The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.

Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis

Oncofertility is a specialty that bridges the disciplines of reproductive endocrinology and infertility and oncology, with the goal of expanding the reproductive options of cancer patients. Given fertility risks associated with specific cancer treatments, as well as the improved long-term survival made possible by these therapies, there has been growing interest in expanding reproductive options for cancer patients. Indeed, both cancer survivors and the medical community have acknowledged the importance of patient counseling and the pursuit of fertility preservation options prior to starting cancer treatment. Oncofertility Medical Practice: Clinical Issues and Implementation is the third in a series of timely and indispensable books on fertility preservation for cancer patients-the first one focused on advances in basic science research and the second one offered ethical, legal, and social perspectives on the theme. This book elucidates the latest practices and emerging treatments in oncofertility and provides necessary information on the successes, risks, and limitations of fertility preserving technologies. Authoritative and insightful, written by an impressive multi-disciplinary cadre of specialists, this book is a valuable up-to-date resource for all those practicing in this demanding field. "This excellent text is an invaluable resource and a "must read" for clinicians and researchers interested in Oncofertility. The editors and authors need to be congratulated for their fine work." Roger A. Lobo, MD, Professor of Obstetrics and Gynecology, Columbia University and Past President of the American Society for Reproductive Medicine

Fetal development in the mouse is routinely and increasingly utilized for advancing translational research and medical innovation for human obstetrical care. This is the first and only manual to provide necessary content on how this should be handled for accurate and effective data collection. Detailed descriptions and examples demonstrate how researchers and clinicians can use murine fetal and obstetrical data to improve future human applications in diseases such as infertility, recurrent pregnancy loss, intrauterine fetal growth restriction, placental insufficiency, and intrauterine fetal demise, as well as organ-specific developmental disease.

This important monograph summarizes a comprehensive study on the maturation of walking in normal children. Research, undertaken at one of the world's leading gait analysis centers, involved over 400 studies on a total of nearly 300 children in ten age-groups from one to seven years. Data are presented on anthropometric measurements; tests of developmental progress; time/distance parameters such as stride length and walking velocity; twelve joint angles on each side measured throughout the gait cycle; dynamic electromyography of phasic activity in seven lower-extremity muscle groups; and force measurements including vertical force, fore/aft shear, medial/lateral shear and torque. At each age, composite joint-angle graphs and time/distance parameters are brought together with film tracings of a representative child in that age group. In addition, advanced methods of statistical analysis have been applied to the joint-angle data to define prediction regions within which ninety-five percent of normal children should lie throughout the gait cycle. Finally, a 'decision tree' is presented from which a fitted age can be inferred for a subject based on non-age-specific data gathered in a motion analysis lab. Practical applications are demonstrated in a chapter devoted to two case studies.

Western thought traditionally divides the human being into a body-mind dualism, a divide realized in the divergent research fields of geriatrics and gerontology; the first examines the physical body, and the second focuses instead upon psychological and social aspects of aging. Research Health Scientist Christopher Faircloth's edited volume of original pieces attempts to bridge this rift: reinserting the physical aging body and its lived experiences back into gerontology's study of aging. He asks, 'Is it not the physical body that readily marks us as aging?' Faircloth organizes this text around two major themes of the aging body: everyday experience, and the social and personal impact of its imagery, while concentrating on three areas of substantive concern: medicalization, gender/sexuality, and the body as consumer. This book would be of interest to gerontologists, social scientists, and students of these fields concerned with the aging body, both object and subject, as experienced and alternatively perceived in relation to contemporary society.

In this book, leading academics and practitioners in the field of reproductive health address topics such as contraception, abortion, sexually transmitted infections, maternal and prenatal health, sexuality and reproductive rights by examining a number of critical issues in these areas. The authors describe new research, identify gaps and priorities in policy and practice, and illustrate innovative solutions. The book further addresses such current imperatives as understanding the social meanings of emergency contraception, measuring gender-based violence, improving reproductive health governance, strengthening health systems and services, and redressing institutional barriers. The book also assesses how reproductive health programs can be reconfigured to new challenges such as those posed by climate change, vulnerable youth in fragile states, and risks from new infertility treatments. Using a rich and varied set of cases, a broad public health and social science perspective, and novel methodological approaches, this book questions common assumptions, illustrates effective solutions and sets out research, policy, and programmatic agendas for the present and future. This is a comprehensive volume which provides a valuable resource to researchers, educators, practitioners, policymakers and students, as well as anyone studying or advocating for reproductive health.

Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded Third Edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicologya (TM)s contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research.

This ground-breaking resource includes:

• New and important critical mechanistic topics such as epigenetics and omics
• The first significant compilation of epigenetic mechanisms
• An in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction
• New guidelines with respect to the latest research applications in the field

This book presents the contemporary history and dynamics of Mexican midwifery - professional, (post)modern or autonomous, traditional and Indigenous - as profoundly political and embedded in differing societal stratifications. By situated politics, the authors refer to various networks, spaces and territories, which are also constructed by the midwives. By politically situated, the authors refer to various intersections, unsettled relations and contexts in which Mexican midwives are positioned. Examining Mexican midwiferies in depth, the volume sharpens the focus on the worlds in which midwives are profoundly immersed as agents in generating and participating in movements, alliances, health professions, communities, homes, territories and knowledges. The chapters provide a complex panorama of midwives in Mexico with an array of insights into their professional and political autonomy, (post)coloniality, body-territoriality, the challenges of defining midwifery, and above all, into the ways in which contemporary Mexican midwiferies relate to a complex set of human rights. The book will be of interest to a range of scholars from anthropology, sociology, politics, global health, gender studies, development studies, and Latin American studies, as well as to midwives and other professionals involved in childbirth policy and practice.

This book brings together the most up-to-date information about the physiology of progestogens. Addressing the bidirectional communication between hormones, fertility, tumors, and autoimmunity, it provides the basic science and clinical perspectives of progestogens which have not been previously available in one volume. In addition to estrogens, androgens, mineralocorticoids and glucocorticoids, progestogens are a major class of steroid hormone. While present in certain phases of estrous and menstrual cycles, progestogens are named for their function in maintaining pregnancy. This book is essentially practical in orientation, addressing the specific issues that confront the practitioner, and provides information to Obstetricians, Gynecologists, Reproductive endocrinologists, as well as Gynecological Oncologists and Rheumatologists. Contributions are from an international team of experts in the field, now completely updated in this new edition with new developments in primary dysmenorrhea and contraception.

In the twentieth century, all developed nations began to undergo unprecedented demographic changes, as their birth rates declined, and life expectancies increased significantly --an average of thirty years in less than a century. These developments have caused major transformations in the composition of populations in these countries, especially in terms of the proportions of the various age groups. While the age groups of children and adolescents have decreased, those of elderly persons aged 65 and over, have increased.

Consistent with the situation in other developed nations, the absolute number and percentage of elderly persons in the Israeli population is increasing, while the percentage of younger persons is decreasing. Israel, however, differs from other developed countries in the pace of this demographic change, the composition of its population, and the ways it can address needs related to aging. The demographic figures in Israel indicate that not only is the proportion of elderly persons in the total population growing, but that the old population itself is rapidly aging as well.

This volume exemplifies how social science research can promote knowledge about and understanding of needs and opportunities for adaptation, and assist in evaluating the outcomes of policies and services on the personal, community and national levels, as well as suggest required changes. The variety of topics covered in this volume on age-related research, policies and practice reflects a wide range of research by Israeli scholars on social aspects of aging. Their research offers a glimpse into the knowledge base that has been built over the years on the aging process in Israel, the population of elderly people, and the national policies and network of services for the aged. Other developed countries with aging populations have much to learn from the Israeli experience.

In the twentieth century, all developed nations began to undergo unprecedented demographic changes, as their birth rates declined, and life expectancies increased significantly --an average of thirty years in less than a century. These developments have caused major transformations in the composition of populations in these countries, especially in terms of the proportions of the various age groups. While the age groups of children and adolescents have decreased, those of elderly persons aged 65 and over, have increased.

Consistent with the situation in other developed nations, the absolute number and percentage of elderly persons in the Israeli population is increasing, while the percentage of younger persons is decreasing. Israel, however, differs from other developed countries in the pace of this demographic change, the composition of its population, and the ways it can address needs related to aging. The demographic figures in Israel indicate that not only is the proportion of elderly persons in the total population growing, but that the old population itself is rapidly aging as well.

This volume exemplifies how social science research can promote knowledge about and understanding of needs and opportunities for adaptation, and assist in evaluating the outcomes of policies and services on the personal, community and national levels, as well as suggest required changes. The variety of topics covered in this volume on age-related research, policies and practice reflects a wide range of research by Israeli scholars on social aspects of aging. Their research offers a glimpse into the knowledge base that has been built over the years on the aging process in Israel, the population of elderly people, and the national policies and network of services for the aged. Other developed countries with aging populations have much to learn from the Israeli experience.

Based on the "Pathways to Life Quality" longitudinal research study, this book explores the ways in which older adults' residential choices impact their health and well-being. The study examines the factors associated with life quality for persons living on their own in the local community, as well as those in various housing arrangements such as a continuing care retirement facility, adult home, income-subsidized housing, and senior apartments. Topics include plans and adjustment to moving; role identities; social relationships, participation, and integration; health and activity patterns; and coping with life events.

Although attitudes toward the aged and their care are inherent in any society, gerontology itself is a relatively recent field of study and practice. "Gerontology and the Construction of Old Age" applies the methods of discourse analysis and textual analysis to texts and documents in this newly evolved and eclectic fi eld. Green explores and identifies the literary methods and discursive regularities through which aging and the aged have been made into objects of study and treatment, and which together form a mode of knowledge production that will infl uence future texts in the field.

Because such formats of representation limit rational diagnoses of problems and rational courses of ameliorative action, policy implications in the fi eld of gerontology are a major interest of this study. Another interest is methodological. Within the broader constructionist approach to social reality, Green takes the position of "constitutive realism" the notion that social reality is linguistically constructed, primarily in speech and writing.

The book's two aims are to describe analytically the fi eld of gerontology. The field is important both for its growing academic presence and for its practical eff ects on discourse and policy concerning old age. It also hopes to help develop possibilities of inquiry associated with the linguistic, literary, and rhetorical turns of social science in recent years. "Gerontology and the Construction of Old Age" is a substantive investigation, at considerable theoretical depth, of gerontology itself, as well as a methodological treatise with broader implications for social science as it focuses upon the discourse of various professional fields.

This comprehensive volume focuses on recent trends and new technologies used in the management of reproduction in major farm animals, focusing on both males and females of bovine, equine, and porcine species. With chapters written by scientists who specialize in their respective topics, the volume presents a selection of different technologies that have been developed to assure reproductive success by improving reproductive efficiency, generating germplasm banks, and maintaining genetic diversity in cattle, horses, and pigs. In the last decade, reproductive technologies in veterinary medicine have progressed considerably, providing high profitability to livestock farms. This book provides basic and applied information on the most used reproductive technologies in bovine, equine, and porcine species for academics, scientists, and veterinarians. The volume discusses reproductive and postpartum management, reproductive ultrasound, sperm management, egg retrieval, artificial insemination, embryo transfer, nutrition, genetics, and certain clinical aspects, such as endocrinology and robustness of reproductive systems.

The transnational industry surrounding assisted reproductive technology and regenerative medicine is based on the unacknowledged labour of gamete providers, surrogates and research subjects, and benefits from low labour costs in 'enabling' sectors such as logistics and transport. This finding calls for a comprehensive analysis of how the contemporary intersection of neoliberal capitalism and the life sciences - in short, the bioeconomy - capitalises on the body and its (re)productive capacities. The Reproductive Body at Work uptakes this challenge as it explores the relations between value production, labour and the body in one particular realm of the global bioeconomy: the South African bioeconomy of 'egg donation'. It highlights different forms and dimensions of unacknowledged or precarious human labour that are constitutive for the procurement, brokering and circulation of oocytes as valuable resources. The analysis illustrates that the respective organisation of value and labour renegotiate what 'the' (re)productive body can do, which status and roles it is ascribed, which cultural and economic values it signifies and how it is experienced and enacted within a matrix of intersectional power relations. A theoretically profound contribution to the interdisciplinary debate on 'New materialism', The Reproductive Body at Work will appeal to students and researchers interested in fields such as gender studies, medical anthropology, cultural studies, sociology, political economy and science and technology studies.

Unlike other areas of medicine where statistics are meticulously kept by governments and global organizations, there are no accurate data to describe the number of the world's inhabitants who are overweight, obese, or morbidly obese. Despite this knowledge deficit, it should come as no surprise to readers that the medical community is facing an epidemic. Obesity is present in many of the developed countries and can also be observed in some urban areas of developing nations. The cause of this epidemic, simply stated, is overeating, but the overriding concern is more complex. Social factors, such as growing affluence since the 1950s, increasing reliance on pre-prepared meals, and the popularity of fast foods and sweetened drinks, have all contributed to the problem. Without doubt, the obesity epidemic has had adverse effects on both men and women, but in the case of women, some of its worse complications occur with those who are severely obese and pregnant. Obviously, this combination has been seen in the past, but it has increased so dramatically in its frequency that research has yet to catch up. Studies may discuss one or another aspect of caring for the obese pregnant patient, but until now, there has been no attempt to draw all such material together to try and present a comprehensive appraisal of the problem. Written by international experts, this practical guide draws on evidence-based material and is an invaluable resource for healthcare professionals dealing with obese pregnant women on a day-to-day basis.

This new book provides a clear and accessible analysis of the various ways in which human reproduction is regulated. A comprehensive exposition of the law relating to birth control,abortion, pregnancy, childbirth, surrogacy and assisted conception is accompanied by an exploration of some of the complex ethical dilemmas that emerge when one of the most intimate areas of human life is subjected to regulatory control. Throughout the book, two principal themes recur. First, particular emphasis is placed upon the special difficulties that arise in regulating new technological intervention in all aspects of the reproductive process. Second, the concept of reproductive autonomy is both interrogated and defended. This book offers a readable and engaging account of the complex relationships between law, technology and reproduction. It will be useful for lecturers and students taking medical law or ethics courses. It should also be of interest to anyone with a more general interest in women's bodies and the law, or with the profound regulatory consequences of new technologies.

This book explores the cultural history of embryology in Tibet, in culture, religion, art and literature, and what this reveals about its medicine and religion. Filling a significant gap in the literature this is the first in-depth exploration of Tibetan medical history in the English language. It reveals the prevalence of descriptions of the development of the human body - from conception to birth - found in all forms of Tibetan religious literature, as well as in medical texts and in art. By analysing stories of embryology, Frances Garrett explores questions of cultural transmission and adaptation: How did Tibetan writers adapt ideas inherited from India and China for their own purposes? What original views did they develop on the body, on gender, on creation, and on life itself? The transformations of embryological narratives over several centuries illuminate key turning points in Tibetan medical history, and its relationship with religious doctrine and practice. Embryology was a site for both religious and medical theorists to contemplate profound questions of being and becoming, where topics such as pharmacology and nosology were left to shape secular medicine. The author argues that, in terms of religion, stories of human development comment on embodiment, gender, socio-political hierarchy, religious ontology, and spiritual progress. Through the lens of embryology, this book examines how these concerns shift as Tibetan history moves through the formative 'renaissance' period of the twelfth through to the seventeenth centuries.

The fastest growing demographic in both developed and developing societies around the world, the elderly bring unique medical and financial health-care burdens. In response to this phenomenon, a large and growing body of research is directed toward the science of healthy aging. A substantial amount of observational data points to the consumption of a plant-based diet as a factor in lowering the risk of multiple chronic degenerative age-related diseases. The 6th International Phytochemical Conference, Phytochemicals: Aging and Health, focused on the particular concerns of nutrition in the aging population, as well as new aspects of research methodology, real-world applications, and updates or expansions of previously introduced topics. Drawn from the illustrious panel of scientists and researchers who spoke at the conference, Phytochemicals: Aging and Health begins by highlighting the prevailing theories on aging, including dietary manipulation and the role of phytochemical medicinals or supplements in health. Contributions present state-of-the-art methodologies for polyphenolic analysis, bioavailability, and metabolism-crucial tools that answer pressing questions such as "are there age related changes in flavonoid bioavailability?" The following chapters provide research results on botanicals and inflammation, green tea formulations and skin health, and the effects of phytochemicals on vision, brain function, and cardiovascular disease. The book concludes with forward-looking discussions on applying nutrient-gene interaction research findings to individual dietary recommendations, along with the step-by-step process to commercialize botanical products for allergy relief. Continuing to introduce the highest-quality, groundbreaking research, Phytochemicals: Aging and Health provides pragmatic information for food companies, supplement manufacturers, and researchers interested in developing functional foods and nutraceuticals for the aging population.

With the rigor of a dedicated scholar and the passion of a committed activist, Nancy Lublin offers a fresh perspective on the ethical dimensions of providing and using reproductive technologies, including contraception, assisted conception, and antenatal and childbirth interventions. Combining feminist philosophy and legal theory, Lublin considers these issues under a single category that she calls 'technological intervention in the womb.' She addresses the positions of technophiles (who advocate acceptance of technological intervention in the womb as a source of liberation), technophobic feminists (who reject artificial invasions as anti-natural and anti-women), and other feminists who have argued that technological intervention in the womb should be legal and available to women because freedom of choice should be gender-neutral. Lublin identifies core principles that are common to a kaleidoscope of feminist theories, and she argues that a materialist feminism provides the most effective framework for establishing public policy and creating social change in the name of gender justice.

This book examines the United States as a destination for international consumers of assisted fertility services, including egg donation, surrogacy, and sex selection. Based on interviews conducted with fertility industry insiders who market their services to an international clientele in three of the largest American hubs of the global fertility marketplace - New York City, Los Angeles, and San Francisco - and focusing on the providers rather than the consumers of assisted fertility services, the book shines a light on how professional ethics and norms, in addition to personal moralities, shape the practice of reproductive tourism.

Preimplantation genetic testing (PGT) is now well established as a valuable treatment option for patients wishing to start or continue a family, for a range of indications from advanced maternal age to high risk of transmitting inherited disease. This text brings together contemporary thinking from international opinion leaders and will be an invaluable guide for practitioners in Reproductive Medicine wishing to keep pace with the latest developments and clinical data.

Statistical Analysis of Human Growth and Development is an accessible and practical guide to a wide range of basic and advanced statistical methods that are useful for studying human growth and development. Designed for nonstatisticians and statisticians new to the analysis of growth and development data, the book collects methods scattered throughout the literature and explains how to use them to solve common research problems. It also discusses how well a method addresses a specific scientific question and how to interpret and present the analytic results. Stata is used to implement the analyses, with Stata codes and macros for generating example data sets, a detrended Q-Q plot, and weighted maximum likelihood estimation of binary items available on the book's CRC Press web page. After reviewing research designs and basic statistical tools, the author discusses the use of existing tools to transform raw data into analyzable variables and back-transform them to raw data. He covers regression analysis of quantitative, binary, and censored data as well as the analysis of repeated measurements and clustered data. He also describes the development of new growth references and developmental indices, the generation of key variables based on longitudinal data, and the processes to verify the validity and reliability of measurement tools. Looking at the larger picture of research practice, the book concludes with coverage of missing values, multiplicity problems, and multivariable regression. Along with two simulated data sets, numerous examples from real experimental and observational studies illustrate the concepts and methods. Although the book focuses on examples of anthropometric measurements and changes in cognitive, social-emotional, locomotor, and other abilities, the ideas are applicable to many other physical and psychosocial phenomena, such as lung function and depressive symptoms.

Relevant to students, academics and practitioners across the globe, this original volume highlights contemporary issues associated with assisted reproduction and embryology and critically analyzes the law surrounding human reproduction in the light of case law and technological developments since the Human Fertilisation and Embryology Act (HFE Act) Act was passed in 1990. Tackling issues from an interdisciplinary perspective, the authors identify and evaluate areas that have provoked intense public and academic debate as well as those where further or renewed regulation is needed. Focusing primarily on the legal and ethical issues involved in regulating this area in the UK, which is at the forefront of developing legislation in this area, this book has international relevance as many countries have used the UK as a model for their own legislation. This text is suitable for a broad range of readers, including legal academics, law students and practitioners interested in the areas of medical/healthcare law and ethics, bioethics and moral philosophy, family law, sociology and reproductive medicine and genetics.