Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction is an essential reference for fertility practitioners and research and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology. The book focuses on unravelling the pathophysiology of oxidative stress mediated male infertility, recruiting top researchers and clinicians to contribute chapters. This collection of expertise delves into the physico-chemical aspects of oxidative stress, including a new focus on reductive stress. Furthermore, the inclusion of clinical techniques to determine oxidative stress and the OMICS of reductive oxidative stress are also included. This is a must-have reference in the area of oxidative stress and male reproductive function.

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

Collectively, the chapters in this work will provide the reader with novel insight into the inter-relationships of the function of different organelles in the sequences of events that lead to cellular dysfunction and degeneration in the aging human population. The chapters are rich in information for cell and molecular biologists pursuing studies of the different diseases covered. In addition, the clinician will find value in understanding mechanisms underlying age-related disease as such an understanding will lead to novel therapeutic approaches for an array of age-related diseases.

This book describes in fascinating detail the history of the use of anesthesia in childbirth and in so doing offers a unique perspective on the interaction between medical science and social values. Dr. Donald Caton traces the responses of physicians and their patients to the pain of childbirth from the popularization of anesthesia to the natural childbirth movement and beyond. He finds that physicians discovered what could be done to manage pain, and patients decided what would be done. Dr. Caton discusses how nineteenth-century physicians began to think and act like scientists; how people learned to reject the belief that pain and suffering are inevitable components of life; and how a later generation came to think that pain may have important functions for the individual and society. Finally he shows the extent to which cultural and social values have influenced "scientific" medical decisions.

People in developed countries are living longer and, just as the aged population around the world is steadily growing, the number of adults eighty-five and older in the United States is projected to quadruple to twenty-one million people by 2050. The aging of our population has huge implications for baby boomers and their children, and has generated a greater interest in the causes and effects of aging.
"Our Aging Bodies" provides a clear, scientifically based explanation of what happens to all the major organ systems and bodily processes--such as the cardiovascular and digestive systems--as people age. The first section is an overview of secondary aging--changes that occur with age that are related to disease and the environment--and include the effect of such things as diet, humor, and exercise. Readers will also learn about primary aging--intrinsic changes that occur with the aging of specific organs and body systems (including the prostate, the heart, the digestive system, and the brain). Throughout the book, Gary F. Merrill weaves in personal anecdotes and stories that help clarify and reinforce the facts and principles of the underlying scientific processes and explanations. "Our Aging Bodies" is accessible to a general reader interested in the aging phenomenon, or baby boomers wanting to be more informed when seeing their doctor and discussing changes to their bodies as they age.

Human Reproductive and Prenatal Genetics presents the latest material from a detailed molecular, cellular and translational perspective. Considering its timeliness and potential international impact, this all-inclusive and authoritative work is ideal for researchers, students, and clinicians worldwide. Currently, there are no comprehensive books covering the field of human reproductive and prenatal genetics. As such, this book aims to be among the largest and most useful references available. Named a Highly Commended book in the Basic and Clinical Sciences by the British Medical Association.

The Ovary, Third Edition, includes more than 60% new material that highlights the clinical aspects of human ovarian functions. It covers advances in the areas of genomics, assisted reproductive technology, and cancer diagnosis and treatment. This updated edition synthesizes new information at the molecular, cellular and organismal levels, while also presenting modern ovarian physiology in a more understandable and comparative context. The book looks at ovarian function from a detailed molecular and cellular level that examines all phases of the ovarian lifecycle that places special emphasis on the pathophysiology of the human ovary, including ovarian carcinogenesis.

This volume of "Advances in Cell Aging and Gerontology" critically reviews the rapidly advancing area of telomerase research with a focus at the molecular and cellular levels. The clearly established function of telomerase is to maintain chromosome ends during successive rounds of cell division by adding a six base DNA repeat on to the telomeric ends of chromosomes. As presented in the chapters of this volume, the mechanisms that regulate telomerase expression and activity are complex. Moreover, emerging data suggest additional roles for telomerase in the regulation of cell differentiation and survival.

It is expected that this quite comprehensive volume will provide a valuable resource for graduate students and postdocs in the telomerase field and for established investigators in other fields who are beginning to study telomerase in their particular research program. With an increasing number of proteins being brought into the fold of telomerase research (e.g., DNA damage and repair response proteins, heat-shock proteins, and proteins in various signal transduction cascades) many new scientists are beginning to study this enzyme from novel vantage points.

Since the first randomized controlled studies were conducted on medical circumcision to assess their effectiveness on reducing HIV transmission, health systems have made considerable progress in adopting this practice in their HIV/AIDS and sexual reproductive health policies. As such, medical circumcision is being adopted as an additional intervention measure to support previous practices for reducing HIV infections in various countries or settings. James Kityo's pioneering book examines contexts, processes, policy projections, and likely engagements by reviewing sexual reproductive health policies or practices, and literature on medical circumcision, and identifies existing opportunities and challenges. His book also explores the medical, gender, ethical, socio-economic, and human rights dimensions of medical circumcision as an HIV/AIDS prevention method. Following peer-reviewed studies, Kityo found compelling evidence documenting the effectiveness of medical circumcision in reducing HIV transmission, and discusses this evidence in the context of HIV/AIDS in a developing health system in Sub-Saharan Africa. The author concludes that there is a range of opportunities from research and current practice to enable policy makers to adopt medical circumcision and other interventions at their disposal in order to reduce infections from HIV and AIDS-related deaths. The author suggests feasible recommendations for implementing successful HIV/AIDS prevention programs in developing nations' health systems, including medical circumcision's gradual inclusion in health practices; stakeholder support; an elaborate review of this intervention by women, politicians, religious communities, and funding agencies. The author introduces a guided action plan, which can be used as a launch pad to enhance the learning process in the integration of medical circumcision in existing health practices.

This pioneering text formally introduces an all-inclusive approach to preventive health care that is targeted at female factor associated infertility. All female factor problems and related issues are examined critically. This is followed by the proposal of preventive strategies that are based on the three tiers of preventive health care (primary, secondary and tertiary prevention). This exceptional book is currently the only available comprehensive text on the subject. It is an invaluable resource guide for a wide range of medical, health and allied professionals. You will find:

At a moment when reproduction is increasingly politicized, this volume explores the breadth of contemporary research on reproduction from the perspective of medical sociology, illuminating the lived experience of reproduction and offering insights to inform sociology and health policy. Reproduction, Health, and Medicine elucidates the tensions and contradictions between the normal physiologic processes of pregnancy and birth and the sociocultural beliefs, values, and arrangements that shape how we experience these biological phenomena. Investigating a range of reproductive events and experiences, including pregnancy, birth, abortion and fertility planning, the volume advances our understanding of how lay people and professionals make cultural meaning out of these processes in diverse settings. The chapters highlight how studies of reproduction, health, and medicine interface with core sociological concepts such as stratification, inequality, intersectionality, family and kinship, risk, and social control, and how experiences of reproduction are shaped by gender, race, class, sexuality and citizenship, as well as culture, health care systems, and health politics.

This is part of a series of integrative work by infancy researchers of both humans and animals. The articles seek to serve as references on programmatic series of studies, critical correlations of diverse data that yield to a common theme, and constructive attacks on old issues.

This text is a practical guide for primary-care doctors and health visitors involved in the detection of developmental problems in children whose parents are worried that their child is not developing like other children. It will be of assistance to paediatricians and paediatric neurologists in providing a developmental perspective in the diagnostic process in their work with children with chronic neurological disorders. The tests described have been standardized by the author and cover the essentials of developmental examination: history - including parents' views of their child's development; clinical tests of hearing; examination of visual behavior and visual acuity; observation of developing motor skills; language/performance profiles in which any substantial unevenness or an overall low score may reveal a developmental problem. In practice the range of average ability is wide, so a distinctive feature of this book is a standardized data base in graphical form that can be used to identify readily those children (lowest 20%) who warrant further specialist investigation or treatment.

Molecular Biology of Placental Development and Disease, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on placental development and disease.

Intended for readers with a background in fertility medicine as well as those less familiar with IVF, this comprehensive work presents an update on preimplantation genetic testing to enable single embryo transfer (SET). An international cast of contributors explains the treatment sequence-from ovulation induction to luteal support-aiming to transfer only one euploid embryo. Applications of molecular techniques for gamete and embryo assessment are fully detailed, with a focus on the strengths and limitations of each. In addition, expert commentary is shared across a range of regulatory challenges associated with embryo screening and cryopreservation. As access to advanced reproductive technology increases against a sharper background of healthcare reform, clinicians, economists, bioethicists and legislators alike will find this new volume relevant and highly accessible.

Given that millions of women have entered menopause each year since the dawn of time, it's bizarre that it still feels like uncharted territory for the women who are going through it. Dr. Heather Hirsch is committed to changing that. Unlock Your Menopause Type helps women cut through the informational noise and learn how to manage their symptoms most effectively by identifying their personal Menopause Type(s). This is not a one-size fits all solution. Unlock Your Menopause Type features a helpful quiz to identify women's individual Menopause Type(s) such as: -Premature -Sudden -Full-Throttle -Mind-Altering -Seemingly Never-ending -Silent Each type gets a full prescription for exercises, diet and strategies to regain mental focus and make menopause a routine part of maturity rather than a rollercoaster ride of unexpected symptoms and discomfort. The book also includes: -The last word on whether to replace declining hormones -What to do if you're a combination of types -How to get on top of (as it were) changes in your sex life -Crowd-sourced tips and tricks from Dr Hirsch's friend group and patients Dr Hirsch addresses the physical and emotional challenges of menopause and provides solutions from her years of practice. With knowledge, priorities and a plan, you can feel great through midlife and beyond.

This major reference is a substantially revised edition of Palmore's "International Handbook on Aging," which was voted Choice Outstanding Academic Book of 1980. The reference collects and summarizes information on programs and research in gerontology in most countries where significant work is taking place. The chapters are arranged alphabetically, with each chapter devoted to a particular country. The countries selected represent a wide range of social, political, geographic, and economic conditions, and ten new countries are included in this edition.

Each chapter provides current information on the unique features of the country profiled; the roles and status of the aged; problems of the elderly; programs for older adults; research in biomedical, psychological, and sociological aspects of aging; and sources of additional information. Each chapter closes with a list of works for further consultation, and the handbook concludes with an appendix of gerontological associations and a bibliography. Gerontologists, social scientists, and policymakers will find this reference a valuable and current guide to developments and research on aging around the world.

Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood. This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known. The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function. Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.