This volume provides a comprehensive account of the evaluation and treatment of the infertile male. It is suitable for all physicians who encounter this common medical problem. Despite the prevalance of male infertility as a common underlying cause of infertility, its evaluation and treatment remains a difficult and misunderstood area for many doctors - a problem this volume aims to overcome. It includes chapters which review the full range of modern techniques now available for analysing semen and identifying the underlying cause of infertility, and then goes on to consider the various treatment options. The volume also discusses endocrine assessment and treatment, psychological aspects of male infertility, and includes a chapter on female infertility. This will be a valuable source of reference for general practitioners and physicians, urologists and gynaecologists.

This volume collects essays from prominent intellectuals and public figures based on talks given at the 2015 Darwin College Lectures on the theme of 'development'. The writers are world-renowned experts in such diverse fields as architecture, astronomy, biology, climate science, economy, psychology, sports and technology. Development includes contributions from developmental biologist and Nobel laureate John B. Gurdon, Olympic gold medallist Katherine Grainger, astronomer and cosmologist Richard Ellis, developmental psychologist Bruce Hood, former Met Office Chief Scientist Julia Slingo, architect Michael Pawlyn, development economist Ha-Joon Chang and serial entrepreneur Hermann Hauser. While their perspectives and interpretations of development vary widely, their essays are linked by a common desire to describe and understand how things change, usually in the direction of ever-increasing complexity. Written with the lay reader in mind, this interdisciplinary book is a must-read for anybody interested in the mechanisms underlying the changes we see in the world around us.

Gender, Identity and Reproduction draws on a variety of perspectives relevant to an understanding of reproduction across the life-course. Through a consideration of the representation of reproductive identities and experiences, the book highlights difference and diversity in relation to contemporary reproductive choices. The book focuses on women's and men's experiences of agency, control and negotiation within the context of cultural, medical, political, theoretical and lay ideologies of the reproductive process in contemporary Western societies.

Combining anthropological, gerontological and biocultural evidence, this study explores how humans came to grow old as slowly as they do, and what impacts this has had on their health and lives. It is only comparatively recent that humans have developed late-life survival, but much of the research on senescence is based on isolated cells, worms, and fruit flies, which may be only of peripheral relevance to human aging.

This book, by two of the most distinguished figures in fertility and reproduction research, answers all the most common questions about menaupause and andropause, and hormone resupplement therapy (HRT) for menopausal women. It offers explanations of all aspects of this subject, presenting balanced and reliable information about benefits, risks, and prospects for this field. Segal invented Norplant, the first long-term implantable contraceptive, and as the leader of Reproductive Biology at the Population Council, he orchestrated and coordinated the research and trials leading to basically every new contraceptive introduced over a period of about 25 years. Mastroianni did more than anyone else to develop in vitro fertizilation as a viable treatment option, and was for many years the chairman of the largest department of obstetrics and gynecology, and the director of the most successful IVF clinic. This book is unique in including coverage of the climacteric in men.

This book represents an attempt to review the most recent knowledge concerning basic processes occurring in the most important female reproductive organ -- the ovaries and their regulators. The most important processes (ovarian cyclic changes and oogenesis), as well as their extracellular (hormones and growth factors) and intracellular (protein kinases, transcription factors, small RNAs) regulators are described. Data concerning processes or substances well described in previous reviews are summarised here in a short form with references to corresponding reviews.

Reproduction is a fundamental feature of life, it is the way life persists across the ages. This book offers new, wider vistas on this fundamental biological phenomenon, exploring how it works through the whole tree of life. It explores facets such as asexual reproduction, parthenogenesis, sex determination and reproductive investment, with a taxonomic coverage extended over all the main groups - animals, plants including 'algae', fungi, protists and bacteria. It collates into one volume perspectives from varied disciplines - including zoology, botany, microbiology, genetics, cell biology, developmental biology, evolutionary biology, animal and plant physiology, and ethology - integrating information into a common language. Crucially, the book aims to identify the commonalties among reproductive phenomena, while demonstrating the diversity even amongst closely related taxa. Its integrated approach makes this a valuable reference book for students and researchers, as well as an effective entry point for deeper study on specific topics.

The development of new reproductive technologies has raised urgent questions and debates about how and by whom these treatments should be controlled. On the one hand individuals and groups have claimed access to assisted reproduction as a right, and some have also claimed that this access should be available free of charge. As well as clinically infertile heterosexual couples, this right has been claimed by single women, gay couples, post-menopausal women, and couples who wish to delay having children for various reasons. Others have argued that a desire to have children does not make it a human right, and, moreover, that there are some people who should not be assisted to become parents, on grounds of age, sexuality, or lifestyle. Mary Warnock steers a clear path through the web of complex issues underlying these views. She begins by analyzing what it means to claim something as a 'right', and goes on to discuss the cases of different groups of people. She also examines the ethical problems faced by particular types of assisted reproduction, including artificial insemination, in-vitro fertilization, and surrogacy, and argues that in the future human cloning may well be a viable an

The concept of reproductive health promises to play a crucial role in improving health care provision and legal protection for women around the world. This is an authoritative and much-needed introduction to and defence of the concept of reproductive health, which though internationally endorsed, is still contested. The authors are leading authorities on reproductive medicine, women's health, human rights, medical law, and bioethics. They integrate their disciplines to provide an accessible but comprehensive picture. They analyse 15 cases from different countries and cultures, and explore options for resolution. The aim is to equip readers to fashion solutions in their own health care circumstances, compatibly with ethical, legal and human rights principles.

The book offers a comprehensive review of current research regarding the influences of environmental factors involved in human health and ageing. Many environmental compounds promote excessive oxidative stress, which is the primary cause of accelerated ageing and which also contributes to the development of human diseases. The basic concepts of ageing theories are discussed, as is the promotion of oxidative stress which has been identified as one of the most important mechanisms responsible for the toxic effects of the majority of environmental pollutants. Antioxidants play an important role in the defence against pollutant-induced toxicity.

In this book, the authors present current research in the study of ovulation detection, its signs, symptoms and outcomes. Topics discussed in this compilation include the importance of up and down regulation of receptors for FSH, progesterone and GnRH in the ovary, endometrium and lymphocytes in correcting various ovulatory disorders and achieving live deliveries; polycystic ovary syndrome and implications in metabolic disorders; cancer risk of drugs for ovarian stimulation; alternatives to laparoscopic ovarian drilling for ovulation induction in clomiphene resistent women with polycystic ovary syndrome; reproductive outcomes and obesity; ovarian hyperstimulation syndrome and a focus on neurovascular complications; and new methods for ovulation detection.

Few of us know much about the biology of sex determination, but what could be more interesting than to discover how we are shaped into males and females? In this book, Elof Carlson tells the incredible story of the difficult quest to understand how the body forms girls and boys. Carlson s history takes us from antiquity to the present day to detail how each component of human reproduction and sexuality was identified and studied, how this knowledge enlarged our understanding of sex determination, and how it was employed to interpret such little understood aspects of human biology as the origin of intersex births."

The fetus occupies a critical phase during human development. It is at this stage when the body systems that will support us throughout our lives begin to face up to the challenge of life outside the womb. While the fetus can demonstrate a remarkably robust response to challenges in the uterus, it is also an exquisitely sensitive phase of development. It is now well recognized that disturbances to the materno-fetal environment can influence and even undermine our state of health well into adulthood. This exciting new publication provides a valuable insight into fetal growth and development across all the main body systems, and examines the influence of the materno-fetal environment on adult-onset diseases. This text contains additional chapters on the embryo, placenta, and parturition, to insure that this is a fully self-contained introduction. This book is written by world-renowned experts from leading centers of excellence and will be an invaluable introduction for students of medicine, reproductive biology, and human biology.

The possibility that human beings may soon be cloned has generated enormous anxiety and fueled a vigorous debate about the ethics of contemporary science. Unfortunately, much of this debate about cloning has treated cloning as singular and revolutionary. The essays in Cloning and the Future of Human Embryo Research place debates about cloning in the context of reproductive technology and human embryo research. Although novel, cloning is really just the next step in a series of reproductive interventions that began with in vitro fertilization in 1978. Cloning, embryo research, and reproductive technology must therefore be discussed together in order to be understood. The authors of this volume bring these topics together by examining the status of preimplantation embryos, debates about cloning and embryo research, and the formulation of public policy. The book is distinctive in framing cloning as inextricably tied to embryo research and in offering both secular and religious perspectives on cloning and embryo research.

As we enter the twenty-first century, a number of medical, environmental, and social changes have profoundly affected human reproduction. This book discusses some of the more dramatic changes in an accessible manner, illustrating the ways in which human biology and culture can affect fertility. It provides a unique interdisciplinary perspective on the subject. Topics of discussion include medical technological advances that equip us with potential cures for many causes of infertility; diseases, such as AIDS, that have a devastating impact on the reproductive and social lives of humans; increasing industrialization and the development of fabricated materials that pollute our environment in unforeseen ways with possibly devastating effects on human health and fertility; and social revolutions that profoundly alter human relationships, such as nonmarital unions between heterosexual couples, same-sex relationships, and adoption and surrogacy.

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases

Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging.

"Protein Oxidation and Aging" begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation processCellular mechanisms for managing oxidized proteinsRole of protein oxidation in agingInfluence of genetic and environmental factors on protein oxidationMeasuring protein oxidation in the aging processProtein oxidation in age-related diseases

References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

This book describes mechanisms of skin damage generation and examines the potential impact of free radicals, reactive oxygen species (ROS) and oxidative damage on the skin ageing process. It also evaluates methods to decrease skin oxidative stress, oxidative damage, and skin ageing. The identification of free radical reactions as promoters of the skin ageing process implies that interventions aimed at limiting or inhibiting free radical reactions should be able to reduce the rate of formation of ageing-related changes with a consequent reduction of the ageing rate. This book highlights how ageing of the skin happens, as well as what are the causes and the best ways to prevent and treat it.

Food intake is affected by many internal biological stimuli such as hormones and neuropeptides, and by social factors such as commercial standards, food palatability and composition. This book presents current research in the regulation and control of food intake. Topics discussed include understanding food intake regulation in chicks; indigenous fermented foods and beverages produced in Latin America; dopaminergic regulation of food intake; peptidergic regulation of food intake and its relation to age and body composition and food-borne carcinogens.

Part of the renowned Donald School series, this book is a comprehensive guide to the diagnosis and management of reproductive and gynaecological endocrinology disorders. The book begins with an overview of ovulation and investigation and causes of female infertility including anovulation, tubal block, endometriosis and congenital uterine anomalies. The following chapters discuss ovarian stimulation and assisted reproductive techniques. The second half of the book covers causes and management of male infertility, and concludes with chapters on recurrent miscarriage, gamete banking, and assessment of early pregnancy. Authored by recognised experts in the field, the text is further enhanced by clinical photographs, illustrations, tables and flowcharts. Key points Comprehensive guide to diagnosis and management of reproductive and gynaecological endocrinology disorders Part of renowned Donald School series Covers investigation, causes and management of both female and male infertility Authored by recognised experts in the field

The second edition of this comprehensive reference provides practitioners with the latest advances in the use of ultrasound for diagnosis and management of subfertility. Divided into thirteen chapters, the book begins with an introduction to the principles and applications of ultrasound, and examination techniques and in pelvic assessment. The next sections cover the use of ultrasound for the diagnosis of different gynaecological conditions that may affect fertility, followed by ultrasound-guided procedures in assisted reproduction and potential complications. The text concludes with chapters on ultrasound in male infertility, and three-dimensional ultrasound in subfertility. Edited by recognised experts in the field, the text is further enhanced by more than 400 ultrasound images and is accompanied by an interactive DVD ROM providing video clips for each clinical scenario described in the book. Key points Second edition presenting latest advances in use of ultrasound in subfertility Includes DVD ROM of video clips demonstrating clinical scenarios Internationally recognised editor team Previous edition (9789351520108) published in 2014

Women and Exercise is an invaluable resource for all physicians, from general practitioners to specialists seeking information outside their specialty, who need up-to-date information and expert advice about women and exercise.

During the last decades as the population has become older, the demand for acute hospital care for elderly people has increased and gerontologically adjusted services have become the norm for the highest standard of care. Compared with younger adults, elderly patients have more severe illnesses, including worsened functional impairment and more frequent and longer hospitalisations. Additionally, diagnosis is often challenging because clinical presentations of common disorders may often be atypical in the elderly. When prescribing medications, physicians have to take into account the pharmacokinetic and pharmacodynamic changes observed with ageing. This book fills the gap in the literature available on acute geriatric care.

Part of the recognised Infertility Management Series, this handbook is a complete guide to basic laboratory procedures in assisted reproductive technology (ART). The book guides clinicians step by step through the processes, beginning with discussion on semen analysis, cryopreservation of semen samples, and semen selection, to embryo culture, selection and transfer, and oocyte and embryo vitrification. The final chapters cover time-lapse imaging - a new technology for embryo development, design and equipment for the laboratory, and future developments in ART laboratory procedures, including the development of gametes from stem cells. Compiled by a recognised team of editors and contributors, the text is enhanced by clinical photographs, illustrations and tables. Other titles in the series include: Investigating Infertility, Intrauterine Insemination, Practical Management of Male Infertility, Polycystic Ovarian Syndrome, Handbook of Ovarian Stimulation, and Abnormalities of the Pelvis. Key points Part of Infertility Management Series providing complete guide to basic laboratory procedures in ART Guides clinicians step by step through the various processes Highly illustrated with photographs, diagrams and tables Edited by recognised team of experts in reproductive medicine

Many health problems are unique to, more common in, or more severe in women than men. This book examines the underpinnings of these gender differences. Sections deal with biological (hormonal, anatomic, immunologic, and pregnancy-related), social, behavioural/psychological, and lifestyle influences. Chapters are heavily referenced, packed full with data, and they provide methodological insights that will guide future women's health research.

IVF is a major treatment in infertility when other methods of assisted reproductive technology have failed. The process involves hormonally controlling the ovulatory process, removing ova (eggs) from the woman's ovaries and letting sperm fertilise them in a fluid medium. This book presents topical research in the study of in vitro fertilisation including management of chronic viral infections in assisted reproduction; posthumous sperm procurement; assisted reproductive technologies for serodiscordant couples with an HIV-1 infection and the impact of laparoscopic ovarian cystectomy for infertile women with endometriomas prior to IVF/ICSI cycles.