A unique point-of-care guide to clinical hematology-oncology Hematology-Oncology Clinical Questions answers the questions most frequently asked by medical students or residents on rotations. The answers provided are concise, specific, evidence-based, and supported by recent references and clinical practice guidelines. Readers will find Hematology-Oncology Clinical Questions to be single-best resource for quickly translating the most current knowledge into practical, diagnostic real-time solutions. * Coverage includes both solid tumor and hematology malignancies, cancer screening and genetic and familial cancer syndrome, supportive care and end of life, chemotherapy agents (including immunotherapy)* The content arrangement is designed to simulate the consultation process: data collection, synthesis of data, solution

The acclaimed full-color review of the underlying principles of blood diseases and disorders - based on a Harvard Medical School hematology course A Doody's Core Title for 2021! LANGE Pathophysiology of Blood Disorders, Second Edition is a well-illustrated, easy-to-absorb introduction to the physiological principles underlying the regulation and function of blood cells and hemostasis, as well as the pathophysiologic mechanisms responsible for the development of blood disorders. Featuring a strong emphasis on key principles, the book also covers diagnosis and management primarily within a framework of pathogenesis. The organization and content of this book are based on a 3-week hematology course given to students in their second year at Harvard Medical School. All of the authors are lecturers in this course and many of the figures have been taken directly or adapted from their lectures. FEATURES OF THE SECOND EDITION: NEW summary boxes with high yield points to remember All figures have been redrawn by a single artist for quality and consistency A more user-friendly presentation Each chapter includes learning objectives, and self-assessment questions with detailed explanations Numerous tables and diagrams encapsulate important information Hailed for its uniformity of style, clarity, brevity, and high level of scientific rigor and clinical relevance, LANGE Pathophysiology of Blood Disorders, Second Edition will prove valuable to medical students, as well as physicians at all stages of their training.

Hippocrates of Cos was one of the first who described spontaneous subarachnoid haemorrhage without special knowledge about neuro-anatomy or neuro-physiology. This haemorrhage represented a life ending event of fate for him. Inventions like computed tomography or angiography gave better insight into the patterns of this life threatening disease. Progress in management was developed by new cranial approaches, new generations of clips and better intensive care modalities. The latter could be represented by the increasing use of nimodipine or the integration of the early sealing mode of an intracranial aneurysm after rupture within 72 hours. Endovascular therapies revolutionised aneurysm management, strengthening the interdisciplinary team-work of neuroradiologists, anesthesists and neurosurgeons. These changes in the past lead to a significant reduction in mortality, producing more survivors who suffer different stages of morbidity. Morbidity in this context is represented by physical handicaps and dependencies, but also mental, emotional and cognitive impairments. However, there are still some challenges to manage, like the cerebral vasospasm or delayed cerebral ischemia including spreading depolarisations, (prolonged) hydrocephalus, and cognitive long-term morbidity that may complicate a smooth and easy reintegration into daily life. Nevertheless, dealing with this long history and the aforementioned challenges, there is still the opinion that there is stagnation in the progress within this field of study. Scientists lack new ideas for surgical procedures or clips, endovascular devices do not always represent safe options, and medication providing protection for vasospasms still remains unknown. This book provides basic knowledge concerning this interesting disease pattern and introduces more intensive work in the field. It is written by a team of individuals from multiple disciplines that represent different parts of therapy management. The literature used is recent and promotes intensive private or independent study. The intended audiences for this book include students, residents, registrars, assistant physicians, and all physicians from neighbouring disciplines.

This is an essay by the Japanese hematologist who is an international member of American society of hematology and now works in Japan. The kindle edition of "Byouki nannte yattsukero" has already been published by Amazon co. jp (https: //www.amazon.co.jp/dp/B00IGUT6GK). Many issues of "Byokinannte yattsukero" have been downloaded since its publication. Because there are also many requests for paperback edition, the author has published this book through createspace com. This essay is written in Japanese.

Twin-to-Twin Transfusion Syndrome (TTTS) is a rare condition that only occurs in identical twins when they are in the womb. It occurs when blood moves from one twin to the other, resulting in one twin having too little blood and the other with too much blood. This concise guide describes the etiology, diagnosis and treatment of TTTS. Divided into six sections, the book begins with the history of the condition, then the basics, clinical features and diagnosis, to the most recent advances in its management and related ethical issues. Edited by Professor Daniel W Skupski of Weill Medical College of Cornell University and New York Hospital Queens, USA, this practical guide includes nearly 100 full colour images and illustrations. Key points Concise guide to Twin-to-Twin Transfusion Syndrome (TTTS) Provides most up to date knowledge on etiology, diagnosis and treatment Edited by Daniel W Skupski of Cornell University and New York Hospital, Queens Includes nearly 100 images and illustrations

Anaemia, or lack of red blood cells, is common, and can be a symptom of a serious underlying disorder. It has a number of causes, and this book stresses that it's vital to find and treat these, rather than simply prescribing iron tablets. Iron tablets do have their place in treatment, but this is rarely the full answer and priority must be given to discovering the underlying cause.

Concise Guide to Hematology is highly practical, user-friendly, and will be invaluable to all residents, fellows, and trainees working with hematology patients. Designed to highlight the important basic concepts and diseases throughout the spectrum of hematology, the book has a clear and accessible format and includes simple line figures, algorithms, and key points thoughout. Each chapter begins with an overview and then main concepts are outlined for each disorder and topic covered. Edited by two leading figures in the rapidly evolving field of hematology, this attractively-produced and concise book is an essential guide and ready resource for all those undertaking rotations and examinations in the discipline.

Hemostasis (coagulation and fibrinolysis) is of importance in a broad range of medical disciplines. A high-quality hemostasis diagnosis enables a good therapy, which can be rather complicated without laboratory help. This yearbook gathers important contributions in this field and presents them in a coherent and logical format.

For over a quarter of a century, Dr. Ferguson has been experimenting with the blood of animals and human beings to unravel the very complex chemical processes that underlie blood clotting. The author gives a detailed account of his many original technical procedures. His experimental data and the described results amply consolidate current theories and provide a firm basis for new advances.
Originally published in 1960.
A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.

This volume, based on the second international symposium on hemophilia held in Rome, includes not only the presented material but also other significant contributions by fifty-five of the most outstanding workers in the field.
Originally published in 1959.
A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.

This volume, the proceedings of the third international conference held in Washington, D.C., in December 1963, consists of forty-five papers representing the current status of knowledge and the advances made since publication of the second symposium volume in 1959.
Originally published in 1964.
A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.

The proceedings of the first symposium ever held to consider in a comprehensive manner the multiple problems of hemophilia are recorded in this volume. Containing the complete material presented at the symposium, the volume provides an authoritative summation of the current status of hemophilia and related diseases.
Originally published in 1957.
A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.

An apoprotein a protein that is normally attached to second molecule that is not a polypeptide, from which it has become disassociated. For example: ferritin that lacks the ferric hydroxide core could be called apoferritin. Lipid supply is a determinant of apoprotein synthesis and secretion, and cholesterol may be of particular importance in initiating apoprotein synthesis. This book presents the latest research results in this field from around the globe.

In malaria endemic areas, red cell polymorphisms that confer protection against acute uncomplicated malaria, severe malaria, and malaria mortality are widespread. However, the mode of selection favouring the red cell disorders and the precise mechanism of malaria protection remains unknown. In this book, the authors describe possible mechanisms by which the red cell disorders might confer resistance or susceptibility to human Plasmodium. This book shows how the interactions between Plasmodium species appear more evident through natural host protection or susceptibility and offer a good opportunity to better knowledge on this subject poorly understood. The authors have evaluated the consequences in vaccines development.

This book presents recent and important research on Chronic lymphocytic leukemia (or "chronic lymphoid leukemia"), known for short as CLL, which is a type of leukemia in which too many lymphocytes are produced. Although the malignant lymphocytes in CLL may look normal and mature, they are not and these cells may not cope effectively with infection. CLL is the most common form of leukemia in adults. Men are twice as likely to develop CLL as women. However, the key risk factor is age; over 75% of new cases are diagnosed in patients over age 50.

Anaemia is the common health problem all over the world. The term "tropical anaemia" means the anaemic disorders, which are predominant in the tropical region of the world. The purpose of this book is to summarise and present the topics specifically relating to the anaemia in the forms that is unique in the tropical countries. Due to the globalisation in the present day, the change in the epidemiology of diseases from one site to the others all around the world can be expected. The summative on the common anaemic problems in the tropical countries can be and should be performed. This book can make them at least realise the problems. The details of this book focus on the anaemia in the aspects relating to the tropical medicine. The book covers specifically the clinical aspects, scientific laboratory aspects, public health aspects as well as the social sciences relating to anaemia in important tropical diseases. The common tropical diseases, including inherited disorders and infectious diseases, which relate to the anaemia are summarised, presented and discussed. Mainly the book presents summative data from the molecular to the population scales, as well as additional metanalysis for important topics. In addition, the diagnostic guideline and clinical practice guideline of the mentioned conditions are presented.

The objective of this book is to review specific haematologic disorders that commonly present in the new-born period. It summarises and presents the topics specifically relating to the haematological disorders in neonates.

Although blood transfusion saves lives and reduces the rate of morbidity in many clinical diseases and conditions, it is associated with certain risks. A transfusion-related adverse event, also called transfusion reaction, is any unfavourable event occurring in a patient during or after blood transfusion. About 0.5 per cent to 3 per cent of all transfusions result in some adverse events, but the majority of them are minor reactions with no significant consequences. In general, transfusion-related adverse events are categorised as infectious and non-infectious. However, there are other classifications in the literature based on time of occurrence (i.e. acute versus delayed) or physiological mechanism (i.e. immune mediated versus non-immune mediated). A significant proportion of adverse events may occur as a result of errors in preparation, ordering or administration of blood and blood products. The book contains the latest research in this essential field, which has been revolutionised in recent decades.

Why is blood red? Because it contains Haemoglobin -- the most important molecule in the human body. In health -- the average person has 4 lbs. of haemoglobin and manufactures seven billion molecules of haemoglobin every second. It carries oxygen from the lungs to the cells and helps the body remove waste carbon dioxide. In sickness -- an estimated one billion people around the world have some disorder related to haemoglobin: sickle-cell anaemia, pernicious anaemias, iron-deficiency anaemia, porphyries, haemoglobin E disease, alpha-thalassemia, beta-thalassemia, and G6PD deficiency. One type of haemoglobin can be used to monitor diabetes. This basic introduction to haemoglobin includes information on the reselection of Richard Nixon, the madness of King George III, werewolves, lead poisoning, legends about Pythagoras, genetics and genetic screening, diabetes, respiration, the production of red cells, and translation of the DNA code. Haemoglobin is a fascinating molecule that touches our lives, our politics, our myths and our history. This new book presents current analyses of one of the most controversial issues of our times -- affirmative action. Proponents on both sides of the issue claim clear-cut evidence for the rightness of their arguments, yet evidence is hazy at best. This volume helps shed light on the underlying basis for affirmative action and elucidates the latest legal and social developments.

Utilizes the proven Secrets Series format to present questions and answers in a convenient, readable, concise manner The text is intended to introduce the reader to the field of pediatric hematology/oncology. Each chapter will emphasize diagnosis, clinical management, therapeutics, and innovative concepts for the future. Highlights of the text include the following chapters: experimental therapeutics, the application of bone marrow and stem cell transplants for pediatric patients, and genetic and molecular diagnostics. There is a section dealing with quality of life and death issues such as supportive care, psychosocial aspects of care of the child with cancer, palliative care, and management of the dying child. Other chapters relate and differentiate disease entities based upon the age of the patient, newborn through adolescent.Each topic covered will discuss diagnosis, clinical management, therapeutics, and innovative concepts for the future. Concise answers that also feature the authors' pearls, tips, memory aids, and "secrets" Bulleted lists and pertinent tables for quick review and reference Succinct chapters written by experts in pediatric hematology and oncology All the most important "need-to-know" questions and answers in the proven format of the highly acclaimed Secrets Series Thorough, highly detailed index

Each year thousands are told they suffer from anemia, but most have only a vague understanding of the condition. In fact, "anemia" is a generic term that includes myriad specific diseases, each of which has its own story regarding cause, manifestations, and treatments.Understanding Anemia gently builds upon elementary knowledge of biology to provide the general reader with a fairly sophisticated understanding of the various causes of anemia, of the methods used to make diagnoses, and of the principles of treatment. The book begins with a definition of anemia and a brief history of the scientific study of blood. It explains how the doctor makes the diagnosis and details the main types of anemia. Since the different conditions result from the failure of various organs, the reader will come away with a surprisingly broad understanding of human anatomy and physiology, encompassing the digestive, circulatory, and immune systems, nutrition, biochemistry, and heredity.Features: Specific anemias: iron deficiency, vitamin deficiencies, hemolytic anemias, hereditary anemias, and others Helpful appendices: a practical guide to the metric system, a brief review of general cell biology, a table of normal values in commonly ordered lab tests, a description of the bone marrow biopsy procedure, a list of pitfalls a doctor faces during the evaluation of the anemic patient, resources for further study (both in print and on the Internet)

Ed Uthman is director of the medical laboratory at Polly Ryon Memorial Hospital in Richmond, Texas. He is an adjunct assistant professor of pathology at the University of Texas School of Medicine, Houston.

With authoritative coverage of rare and common hemostatic disorders, Consultative Hemostasis and Thrombosis, 4th Edition, keeps you both up to date with all that's new in this fast-moving field as well as reviewing background and development and citing pertinent classical literature. Broad differential diagnoses are provided, underscoring the editors' position that correct treatment begins with correct diagnosis. This trusted resource by Drs. Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, Michael B. Streiff, and David A. Garcia is designed for rapid reference and critical decision making at the point of care. Emphasizes real-world problems and solutions, with quick access to concise descriptions of each condition, associated symptoms, laboratory findings, differential diagnosis, and treatment. Features a user-friendly design, full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout. Provides thorough updates on core information on hemostasis and thrombosis, including deep venous thrombosis (DVT), pulmonary embolisms, hypercoagulability, thrombocytopenia, von Willenbrand disease, and more. Covers new treatment information on hemophilia A and B. Contains new chapters on hereditary hemorrhagic telangiectasia, hemolytic uremic syndrome, and paroxymal nocturnal hemoglobinuria. Two new editors, Dr. Michael B. Streiff and Dr. David A. Garcia, offer fresh perspectives and valuable experience. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with and thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.

Understanding the causes of anemia is critical to inform appropriate strategies to prevent and treat anemia, particularly to reduce the risk of anemia and the burden of disease. The strength of this book lies in its cross-disciplinary nature. This publication summarizes the current state of evidence on the multifactorial causes of anemia, with a specific focus on nutritional anemia. The chapter authors are leading experts in nutrition and global health. The introductory chapters provide an overview of the global burden of anemia prevalence, the economic implications and functional consequences of anemia, and the significance of these factors to guide policy and programs. Subsequent chapters provide current evidence on iron and other micronutrient metabolism and homeostasis in regards to anemia, the multifactorial contributors to anemia (e.g. infection and genetics), and the interactions between nutrients that may contribute to anemia. The summarizing chapters detail program and policy approaches to treat, prevent and reduce anemia in the global context. Nutritional Anemia is a comprehensive resource for those involved in global health and nutrition policy, strategy, programming, or research, and serves as a guide for how government, NGO, and international agencies can effectively treat, prevent and reduce anemia globally.