Stillbirth remains a sufficiently frequent outcome of pregnancy to pose great problems for clinicians, who have to treat extremely distressed patients. This concise but comprehensive book from an international team of contributors sets out clear guidelines for clinical procedures and patient management for the obstetrician, as well as the gynecologist and the gynecologic pathologist.

Oocyte cryopreservation entails important potential advantages for human IVF, offering a less ethically disputable alternative to embryo cryopreservation, simplifying and making safer oocyte donation, and giving an opportunity for fertility preservation to women at risk of premature ovarian failure as an effect of genetic factors or chemo- or radiotherapies. Oocyte cryopreservation could also meet the expectations of women wishing to preserve their fertility for social reasons. In the last few years, advances in cryopreservation methodologies have dramatically improved the efficiency of oocyte cryopreservation, leading to the birth of over a thousand babies and challenging the supremacy of embryo cryopreservation as the preferred form of fertility preservation. This text has been conceived with the aim of offering a comprehensive view of the state of the art of oocyte cryopreservation. It covers fundamental concepts of low temperature storage (controlled rate slow cooling and vitrification), aspects of oocyte physiology relevant to the process of cryopreservation, essential biological and clinical evidence, and ethical implications of oocyte cryopreservation, thereby providing a complete overview of progress in this strategy in assisted reproduction.

Personnel working in assisted reproductive technology often lack the opportunities for dedicated training in the specialized techniques and technologies required for the procedures. As such, success in the form of live birth rates can range from over 50% to less than 10% per treatment cycle. This comprehensive introductory textbook is an essential resource for trainee embryologists, medical students and nurses. The recent revolutions in biotechnology and molecular biology involved in delivering assisted reproductive services are thoroughly discussed. Basic knowledge such as the development and physiology of both male and female reproductive systems is covered, with practical aspects of IVF including gamete and embryo manipulation, cryopreservation and genetic testing explained in detail. A full description of the optimal structure and management of the IVF laboratory is given, helping ensure procedures are safe and effective. Extensive and highly detailed colour illustrations bring the content to life and aids readers in their understanding.

'A big-picture forecast of how medicine stands on the threshold of a revolution that will radically change all of our lives' The Times Welcome to a revolution in the science of you! This landmark new book from award-winning scientist Daniel M. Davis explores the future of the human body. Imagine taking drugs to help you acquire new skills, or knowing years in advance the precise likelihood of developing specific cancers, or following a diet and health regime tailored to your microbiome, or even having continuous monitoring of your body's workings and well-being. Written by an award-winning scientist, this landmark book shows how these radical and disconcerting possibilities have been made real. It is at once a gripping drama of scientific ingenuity, discovery and collaboration, and a vision of the human body of dizzying complexity and wonder. 'The startling new discoveries...are radically altering our understanding of how we function and what our future holds' BRIAN COX 'Thrilling' BILL BRYSON 'Brilliant' TIM SPECTOR 'Extraordinary' ALICE ROBERTS

At 11.47pm on July 25th 1978, Louise Brown was the first person ever to be born through science rather than as the result of two people having sex. The birth was hailed as a "miracle" by the world's media, making her instantly famous. For the first time Louise tells the story of her world changing birth and its impact on her life. The book contains many family photographs and letters which have never been published before. It was written by Louise with her long-term publicist Martin Powell of Empica PR.

The first edition of "Textbook of Men's Health" did much to establish and define the scope of the emerging subspecialty of aging men's health. This revised and updated edition offers a unique overview of the male health and offers valuable insights for improved management and critical care.The central mission of the new edition is to unpick normal physiologic aging in men from pathologic processes, eschewing any material that is routinely available in the standard textbooks of medicine and geriatrics in order to maintain a uniquely male perspective. This means a focus on the age-related decline in sex steroids and other hormones and the pathological and clinical consequences. Wherever possible, the book records consensus on diagnostic criteria, emphasizes evidence-based medicine and highlights translational science. Thisnbsp;revised and updated edition, with new sections on basic sciences and sexual dysfunction, unpicks normal physiologic aging in men from pathologic processes, in order to maintain a uniquely male perspective. This revised and updated edition, with new sections on basic sciences and sexual dysfunction, unpicks normal physiologic aging in men from pathologic processes, in order to maintain a uniquely male perspective. The first edition of Textbook of Men's Health did much to establish and define the scope of the emerging subspecialty of aging men's health. This revised and updated edition offers a unique overview of the male health and offers valuable insights for improved management and critical care. The central mission of the new edition is to unpick normal physiologic aging in men from pathologic processes, eschewing any material that is routinely available in the standard textbooks of medicine and geriatrics in order to maintain a uniquely male perspective. This means a focus on the age-related decline in sex steroids and other hormones and the pathological and clinical consequences. Wherever possible, the bo

Cognitive aging is a flourishing area of research. A significant amount of new data, a number of new theoretical notions, and many new research issues have been generated in the past ten years. This new edition reviews new findings and theories, enables the reader to assess where the field is today, and evaluates its points of growth. The chapters are organized to run from reviews of current work on neuroimaging, neuropsychology, genetics and the concept of brain reserve, through the 'mainstream' topics of attention, memory, knowledge and language, to a consideration of individual differences and of cognitive aging in a lifespan context. This edition continues to feature the broad range of its predecessors, while also providing critical assessments of current theories and findings.

The most profound dilemma in assisted reproduction to date is the inability to recognize potentially viable embryos before their replacement into the reproductive tract. Application of increasingly advanced new technology has allowed the field of embryo evaluation to evolve rapidly and dramatically over the past five years.
Human Preimplantation Embryo Selection assembles the leaders in the field of assisted reproduction to discuss their visions of dealing with the topic of embryo selection in the light of the limitations involving the fragility of the early human embryo.
The purpose of this book is to shed light on the ever-expanding techniques that are being employed and evaluated with regard to embryo selection. A comprehensive overview may guide the ART practitioner in choice of techniques and evaluation of benefits and drawbacks.
This book will provide an up-to-date overview and reference source: an invaluable tool for assisted reproductive practice worldwide.

The Human Embryo in vitro explores the ways in which UK law engages with embryonic processes under the Human Fertilisation and Embryology Act 1990 (as amended), the intellectual basis of which has not been reconsidered for almost thirty years. McMillan argues that in regulating 'the embryo' - that is, a processual liminal entity in itself - the law is regulating for uncertainty. This book offers a fuller understanding of how complex biological processes of development and growth can be better aligned with a legal framework that purports to pay respect to the embryo while also allowing its destruction. To do so it employs an anthropological concept, liminality, which is itself concerned with revealing the dynamics of process. The implications of this for contemporary regulation of artificial reproduction are fully explored, and recommendations are offered for international regimes on how they can better align biological reality with social policy and law.

Extensively revised and updated to reflect the current state of knowledge in the study of aging, this Fourth Edition offers a complete profile of the aging process at all levels, from molecules and cells to demography and evolution. Written by international experts in current basic and clinical aging research, this text includes aspects of individual, comparative, and differential aging, and discussions of theories and mechanisms of aging. This invaluable reference illustrates how bodily systems, organs, and functions are affected with aging, describes how genetic and environmental factors influence age-related changes, and addresses some of the clinical consequences of these changes for health and longevity. Well illustrated, with numerous tables and graphs, this book presents up-to-date information from internationally renowned experts in various bio-medical fields. New updated information includes: emphasis on emerging technologies and recent advances in biology and bioengineering that allow greater and longer independence of the elderly recent therapeutic developments in key diseases such as Alzheimer's, osteopenia, osteoporosis, high cholesterol, diabetes, gastritis, sexual impotence, and using transgenic animals as models of aging evaluation of the latest knowledge on the roles of oxidants and antioxidants, and correlates them with other aging-based theories expanded discussion of nutrition and physical exercise chapters on gene and stem cell interventions related to the aging process updated tables to reflect current trends, new research data, and up-to-date statistical information

The use of IVM in assisted reproductive technology continues to increase around the world. The major benefit of IVM is that significant numbers of oocytes can be collected from ovaries without recourse to ovarian stimulation. This reduces the costs, time, and risks associated with conventional IVF. Although initially limited to women with polycystic ovary syndrome who were at higher risk of problems following ovarian stimulation, IVM is increasingly used in women with normal ovulatory menstrual cycles. This authoritative text covers the current scientific knowledge of oocyte development and the understanding behind the techniques involved in the clinical application of IVM in assisted reproductive technologies.
Short Contents

The aim of this book is to fill the gap between the standard textbooks of obstetrics & gynecology - which do not cover (conservative) infertility treatment - and the specialized textbooks on ART - which don't address topics such as ovulation induction/IUI and the typical treatment of disorders associated with infertility, such as hyperandrogenism and endometriosis. In many countries, the management of infertility treatment is not done by IVF specialists but by general gynecologists or primary health practitioners. In most countries, specific training and/or a license is required to do 'invasive' infertility treatments, such as IVF/ICSI; however, conservative or semi-conservative treatments - such as IUI with or without ovulation induction - can be done without specific training/licensing. This concise, clinically oriented handbook is predominantly written for gynecologists, primary health practitioners, and medical students who want to improve their knowledge on this aspect of their work. Furthermore the aim is to highlight which types of disorders may be treated by conservative means and which types of disorder should be treated by invasive treatment options such as IVF/ICSI.

Coping with Infertility is an essential source of emotional support for any couple struggling with involuntary childlessness. The book offers proven techniques and real-life examples from both men and women, in order to outline common emotional reactions and remind couples that they are not alone in their ups and downs. The coping skills discussed in the book have been assembled from years of working with individuals in clinical trials and have undergone rigorous scientific testing. These state-of-the-art techniques have been shown to be effective in helping couples deal with the stress, depression, relationship problems, and grief often associated with infertility. Coping with Infertility is an easily accessible and problem-focused guide for couples to use in overcoming the emotional roadblocks of infertility.

A closer look at your patient's family situation can help you develop a more effective treatment plan Family Behavioral Issues in Health and Illness is a basic but thorough introduction to the impact family dynamics can have on a person's health. Ideal as a supplemental training text for healthcare professionals, this unique book examines the connections between family and health, presenting a concise summary of family systems theory, basic family assessment, and the family life cycle. The book provides an understanding of how the patterns and systems found in a diverse range of family styles can create special health issues, and how the ability to assess and anticipate those issues can ensure the most comprehensive patient care and cost-effective management of time and resources. As long as families continue to be the primary environment where patients learn and develop their beliefs and overall attitudes about life, it remains essential that any primary healthcare model includes a strong background in family dynamics and the critical, pivotal points of family life. Family Behavioral Issues in Health and Illness addresses the most important aspects of family to consider when providing care, presenting practical, real-life case studies that examine the resilience, strengths, and possibilities of families, as well as the problems and dysfunctions. The book looks at how significant events, such as marriage, divorce, birth, and death affect families, and how a knowledge of special family issues, including parenting, abuse, disability, and chronic illness prepares the healthcare professional to provide effective care for traditional, single-parent, multiracial, blended, adoptive, and same-gender families. Family Behavioral Issues in Health and Illness examines: boundaries, roles, and rules triangulation subsystems scapegoating parentification healthy families the family genogram spiritual crises of family members infertility families without children intergenerational families the family in later life coping with alcoholism, dementia, bereavement, and/or mental illness and much more Family Behavioral Issues in Health and Illness is an essential reference for healthcare professionals, educators, parents, and family members. The book provides a practical understanding of family relationships that helps healthcare providers guide patients toward a more complete well-being.

ONE OF PEOPLE MAGAZINE'S BEST SUMMER READS 2022 5* 'A jaw-dropping memoir' - THE TELEGRAPH 'One of the maddest memoirs you'll read this year... a beautiful, warm, funny book.' -The Times 'Extraordinary' -The Guardian 'A wholly absorbing page-turner that everyone will want to read. You should probably buy two.' -Kirkus Starred Review 'A riveting debut.' -People Magazine 'By turns hilarious, wrenching, and achingly tender.' -Susan Orlean, New York Times bestselling author 'A remarkable and wise book, two memoirs braided together with such tendresse that readers will come to believe the ironic title in earnest' -LA TIMES 'Riveting and hilariously funny' - The Times For most of her life, Chrysta Bilton was one member of a small, if dysfunctional, family of four. There was her sister, Kaitlyn, her hedonistic, glamorous, gay mum Debra, and Jeffrey, who Debra hand-picked, in an LA hairdressers, to be the father of her children. During Chrysta's unstable childhood, Debra struggled to keep the family afloat and Jeffrey wandered in and out of their lives. Then, in her twenties, Chrysta discovered that her father had secretly donated his sperm over 500 times - and that she had at least 35 other siblings. A Normal Family is a captivating coming-of-age memoir about Chrysta's reckoning with the secrets both parents had carefully kept from her. Heartfelt, warm and funny, it's a story of embracing the family we have, in all the forms we find it.

Many scientists today are working to retard the aging process in humans so as to increase both life expectancy and the quality of life. Over the past decade impressive results have been achieved in targeting the mechanisms and pathways of aging. In "The Quest for Human Longevity," Lewis D. Solomon considers these scientific studies by exploring the principal biomedical anti-aging techniques. The book also considers cutting edge research on mental enhancements and assesses the scientific doubts of skeptics. "The Quest for Human Longevity" is also about business. Solomon examines eight corporations pursuing various age-related interventions, profiling their scientific founders and top executives, and examining personnel, intellectual property, and financing for each firm. Academic scientists form the link between research and commerce. Solomon notes that the involvement of university scientists and researchers follows one of two models. The first is a traditional model in which scientists leave academia to work for a corporation or remain in academia and obtain business support for their research. The second is a modern model in which scientists use their intellectual property as a catalyst for acquiring equity interests in the firms they organize. Critics have pointed to the dangers of commercialized science, but Solomon's analysis, on balance, finds that the benefits outweigh the costs and that problems of secrecy and conflicts of interest can be addressed. If scientists succeed in unlocking the secrets of aging and developing drugs or therapies that will allow us to live decades longer, the consequences for society will include profound social, political, economic, and ethical questions. Solomon deals with the public policy aspects of significant life extension and looks at the conflict between those who advocate the acceptance of mortality and the partisans of life. "The Quest for Human Longevity" will be of interest to policymakers, sociologists, scientists, and students of business, as well as general readers interested in these compelling issues. "Lewis D. Solomon" is Theodore Rinehart Professor of Business Law at George Washington University Law School. A prolific author on legal, business, public policy, and religious topics, he has written over fifty books and numerous articles. He is an ordained rabbi and interfaith minister.

Andrology, the science of the physiology, pathology and molecular biology of male reproduction, is a relatively new specialty that has become increasingly important with the advent of modern assisted reproductive techniques (ART). The Atlas of Clinical Andrology describes both normal and abnormal reproductive physiology, and summarizes recent research in the fields of endocrinology, immunoandrology, molecular andrology, and ART. Focusing on the cutting edge of recent knowledge and advances in clinical andrology, it incorporates the latest clinical research findings and makes them accessible to clinicians who need this essential information for the most effective application of assisted reproductive techniques.

Wedding up-to-date scientific information to an understanding of the emotional burdens and ethical dilemmas that inhere in reproductive medicine, Frozen Dreams: Psychodynamic Dimensions of Infertility and Assisted Reproduction provides an overview of the psychology of infertility patients and of the evaluative, administrative, and especially psychotherapeutic issues involved in helping them. The contributors to this volume, who include professionals from nationally prestigious reproductive programs and psychotherapists who evaluate and work clinically with infertility patients, explore the complex choices about life and death that are the daily experience of infertility specialists. In voices equally authoritative and intimate, psychotherapists and other health professionals explore the therapeutic process with patients and couples struggling with miscarriage, infertility, childlessness, the possibility of adoption, and the promise of assisted pregnancy. Among the themes that recur throughout this collection are the following: When is a patient's bitterness, anger, and psychopathology extreme enough to disqualify her as a candidate for infertility treatment? the well-being of offspring resulting from an assisted pregnancy? How does the clinician's personal diagnosis of infertility influence an ongoing psychodynamic treatment? How can a therapist help patients overcome the overwhelming grief of miscarriage? And the contributors are equally attentive to the range of issues that challenge physicians and nurses active in reproductive medicine. Intent on providing practical information that will aid decision-making in this demanding area of practice, they examine questions such as: How reproductive medicine programs should handle difficult patients who present with a sense of entitlement. How staff differences within reproductive medicine programs can be constructively addressed and resolved. Why physicians, nurses, and other program personnel experience burnout and what can be done to prevent it. Written for a large audience of psychiatrists, psychologists, social workers, researchers, nurses, physicians, and general readers, Frozen Dreams is a fascinating introduction to the human face of reproductive medicine. mental health professionals who work with adult patients through their childbearing years. For professionals who work inside the complex world of infertility treatment, Frozen Dreams will quickly become an essential text that is turned to repeatedly for information, guidance, reassurance, and revitalization.

There are several possible solutions to the different problems presented with female patients who have been unable to conceive. This completely revised edition provides guidance on the technical aspects of diagnosis and explanations of treatment using a how to, when and why approach, incorporating new expanded sections on endometriosis and polycystic ovary syndrome. Illustrated throughout with tables and graphs as a source for easy reference for guidance and counselling in clinical decision making, it will be essential reading for all those working in the clinical practice setting within infertility, providing all the necessary information required for developing sound clinical judgement in the diagnosis and surgical management of structural abnormalities of the reproductive tract.

Sperm morphology evaluation by strict criteria is the gold-standard used by IVF and andrology units around the world. It is based on an approach to sperm morphology evaluation that utilizes optimal preparation methods, evaluation procedures, and criteria for a morphological normal spermatozoon based on biological evidence. Featuring fresh perspectives from the founders of the Tygerberg strict criteria, Atlas of Human Sperm Morphology Evaluation provides state-of-the-art information on crucial aspects of male factor infertility. The atlas consists of an introductory teaching manual that gives readers the ability to train and test their diagnostic capabilities and enables laboratories to implement quality control measures. Together with a team of internationally renowned experts in the field of human reproduction, the editors explore every avenue you need to know to successfully evaluate and manage male factor infertility. An accompanying interactive CD-ROM training program, STRICT 1-2-3(R) is available from the editors. STRICT 1-2-3(R) has been developed alongside the atlas to provide not only a complete theoretical background on sperm morphology, but also self-training facilities. Laboratory directors and technicians will now be able to set up their own internal quality control program for sperm morphology evaluation.

Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis

Worldwide, approximately 500,000 in vitro fertilization cycles are performed every year. Although the best possible result is a healthy child, the technology carries a number of varying risks and complications leading to a trade-off between the efficacy of these treatments and their quality and safety. Drawing on contributions from international experts with academic and clinical backgrounds, Assisted Reproductive Technologies: Quality and Safety presents an analysis of the medical risks and complications involved in reproductive medicine. Putting the intricacies of reproductive health in the spotlight, the book describes side-effects, risks, and complications related to ART treatments. It discusses ovarian hyperstimulation syndrome, demonstrates the impact of judicious elective single embryo transfer, and focuses heavily on multiple pregnancy as the major risk factor of ART. The editors highlight the relatively less likely, but important risks of oncogenic complications, bleeding at the time of ovum retrieval, and the even smaller but still existing risk for maternal mortality. They include discussions of non-medical factors that can have a major impact on people's lives such as psychological, sexual, financial, moral, ethical, and philosophical dilemmas. In today's litigious climate, modern management of any clinic is all about minimizing risks and complications. Thoroughly addressing quality and safety issues in ART, this book provides succinct, up-to-date information on quality care in reproductive medicine.

Just what is the andropause? Although acceptance of the andropause concept by the medical community is growing, it is still a hotly debated issue. But as a busy clinician you have patients to treat and you need information. So where can you find the information you need to understand, diagnose, and treat this condition? A comprehensive, detailed clinical resource, Androgen Deficiency in the Adult Male: Causes, Diagnosis, and Treatment distills the knowledge acquired by author Malcolm Carruthers in his 20 years of research and clinical experience in diagnosing and treating the andropause.

Carruthers documents the history of testosterone treatment from antiquity to the awarding of the Nobel Prize Adolf Butenandt and Leopold Ruzicka for synthesizing testosterone and patenting its production some 4,000 years later. He discusses the causes of androgen deficiency, the male menopause or andropause, and its differential diagnosis. The text includes reviews of the literature in each section and a fund of bibliographic references gleaned from the author's years of research in this field. This combination of features makes Androgen Deficiency and the Aging Male: Causes, Diagnosis and Treatment a technically thorough clinical guide, a complete and detailed reference volume, and a cohesive and readable textbook.

Contents:
1. The Comparative Policy Design Perspective
2. Belgium: A Bioethical Paradise?
3. ART Policy in Italy: Explaining the Lack of Comprehensive Regulation
4. Policy Networks, Federalism and Managerial Ideas: How ART Non-Decision in Canada Safeguards the Autonomy of the Medical Profession
5. The United States: National Talk and State Action in Governing ART
6. ART in Spain: Technocratic Inheritance and Modernist Aspirations
7. United Kingdom: Regulation Through a National Licensing Authority
8. France: Protecting Human Dignity While Encouraging Scientific Progress
9. The Netherlands: Conflict and Consensus on Assisted Reproductive Technology Policy
10. Germany: ART Policies as Embryo Protection
11. Switzerland: Policy Design and Direct Democracy
12. Legislation for Protection: Why Norway Designed Restrictive Policies in the Field of ART
13. Comparing Policy Design Across Countries: What Accounts for Variation in ART Policy?