Anaemia is defined as the decrease in haemoglobin from normal values either by loss of red blood cells or deficit in production or both. Haemoglobin is the major transporter of oxygen. The variation in haemoglobin is therefore a factor in determining the cardiac output. This book begins by discussing the effects anaemia has on heart diseases. The book then continues to discuss the influence of iron deficiency anaemia and recovery on oxidative/antioxidant status; influence of iron deficiency anaemia on bone metabolism; sickle cell anaemia; anaemia in myelodysplastic syndromes; transfusion in chronic anaemia; the prevalence, risk factors and management with a focus on chronic kidney disease; strategy for treating anaemia in chronic kidney disease patients from the standpoint of iron utility; and parasitic anaemia.

"Hematology in Traditional Chinese Medicine Cardiology" instructs readers on the blood, complement and immune system from the western and Chinese medicine perspectives. The book focuses on the cardiovascular issues concerning blood and the immune system, provides laboratory values concerning blood and the cardiovascular system, and covers cardiovascular diseases from the Chinese medicine and western medicine perspectives. It compares the eight principles in traditional Chinese medicine with basic science perspectives in western medicine, analyzes laboratory blood testing for heart diseases, and discusses the use of blood results for diagnosing and monitoring.
Balances basic theories in Chinese medicine with basic medical sciences on blood, immune system and cardiovascular diseasesProvides laboratory tests and values necessary for the monitoring of blood quality, and other tests for monitoring cardiovascular diseases in integrative Chinese medicinePrepares the practitioner to sit for the Niambi Wellness Integrative anatomy and patho-physiology in cardiology final online exam

Thalassemia is one of the most common genetic disorders worldwide and presents major public health and social challenges in areas of high incidence. The frequency of this disorder varies considerably with geographic locations and racial groups. Thalassemia refers to a group of inherited hemolytic anemia disorders that involve defects in the synthesis of hemoglobin - or -polypeptide chains. It leads to decreased hemoglobin production and hypochromic microcytic anemia associated with erythrocyte dysplasia and destruction. Homozygous -thalassemia (also known as thalassemia major, Cooley's anemia, or Mediterranean anemia) is associated with the most severe signs and symptoms. Thalassemia major (TM) is a life-threatening condition that commonly manifests during early infancy, after which progressive pallor, severe anemia, and failure to thrive are common. Children with TM often develop feeding problems, recurrent fever, bleeding tendencies (especially epistaxis), susceptibility to infection, pathologic fractures of long bones and vertebrae, endocrine abnormalities, splenomegaly, lack of sexual maturation, and growth retardation. This book discusses cures and treatments available for thalassemia, as well as the causes and the type of long-term health outcomes it may cause.

Myeloproliferative disorders are a group of clonal haematological neoplasms characterised by proliferation of one or more cells of myeloid lineage. They are the result of acquired mutations in the progenitor cell leading to hyper proliferation or neoplastic expansion of more mature forms of myeloid cells. Cells retain their functional ability with some degree of defects and also lead to suppression of normal stem cells. The most common type of Myeloproliferative Neoplasms (MPN) can broadly be classified into BCR ABL positive (Chronic Myelogenous Leukemia) and BCR ABL negative Disorders (Polycythemia Vera PV, Essential Thrombocytosis ET and Primary Myelofibrosis PMF). There are other rare types which have relatively low incidence like chronic neutrophilic leukemia, chronic eosinophilic leukemia, systemic mastocytosis and myeloproliferative neoplasms unclassifiable. These are the indolent type of haematological malignancies associated with marrow hypercellularity and organomegaly, with gradual progression to myelofibrosis or transformation to acute leukemias. During the dormant course of the BCR ABL negative MPN, they are more prone to thrombo-hemorrhagic complications and the treatment strategy is directed mostly to prevent complications. The past decade; therapies for BCR ABL positive disease (CML) have been a milestone achievement in keeping the disease in remission for many years, preventing major complications and halting the progression of the disease. This book discusses the classification, diagnosis and treatment of myeloproliferative diseases and provides insight on the symptoms and risk factors involved in the diseases.

Authored by a Registered Dietitian and book 11 in a series of 12 on topics related to Chronic Kidney Disease Iron deficency anemia has affected millions with chronic illnesses including kidney disease. If you should have any chronic illness and you are looking to improve your anemia labs then you should look to read this book on anemia. It covers all of the types of anemia as well as the potential medical treatments. As with any chronic disease, anemia can often be difficult to understand but can be controlled with by using the proper tools. Use the tips and ideas in this book to lead to managing your anemia. Are you always feeling tired? Get the answers here.

Inferior Vena Cava (IVC) filters have become an important part of deep venous thrombosis and pulmonary embolism treatment and prevention. With the advent of retrievable filters a new era of IVC instrumentation has been initiated. This book will begin to review the history of IVC filtration, indications for permanent and temporary filter use and filter use in special populations such as the pregnant patient or those with upper extremity venous thrombosis. The authors also review the technical aspects of filter placement and retrieval and discuss immediate and long-term complications from IVC filters. The book will also continue to discuss how acute spinal cord injury provides risks for developing deep vein thrombosis; and discuss the efficacy and safety of novel oral anticoagulants for venous thromboembolisms.

Plasmapheresis is a therapeutic tool used to treat a wide range of disease processes, and in which the priority aim is to ensure sufficient plasma exchange to reduce or eliminate symptoms resulting from the action of pathogenic elements vehiculised in the plasma. Scientific selective apheresis with principles of evidence-based medicine involves the application of one of the oldest therapeutic modalities (bleeding), widely used between the fourth century B.C. and the second industrial revolution. This book provides information on the use of plasmapheresis during pregnancy; therapeutic use of autologous plasma for the treatment of dry eye disease; and therapeutic plasma exchange in the neurological setting. It also discusses intravenous immunoglobulins. During the past decades intravenous immunoglobulins (IVIG) have gained more and more popularity for the treatment of a wide range of diseases and conditions. This treatment is extensively used in immune deficits, autoimmune thrombocytopenia, Kawasaki's disease, for the prevention of infectious complications due to hypogammaglobulinaemia secondary to myeloma, chronic lymphatic leukaemia and post-bone marrow and stem cell transplantation, in Guillain-Barre syndrome, etc. IV-Ig is obtained from the plasma of healthy blood donors and contains normal, polyclonal, polyspecific immunoglobins (Ig), mostly consisting of intact IgG. These antibodies are directed against non-self-antigens, self-antigens (natural autoantibodies), and other antibodies (idiotypic antibodies). The administration of intravenous immunoglobulin (IVIG) is generally safe and well tolerated. However, the treatment of autoimmune disorders usually requires high dose therapy (1-2 g/kg) that may result in a greater frequency of side effects and adverse events. This book discusses several topics including the clinical application of intravenous immunoglobulins in autoimmune mediated ocular inflammatory diseases; complications of intravenous immunoglobulin therapy; clinical uses; and side effects.

Thrombophilias can be defined as a group of inherited or acquired disorders that increase the risk of developing thrombosis. Venous thromboembolism (VT) is considered a multifactorial disease produced by a sum of risk factors that predispose to the thrombotic event. This predisposition includes genetic and acquired defects. Thrombosis can occur in any section of the venous system, but commonly manifests as deep vein thrombosis of the leg and pulmonary embolism. Major complications of venous thrombosis are a disabling post-thrombotic syndrome, pulmonary hypertension, and sudden death duo to a pulmonary embolism and therefore, it poses a burden on health economy. Venous thrombosis is a common clinical challenge for doctors of all disciplines, as it is a complex multicausal disease. This books discusses in further detail the many complications and risk factors caused by venous thrombosis.

Hemostasis and Thrombosis , Sixth Edition Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs. NEW to the Sixth Edition... * A new team of editors , each a leader in his field, assures you of fresh, authoritative perspectives. * Full color throughout * A companion website that offers full text online and an image bank. * A new introductory section of chapters on basic sciences as related to the field * Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups. * Overview chapters preceding each section address broad topics of general importance.

Defined as red blood cell break down and the release of hemoglobin and intracellular contents into the plasma, haemolysis can seriously impact patient care as well as the laboratory's reputation through its affect on test results. Therefore, the European Preanalytical Scientific Committee, in collaboration with the International Federation of Clinical Chemistry Working Group on Patient Safety, have designed a questionnaire to collect data on prevalence and management of haemolytic specimens referred to the clinical laboratories for clinical chemistry testing. The new book will help identify the areas where haemolysis occurs most frequently, which can, in turn, guide further analysis about why it is occurring. Once these elements are known, practices and procedures can be implemented to dramatically reduce haemolysis and avoid erroneous laboratory results affecting patient care and increasing laboratory costs.

Fully revised throughout, the second edition of Manual of Stem Cell and Bone Marrow Transplantation is based on the in-house handbook used at the world-renowned Dana-Farber Cancer Institute. It is a practical pocket manual for all members of the stem cell and bone marrow transplant team. Written by experts at Dana-Farber, the contents are handily arranged in outline format for maximum usefulness and convenience. This essential and user-friendly manual covers all aspects of the transplantation process, from stem cell processing through management of transplant-related complications. Topics discussed thoroughly include evaluation and counselling of patients and donors, preventative care, graft-versus-host disease and conditioning regimens. A new extensive chapter on oral health in stem cell transplantation has been added. These features make the Manual of Stem Cell and Bone Marrow Transplantation an ideal resource for the entire transplant team.

EMPOWER YOURSELF! Whether you're a newly diagnosed myeloma patient, a survivor, or a friend or relative of either, this book offers help. The only text to provide the doctor's and patient's views, 100 Questions & Answers About Myeloma, Third Edition gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a hematologist-oncologist specializing in myeloma treatment, and featuring "insider" advice from an actual patient, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

"The Gift of Experience" captures the lives and perspectives of twenty-one men, born with hemophilia, and their caregivers, in ways that other resources have failed to do. In vital and personal stories, these individuals speak about the experience of coping with hemophilia. Their accounts capture the impact of the dramatic advances in the treatment of the disease as well as the challenges of chronic pain, joint damage and HIV and hepatitis C infection resulting from the tainted blood supply between the late 1960s and the mid-1980s." Laura Gray and Christine Chamberlain have done a tremendous job weaving these oral histories into a narrative that allows their subjects to speak for themselves. "The Gift of Experience" is a 'must read' for anyone interested in the illness and disability experiences of people with chronic diseases as well as those with bleeding disorders. "The Gift of Experience" is moving and inspiring, a hopeful account of the human experience.

EMPOWER YOURSELF! Whether you're a newly diagnosed patient, survivor, or a friend, relative or caregiver, 100 Questions & Answers About Leukemia offers support and guidance. Now in its third edition, 100 Questions & Answers About Leukemia continues the successful doctor-patient collaboration, providing authoritative, practical answers to your questions regarding diagnostic testing, treatment options, clinical trials and much more. Written by a leukemia survivor and a prominent physician specializing in treatment of leukemia, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

From the perspective of blood flow, blood has some unusual properties: it is a suspension of blood cells of which the red blood cells are most numerous and are both deformable (at moderate and high flow rates) and will aggregate under conditions of slow flow. Also, the cellular volume concentration is high (about 40-45%). These features cause blood to have variable viscosity, dependent on flow conditions, and cause both red blood cell sedimentation and syneresis effects under slow flow conditions (which can lead to rheological artifacts). These effects also cause unusual flow phenomena when blood flows in systems of small diameter vessels (especially for diameters of about 500 m or less). These phenomena are seen in non-uniform cell distributions in vessel cross sections, a cell-poor layer of mostly blood plasma at vessels walls, non-proportionate cellular distribution during blood flow through vascular bifurcations, which leads to a very wide distribution of vessel cellular concentrations (from zero to systemic values) in the smaller vessels of the microcirculation, etc. All these phenomena are discussed in this book, as well as the difficulties presented by in vivo microvessels having non-ideal geometries. Table of Contents: Introduction / The Composition of Blood / Viscometers / Constitutive Equations / At Last, Experimental Data / Some In Vitro Blood Flows / The Fahraeus Effect / The Fahreus-Lindqvist Effect / In Vitro Arterial-Type Bifurcation Experimental Data / In Vivo Experimental Bifurcation Data / Flow in Microvascular Networks / Optimization / Concluding Statement / References

von Willebrand disease (VWD) is an inherited bleeding disorder that is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and also binds and stabilizes blood clotting factor VIII (FVIII) in the circulation. This book examines the need for more information on VWD prevalence and the relationship between low VWF levels of bleeding symptoms or risk and improving clinical and laboratory diagnostic tools.

This book presents topical research in the study of the types, treatments and health risks associated with hematomas. Topics discussed include the physiotherapeutic treatments of hematomas; cerebrospinal hematoma; infected hematomas; the etiology of pelvic hematomas; intracranial hematomas in pediatric patients; massive retroperitoneal hematoma following vaginal correction of vault prolapse and retropharyngeal hematomas.

Anaemia, or lack of red blood cells, is common, and can be a symptom of a serious underlying disorder. It has a number of causes, and this book stresses that it's vital to find and treat these, rather than simply prescribing iron tablets. Iron tablets do have their place in treatment, but this is rarely the full answer and priority must be given to discovering the underlying cause.

Hemostasis (coagulation and fibrinolysis) is of importance in a broad range of medical disciplines. A high-quality hemostasis diagnosis enables a good therapy, which can be rather complicated without laboratory help. This yearbook gathers important contributions in this field and presents them in a coherent and logical format.

Fallon Bentley's life outside the fence seemed perfect and was often envied. Yet her journey was like walking through a garden of china roses, fearing every step. Her family, her friends, her soul, the future lay in the balance. How would she survive? Fallon had a choice - conquer her cancer or the government. Her decision: BOTH! Those who said, she would never win these battles, had never walked a step in her shoes. Her determination - Endless. Her mind echoed a story, a continuous maze of moments set in time, building a stairway to a destiny...a future...unknown. Her new found voice of wisdom and an angelic spiritual connection removed the word "No" from her vocabulary forever. Yet with her new found wisdom and spiritual connection, would the growing mystery in her life be revealed?

This volume, the proceedings of the third international conference held in Washington, D.C., in December 1963, consists of forty-five papers representing the current status of knowledge and the advances made since publication of the second symposium volume in 1959.
Originally published in 1964.
A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.

The proceedings of the first symposium ever held to consider in a comprehensive manner the multiple problems of hemophilia are recorded in this volume. Containing the complete material presented at the symposium, the volume provides an authoritative summation of the current status of hemophilia and related diseases.
Originally published in 1957.
A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.

For over a quarter of a century, Dr. Ferguson has been experimenting with the blood of animals and human beings to unravel the very complex chemical processes that underlie blood clotting. The author gives a detailed account of his many original technical procedures. His experimental data and the described results amply consolidate current theories and provide a firm basis for new advances.
Originally published in 1960.
A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.

This volume, based on the second international symposium on hemophilia held in Rome, includes not only the presented material but also other significant contributions by fifty-five of the most outstanding workers in the field.
Originally published in 1959.
A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.

In the human body, iron is present in all cells and has several vital functions: as a carrier of oxygen to the tissues from the lungs in the form of hemoglobin; as a transport medium for electrons within the cells in the form of cytochromes and as an integral part of enzyme reactions in various tissues. Too little iron can interfere with these vital functions and lead to morbidity and death. This book presents current research from across the globe in the study of iron deficiency, including iron deficiency anemia in pregnant women and in gastric bypass surgery patients; the metabolic adjustment under Fe deficiency in roots of dicotyledonous plants and strategies for the fortification of food with iron.