At 11.47pm on July 25th 1978, Louise Brown was the first person ever to be born through science rather than as the result of two people having sex. The birth was hailed as a "miracle" by the world's media, making her instantly famous. For the first time Louise tells the story of her world changing birth and its impact on her life. The book contains many family photographs and letters which have never been published before. It was written by Louise with her long-term publicist Martin Powell of Empica PR.

In this volume Smith examines the early modern science of generation, which included the study of animal conception, heredity, and fetal development. Analyzing how it influenced the contemporary treatment of traditional philosophical questions, it also demonstrates how philosophical pre-suppositions about mechanism, substance, and cause informed the interpretations offered by those conducting empirical research on animal reproduction. Composed of cutting-edge essays written by an international team of leading scholars, the book offers a fresh perspective on some of the basic problems in early modern philosophy. It also considers how these basic problems manifested themselves within an area of scientific inquiry that has not previously received much consideration by historians of philosophy.

This unique source of reference provides the first comprehensive guide to the adverse side-effects of many commonly prescribed drugs on fertility and sexual health. More than 150 drugs are listed in this compilation, and the evidence linking them with infertility and sexual dysfunction is carefully reviewed. The volume is designed to provide a rapid source of reference to alert doctors and pharmacists to these hazardous side-effects. The volume also includes an introductory account of the reproductive process and a review of the mechanisms by which these drugs can interfere with or inhibit reproduction. Another important theme of the volume is the effect of social and recreational drugs and environmental agents on reproductive health.

This volume collects essays from prominent intellectuals and public figures based on talks given at the 2015 Darwin College Lectures on the theme of 'development'. The writers are world-renowned experts in such diverse fields as architecture, astronomy, biology, climate science, economy, psychology, sports and technology. Development includes contributions from developmental biologist and Nobel laureate John B. Gurdon, Olympic gold medallist Katherine Grainger, astronomer and cosmologist Richard Ellis, developmental psychologist Bruce Hood, former Met Office Chief Scientist Julia Slingo, architect Michael Pawlyn, development economist Ha-Joon Chang and serial entrepreneur Hermann Hauser. While their perspectives and interpretations of development vary widely, their essays are linked by a common desire to describe and understand how things change, usually in the direction of ever-increasing complexity. Written with the lay reader in mind, this interdisciplinary book is a must-read for anybody interested in the mechanisms underlying the changes we see in the world around us.

Developmental theorists have struggled with defining the relations among biology, psychology, and sociocultural context, often reducing psychological functions of a person to either biological functioning or the role of sociocultural context - nature or nurture - and considering each area of human development separately. New Perspectives on Human Development addresses fundamental questions of development with a unified approach. It encompasses theory and research on cognitive, social and moral, and language and communicative development, in various stages of life, and explores interdisciplinary perspectives. New Perspectives on Human Development revisits old questions and applies original empirical findings, offering new directions for future research in the field.

This volume provides a comprehensive account of the evaluation and treatment of the infertile male. It is suitable for all physicians who encounter this common medical problem. Despite the prevalance of male infertility as a common underlying cause of infertility, its evaluation and treatment remains a difficult and misunderstood area for many doctors - a problem this volume aims to overcome. It includes chapters which review the full range of modern techniques now available for analysing semen and identifying the underlying cause of infertility, and then goes on to consider the various treatment options. The volume also discusses endocrine assessment and treatment, psychological aspects of male infertility, and includes a chapter on female infertility. This will be a valuable source of reference for general practitioners and physicians, urologists and gynaecologists.

Gender, Identity and Reproduction draws on a variety of perspectives relevant to an understanding of reproduction across the life-course. Through a consideration of the representation of reproductive identities and experiences, the book highlights difference and diversity in relation to contemporary reproductive choices. The book focuses on women's and men's experiences of agency, control and negotiation within the context of cultural, medical, political, theoretical and lay ideologies of the reproductive process in contemporary Western societies.

Combining anthropological, gerontological and biocultural evidence, this study explores how humans came to grow old as slowly as they do, and what impacts this has had on their health and lives. It is only comparatively recent that humans have developed late-life survival, but much of the research on senescence is based on isolated cells, worms, and fruit flies, which may be only of peripheral relevance to human aging.

This book represents an attempt to review the most recent knowledge concerning basic processes occurring in the most important female reproductive organ -- the ovaries and their regulators. The most important processes (ovarian cyclic changes and oogenesis), as well as their extracellular (hormones and growth factors) and intracellular (protein kinases, transcription factors, small RNAs) regulators are described. Data concerning processes or substances well described in previous reviews are summarised here in a short form with references to corresponding reviews.

"Motor Learning and Performance: From Principles to Application, Fifth Edition With Web Study Guide," describes the principles of motor performance and learning in a style that is accessible even to students with little or no knowledge of physiology, psychology, statistical methods, and other basic sciences. Constructing an easy-to-understand conceptual model of motor performance along the way, this text outlines the principles of motor skill learning, building a strong understanding of how skills are acquired and perfected with practice and showing students how to apply the concepts to a variety of real-world settings. Incorporating familiar scenarios brings the material to life for students, leading to better retention of information and greater interest in practical application of motor performance and learning in their everyday lives and future careers.

The fifth edition of "Motor Learning and Performance" features a more streamlined organization, with practice situations integrated directly into chapters rather than appearing at the end of the text, facilitating a stronger link between principles derived from research and practical applications. The addition of author Timothy Lee adds a fresh perspective to the text. Other key changes include the following:

- An improved web study guide offers a principles-to-application exercise and multiple interactive activities for each chapter, ensuring that students will be able to transfer core content from the book to various applied settings.

- A full-color interior provides a more engaging presentation.

- Focus on Research and Focus on Application sidebars deliver more detailed research information and make connections to real-world applications in areas such as teaching, coaching, and therapy.

- Updates to instructor ancillaries feature the addition of lab activities to the instructor guide and new chapter quizzes that assess students' mastery of the most important concepts covered in the textbook.

- Pedagogical aids such as learning objectives, glossary of terms, and Check Your Understanding questions throughout help students stay on track with learning in each chapter.

"Motor Learning and Performance, Fifth Edition," provides optimal student comprehension, offering a strong conceptual understanding of skills and then building on this with the intricacies of skilled motor performance. Part I investigates the principles of human performance, progressively developing a conceptual model of human actions. The focus is mainly on human performance as based on an information-processing perspective. In part II, the text uses the conceptual model to impart an understanding of human motor learning processes. The presentation style remains simple and straightforward for those without extensive backgrounds in motor performance.

The fifth edition of "Motor Learning and Performance: From Principles to Application" goes beyond simply presenting research, challenging students not only to grasp but also to apply the fundamental concepts of motor performance and learning. The fifth edition is a valuable tool for anyone who appreciates high-level skilled activity or would like to learn more about how such performances occur.

The book offers a comprehensive review of current research regarding the influences of environmental factors involved in human health and ageing. Many environmental compounds promote excessive oxidative stress, which is the primary cause of accelerated ageing and which also contributes to the development of human diseases. The basic concepts of ageing theories are discussed, as is the promotion of oxidative stress which has been identified as one of the most important mechanisms responsible for the toxic effects of the majority of environmental pollutants. Antioxidants play an important role in the defence against pollutant-induced toxicity.

In this book, the authors present current research in the study of ovulation detection, its signs, symptoms and outcomes. Topics discussed in this compilation include the importance of up and down regulation of receptors for FSH, progesterone and GnRH in the ovary, endometrium and lymphocytes in correcting various ovulatory disorders and achieving live deliveries; polycystic ovary syndrome and implications in metabolic disorders; cancer risk of drugs for ovarian stimulation; alternatives to laparoscopic ovarian drilling for ovulation induction in clomiphene resistent women with polycystic ovary syndrome; reproductive outcomes and obesity; ovarian hyperstimulation syndrome and a focus on neurovascular complications; and new methods for ovulation detection.

Reproduction is a fundamental feature of life, it is the way life persists across the ages. This book offers new, wider vistas on this fundamental biological phenomenon, exploring how it works through the whole tree of life. It explores facets such as asexual reproduction, parthenogenesis, sex determination and reproductive investment, with a taxonomic coverage extended over all the main groups - animals, plants including 'algae', fungi, protists and bacteria. It collates into one volume perspectives from varied disciplines - including zoology, botany, microbiology, genetics, cell biology, developmental biology, evolutionary biology, animal and plant physiology, and ethology - integrating information into a common language. Crucially, the book aims to identify the commonalties among reproductive phenomena, while demonstrating the diversity even amongst closely related taxa. Its integrated approach makes this a valuable reference book for students and researchers, as well as an effective entry point for deeper study on specific topics.

The fetus occupies a critical phase during human development. It is at this stage when the body systems that will support us throughout our lives begin to face up to the challenge of life outside the womb. While the fetus can demonstrate a remarkably robust response to challenges in the uterus, it is also an exquisitely sensitive phase of development. It is now well recognized that disturbances to the materno-fetal environment can influence and even undermine our state of health well into adulthood. This exciting new publication provides a valuable insight into fetal growth and development across all the main body systems, and examines the influence of the materno-fetal environment on adult-onset diseases. This text contains additional chapters on the embryo, placenta, and parturition, to insure that this is a fully self-contained introduction. This book is written by world-renowned experts from leading centers of excellence and will be an invaluable introduction for students of medicine, reproductive biology, and human biology.

As we enter the twenty-first century, a number of medical, environmental, and social changes have profoundly affected human reproduction. This book discusses some of the more dramatic changes in an accessible manner, illustrating the ways in which human biology and culture can affect fertility. It provides a unique interdisciplinary perspective on the subject. Topics of discussion include medical technological advances that equip us with potential cures for many causes of infertility; diseases, such as AIDS, that have a devastating impact on the reproductive and social lives of humans; increasing industrialization and the development of fabricated materials that pollute our environment in unforeseen ways with possibly devastating effects on human health and fertility; and social revolutions that profoundly alter human relationships, such as nonmarital unions between heterosexual couples, same-sex relationships, and adoption and surrogacy.

Understand the menopause with all its changes and challenges and choose practices and treatments, brought to you by a team of experts, to make this next stage in your wellness journey healthy and positive. Find the right combination of resources for you - to stay physically, mentally, and spiritually well throughout the menopause. Your journey is unique. This insightful book will help you find the right combination of resources that work for you. It includes: - Specialist expert writers for each section of the book - HRT, Natural Remedies, Exercise, Nutrition and Mental Wellness - Practical strategies on how to manage menopause naturally and make it a more positive, empowering experience - Symptom Finder in the introductory pages to help direct you to the correct section in the book Coping with menopause can be tough, draining and sometimes utterly debilitating for women. For years it has been seen as an illness that needed to be cured. Natural Menopause takes a different approach. Throughout the pages of this calm, authoritative, beautiful reference book, you'll be able to learn about the natural process of menopause. Explore an extensive collection of natural menopause remedies and complements to hormone replacement therapy. Adopt yoga poses to reduce stress and help you sleep. Use essential oils to manage mood swings and soothe headaches. Discover detoxifying foods that aid weight management and regulate hormones. Find the best exercises to boost your mood and energy levels. Finally, use CBT and mindfulness to relieve anxiety and calm hot flushes. Embrace the Change Filled with a wealth of invaluable information, this book will help you stay physically, mentally, and spiritually well throughout your menopause journey. It's perfect for women over 40 who are already invested in natural wellness and want to apply the same principles to their menopause.

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases

Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging.

"Protein Oxidation and Aging" begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation processCellular mechanisms for managing oxidized proteinsRole of protein oxidation in agingInfluence of genetic and environmental factors on protein oxidationMeasuring protein oxidation in the aging processProtein oxidation in age-related diseases

References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

In this book, the authors present current research in the study of the anatomy, physiology and pathology of the testes. Topics discussed in this compilation include the roles and regulatory mechanism of proton pumping V-ATPase in spermatozoa and epididymis physiology; oxidative stress as a converging mechanism of testicular damage; the pathophysiology of the testis after ischemia reperfusion injury; beta-actin implications in the seminiferous tubule; heat stress damage in mammalian testis; and the effect of plasticisers on testis and Sertoli cell functions.

This book describes mechanisms of skin damage generation and examines the potential impact of free radicals, reactive oxygen species (ROS) and oxidative damage on the skin ageing process. It also evaluates methods to decrease skin oxidative stress, oxidative damage, and skin ageing. The identification of free radical reactions as promoters of the skin ageing process implies that interventions aimed at limiting or inhibiting free radical reactions should be able to reduce the rate of formation of ageing-related changes with a consequent reduction of the ageing rate. This book highlights how ageing of the skin happens, as well as what are the causes and the best ways to prevent and treat it.

Food intake is affected by many internal biological stimuli such as hormones and neuropeptides, and by social factors such as commercial standards, food palatability and composition. This book presents current research in the regulation and control of food intake. Topics discussed include understanding food intake regulation in chicks; indigenous fermented foods and beverages produced in Latin America; dopaminergic regulation of food intake; peptidergic regulation of food intake and its relation to age and body composition and food-borne carcinogens.

During the last decades as the population has become older, the demand for acute hospital care for elderly people has increased and gerontologically adjusted services have become the norm for the highest standard of care. Compared with younger adults, elderly patients have more severe illnesses, including worsened functional impairment and more frequent and longer hospitalisations. Additionally, diagnosis is often challenging because clinical presentations of common disorders may often be atypical in the elderly. When prescribing medications, physicians have to take into account the pharmacokinetic and pharmacodynamic changes observed with ageing. This book fills the gap in the literature available on acute geriatric care.

IVF is a major treatment in infertility when other methods of assisted reproductive technology have failed. The process involves hormonally controlling the ovulatory process, removing ova (eggs) from the woman's ovaries and letting sperm fertilise them in a fluid medium. This book presents topical research in the study of in vitro fertilisation including management of chronic viral infections in assisted reproduction; posthumous sperm procurement; assisted reproductive technologies for serodiscordant couples with an HIV-1 infection and the impact of laparoscopic ovarian cystectomy for infertile women with endometriomas prior to IVF/ICSI cycles.

Personalisation in British social care is linked to both the principle and process that every adult who receives support, whether provided by statutory services or funded by them, will have choice and control over the shape of that support in all care settings. This adult social care policy agenda is firmly focused on the development of personalisation of support. The overall aim is for social care service users to have control over how money allocated to their care is spent. This book examines the social welfare system in Britain, with a particular focus on personal budgets and the quality of care received.

The reproductive system and all of its functions related to sex, conception, pregnancy and delivery, all actions aimed at keeping it functioning optimally and free from diseases and harmful traditional practices are explored in this book.