The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.

This extensive book provides an up-to-date overview by leading international authorities, spanning the disciplines of neuroscience, psychology, ophthalmology, optometry, and paediatrics, of normal and pathological infant visual development. It covers the development of retinal receptors; infant sensitivity to detail, colour, contrast, and movement; binocularity, eye movements, and refraction, and cognitive processing. Childrens' visual deficits, including amblyopia and cataract are covered.

The Human Embryo in vitro explores the ways in which UK law engages with embryonic processes under the Human Fertilisation and Embryology Act 1990 (as amended), the intellectual basis of which has not been reconsidered for almost thirty years. McMillan argues that in regulating 'the embryo' - that is, a processual liminal entity in itself - the law is regulating for uncertainty. This book offers a fuller understanding of how complex biological processes of development and growth can be better aligned with a legal framework that purports to pay respect to the embryo while also allowing its destruction. To do so it employs an anthropological concept, liminality, which is itself concerned with revealing the dynamics of process. The implications of this for contemporary regulation of artificial reproduction are fully explored, and recommendations are offered for international regimes on how they can better align biological reality with social policy and law.

Aristotle believed semen to be the purest of all bodily secretions, a vehicle for the spirit or psyche that gives form to substance. For Proust's narrator in "Swann's Way," waking to find he has experienced a nocturnal emission, it is the product of "some misplacing of my thigh." The heavy metal band Metallica used it to adorn an album cover. Beyond its biological function, semen has been applied with surprising frequency to metaphorical and narratological purposes.
In "Images of Bliss," Murat Aydemir undertakes an original and extensive analysis of images of male orgasm and semen. In a series of detailed case studies-Aristotle's "On the Generation of Animals;" Andres Serrano's use of bodily fluids in his art; paintings by Holbein and Leonardo; Proust's "In Search of Lost Time; "hard-core pornography (both straight and gay); and key texts from the poststructuralist canon, including Lacan on the phallus, Bataille on expenditure, Barthes on bliss, and Derrida on dissemination-Aydemir traces the complex and often contradictory possibilities for imagination, description, and cognition that both the idea and the reality of semen make available. In particular, he foregrounds the significance of male ejaculation for masculine subjectivity. More often than not, Aydemir argues, the event or object of ejaculation emerges as the instance through which identity, meaning, and gender are not so much affirmed as they are relentlessly and productively questioned, complicated, and displaced.
Combining close readings of diverse works with subtle theoretical elaboration and a keen eye for the cultural ideals and anxieties attached to sexuality, "Images of Bliss" offers a convincing and longoverdue critical exploration of ejaculation in Western culture.
Murat Aydemir is assistant professor of comparative literature at the University of Amsterdam.

A much-needed overview of the available information now accumulating to indicate that assisted reproductive technologies are generally safe for both babies and mothers. However, the literature abounds with reports of a higher risk of obstetric and perinatal complications; regarding the long term outcomes for both women and children, the data are still scarce. The chapters summarized in this book review the current knowledge on long term safety of assisted reproduction and indicate the need for continued research to cover the lack of data in some specific patient groups and for recently developed treatments that only have a short period of follow-up.

Multidisciplinary collection of essays on the relationship of infertility and the "historic" STIs--gonorrhea, chlamydia, and syphilis--producing surprising new insights in studies from across the globe and spanning millennia. A multidisciplinary group of prominent scholars investigates the historical relationship between sexually transmitted infections and infertility. Untreated gonorrhea and chlamydia cause infertility in a proportion of women and men. Unlike the much-feared venereal disease of syphilis--"the pox"--gonorrhea and chlamydia are often symptomless, leaving victims unaware of the threat to their fertility. Science did not unmask the causal microorganisms until thelate nineteenth and twentieth centuries. Their effects on fertility in human history remain mysterious. This is the first volume to address the subject across more than two thousand years of human history. Following asynoptic editorial introduction, part 1 explores the enigmas of evidence from ancient and early modern medical sources. Part 2 addresses fundamental questions about when exactly these diseases first became human afflictions, withnew contributions from bioarcheology, genomics, and the history of medicine, producing surprising new insights. Part 3 presents studies of infertility and its sociocultural consequences in nineteenth- and twentieth-century Africa, Oceania, and Australia. Part 4 examines the quite different ways the infertility threat from STIs was perceived--by scientists, the public, and government--in late nineteenth- and early twentieth-century Germany, France, and Britain, concluding with a pioneering empirical estimate of the infertility impact in Britain. Simon Szreter is Professor of History and Public Policy, University of Cambridge, and Fellow of St. John's College, Cambridge.

Recurrent pregnancy loss (RPL) includes recurrent first- and second-trimester abortions and recurrent preterm delivery, second- or third-trimester intrauterine fetal death, intrapartum stillbirth, and early neonatal death. This book includes protocols for case scenarios of early and late pregnancy loss as well as instances of poor obstetric history. Key Features Explores the management of different clinical presentations of RPL Includes preeclampsia, intrahepatic cholestasis of pregnancy, and hypertension-related disorders in pregnancy Includes clinical protocols with flowcharts Features tip boxes with learning points for easy reference

In the space of one generation major changes have begun to take place in the field of human reproduction. A rapid increase in the control of fertility and the understanding and treatment of sexual health issues have been accompanied by an emerging threat to reproductive function linked to increasing environmental pollution and dramatic changes in lifestyle. Organised around four key themes, this book provides a valuable review of some of the most important recent findings in human reproductive ecology. Major topics include the impact of the environment on reproduction, the role of physical activity and energetics in regulating reproduction, sexual maturation and ovulation assessment and demographic, health and family planning issues. Both theoretical and practical issues are covered, including the evolution and importance of the menopause and the various statistical methods by which researchers can analyse characteristics of the menstrual cycle in field studies.

This book looks at the major changes that have occurred in the theory and practice of speech therapy for children with developmental speech disorders. It looks at current issues and their clinical implications, but the overall aim of the book is to set clinical practice firmly in a theoretical framework. While it is therefore essentially a practical book for practitioners, it also engages in the academic investigation of the nature of the different types of developmental speech disorders and their consequences for the children. This discussion provides the framework in which to consider clinical management and specific clinical techniques.

A recurrent theme throughout each chapter is the impact of linguistics upon our understanding and management of children' s problems in learning to pronounce. There is no doubt that the linguistic revolution in speech and language pathology has produced an entirely new perspective on these disorders by identifying the phonological dimension of speech development.

Of equal importance is the expansion of knowledge about children' s language development. Much more information is now available about phonological development in terms of what the developmental changes are and when they occur. This information is valuable in assessment and diagnosis. The book also includes a number of competing theories explaining how children develop their pronunciation patterns. These theories provide the premises upon which to establish a principled theory of therapy.

To reflect these issues and their clinical implications the book is divided into three sections. The first section explores the framework within which to discuss developmental speech disorders.The second section covers three specific types of pathological conditions with which developmental speech disorders are associated. The third section examines the problems of children who have no evident major disabling condition and yet they experience severe difficulties learning to pronounce and subsequently, more often than not, learning to read and write.

This important new book presents a comprehensive integration of psychoanalytic theories of human development from Freud to the present, showing their implications for the evaluation and treatment of children and adults. Phyllis Tyson and Robert L. Tyson not only review the literature on emotional growth but also provide a developmental theory of their own, one that examines psychosexual development in the context of a number of other simultaneously evolving systems-emotional, behavioral, cognitive, and social-all of which work in relation to one another in a dynamic way. The authors describe the developmental sequences of these systems and how they coalesce to form the human personality. The Tysons view development as it occurs rather than retrospectively from reconstructions of earlier life experience. They begin by tracing the history of this perspective, describing the developmental process, then critically reviewing psychoanalytic theories of development. The authors present developmental sequences for psychosexuality, object relations, the sense of self, affect, cognition, the superego, gender identity, and the ego. Throughout they maintain a central and orienting focus on the intrapsychic-on what happens in the mind as it evolves. In contrast to recent psychoanalytic emphases on interpersonal aspects of early development, they view perceived and felt interpersonal interactions as working in conjunction with innate factors to provide the basis for the internal world. According to the Tysons, it is the evolution and elaboration of this internal world that is the domain of psychoanalytic theory of development.

The Age-Well Project dived deep into the science of ageing well, and authors Annabel and Susan explained how they overhauled their own lives to prioritise healthy longevity. In The Age-Well Plan, Susan draws on almost a decade of extensive research into healthy longevity and her experience as a health coach to give you the tools you need to live your own age-well life. Her simple, clear and easy-to-follow six-week plan will show you how to make changes -- small and large -- to support healthy ageing, and prioritise the changes most appropriate for your body, lifestyle and circumstances. The first week of the plan guides you to understand your goals as you age and explains how to evaluate your current health and risk factors, in order to devise a bespoke plan for your body and brain. The subsequent weeks focus on the key elements of healthy ageing -- diet, exercise, sleep, engagement and the environment -- to help you build a personalised plan that will kickstart your age-well life.

Different technologies have been introduced to improve management of labor. To date there is no single text that aims at covering all these technologies that address different problems and issues in labor management. The book reviews new technologies and devices aimed to improve labor management and outcomes. These diverge between looking at a better way to use fetal heart rate monitors (that are used in 90% of labours); using new monitors to detect the <1% of babies that are damaged in labor and account for 99% of the medico-legal costs in labor; and early detection of non-progressive labors that complicate 30-50% of labors. This is the only book about all these technologies from the perspectives of new devices and technologies in labor.

This book will serve as a scientifically accurate yet easy-to-read introduction to birth control for teens and young adults. The information, guidance, and resources it offers will help readers to make better decisions regarding their sexual health. From barrier methods such as condoms and diaphragms to oral contraceptive pills and from hormone-based implants and injectables to permanent sterilization techniques, there are a number of ways to prevent unwanted pregnancy today. But which are the most effective, and how do you choose the method that's right for you? What about side effects and long-term implications for health, such as increased risk for cancer? Does birth control affect your chances of getting pregnant in the future? Birth Control: Your Questions Answered, a part of Greenwood's Q&A Health Guides series, provides clear, concise answers to these and other questions young readers may have about this sometimes embarrassing, yet very important, topic. Each book in this series follows a reader-friendly question-and-answer format that anticipates readers' needs and concerns. Prevalent myths and misconceptions are identified and dispelled, and a collection of case studies illustrates key concepts and issues through relatable stories and insightful recommendations. The book also includes a section on health literacy, equipping teens and young adults with practical tools and strategies for finding, evaluating, and using credible sources of health information both on and off the internet—important skills that contribute to a lifetime of healthy decision-making.

In Taking Baby Steps, Jody Lynee Madeira takes readers inside the infertility experience, from dealing with infertility-related emotions through forming treatment relationships with medical professionals to confronting difficult medical decisions. Based on hundreds of interviews, this book investigates how women, men, and medical professionals negotiate infertility's rocky terrain to create life and build families-a journey across personal, medical, legal, and ethical minefields that can test mental and physical health, friendships and marriages, spirituality, and financial security.

Reproduction is a fundamental feature of life, it is the way life persists across the ages. This book offers new, wider vistas on this fundamental biological phenomenon, exploring how it works through the whole tree of life. It explores facets such as asexual reproduction, parthenogenesis, sex determination and reproductive investment, with a taxonomic coverage extended over all the main groups - animals, plants including 'algae', fungi, protists and bacteria. It collates into one volume perspectives from varied disciplines - including zoology, botany, microbiology, genetics, cell biology, developmental biology, evolutionary biology, animal and plant physiology, and ethology - integrating information into a common language. Crucially, the book aims to identify the commonalties among reproductive phenomena, while demonstrating the diversity even amongst closely related taxa. Its integrated approach makes this a valuable reference book for students and researchers, as well as an effective entry point for deeper study on specific topics.

This book explores how conditions for childbearing are changing in the 21st century under the impact of new biomedical technologies. Selective reproductive technologies (SRTs) - technologies that aim to prevent or promote the birth of particular kinds of children - are increasingly widespread across the globe. Wahlberg and Gammeltoft bring together a collection of essays providing unique ethnographic insights on how SRTs are made available within different cultural, socio-economic and regulatory settings and how people perceive and make use of these new possibilities as they envision and try to form their future lives. Topics covered include sex-selective abortions, termination of pregnancies following detection of fetal anomalies during prenatal screening, the development of preimplantation genetic diagnosis techniques as well as the screening of potential gamete donors by egg agencies and sperm banks. This is invaluable reading for scholars of medical anthropology, medical sociology and science and technology studies, as well as for the fields of gender studies, reproductive health and genetic disease research.

This book provides the first clinically comprehensive and practical approach to ethical challenges in perinatal medicine.The first chapter introduces and explains the professional responsibility model of perinatal ethics.The professional responsibility model is based on the medical ethics of two major physician-ethics in the history of Western medical ethics, Dr. John Gregory (1724-1773) of Scotland and Dr. Thomas Percival (1740-1804) of England.The professional responsibility model is used to articulate the ethical concept of the fetus as a patient and to operationalize the ethical principles of beneficence and respect for autonomy.The book provides practical guidance for clinical judgment and decision making with patients about the responsible clinical management of the wide range of issues encountered by perinatologists in clinical practice and research.Topics included: periviability; feticide; intrapartum management; maternal-fetal conflict; innovation for fetal benefit; research for fetal benefit; non-aggressive obstetric management; managing the transition from pregnancy to birth; destructive procedures such as cephalocentesis; critical care for the pregnant patient; home birth; patient-choice cesarean delivery; neonatal care as a trial of management; and setting limits on neonatal care on the basis of clinical judgments of futility.

This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

This text offers a readable and friendly presentation of the important methods, findings, and theories of human aging, while actively involving the reader in meaningful exercises and critical thinking. Students are repeatedly challenged to apply information in the text to the older adults in their own lives. Specifically, suggestions for enhancing the lives of their older relatives are offered and encouraged. These include guidelines for discussions they might have regarding social, emotional, and environmental changes as well encouraging intellectual and social interaction. In this Edition: Emphasis on the science of the study of aging and why questions in aging are difficult to answer, how social scientists attempt to handle such difficulties, and the successes and failures social scientists have had thus far in answering those questions. The text also demonstrates how current research findings are now being applied in the real world and/or how they might be applied in the future. Cross-cultural comparisons and ethnic group comparisons are included wherever possible. Each chapter begins with "Senior View," which introduces students to a real person and gives them a chance to hear what older adults think and say about important issues related to the chapter and a chance to compare those opinions to the research findings. Each chapter ends with "Making Choices," emphasizing the important behavioral, emotional, and social choices that students can make now to prolong a healthy, happy life. "Chapter Projects" offer the opportunity for active learning, as students investigate for themselves an issue related to the chapter. Instructors can expand these projects for students who want to learn more, or for independent study. "Focus on Aging" boxes compliment the material in the text, providing additional insight and examples, and encouraging critical thinking. Every chapter includes discussion questions, study questions, chapter exercises, and related online resources.

A collection of objective essays reviewing the principal arguments for and against stem cell research. Among the issues considered are whether stem cell research treats embryos as "commodities," violates the rights of human embryos, or alienates women from their reproductive labor, and whether human embryos are entitled to full membership in the moral community.

Aging: Oxidative Stress and Dietary Antioxidants, Second Edition, bridges the trans-disciplinary divide and covers the science of oxidative stress in aging and the therapeutic use of natural antioxidants in the food matrix in a single volume. The second edition covers new trials and investigations used to determine the comprehensive properties of antioxidants, food items and extracts, as well as any adverse properties they may have. It has been updated to include new clinical human trials and a new section dedicated to animal models of aging. Throughtout the book the processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. This will aid in better research, treatment and outcome for patients.

In order to maximize the chance of IVF success, couples need to ensure that their preconceptual health is optimal to increase the quality of gametes and reproductive fitness. This text reviews the medical and lifestyle factors that can affect the body at preconception stage, such as micronutrients, stress, hormonal and gynecologic assessment, as well as environmental factors such as optimal weight and age for childbirth. This book will enable all medical practitioners and healthcare professionals to give evidence-based advice to influence the success rate of subsequent IVF cycles, and ensure that every child is born in the best possible condition. Part of a four-book series on optimizing different aspects of the IVF cycle, this book focusses on preparing the body for assisted conception. Other books in the series focus on the egg and embryo, the endometrium, and the sperm.