In January 1979, Robert Edwards and Patrick Steptoe delivered a lecture detailing the ten-year clinical and scientific research programme that led to the birth of Louise Brown, the first baby born utilising IVF. This thoroughly-researched book provides both a full annotated transcript of the lecture as well as recorded reminiscences from those who attended, detailing the contemporary understandings of the event. An essay on the lecture's historical context adds fresh insight into the biographies of Edwards and Steptoe and highlights sources from print and broadcast media that have received scant attention in earlier publications. Current and future implications of the advances in IVF since the first procedure are also explored, examining future medical and scientific possibilities as well as ethical issues that may arise. A foreword by Louise Brown herself places this remarkable leap of science in a personal context, one that so many families have since experienced themselves.

Despite incredible and previously undreamed-of advances in modern medicine, for many women the issue of infertility remains a heart-breaking reality. Using a combination of traditional and modern astrological techniques, the author has delved deeply into the charts of hundreds of infertile women, and in many cases has unravelled what might be at the root of the problem. Sometimes it's a matter of location or timing, or it could be psychological issues in the relationship that are causing the block; whatever the reason, the author works closely with the couple - and often the medical profession - to produce results that are frequently positive where there has been no hope before. Although this is an advanced textbook for astrologers, the human element of the case histories is nothing short of inspiring, and from that perspective can be enjoyed by readers with no knowledge of astrology.

This book presents a comprehensive review of the morphology and function of chromosomes in elderly people. The wide range of topics includes cyclical chromosome properties, mutations, repair, progressive chromosome heterochromatinization with increasing age, roles of nucleolar organiser regions, sister chromatid exchanges, homologue relationships, heterochromatin regions and other chromosomal features in very old age. This ground-breaking book focuses on heterochromatinisation as a key determinant of the genetic apparatus function during senescence and an area to seek life-prolonging interventions. The book illustrates and updates progress in the field of cytogenetics of ageing. The book contains 16 tables and 25 figures.

Science is on the cusp of a revolutionary breakthrough. We now understand more about ageing - and how to prevent and reverse it - than ever before. In The Telomerase Revolution, Dr Michael Fossel, who has been at the cutting edge of ageing research for decades, describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to intervene in age-related disease, dramatically extend life spans and even reverse human ageing. Telomerase-based treatments are already on offer, and have shown early promise, but much more potent treatments will become available over the next decade. This is the definitive work on the latest science of human ageing, covering both the theory and the clinical implications, taking readers to the forefront of one of the most remarkable advances in human medicine.

This volume comprehensively focuses on polycystic ovary, metabolic syndrome and obesity and their impact on women's health, reproduction and quality of life from adolescence to old age. PCOS is analyzed form the early origins - highlighting the importance of diagnosis, management and treatment starting from the high-risk period of adolescence - throughout infertility PCOS-related issues, pregnancy and menopause transition. All aspects of this syndrome are covered also in relation with endocrine and metabolic features that affects women's health. This book is a very useful tool for gynecologists, endocrinologists, obstetricians, reproductive medicine and general practitioners and is an important resource for all physicians involved in women's health.

Penile implants have been an effective treatment for erectile dysfunction (ED) for more than 40 years. However, there is now a growing interest in this treatment option, as the number of procedures is expected to increase in the future. This book offers a reference guide for all those practitioners interested in understanding and/or performing this procedure. It will also benefit those in medical education who want to obtain specialized and high-quality knowledge regarding the complexities involved in penile implant surgery. Although the basic description of penile implant surgery is well documented in the literature, a detailed and comprehensive guide with a special focus on the most challenging and controversial aspects is lacking. The few books available on the topic provide a broad overview of prosthetic surgery in general, mainly discuss basic principles, and fail to provide a more detailed perspective. This comprehensive book discusses various aspects of penile implant surgery, ranging from indications to long-term complications. It addresses the most common and serious challenges regarding penile implants, which are rarely discussed elsewhere. The respective chapters were written by internationally respected experts on the controversies of penile prosthetic surgery. The book is intended for all those who plan to specialize in penile implant surgery, which include, but are not limited to, residents and fully trained urologists, as well as fellows and practitioners in sexual medicine and reconstructive urology.

This second edition of the essential guide for reproductive professionals is now available in a Clinical Guide and a Case Studies Guide, presenting the most current knowledge on counseling patients with diverse needs amidst rapidly advancing modern technology. The Case Studies guide relates the accessible, real-world experiences and perspectives as leading international practitioners share their stories applying clinical concepts to treatment practice. Chapters cover current, unaddressed and emerging areas in reproductive mental health including consequences of direct-to-consumer DNA testing, racial and cultural sensitivity and tele-mental health. Among the new topics are transgender ART, recurrent pregnancy loss, post-partum adjustment, and the pregnant therapist. For an in-depth presentation of clinical concepts, discover the Clinical Guide, which provides a foundational understanding of the medical and psychosocial experience of fertility treatment. An essential aid for medical and mental health professionals, this comprehensive guide allows clinicians to develop and refine the skills required to address the increasingly complex needs of fertility patients.

Neurogenesis, or the birth of new neuronal cells, was thought to occur only in developing organisms. However, recent research has demonstrated that neurogenesis does indeed continue into and throughout adult life. On going neurogenesis is thought to be an important mechanism underlying neuronal plasticity, enabling organisms to adapt to environmental changes and influencing learning and memory throughout life. A number of different factors that regulate neurogenesis have been identified. Physicial activity and environmental conditions have been known to affect proliferation and survival of neurons. Hormones have also been found to influence the rate of neurogenesis in vertebrates (e.g. testosterone) and invertebrates (eg: ecdysone). Serotonin is believed to play a key role in neurogenesis.

This book presents research on cell growth and the ageing process. Emphasis is given to implications for cancer therapy, abnormal mitosis and aberrant nuclear morphology, neoplastic transformations, negative charges on various malignant cell types.

Human embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science. Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.

'Informative, powerful' VOGUE 'A fascinating and friendly guide for you to understand you better' MELISSA HEMSLEY 'Amy's book is everything I should have learned at school' EMMA GANNON Hormones were something Amy Thomson, founder and CEO of leading women's health app and tech service Moody, never paid attention to, until one day her periods stopped. When she discovered that her hormonal burnout was driven by stress, she quit her job and focused on trying to understand how our hormones can work for twenty-first-century survival. In this eye-opening guide, Thomson draws upon leading research from nutritionists, gynaecologists, endocrinologists, personal trainers and others to explain how understanding our systems and cycles can help you avoid burnouts, build better and healthier routines and optimise your life.

Obtaining good quality oocytes and preparing them for in-vitro fertilization (IVF) is a key stage in assisted reproduction. This is a complex process with many pitfalls, making good clinical preparation and laboratory technique essential for success. Illustrated throughout, this book will be valuable to clinical embryologists, laboratory personnel wishing to redefine or develop technique and improve outcomes, IVF quality managers, and gynecologists performing oocyte retrieval. Featuring descriptions of the underlying science along with practical advice on methods and trouble-shooting, this comprehensive manual will aid all those involved in this complex process of oocyte retrieval and preparation in navigating towards optimal outcomes.

Understanding immunology is increasingly important in obstetrics and gynecology. This book explores the role of immunological processes in reproduction. It presents immunologic concepts and illustrates important points with examples familiar to the clinician. It is organized into four sections: fundamentals of the immune system; the immunological paradox of pregnancy; clinical applications of immunology in obstetric and gynecologic practice, and immunopathology in obstetric and gynecologic practice. Written mainly for practicing obstetricians and gynecologists, the research results cited in the book are confined to human experimentation.

This book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone deficiency; what factors actually impact testosterone levels, polycythemia, gynecomastia, bone density, and hyperprolactinemia in the testosterone deficient patient; critical analysis of the numerous questionnaires that are available to clinicians; and the impact of testosterone therapy on male fertility, cardiovascular disease, and prostate events including prostate cancer. Guiding the reader in both evaluation and management, the book also illuminates novel concepts in the T space such as testosterone use in the transgender population, T therapy as an endothelial modulator, bipolar testosterone therapy in the patient with advanced prostate cancer, and testosterone therapy as a performance enhancer. Controversies in Testosterone Deficiency is intended for any clinician involved in the care of patients with testosterone deficiency, exploring hot topics and correcting existent misinformation in the routine care of patients.

This new volume in the Reproductive Medicine for Clinicians series focuses on the practical clinical impact of problems linked to infertility, discussing topics such as luteal support in ART cycles, ovulation induction using pulsatile administration of GnRH, how to deal with the metabolic changes in PCOS, treatment to restore fertility in endometriosis and how to improve implantation, which are common aspects of daily clinical practice. It also addresses significant novel areas like the biological clock in human reproduction, reproduction at advanced parental age and medical and social egg freezing, offering valuable insights for patients and their doctors. Further, the book covers various areas of growing importance, such as how to access the uterine cavity; the future of imaging in reproduction; non-invasive prenatal testing; ART and male infertility; as well as breast cancer and fertility preservation. Last but not least, it examines the medical, ethical and legal aspects of a number of challenges for current and future reproductive medicine, including uterine transplantation and human genetic modification. Bringing together updates on some of the most important problems in reproductive medicine and also covering ethical and legal bases, this book offers an overview of potential treatments for infertility. As such, it is a valuable resource for gynecologists, obstetricians, endocrinologists and all specialists dealing with reproductive health.

Infertility Saved My Life: Healing PCOS From The Inside Out exposes the raw teaching moments of Sarah Willoughby's journey to self-love through Polycystic Ovary Syndrome and secondary infertility. Within Infertility Saved My Life, Sarah Willoughby addresses the challenges and heartbreak she experienced while becoming a mum to three amazing children. She writes about her multiple miscarriages, as well as the trauma she endured, so that anyone still on their journey to parenthood can feel less alone in their loss and grief. Sarah's story peaks in 2009, when she ended up in intensive care after a disastrous IVF cycle. Lying in her hospital bed, she promised herself that if she survived, she would embrace her fears and empower others to do the same. Seven months later, Sarah Willoughby left the corporate world, emigrated to Australia and fell pregnant naturally twice with her daughters. Infertility Saved My Life shares the wisdom and insight that enabled Sarah to complete her family and begin a heart-centered life and business. She includes practical exercises and tools to help balance the reader's mind, body and spirit and improve their chances of having a baby.

This volume focuses on endometriosis from its pathogenesis and the importance of the early diagnosis to treatment, throughout all aspects of femininity that this disease affects, impacting health and quality of life. It also covers treatment strategies for the pain and for the disease management according to the age and needs of the patient, from adolescence to menopause, passing through the fertile age and the consequences that this disease can have on fertility and pregnancy. This book is a useful, clear and up-to-date tool for gynecologists, gynecological surgeons, reproductive medicine and general practitioners and is an important source of information to face this more and more frequent and devastating disease.

In the late 1990s, Egypt experienced a boom period in in vitro fertilization (IVF) technology and now boasts more IVF clinics than neighboring Israel. In this book, Marcia Inhorn writes of her fieldwork among affluent, elite couples who sought in vitro fertilization in Egypt, a country which is not only at the forefront of IVF technology in the Middle East, but also a center of Islamic education in the region. Inhorn examines the scientific, religious and cultural ramifications of the transfer of IVF technology from Euro-American points of origin to Egypt - showing how cultural ideas reshape the use of this technology and in turn, how the technology is reshaping cultural ideas in Egypt.

This new handbook provides private-practice and hospital gynecologists with a practical guide for advising and treating patients in the case of maternal disease during pregnancy. More than 100 diagnoses are presented from A to Z and described with respect to disease definition, clinical care and obstetrical management. One easy-to-remember guideline summarizes what is most important for the treatment of each disease.

This text will provide doctors both in training and in practice with useful advice on managing women and men who are having trouble conceiving and couples with infertility and related disorders. Its combination of scientific information and practical advice for tackling problematic cases make this an accessible handy reference in outpatient clinics or in revision for professional exams, as well as a fully referenced information resource. Contents: Glossary of terms * Problems with puberty and its onset * Understanding infertility * Investigations in infertility * Influencing the sperm count * Helping women to ovulate * Damage to the uterus, the fallopian tubes and the ovaries * What to do if nothing wrong can be found and how to answer when a couple asks 'what can we do to improve our fertility?' *Assisted conception * Preserving fertility * Global perspectives on reproductive medicine * Reproductive biology in one other great ape (the gorilla) * Research questions still unanswered - And further reading

This volume focuses on endometriosis from its pathogenesis and the importance of the early diagnosis to treatment, throughout all aspects of femininity that this disease affects, impacting health and quality of life. It also covers treatment strategies for the pain and for the disease management according to the age and needs of the patient, from adolescence to menopause, passing through the fertile age and the consequences that this disease can have on fertility and pregnancy. This book is a useful, clear and up-to-date tool for gynecologists, gynecological surgeons, reproductive medicine and general practitioners and is an important source of information to face this more and more frequent and devastating disease.

The assessment and selection of oocytes and embryos is fundamental to the live birth rate data of all IVF units, the parameter that is used to gauge a clinic's success and credibility. This new atlas contains over 1000 high-quality images of oocytes, zygotes and embryos, presented with accompanying data on indications for treatment, stimulation type and duration, as well as short medical histories of each couple and final outcome of treatment. All images in the book can be downloaded from the accompanying CD-ROM. Structured on a patient-by-patient basis, the atlas describes 100 clinically documented case studies that follow the evolution of oocytes and zygotes between day two and day five. Pronuclear morphology and synchrony as well as embryo morphology are reported and described for each case. Written and produced by experienced embryologists, this practical atlas is an important resource for clinical embryologists and physicians in reproductive medicine.

This book brings together the most up-to-date information about the physiology of progestogens. Addressing the bidirectional communication between hormones, fertility, tumors, and autoimmunity, it provides the basic science and clinical perspectives of progestogens which have not been previously available in one volume. In addition to estrogens, androgens, mineralocorticoids and glucocorticoids, progestogens are a major class of steroid hormone. While present in certain phases of estrous and menstrual cycles, progestogens are named for their function in maintaining pregnancy. This book is essentially practical in orientation, addressing the specific issues that confront the practitioner, and provides information to Obstetricians, Gynecologists, Reproductive endocrinologists, as well as Gynecological Oncologists and Rheumatologists. Contributions are from an international team of experts in the field, now completely updated in this new edition with new developments in primary dysmenorrhea and contraception.

Engage with practical and active solutions to day-to-day issues of reproductive medicine and the use of artificial reproductive techniques (ART), occurring in clinical and laboratory environments. Authored by leading experts in the field, this user-friendly guide is invaluable for any IVF practitioner and embryologist, facing everyday hands-on issues, through to high-pressure laboratory problems, efficiency ratings and ensuring cost-effective delivery of care. With the strict governance of regulatory bodies worldwide, the success of any fertility centre depends on successful problem solving, all day every day. Based on a wealth of experience, identify commonly occurring problems, and fresh perspectives of problem-solving, with 'must-have' protocols, patient information sheets and suggested equipment. This go-to companion tackles operational, organisational, clinical and laboratory issues to financial and clinical governance, with a focus on quick and effective solutions for the busy practitioner.

Sugden and Wade, leading authors in this area, comprehensively cover motor development and motor impairment, drawing on sources in medicine and health-related studies, motor learning and developmental psychology. A theme that runs through the book is that movement outcomes are a complex transaction of child resources, the context in which movement takes place, and the manner in which tasks are presented. The core themes of the book involve descriptions of motor development from conception through to emerging adulthood, explanations of motor development from differing theoretical, empirical, and experiential perspectives, and descriptions and explanations of atypical motor development when the resources of the child are limited in some way. Readership: Occupational therapists, physiotherapists, paediatricians, teachers (physical education, early childhood development, elementary education), educational psychologists, kinesiology and sports scientists.