Intrauterine insemination (IUI), also known as artificial insemination, is a fertility treatment that uses a catheter to place washed sperm directly into the uterus. Its aim is to increase the number of sperm reaching the fallopian tubes and subsequently increase the chances of fertilisation (American Pregnancy Association). This book is the first in a new series, Handbook on Infertility. Beginning with an overview of Intrauterine Insemination, the following chapters guide readers step by step through the process, from basic science to clinical application. Ethical, psychosocial and medicolegal aspects are also covered. Written by an internationally recognised author and editor team, this useful manual serves as a quick reference guide and includes photographs, illustrations and tables to enhance learning. Key points First title in new series Handbook on Infertility Presents complete overview of intrauterine insemination Includes chapters on ethical, psychosocial and medicolegal aspects Internationally recognised author and editor team

A Practical Guide to Clinical Supervision in Genetic Counseling provides a comprehensive overview of clinical supervision, emphasizing the supervision of genetic counseling students. The book draws on theory and research in genetic counseling, psychology, counselor education, and Dr. Veach's many years of experience in supervision practice. Chapters address key issues in clinical supervision, including the infrastructure required for effective supervision; relationship dynamics inherent in supervision; and critical supervision processes, such as goal setting, feedback, evaluation, culturally-responsive supervision, and common clinical supervision challenges. Additional chapters cover models of supervisor and supervisee development, strategies to promote student wellness, how to recognize and address problematic performance, and supervision delivery models. Each chapter contains instructional objectives, illustrations of major topics with supervision vignettes and examples, and descriptions of specific strategies for promoting self-reflective supervision practice. Experiential activities at the end of each chapter provide opportunities for readers to strengthen and maintain competencies associated with effective supervision processes and outcomes. The activities are appropriate for both current and future supervisors at all levels of experience and are suitable for use in the classroom and by individuals engaged in self-study. A Practical Guide to Clinical Supervision in Genetic Counseling also features three contributed chapters by experts in supervision, education, and research and an appendix with instructional tips for designing and conducting supervision training opportunities to facilitate participants' learning experiences.

This second edition has been fully updated to provide infertility specialists with the latest advances in ovulation induction. It describes the latest therapies and their relevance to treatment for different gynaecological disorders, integrating the information into a practical management protocol for everyday practice. Chapters from the first edition have been revised to reflect current techniques and five new chapters have been added to the new edition. The book includes numerous clinical photographs, flow charts and tables to enhance learning, and a CD ROM demonstrates techniques for surgical ovulation induction and multi-foetal pregnancy reduction. Key points Fully revised new edition providing infertility specialists with latest advances in ovulation induction Five new chapters added to second edition Includes CD ROM demonstrating techniques Previous edition published in 2006

An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM. Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle.
* Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists
* Provides a novel synthesis of existing ideas about the biology of longevity and aging
* Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

As a biological, cultural, and social entity, the human fetus is a multifaceted subject which calls for equally diverse perspectives to fully understand. Anthropology of the Fetus seeks to achieve this by bringing together specialists in biological anthropology, archaeology, and cultural anthropology. Contributors draw on research in prehistoric, historic, and contemporary sites in Europe, Asia, North Africa, and North America to explore the biological and cultural phenomenon of the fetus, raising methodological and theoretical concerns with the ultimate goal of developing a holistic anthropology of the fetus.

Bringing together the latest information on the organization, management and quality of in-vitro fertilization (IVF) units, this is the first true field guide for the clinician working in assisted reproductive technologies (ART). Divided thematically into four main sections, part one discussed the establishment and organization of the IVF unit, including location, design and construction, practical considerations for batching IVF cycles, and regulations and risk management. Part two, the largest section, covers the many aspects of overall quality management and its implementation - staff and patient management, cryobank and PGD/PGS management, and data management - as well as optimization of treatment outcomes and statistical process control analysis to assess quality variation. Part three addresses the relationship between IVF units and society at large, including the ethics of IVF treatment, as well as public/low-cost and private/corporate IVF units. Advertising and marketing for IVF units is discussed in part four, including the building and managing of websites and the use of traditional print and social media. With approximately five thousand IVF units worldwide and a growing number of training programs, Organization and Management of IVF Units is a key resource for clinic directors, unit managers, embryologists, quality experts, and students of reproductive medicine and clinical embryology.

Exploring the potential of poetry and poetic language as a means of conveying perspectives on ageing and later life, this book examines questions such as 'how can we understand ageing and later life?' and 'how can we capture the ambiguities and complexities that the experiences of growing old in time and place entail?' As poetic language illuminates, transfigures and enchants our being in the world, it also offers insights into the existential questions that are amplified as we age, including the vulnerabilities and losses that humble us and connect us. Literary gerontology and narrative gerontology have highlighted the importance of linguistic representations of ageing. While the former has been concerned primarily with the analysis of published literary works, the latter has foregrounded the individual and collective meaning making through narrative resources in old age. There has, however, been less interest in how poetic language, both as a genre and as a practice, can illuminate ageing. This volume suggests a path towards the poetics of ageing by means of presenting analyses of published poetry on ageing written by poets from William Shakespeare to Wallace Stevens; the use of reading and writing poetry among ordinary people in old age; and the poetic nuances that emerge from other literary practices and contexts in relation to ageing - including personal poetic reflections from many of the contributing authors. The volume brings together international scholars from disciplinary backgrounds as diverse as cultural psychology, literary studies, theology, sociology, narrative medicine, cultural gerontology and narrative gerontology, and will deploy a variety of empirical and critical methodologies to explore how poetry and poetic language may challenge dominant discourses and illuminate alternative understandings of ageing.

Why do American couples differ in the number of children they have? To answer this question the first major longitudinal study in American fertility was begun in 1957 with a series of interviews with parents of two children. Family Growth in Metropolitan America (1961) and The Third Child (1963) reported the results of the first two phases of this research project. In this book, in addition to evaluating the longitudinal design of the study, the authors report the results of the third and final interviews, a decade after the first, and attempt to answer such questions as: How well are couples able to predict their own fertility over the years? To what extent does the number of children desired affect the spacing of births? How is fertility affected by peer group relations, by the wife's participation in the labor force, by religion? Originally published in 1971. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Has the college experience of women been an influence on the number of children desired and the number and spacing of their children? Do women come to college with their attitudes and values in this regard already formed? This study of 15,000 women, freshmen and seniors in 45 American colleges and universities, both secular and nonsecular, attempts to answer this question and to determine how such characteristics as religious preference, career intentions, and the number of children in her own family influence a woman's fertility values. Attention is paid to an earlier finding that Catholic college graduates have higher fertility than Catholic high school graduates, although higher education is usually associated with lower fertility. Originally published in 1967. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Written by established and emerging leaders in a broad array of disciplines, this two-volume set provides undergraduate and graduate students, scholars, professionals, and policymakers with an overview of the field of aging that examines the social landscape as well as key changes, challenges, and solutions. The people who make up the rapidly growing population of Americans over age 65 are changing, and as a result, our nation will change. This shift presents new issues, controversies, and challenges that affect health, wellness, welfare, retirement, politics, and economics. This two-volume work examines where we are and where we are headed, paying careful attention to the differential impacts of gender, race, class, marital status, and other social variables. It considers key changes in demographics, old-age policies, families, work, and death and dying. Volume one covers an array of demographic issues, policies, and politics, highlighting how factors such as gender and race shape families, income, retirement, immigrants, and veterans across the life course. The second volume covers education, religion, volunteering, exercise, nutrition, and health care policies across the life course. Topics addressed include the old-age welfare state, the extension of retirement age, home care, care work, nursing home care, end of life planning, and euthanasia. Provides an up-to-date, multidisciplinary, and forward-thinking look at the key areas and issues in gerontology Highlights links between topics and relevant demographic, social, economic, and health trends with implications for immediate and long-range work in aging Includes contributions from experts in the fields of sociology, psychology, medicine, education, politics, and government Identifies the key changes, challenges, and solutions in each subfield Includes an appendix containing lists of descriptions and contact information for aging organizations as well as an annotated list of documentaries about aging

It can be argued that ATP is the most important molecule in cells. Not only is ATP the key energy source for cells, but it is also the source of phosphate groups that are transferred to a variety of substrate proteins via the action of elaborate families of protein kinases. An equally elaborate array of protein phosphatases can remove phosphate groups from proteins. It is now well established that protein phosphorylation is a widely used mechanism for cells to selectively modulate the function of a variety of proteins including enzymes, ion channels and pumps and structural proteins. In this volume of ACAG leading experts describe the evidence that protein phosphorylation is altered in aging and age-related disease. Protein phosphorylation controls fundamental processes such as transcription and translation, regulation of the cell cycle, signalling within and between cells, cell motility, synaptic function and so on. Recent findings are revealing how phosphorylation dependent signalling cascades may control lifespan with a prime example being the insulin-signalling pathway first described in c-elegans and now emerging as an important regulator of lifespan of mammals also. Many of the functional changes that occur during aging such as impaired learning and memory and altered energy metabolism are controlled by protein phosphorylation and it is, therefore, important to understand how mechanisms of protein phosphorylation may either mediate aging or provide adaptive responses that allow successful disease-free aging. The authors in addition to considering the roles of protein phosphorylation in aging describe the evidence that abnormalities in protein phosphorylation contribute to the pathogenesis of major age-related diseases including diabetes, atherosclerosis and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

Experts in the fields of energy metabolism, aging and oxidative stress provide an integrated view of how mechanisms involved in regulating energy metabolism are linked to fundamental processes of aging including cellular stress resistance and free radical production.

During evolution signal transduction pathways and organ systems have been optimised for the efficient seeking, ingestion, storing and using of energy. These signalling pathways play prominent roles in lifespan determination with insulin and related signalling pathways being prime examples. The authors consider how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG will foster novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.

The world can often feel like a very scary, complicated and messy place. It's not always clear what is the correct thing to say, the best thing to do or the right way to be. HOPE THIS HELPS offers an easy guide that can help you feel and do better, and gives guidance on things that can appear incredibly difficult to navigate. Centring tolerance, kindness and empathy, the book takes us back to our roots as a human race of simply wanting to connect, be heard and enjoy life. Written in short, bite-sized entries, you can turn straight to the section you need depending on the challenge you're facing. Benjy Kusi will provide insight on . . . - Why it's not selfish to choose yourself - Why it's OK to change your opinion as you learn - Why impact means more than intent - Why we should listen to others more - How we can be kinder online And much, much more. More than anything this book reminds you that not everyone can be everything all the time, but the little things each of us can do to make the world slightly better can amount to something incredible. We hope this helps.

Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice offers a collection of concise, practical review articles on cutting-edge topics within reproductive medicine. Each article presents a balanced view of clinically relevant information and looks ahead to how practice will change over the next five years. The clinical section discusses advances in reproductive surgery and current use of robotic surgery for tubal reversal and removal of fibroids. It looks into the refinement of surgical procedures for fertility preservation purposes. Chapters also discuss non-invasive diagnosis of endometriosis with proteomics technology, new concepts in ovarian stimulation and in the management of polycystic ovary syndrome, and evidence-based ART. The embryology section discusses issues ranging from three-dimensional in-vitro ovarian follicle culture, and morphometric and proteomics analysis of embryos, to oocyte and embryo cyropreservation. This forward-looking volume of review articles is key reading for reproductive medicine physicians, gynecologists, reproductive endocrinologists, urologists and andrologists.

This book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment.

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases.

This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

Frank Nawroth thematisiert das Social Freezing und die zugehoerige Beratung, die nicht nur Chancen, sondern auch denkbare Komplikationen und Grenzen der Methode aufzeigen muss. Zum Beispiel haben die gesellschaftspolitisch nicht optimal geloeste Problematik des moeglichen Karriere-Nachteils einer berufstatigen Mutter oder die haufig bestehende Schwierigkeit, den geeigneten Partner zu finden, bei gleichzeitig verbesserten Kryokonservierungsmethoden dazu gefuhrt, dass Frauen ohne medizinische Indikation uber das Einfrieren ihrer Eizellen nachdenken. Die Technologie selbst ist seit Langerem Routine vor fertilitatsbeeintrachtigenden Therapien onkologischer Erkrankungen (Operation, Strahlen- und/oder Chemotherapie) im reproduktiven Alter.

This new handbook provides private-practice and hospital gynecologists with a practical guide for advising and treating patients in the case of maternal disease during pregnancy. More than 100 diagnoses are presented from A to Z and described with respect to disease definition, clinical care and obstetrical management. One easy-to-remember guideline summarizes what is most important for the treatment of each disease.

A beautifully illustrated, one-stop resource that bridges all four anatomical sciences Clinical Anatomy, Histology, Embryology, and Neuroanatomy: An Integrated Textbook by Jamie C. Wikenheiser bridges all four anatomical sciences in one volume with clinically focused anatomical text and exceptional illustrations. The book fills a gap in the literature, serving as a one-stop resource for multiple courses and board-review preparation, and also provides an invaluable reference for professional practice. The primary goals of integrating the four sciences into one book are to enhance students' understanding of the subject matter, better prepare them for national exams, and most importantly-enable them to deliver optimal care to their future patients. The introductory chapter includes clear explanations of anatomic terminology and an overview describing all systems of the body. The rest of the textbook is organized by region to better align with how most professional schools organize their curriculums, while also providing flexibility to fit alternate curriculums. Chapters on the Back, Thorax, Abdomen, Pelvis and Perineum, Lower Extremity, Upper Extremity, and Head and Neck regions are followed by multiple chapters focused on Neuroanatomy. Region-based chapters with multiple organs begin with an introduction to gross anatomy, followed by descriptions of the associated neurovasculature and lymphatic drainage. Development and the histology of organs is presented alongside the neurovasculature. Key Highlights Over 350 surgical, nonsurgical, and developmental clinical correlates prepare readers for potential issues encountered during rotations, residency, or private practice Nearly 250 USMLE (R) Step 1 board review questions facilitate learning Plain and contrast radiographs, CTs, MRIs, and ultrasonography studies enhance understanding of normal anatomy and specific conditions More than 1,100 exceptional images derived from three widely acclaimed Thieme anatomical atlases and a histology textbook, coupled with exquisite new artwork, provide in-depth visual insights This is essential reading for allopathic and osteopathic medical students and will also benefit allied health professionals, especially physician assistants and physical therapists. This print book includes complimentary access to a digital copy on https://medone.thieme.com. Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

In the last 15 years, fertility treatment has become mainstream medical practice. With this evolution has come a change in focus from effectiveness ('success rates') to safety, patient acceptability and ethical questions. It is recognized that effectiveness also depends crucially on safety and good risk management. The purpose of this book is to address this wider change in focus. Reducing Risk in Fertility Treatment examines risk in assisted conception, covering a wide range of topics and areas. 'Risk' refers to situations in which an outcome of value to people is uncertain. Specifically for the purpose of this book, 'Risk' means situations where patients or professionals or society as a whole is at risk of an adverse outcome in relation to fertility treatment. It therefore encompasses clinical complications, risks inherent in laboratory practice, reputational and business risks to clinics and ethical risks to society as a whole. It will be an essential resource for all clinic staff to consult in reducing the risk associated with their work. It will provide practical resources such as 'how to' guides, but also a theoretical discussion of uncertainty where this exists. The book is primarily directed to practitioners in the area of fertility treatment, namely clinicians, embryologists, nurses, counsellors and administrators. However, it is likely also to be relevant to policy-makers, commissioners of health services, researchers in this field and biomedical ethicists.

This book presents the latest insights into all the critical aspects of Klinefelter's Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more "evidence-based" support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.