Because of the recent advances in embryo modeling techniques, and at the request of the Office of Science Policy in the Office of the Director at the National Institutes of Health, the National Academies of Sciences, Engineering, hosted a 1-day public workshop that would explore the state of the science of mammalian embryo model systems. The workshop, which took place on January 17, 2020, featured a combination of presentations, panels, and general discussions, during which panelists and participants offered a broad range of perspectives. Participants considered whether embryo model systems - especially those that use nonhuman primate cells - can be used to predict the function of systems made with human cells. Presentations provided an overview of the current state of the science of in vitro development of human trophoblast. This publication summarizes the presentation and discussion of the workshop. Table of Contents Front Matter 1 Introduction and Overview 2 Mammalian Embryo Research and Pluripotent Stem Cells 3 Examining the Development of Extraembryonic Lineages 4 Stem CellBased Models of Human Embryos 5 Comparative Embryonic Development Across Species 6 Exploring Opportunities and Challenges with Mammalian Embryo Model Systems References Appendix A: Workshop Agenda Appendix B: Speaker Biographical Sketches Appendix C: Statement of Task Appendix D: Registered Attendees

From Viagra to in vitro fertilization, new technologies are rapidly changing the global face of reproductive health. They are far from neutral: religious, cultural, social, and legal contexts condition their global transfer. The way a society interprets and adopts (or rejects) a new technology reveals a great deal about the relationship between bodies and the body politic. Reproductive health technologies are often particularly controversial because of their potential to reconfigure kinship relationships, sexual mores, gender roles, and the way life is conceptualized. This collection of original ethnographic research spans the region from Morocco and Tunisia to Israel and Iran and covers a wide range of technologies, including emergency contraception, medication abortion, gamete donation, hymenoplasty, erectile dysfunction, and gender transformation.

This book is a practical guide to the detection, diagnosis and treatment of infertility. Beginning with an overview of human reproduction, the importance of accurate history taking and examination, and general preconception evaluation, the following chapters discuss the different investigational methods in the assessment of female infertility. The final sections examine male infertility and the role of semen analysis in understanding the potential of fertility. Genetic, environmental and behavioural risk factors are also covered. This comprehensive text is enhanced by clinical images, diagrams and tables. Key Points Practical guide to detection, diagnosis and treatment of infertility Covers assessment of both female and male infertility Covers genetic, environmental and behavioural risk factors Enhanced by clinical images, diagrams and tables

This volume focuses on endometriosis from its pathogenesis and the importance of the early diagnosis to treatment, throughout all aspects of femininity that this disease affects, impacting health and quality of life. It also covers treatment strategies for the pain and for the disease management according to the age and needs of the patient, from adolescence to menopause, passing through the fertile age and the consequences that this disease can have on fertility and pregnancy. This book is a useful, clear and up-to-date tool for gynecologists, gynecological surgeons, reproductive medicine and general practitioners and is an important source of information to face this more and more frequent and devastating disease.

Manual of Ovulation Induction and Ovarian Stimulation Protocols encompasses all aspects of ovulation induction and current stimulation protocols in detail. This detailed text provides the reader with a reliable overview of the principles involved and the management required for ovulation induction in the treatment of infertility. This book is comprised of 68 chapters which cover the tailoring of ovarian stimulation regimens to a patient's medical history and previous response to treatment. Both the clinical and sonographic findings in evaluating ovulatory function and dysfunction are discussed in detail. Methods for monitoring folliculogenesis, which in turn allows the ART specialist to accurately predict the number, as well as the timing of the high quality of oocyte retrieval, are discussed in detail. The book features discussion on basic and clinical research evidence, which is accumulating to propose the future use of recombinant FSH and LH in order to achieve controlled ovarian stimulation. The inclusion of the most current research in this second edition makes Manual of Ovulation Induction and Ovarian Stimulation Protocols a valuable book for gynaecologists, infertility specialists, and healthcare professionals dealing with IVF. Key Points Includes current research and future implications 60+ full colour images and illustrations New edition. First published 2005

Human embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science. Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.

This atlas presents a series of photographic illustrations and line drawings that summarize the major developmental events that occur during organogenesis in the opossum (Didelphis virginiana).It will be of interest to General Biologists, Zoologists, Wildlife Biologists, Embryologists and Medical Scientists.

Written by the authors of the renowned embryology textbooks The Developing Human and Before We Are Born, Concise Clinical Embryology: An Integrated, Case-Based Approach offers essential, high-yield information and high-quality clinical cases to illustrate key principles of embryology and their relevance to everyday practice. Ideally tailored to the needs of today's medical students and medical courses, this concise text clearly explains how embryology relates to other medical disciplines and its importance in safe, effective clinical practice. Abundant illustrations throughout help you grasp highly visual concepts quickly and easily. Provides easily digestible, clinically oriented coverage of human development, establishing key principles in a week-by-week, stage-by-stage approach, before moving on to fetal organ development by body system. Includes clinical cases and follow-up questions in each chapter that help relate key principles to everyday practice, aid in problem-based learning, and offer review for exam preparation. Covers the latest advances in embryology, including normal and abnormal embryogenesis, causes of birth defects, and the role of genes in human development. Contains superb illustrations from cover to cover, including diagnostic images, full color figures, histology, and more. Summarizes molecular biology highlights throughout the text. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access 18 3D animations with expert commentary, plus all of the text, figures, and references from the book on a variety of devices.

Thirty-five years after its initial success as a form of technologically assisted human reproduction, and five million miracle babies later, in vitro fertilization (IVF) has become a routine procedure worldwide. In Biological Relatives, Sarah Franklin explores how the normalization of IVF has changed how both technology and biology are understood. Drawing on anthropology, feminist theory, and science studies, Franklin charts the evolution of IVF from an experimental research technique into a global technological platform used for a wide variety of applications, including genetic diagnosis, livestock breeding, cloning, and stem cell research. She contends that despite its ubiquity, IVF remains a highly paradoxical technology that confirms the relative and contingent nature of biology while creating new biological relatives. Using IVF as a lens, Franklin presents a bold and lucid thesis linking technologies of gender and sex to reproductive biomedicine, contemporary bioinnovation, and the future of kinship.

' Charlotte Grand gives sensible practical advice' Dr Clare Bailey 'Full of insightful information, valuable health hacks and delicious recipes' Dr Mark Surrey The Fertility Kitchen is the go-to nutrition and lifestyle cookbook for anyone who wants to become pregnant - whether they are just starting to think about having a baby, have been trying for a while, are navigating infertility or exploring assisted conception. In today's fast-paced society, we are so used to getting what we want, when we want it. For women suffering with infertility it can be the first time they find themselves in a situation they have little control over: they can feel powerless. The Fertility Kitchen will help to reclaim some of that lost power. Part one of The Fertility Kitchen is based around the three 'pillars' of 'Fertility', 'Food', and 'Life', that sit at the heart of everything Charlotte is passionate about, giving a framework for an achievable life-style change. Charlotte shares her expertly tailored, nutrient-rich fertility nutrition and lifestyle plan, covering stress, movement, sleep, and social connection. Part two will help readers put this plan into practice with over 60 original flavour-packed yet simple recipes that embrace everything that's good for fertility. Charlotte explains the food philosophy that she teaches her clients, the foundations of good nutrition and its importance for optimal fertility. She addresses the key areas of health that can affect fertility, enabling readers to personalise their diet to suit their unique needs, as well as outlining the impact lifestyle can have on fertility, giving readers the strategies to achieve balance across all aspects of their life.

Reproductive Health: Women and Men's Shared Responsibility is a much needed reference for both leaders and students in community health. The author's basic premise, that reproductive health must be addressed in an individual, community, and global context, is reflected in this integrated orientation to reproductive health that befits the needs of students of the twenty first century. It offers a cutting-edge approach in its presentation of information about reproductive health, complete with recognition of the role of men, human rights, social justice, global health, infertility, environmental threats, gender violence, and more.

This book presents an anatomical overview of the changing form and structure of the human body. Although biomechanical embryology can be traced back to the 19th century, up until recently the most commonly accepted framework for the study of human ontogeny (development of the individual) was molecular biology, which all too frequently relied on findings from animal experiments that remained untested for humans. German embryologist and anatomist Erich Blechschmidt's research concentrates on the evidence presented by the human embryo itself. He offers a new approach to the study of early human growth as a way to shed light on the development of body build, instincts, gestures, language, mathematics, tools, and dress.

Abortion and Mothering: Research, Stories, and Artistic Expressions of a Common Intersection is a collection of academic research, personal narratives, and art that comments on different perspectives on abortion and mothering. Scholarly research is balanced with voices and experiences from outside of academia, through the inclusion of personal narratives, poetry, and art. The collection is rooted in the idea that there are not 'women who have abortions' and 'women who have babies', but that they are the same women at different points in their lives. By considering the intersection of abortion and mothering, and the liminal spaces in between, the reader is challenged to explore some of the culturally and socially constructed complexities that surround the decisions that people make about to their reproductive lives.

This book contributes in an important way to the psychoanalytic understanding and impact of Assisted Reproductive Technology on a majority of patients who have difficulties starting new families. Recent advances in reproductive technology and the increased use of techniques based upon it have created a need for psychoanalytic thinking and understanding of the psychological implications of Assisted reproductive procedures, in-vitro fertilization and other similar procedures.The recent and rapid advances in medical technologies confront us with a mandate in our clinical work to understand their complex impact on women, men, and children. However, attention to the intra psychic conflicts, traumatic experience of the use of such techniques has not been addressed in psychoanalytic literature. The developmental trauma and intra psychic conflicts of individuals using reproductive technologies are ubiquitous, yet it has been neglected as a topic of special interest in our clinical work.The centerpiece of these collective chapters deal with psychic trauma of infertility, the compulsion to repeat through persistent repeated use of assisted reproductive technology, anxiety about motherhood, and finally the lives of children who are born and do not know from where they came.These poignant topics deal with family complexes and the Oedipal circle, repetition compulsion, trials and failures, anxiety related to motherhood, egg and sperm donors, parental identity formation, infertility, trauma, and discussion of a contemporary film depicting the challenging and newly defined family structure.

This book is a contemporary statement of what is known about morphological development of the normal and abnormal human nervous system and puts into perspective the continued importance of changes that occur in the course of foetal development and how these processes may become defective. The first part of the book deals with the development of the central nervous system (CNS) from a morphological point of view including data from the fields of biochemistry, immunology and genetics. The second part reviews the genetic and nongenetic etiology of abnormal CNS development and discusses throughly all patologic syndromes that are related to disturbances of brain development. With the rapid progress in such modern branches of science as neurochemistry, genetics and molecular biology, this book will be invaluable for researchers working in these fields.

A Practical Guide to Clinical Supervision in Genetic Counseling provides a comprehensive overview of clinical supervision, emphasizing the supervision of genetic counseling students. The book draws on theory and research in genetic counseling, psychology, counselor education, and Dr. Veach's many years of experience in supervision practice. Chapters address key issues in clinical supervision, including the infrastructure required for effective supervision; relationship dynamics inherent in supervision; and critical supervision processes, such as goal setting, feedback, evaluation, culturally-responsive supervision, and common clinical supervision challenges. Additional chapters cover models of supervisor and supervisee development, strategies to promote student wellness, how to recognize and address problematic performance, and supervision delivery models. Each chapter contains instructional objectives, illustrations of major topics with supervision vignettes and examples, and descriptions of specific strategies for promoting self-reflective supervision practice. Experiential activities at the end of each chapter provide opportunities for readers to strengthen and maintain competencies associated with effective supervision processes and outcomes. The activities are appropriate for both current and future supervisors at all levels of experience and are suitable for use in the classroom and by individuals engaged in self-study. A Practical Guide to Clinical Supervision in Genetic Counseling also features three contributed chapters by experts in supervision, education, and research and an appendix with instructional tips for designing and conducting supervision training opportunities to facilitate participants' learning experiences.

This book is dedicated to an update on metabolic disorders and their consequences on the developing nervous system. In the last ten years, major scientific advances in biochemical diagnosis have enabled the identification of many new disease entities, as well as a better classification of clinical symptoms and their correlation to biochemical defects. This volume provides an introduction to basic sciences specifically relevant to this disease group, then focuses on each subgroup in turn: hyperphenylalaninaemias, mitochondrial encephalomyopathies, organic acidoses, urea cycle defects, lysosomal storage and peroxylsomal disorders. Finally, a discussion of long term follow-up and family related issues also reports the results of a four-year research project led by the Mariani Foundation.

This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells. The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed. The book follows on from Parts I and II of Biochemistry and Cell Biology of Ageing (Volumes 90 and 91 of the Subcellular Biochemistry book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.

This revised and updated second edition provides a comprehensive account of the human male gamete. Detailed overviews of human sperm production, maturation, and function - and how these processes affect and influence fertility, infertility, and assisted reproduction - are given. A wide range of new developments including proteomics, spermatogenesis, sperm-specific WW domain-binding proteins, Ca2+ signalling, DNA packaging, epididymis are explored, whilst a new chapter presents information gained from mouse genetics, highlighting how it informs male fertility research. The impact of environmental factors during pre-pubertal and pubertal stages of life is also investigated. Featuring engaging prose with chapters organized topographically, The Sperm Cell remains an essential resource for andrologists, clinical scientists, and laboratory personnel.

The essential guide to making sure you have a fabulous later life. You're likely to live longer than you think. Today's fifty-year olds could have an astounding 36 or more years of life. What's your dream life for your later years? When We're 64 is a friendly, practical guide to preparing for what could be the best years of your life - from the essentials on work and how to fund retirement, to volunteering, where to live and what kind of housing you'll need. It covers how to stay healthy - and still live a full life if you get a health condition - and reveals how your attitude to ageing could actually increase your lifespan. There are sections on relationships with family and friends, as well as caring for older relatives and how to tackle loneliness. Packed with expert advice and new evidence and tips on how to age well, this route map will help you plan and prepare for the future.

Senior investigators internationally have here collaborated to produce an international reference work. Each contributor provides critical and thought provoking concepts and ideas based on the latest developments in their field. The result is a must read and timely reference work for investigators who are interested in how spermatogenesis is currently understood and which are the most promising avenues for future research; an Introduction sets the context for the chapter and points out the relevance of the research for basic research scientists and clinicians.

Despite incredible and previously undreamed-of advances in modern medicine, for many women the issue of infertility remains a heart-breaking reality. Using a combination of traditional and modern astrological techniques, the author has delved deeply into the charts of hundreds of infertile women, and in many cases has unravelled what might be at the root of the problem. Sometimes it's a matter of location or timing, or it could be psychological issues in the relationship that are causing the block; whatever the reason, the author works closely with the couple - and often the medical profession - to produce results that are frequently positive where there has been no hope before. Although this is an advanced textbook for astrologers, the human element of the case histories is nothing short of inspiring, and from that perspective can be enjoyed by readers with no knowledge of astrology.

Part of the Infertility Management Series, this book is a concise guide to the diagnosis and management of polycystic ovary syndrome (PCOS), caused by an imbalance of hormones in women, often leading to infertility if untreated. Beginning with an overview of prevalence, symptoms, genetics and physiology, the following sections examine different treatment options, from lifestyle management, to ovulation induction and surgical management. The final chapters discuss ART in women with PCOS, identification and treatment of ovarian hyper stimulation syndrome, and long term effects and metabolic syndrome. Edited by recognised experts in the field, the book is enhanced by clinical images and figures. Other titles in the Infertility Management Series include: Practical Management of Male Infertility, Intrauterine Insemination, and Investigating Infertility. Key Points Practical guide to diagnosis and management of PCOS Part of Infertility Management Series Covers all treatment methods, from lifestyle management, to surgical procedures Edited by recognised experts in the field

Extensively revised to incorporate recent research and current clinical practice, The Developing Human: Clinically Oriented Embryology, 11th Edition, covers all aspects of normal and abnormal embryonic and fetal development. In a clear, concise manner and lavishly illustrated throughout, this textbook is designed to successfully meet the needs of medical and health sciences profession students, as well as those in graduate programs. It provides an easy-to-digest, comprehensive review of what can be a complex and challenging subject. BONUS online features such as multiple-choice questions and narrated animations further support student success. Guides readers month by month and stage by stage through embryo and fetal organ and systems development, using full-color photographs of clinical cases, relevant modern medical imaging, and numerous high-quality supportive figures. Includes many new 3D HD color rendered images of embryos and fetuses, as well as 3D reconstructions of whole embryos. Provides clinically-oriented problems for each chapter, with corresponding answers and explanations designed to facilitate discussion and learning. In addition, multiple-choice questions and answers are available online for supportive self-assessment. Features 18 exceptional color animations, now with narration, to help students as they explore and learn the complexity of embryological development. Provides the knowledge base needed for today's examinations, including USMLE Step 1, as well as for future clinical practice. Thoroughly updated information includes new annotations on fundamental molecular events during embryogenesis, now required for many professional examinations. Includes enhanced clinical material in all chapters, with updated tables, Clinical Case highlights and a critical chapter on common signalling pathways during development that covers gene editing (CRISPR/Cas9), induced pluripotent stem cells (iPS), a revision of the sonic hedgehog signalling pathway; and more. Details how molecular biology has affected clinical practice, including techniques such as recumbent DNA technology and stem cell manipulation. Includes an Enhanced eBook version with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

How do we find the life that's right for each of us? More and more of us are feeling overwhelmed by the everyday struggle to lead the lives to which we aspire. Children are placed under unbearable pressure to achieve; adults fight a constant battle to balance family life with work and economic demands; old people suffer from social isolation and a lack of emotional security. People of every age are feeling increasingly at odds with the world, and less able to live a life that corresponds to their individual needs and talents. At the root of this problem, argues internationally renowned child development expert Remo Largo, is a mistaken idea of what makes us human. A distillation of forty years of research and medical experience, The Right Life sets out a new theory of human thriving. Tracing our development as individuals from the beginnings of evolution to the twenty-first century, he sets out his own theory, the 'Fit Principle', which proposes that every human strives to live in harmony with their fellow humans and their environment. Rather than a ceaseless quest for self-improvement and growth, he argues, our collective goals should be individual self-acceptance, as we embrace the unique matrix of skills, needs and limitations that makes each of us who we are. Not only, Largo suggests, can a true understanding of human thriving help people find their way back to their individuality; it can help us to reshape society and economy in order to live as fully as possible.