalassemia is one of the most common genetic disorders worldwide and presents major public health and social challenges in areas of high incidence. The frequency of this disorder varies considerably with geographic locations and racial groups. Thalassemia refers to a group of inherited hemolytic anemia disorders that involve defects in the synthesis of hemoglobin - or -polypeptide chains. It leads to decreased hemoglobin production and hypochromic microcytic anemia associated with erythrocyte dysplasia and destruction. Homozygous -thalassemia (also known as thalassemia major, Cooley's anemia, or Mediterranean anemia) is associated with the most severe signs and symptoms. Thalassemia major (TM) is a life-threatening condition that commonly manifests during early infancy, after which progressive pallor, severe anemia, and failure to thrive are common. Children with TM often develop feeding problems, recurrent fever, bleeding tendencies (especially epistaxis), susceptibility to infection, pathologic fractures of long bones and vertebrae, endocrine abnormalities, splenomegaly, lack of sexual maturation, and growth retardation. This book discusses cures and treatments available for thalassemia, as well as the causes and the type of long-term health outcomes it may cause.

Myeloproliferative disorders are a group of clonal haematological neoplasms characterised by proliferation of one or more cells of myeloid lineage. They are the result of acquired mutations in the progenitor cell leading to hyper proliferation or neoplastic expansion of more mature forms of myeloid cells. Cells retain their functional ability with some degree of defects and also lead to suppression of normal stem cells. The most common type of Myeloproliferative Neoplasms (MPN) can broadly be classified into BCR ABL positive (Chronic Myelogenous Leukemia) and BCR ABL negative Disorders (Polycythemia Vera PV, Essential Thrombocytosis ET and Primary Myelofibrosis PMF). There are other rare types which have relatively low incidence like chronic neutrophilic leukemia, chronic eosinophilic leukemia, systemic mastocytosis and myeloproliferative neoplasms unclassifiable. These are the indolent type of haematological malignancies associated with marrow hypercellularity and organomegaly, with gradual progression to myelofibrosis or transformation to acute leukemias. During the dormant course of the BCR ABL negative MPN, they are more prone to thrombo-hemorrhagic complications and the treatment strategy is directed mostly to prevent complications. The past decade; therapies for BCR ABL positive disease (CML) have been a milestone achievement in keeping the disease in remission for many years, preventing major complications and halting the progression of the disease. This book discusses the classification, diagnosis and treatment of myeloproliferative diseases and provides insight on the symptoms and risk factors involved in the diseases.

Authored by a Registered Dietitian and book 11 in a series of 12 on topics related to Chronic Kidney Disease Iron deficency anemia has affected millions with chronic illnesses including kidney disease. If you should have any chronic illness and you are looking to improve your anemia labs then you should look to read this book on anemia. It covers all of the types of anemia as well as the potential medical treatments. As with any chronic disease, anemia can often be difficult to understand but can be controlled with by using the proper tools. Use the tips and ideas in this book to lead to managing your anemia. Are you always feeling tired? Get the answers here.

Inferior Vena Cava (IVC) filters have become an important part of deep venous thrombosis and pulmonary embolism treatment and prevention. With the advent of retrievable filters a new era of IVC instrumentation has been initiated. This book will begin to review the history of IVC filtration, indications for permanent and temporary filter use and filter use in special populations such as the pregnant patient or those with upper extremity venous thrombosis. The authors also review the technical aspects of filter placement and retrieval and discuss immediate and long-term complications from IVC filters. The book will also continue to discuss how acute spinal cord injury provides risks for developing deep vein thrombosis; and discuss the efficacy and safety of novel oral anticoagulants for venous thromboembolisms.

Plasmapheresis is a therapeutic tool used to treat a wide range of disease processes, and in which the priority aim is to ensure sufficient plasma exchange to reduce or eliminate symptoms resulting from the action of pathogenic elements vehiculised in the plasma. Scientific selective apheresis with principles of evidence-based medicine involves the application of one of the oldest therapeutic modalities (bleeding), widely used between the fourth century B.C. and the second industrial revolution. This book provides information on the use of plasmapheresis during pregnancy; therapeutic use of autologous plasma for the treatment of dry eye disease; and therapeutic plasma exchange in the neurological setting. It also discusses intravenous immunoglobulins. During the past decades intravenous immunoglobulins (IVIG) have gained more and more popularity for the treatment of a wide range of diseases and conditions. This treatment is extensively used in immune deficits, autoimmune thrombocytopenia, Kawasaki's disease, for the prevention of infectious complications due to hypogammaglobulinaemia secondary to myeloma, chronic lymphatic leukaemia and post-bone marrow and stem cell transplantation, in Guillain-Barre syndrome, etc. IV-Ig is obtained from the plasma of healthy blood donors and contains normal, polyclonal, polyspecific immunoglobins (Ig), mostly consisting of intact IgG. These antibodies are directed against non-self-antigens, self-antigens (natural autoantibodies), and other antibodies (idiotypic antibodies). The administration of intravenous immunoglobulin (IVIG) is generally safe and well tolerated. However, the treatment of autoimmune disorders usually requires high dose therapy (1-2 g/kg) that may result in a greater frequency of side effects and adverse events. This book discusses several topics including the clinical application of intravenous immunoglobulins in autoimmune mediated ocular inflammatory diseases; complications of intravenous immunoglobulin therapy; clinical uses; and side effects.

A multi-disciplinary team approach within this new book which evaluates the current state-of-play with regard to blood conservation, including a fresh look at the evidence. Contents will cover the Supply and Demand issues; why/how changes have occurred; a historical overview; transfusion transmitted diseases; changing demographics and the projected impact on blood supplies; considerations for transfusion practice; surgical peri-operative techniques; medical management; risk management issues; the role of the Hospital Transfusion Team; educational issues; National Reports/Edicts; clinical networks in blood transfusion.

Thrombophilias can be defined as a group of inherited or acquired disorders that increase the risk of developing thrombosis. Venous thromboembolism (VT) is considered a multifactorial disease produced by a sum of risk factors that predispose to the thrombotic event. This predisposition includes genetic and acquired defects. Thrombosis can occur in any section of the venous system, but commonly manifests as deep vein thrombosis of the leg and pulmonary embolism. Major complications of venous thrombosis are a disabling post-thrombotic syndrome, pulmonary hypertension, and sudden death duo to a pulmonary embolism and therefore, it poses a burden on health economy. Venous thrombosis is a common clinical challenge for doctors of all disciplines, as it is a complex multicausal disease. This books discusses in further detail the many complications and risk factors caused by venous thrombosis.

"HEMATOLOGY - An updated review through Extended Matching Questions" is the first of its kind in the field of hematology. It offers the reader a chance to review the subject through extended matching questions and interesting supplementary information is provided along with each answer. Few selected references as suggested readings are also listed. A wide range of topics are covered in multiple sections including: General and Laboratory Hematology Themes, Hematological Oncology Themes, Hemostasis and Thrombosis Themes, Transfusion Medicine Themes, Therapeutics Themes, Management Themes, Research, Ethics and Statistical Themes. This publication was the first one to bridge the gap in the markets as EMQ books in Hematology were lacking. It has attracted wide readership across the globe from those who are interested in refreshing their knowledge in Hematology and Transfusion Medicine, or those who are planning to appear in examinations. In this revised edition, feedback from readers and reviewers has been incorporated to enhance readers' satisfaction. New questions have been added on paraneoplastic syndromes, Rh antigen system nomenclature and related antibodies, monoclonal antibodies based targeted therapies, and supplementary information has also been updated for several chapters. This book has something for every reader Few words about the author... Dr. Zaidi is a consultant hematologist with more than 20 years of experience in the field of Hematology (both clinical & laboratory), transfusion medicine, hematopoietic stem cell transplantation and medical teaching at undergraduate & postgraduate levels. He has moved around the world gathering this outstanding experience. He has also mentored many young physicians making their career path in Hematology. He has several presentations & peer reviewed publications on his credit, some of which brought up novel ideas to the medical literature

Defined as red blood cell break down and the release of hemoglobin and intracellular contents into the plasma, haemolysis can seriously impact patient care as well as the laboratory's reputation through its affect on test results. Therefore, the European Preanalytical Scientific Committee, in collaboration with the International Federation of Clinical Chemistry Working Group on Patient Safety, have designed a questionnaire to collect data on prevalence and management of haemolytic specimens referred to the clinical laboratories for clinical chemistry testing. The new book will help identify the areas where haemolysis occurs most frequently, which can, in turn, guide further analysis about why it is occurring. Once these elements are known, practices and procedures can be implemented to dramatically reduce haemolysis and avoid erroneous laboratory results affecting patient care and increasing laboratory costs.

EMPOWER YOURSELF! Whether you're a newly diagnosed myeloma patient, a survivor, or a friend or relative of either, this book offers help. The only text to provide the doctor's and patient's views, 100 Questions & Answers About Myeloma, Third Edition gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a hematologist-oncologist specializing in myeloma treatment, and featuring "insider" advice from an actual patient, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

"The Gift of Experience" captures the lives and perspectives of twenty-one men, born with hemophilia, and their caregivers, in ways that other resources have failed to do. In vital and personal stories, these individuals speak about the experience of coping with hemophilia. Their accounts capture the impact of the dramatic advances in the treatment of the disease as well as the challenges of chronic pain, joint damage and HIV and hepatitis C infection resulting from the tainted blood supply between the late 1960s and the mid-1980s." Laura Gray and Christine Chamberlain have done a tremendous job weaving these oral histories into a narrative that allows their subjects to speak for themselves. "The Gift of Experience" is a 'must read' for anyone interested in the illness and disability experiences of people with chronic diseases as well as those with bleeding disorders. "The Gift of Experience" is moving and inspiring, a hopeful account of the human experience.

EMPOWER YOURSELF! Whether you're a newly diagnosed patient, survivor, or a friend, relative or caregiver, 100 Questions & Answers About Leukemia offers support and guidance. Now in its third edition, 100 Questions & Answers About Leukemia continues the successful doctor-patient collaboration, providing authoritative, practical answers to your questions regarding diagnostic testing, treatment options, clinical trials and much more. Written by a leukemia survivor and a prominent physician specializing in treatment of leukemia, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

High pressure in the lungs, or pulmonary hypertension, is most commonly due to smoking-related lung disease and conditions affecting the left heart, for example, high blood pressure in the arteries, faulty heart valves, and a weakened heart muscle. Pulmonary arterial hypertension (PAH), is a rare and complex disease, associated with many different medical conditions, which is caused by a growth of cells lining the inside of the lung arteries, resulting in high pressure in areas of the body. Both conditions lead to strain and potential failure of the right heart, and therefore awareness and early diagnosis of the condition is needed to lead to better outcomes: however this depends on education of all specialists and primary care clinicians about PAH. This practical handbook covers both PH and PAH, providing information required by the wide range of clinicians who will encounter these conditions, including cardiologists, respiratory physicians, rheumatologists, specialists in liver and AIDS medicine, and haematologists. It covers what it is, who it is likely to affect, how it is diagnosed, including the pitfalls of the various diagnostic tests, the different and evolving forms of treatment, long term management of this often devastating chronic disease, and the crucial role of multidisciplinary management in optimizing clinical care of these patients who usually have multi-system diseases. It also covers the up new classification for both PH and PAH, and new drugs that have recently become available.

From the perspective of blood flow, blood has some unusual properties: it is a suspension of blood cells of which the red blood cells are most numerous and are both deformable (at moderate and high flow rates) and will aggregate under conditions of slow flow. Also, the cellular volume concentration is high (about 40-45%). These features cause blood to have variable viscosity, dependent on flow conditions, and cause both red blood cell sedimentation and syneresis effects under slow flow conditions (which can lead to rheological artifacts). These effects also cause unusual flow phenomena when blood flows in systems of small diameter vessels (especially for diameters of about 500 m or less). These phenomena are seen in non-uniform cell distributions in vessel cross sections, a cell-poor layer of mostly blood plasma at vessels walls, non-proportionate cellular distribution during blood flow through vascular bifurcations, which leads to a very wide distribution of vessel cellular concentrations (from zero to systemic values) in the smaller vessels of the microcirculation, etc. All these phenomena are discussed in this book, as well as the difficulties presented by in vivo microvessels having non-ideal geometries. Table of Contents: Introduction / The Composition of Blood / Viscometers / Constitutive Equations / At Last, Experimental Data / Some In Vitro Blood Flows / The Fahraeus Effect / The Fahreus-Lindqvist Effect / In Vitro Arterial-Type Bifurcation Experimental Data / In Vivo Experimental Bifurcation Data / Flow in Microvascular Networks / Optimization / Concluding Statement / References

von Willebrand disease (VWD) is an inherited bleeding disorder that is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and also binds and stabilizes blood clotting factor VIII (FVIII) in the circulation. This book examines the need for more information on VWD prevalence and the relationship between low VWF levels of bleeding symptoms or risk and improving clinical and laboratory diagnostic tools.

This book presents topical research in the study of the types, treatments and health risks associated with hematomas. Topics discussed include the physiotherapeutic treatments of hematomas; cerebrospinal hematoma; infected hematomas; the etiology of pelvic hematomas; intracranial hematomas in pediatric patients; massive retroperitoneal hematoma following vaginal correction of vault prolapse and retropharyngeal hematomas.

Hemostasis (coagulation and fibrinolysis) is of importance in a broad range of medical disciplines. A high-quality hemostasis diagnosis enables a good therapy, which can be rather complicated without laboratory help. This new yearbook gathers important contributions in this field and presents them in a coherent and logical format.

This book presents topical research in the study of the kinetics, structure formation and disorders related to coagulation. Topics discussed include Brownian coagulation and diffusion-limited reactions; deregulation of coagulation during sepsis-induced disseminated intravascular coagulation; substrate induced coagulation (SIC) in aqueous and non-aqueous media for the preparation of advanced battery materials and neonatal coagulation problems. (Imprint: Nova)

Hemostasis (coagulation and fibrinolysis) is of importance in a broad range of medical disciplines. A high-quality hemostasis diagnosis enables a good therapy, which can be rather complicated without laboratory help. This yearbook gathers important contributions in this field and presents them in a coherent and logical format.

Fallon Bentley's life outside the fence seemed perfect and was often envied. Yet her journey was like walking through a garden of china roses, fearing every step. Her family, her friends, her soul, the future lay in the balance. How would she survive? Fallon had a choice - conquer her cancer or the government. Her decision: BOTH! Those who said, she would never win these battles, had never walked a step in her shoes. Her determination - Endless. Her mind echoed a story, a continuous maze of moments set in time, building a stairway to a destiny...a future...unknown. Her new found voice of wisdom and an angelic spiritual connection removed the word "No" from her vocabulary forever. Yet with her new found wisdom and spiritual connection, would the growing mystery in her life be revealed?

Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions.Table of Contents: Introduction / General Characteristics of Platelets / Platelet Adhesion to Vascular Walls / Platelet Aggregation / Platelet Recruitment and Blood Coagulation / Arterial, Venous, and Microvascular Hemostasis/Thrombosis / Summary

This volume, the proceedings of the third international conference held in Washington, D.C., in December 1963, consists of forty-five papers representing the current status of knowledge and the advances made since publication of the second symposium volume in 1959.
Originally published in 1964.
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