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Books > Medicine > Pre-clinical medicine: basic sciences > Human reproduction, growth & development
This book analyzes the basic science and treatment of male factor infertility with Dr. Silber's characteristic honesty and clear thinking. It describes finally what works and what doesn't work. It will inspire everyone in reproductive medicine (Gynecologists, Urologists, Embryologists and Endocrinologists) who wish to better understand male infertility.
This book summarizes the contributions at an April 2016 conference held at Albany Medical College, Reproductive Ethics: New Challenges and Conversations. Reproductive ethics does not suffer from a lack of challenging issues, yet a few "hot button" issues such as abortion and surrogacy seem to attract most of the attention, while other issues and dilemmas remain relatively underdeveloped in bioethics literature. The goal of this book is to explore and expand the range of topics addressed in reproductive ethics. This is a multi-disciplinary book bringing together philosophers, clinicians, sociologists, anthropologists, and other scholars whose research or clinical interests touch reproductive issues. The results of this compilation are a comprehensive and unique discussion of the evolving issues in the rapidly changing field. The majority of the popular reproductive ethics anthologies were published at least 10 years ago. The field of reproductive ethics would benefit from a new anthology that addresses some of the perennial dilemmas in reproductive ethics (e.g. abortion, sex selection) from updated perspectives and that also covers new technologies that have emerged only in the last few years, such as social egg freezing.
The Female Reproductive System chart presents an overview of the structure and function of female reproductive anatomy. The primary image illustrates the overall structure, including the ovary, uterine tube and uterus. Diagrams show the process of the menstrual cycle and ovulation. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).
This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system. This volume covers various clinical pathologies related to the reproductive system that arise from or produce oxidative stress, both in the male and female. The use of antioxidants as a therapeutic measure to keep ROS levels in check are highlighted, describing the outcome of various clinical studies involving antioxidant supplementation in infertile patients. Infertility is a global disease that affects 15-25% of all couples, and oxidative stress arising from a multitude of sources has been implicated as one of the major contributing factors to the decline in human fertility. As such, this book provides an up-to-date review on the significance of ROS in human reproduction.
Reflecting the increasing interest in fertility management for pediatric and adolescent patients and fulfilling an urgent need to have a comprehensive guide to the management of these individuals, this is the first book of its kind to present a comprehensive discussion of pediatric and adolescent oncofertility. It carefully examines the impact of pediatric cancer and cancer therapy on fertility and presents both current and emerging fertility preservation techniques for both males and females, such as cryopreservation. Fertility concerns beyond cancer are also discussed, including disorders of sexual differentiation, gender dysphoria and thalassemia. Practical chapters on pediatric oncofertility in the clinic round out the book, covering setting up a practice, counseling and consent, disclosure and insurance considerations. Concluding chapters document fertility preservation techniques and outcomes internationally, with contributions from Portuguese, Brazilian and Japanese authors. Timely and wide-ranging, Pediatric and Adolescent Oncofertility is an ideal resource for reproductive medicine specialists, pediatric oncologists, and primary care physicians treating pediatric and adolescent cancer patients looking to protect fertility options.
This book provides comprehensive information on Intracytoplasmic Sperm Injection (ICSI), its clinical considerations, outcomes and potential health effects. Male and female infertility is increasing all over the world. The basic techniques of assisted reproduction like ovulation control and intrauterine insemination are ineffective if the sperm quality or number is inadequate. The advanced fertilization techniques are in-vitro fertilization (IVF) and ICSI. In 15% cases of infertility, IVF results in total failed fertilization; therefore, ICSI must be used. Some clinics exclusively use ICSI for all infertility patients due to its reliability of fertilization outcome or to avoid total fertilization failure. ICSI was first used in humans in 1992. Since then, tremendous advances have been made in assisted reproductive technology. ICSI has enabled even those men who have rare sperm in their testes to father a biological child. If no sperm are observed in the ejaculate, in almost all cases, they can be recovered from the testicles. Such retrieved sperm can only be used by ICSI. Therefore, its understanding is essential not only for medical staff but also for patients suffering from infertility. This book is highly recommended for patients suffering from infertility or currently undergoing infertility treatment. It explains the factors affecting ICSI success rate. In ICSI, the embryologist picks a sperm for injection to fertilize oocytes whereas in intrauterine insemination and IVF, one sperm penetrates naturally. This manual selection of sperm has raised concerns especially in those patients suffering from severe male factor infertility. The nature of sperm defects varies and could be congenital, acquired or genetic. Children born through ICSI are, therefore, considered at higher risk of carrying the defect. Many investigations have been carried out to compare incidence of the defects between children conceived naturally and conceived through ICSI. Additional technologies have been developed to ensure the birth of a normal child. These include pre-implantation genetic testing and non-invasive prenatal testing. This book addresses these concerns and explains the health effects on children born through ICSI. This book is very useful for medical students, andrologists, embryologists, nurses or anyone else interested in learning basic or advanced knowledge of assisted reproductive technology, especially ICSI. The authors of the chapters of this book are highly experienced and from different parts of the world. Many of them are directing very busy ART laboratories at leading infertility clinics in the United States of America, Canada and the Middle East.
This authoritative reference work contains more than 300 entries covering all aspects of the multi-disciplinary field of adult development and aging Brings together concise, accurate summaries of classic topics as well as the most recent thinking and research in new areas Covers a broad range of issues, from biological and physiological changes in the body to changes in cognition, personality, and social roles to applied areas such as psychotherapy, long-term care, and end-of-life issues Includes contributions from major researchers in the academic and clinical realms 3 Volumes www.encyclopediaadulthoodandaging.com
An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM. Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.
This unique book is a comprehensive guide for healthcare providers who treat patients with complex medical conditions but lack the resources to address fertility and sexuality concerns and help patients navigate their fertility decision-making process. It presents up-to-date information concerning fertility preservation and restoration for patients with hereditary cancer syndromes, disorders of sex development, hematologic diseases, genetic disorders of gonadal dysfunction, immunologic diseases, gynecologic diseases, endocrine disorders, and autoimmune and inflammatory diseases. Utilizing a practical, user-friendly format, each chapter discusses the epidemiology, classification, risk factors and/or clinical manifestations, and diagnosis and treatment modalities specific to each condition, as well as the effect of it or its treatment on fertility and unique options that may exist. Complex medical conditions are inherently difficult to manage, and reproductive interventions are often not part of the conversation. As such, Fertility Preservation and Restoration for Patients with Complex Medical Conditions will be an excellent resource for primary care physicians, obstetrician/gynecologists, endocrinologists, oncologists, and other health professionals working with patients with fertility concerns. This book, together with Oncofertility: Fertility Preservation for Cancer Survivors; Oncofertility: Ethical, Legal, Social, and Medical Perspectives; Oncofertility Medical Practice: Clinical Issues and Implementation; Oncofertility Communication: Sharing Information and Building Relationships across Disciplines; and Pediatric and Adolescent Oncofertility: Best Practices and Emerging Technologies, provides scientific and medically relevant information on fertility preservation from all vantage points and is an indispensable series for those interested in fertility management in cancer or complex settings.
This book describes the life cycle of a unique endocrine gland that is absolutely essential for the establishment and maintenance of pregnancy in all mammalian species. The corpus luteum is unique because it is formed and destroyed every (non-fertile) reproductive cycle. When fertilization occurs, the corpus luteum is rescued or maintained. The processes that control corpus luteum formation, demise (luteolysis), or maintenance are just beginning to be unraveled in recent years; they involve diverse cell types and mechanisms. Some of these processes resemble tumor development-angiogenesis, for instance-but interestingly enough, this resemblance is only up to a point. The corpus luteum uses mechanisms that allow its normal, physiological growth and disappearance. Pulling together key research on the corpus luteum, this volume is of interest to both reproductive endocrinologists and comparative physiologists, with clinical relevance spanning comparative animal studies to women's health.
The role of male-derived factors in infertility now receives increasing prominence, as investigations focus more on the couple, rather than solely the female partner. Although there are many books on infertility, few devote themselves wholly to the male partner. Male Infertility redresses this balance by increasing awareness of both the causes and management of infertility in the male. This revised and updated edition contains new chapters covering urological disorders that may occur concomitantly with male infertility, such as testicular cancer, penile disorders and prostate cancer. A practical and clinical guide, Male Infertility enables clinicians to make quick and accurate diagnoses of the cause before pursuing the most appropriate treatment option to maximise the chances of conception. Of particular value to gynaecologists and andrologists, this text will be of great interest to any clinician working in the infertility clinic, as well as primary care practitioners and trainees.
Bringing together the latest knowledge on the growth and development of children and the most important abnormalities of puberty, this comprehensive text presents the current views on the pathogenesis, diagnostic possibilities and therapeutic options of the main deviations from the normal course of puberty (e.g., precocious and delayed puberty). The chain of physical and hormonal changes in the transitional years is carefully followed, including the regulation of the hypothalamic pulse generator as well as the timing of puberty. Further topics include growth disturbances, adolescent varicocele, adolescent gynecomastia, polycystic ovary syndrome, pubertal acne, and the psychosocial development of adolescents with pubertal abnormalities. Written and edited by internationally noted experts, Puberty will be an excellent resource for pediatricians, endocrinologists, gynecologists, andrologists, urologists, family practitioners, child psychologists and public health specialists - all those who will be challenged in their everyday practice with the problems of puberty.
'Mind-blowing ... It is a hugely important book ... His story is crucial' Matt Ridley, The Times One of the world's top behavioural geneticists argues that we need a radical rethink about what makes us who we are The blueprint for our individuality lies in the 1% of DNA that differs between people. Our intellectual capacity, our introversion or extraversion, our vulnerability to mental illness, even whether we are a morning person - all of these aspects of our personality are profoundly shaped by our inherited DNA differences. In Blueprint, Robert Plomin, a pioneer in the field of behavioural genetics, draws on a lifetime's worth of research to make the case that DNA is the most important factor shaping who we are. Our families, schools and the environment around us are important, but they are not as influential as our genes. This is why, he argues, teachers and parents should accept children for who they are, rather than trying to mould them in certain directions. Even the environments we choose and the signal events that impact our lives, from divorce to addiction, are influenced by our genetic predispositions. Now, thanks to the DNA revolution, it is becoming possible to predict who we will become, at birth, from our DNA alone. As Plomin shows us, these developments have sweeping implications for how we think about parenting, education, and social mobility. A game-changing book by a leader in the field, Blueprint shows how the DNA present in the single cell with which we all begin our lives can impact our behaviour as adults.
Due to the paucity of reviews on this subject, this volume aims to be timely and promote additional basic and translational research on these proteins in reproductive system development and function within the fields of Anatomy, Embryology and Cell Biology. The breadth of the work being conducted within Reproduction is exemplified by the contributors to this series who will provide reviews on: Grp78 roles in female reproduction, small heat shock proteins/co-chaperones as players in uterine smooth muscle function, the role of heat shock proteins in sperm function and maternal contribution to oogenesis and early embryogenesis, heat shock factors and testes development, HSP90 in ovarian biology and pathology, and the role of HSP70 in regulation of autophagy in pregnancy and parturition.
Developmental theorists have struggled with defining the relations among biology, psychology, and sociocultural context, often reducing psychological functions of a person to either biological functioning or the role of sociocultural context - nature or nurture - and considering each area of human development separately. New Perspectives on Human Development addresses fundamental questions of development with a unified approach. It encompasses theory and research on cognitive, social and moral, and language and communicative development, in various stages of life, and explores interdisciplinary perspectives. New Perspectives on Human Development revisits old questions and applies original empirical findings, offering new directions for future research in the field.
Intended for readers with a background in fertility medicine as well as those less familiar with IVF, this comprehensive work presents an update on preimplantation genetic testing to enable single embryo transfer (SET). An international cast of contributors explains the treatment sequence-from ovulation induction to luteal support-aiming to transfer only one euploid embryo. Applications of molecular techniques for gamete and embryo assessment are fully detailed, with a focus on the strengths and limitations of each. In addition, expert commentary is shared across a range of regulatory challenges associated with embryo screening and cryopreservation. As access to advanced reproductive technology increases against a sharper background of healthcare reform, clinicians, economists, bioethicists and legislators alike will find this new volume relevant and highly accessible.
Humans and flies look nothing alike, yet their genetic circuits are remarkably similar. Here, Lewis I. Held, Jr compares the genetics and development of the two to review the evidence for deep homology, the biggest discovery from the emerging field of evolutionary developmental biology. Remnants of the operating system of our hypothetical common ancestor 600 million years ago are compared in chapters arranged by region of the body, from the nervous system, limbs and heart, to vision, hearing and smell. Concept maps provide a clear understanding of the complex subjects addressed, while encyclopaedic tables offer comprehensive inventories of genetic information. Written in an engaging style with a reference section listing thousands of relevant publications, this is a vital resource for scientific researchers, and graduate and undergraduate students.
Reproductive medicine and surgery is a major subspecialty in the practice of obstetrics and gynaecology. This textbook provides an introduction to the field of subfertility and reproductive endocrinology, with contributions written by leading experts in the field. This book is based on and compliments a training programme run jointly by the British Fertility Society and the Royal College of Obstetricians and Gynaecologists, making it an indispensable handbook for medical trainees. It will also appeal to clinicians embarking on a career in obstetrics and gynaecology who want an excellent grounding in this area. Specialist nurses will also find the book a valuable resource, and scientists specialising in reproductive medicine and embryology will gain insight into the related clinical areas.
The first IVF conceived birth in 1978 resulted in a significant growth of third party reproductive options which continue to raise ethical, legal, and psychological questions. Third party reproduction procedures can involve as many as five people: sperm donor, egg donor, gestational carrier, and intended parents. Third-Party Reproduction: A Comprehensive Guide utilizes experts in the field to address the medical, psychological, ethical and legal aspects of sperm donation, egg donation, embryo donation, and the use of gestational carriers. In addition, there are chapters on the medical and ethical aspects of posthumous reproduction, religious aspects of third party reproduction, and how to avoid pitfalls of third party reproduction. Aimed at physicians, trainees, psychologists, nurses, and social workers whose practices may include patients considering third party reproduction, the intent of this book is to provide a comprehensive and practical overview of the many aspects of third party reproduction to help all those involved to better understand them. Patients considering third party reproduction may also find value in this book.
Oncofertility integrates the two previously distinct fields of cancer treatment and fertility research and aims to explore and expand the reproductive future of cancer survivors. In order to achieve the goal of fertility preservation, the Oncofertility community must focus on communication and the way data is provided and received. Concomitant with the rapidly changing technology of Oncofertility, there have been radical shifts and advances in the way health educators and clinicians can produce and share information. As success rates of reproductive techniques such as egg freezing and banking continue to rise, providing increasing opportunities for young cancer patients to preserve their fertility prior to the onset of cancer treatments, communication among professionals in oncology, reproductive medicine, and psychosocial work, among others, becomes crucial, and clinical demand for Oncofertility information is expected to rise considerably. Oncofertility Communication describes and addresses the myriad channels through which the multiple audiences involved in Oncofertility can be served with appropriate and accurate information about cancer-related fertility issues. The text answers frequently asked questions and provides invaluable insights to scientific and health care professionals about communication among the diverse Oncofertility audiences. It incorporates timely discussions about traditional and emerging electronic communication tools and discusses the impact of health care policy changes on the Oncofertility field.
The average physician and even cancer care-givers are not knowledgeable about the effects of cancer treatment on sex and reproductive life. They are even less aware of the options available for treatment of such patients. Cancer and Sexual Health fills a great need for a reference work devoted to the link between cancer and human sexuality. The volume is designed to give a comprehensive and state-of-the-art review of the sexual and reproductive consequences of cancer diagnosis and treatment. It will prove an invaluable resource for those clinicians caring for cancer patients as well as acting as a reference text for the sexual medicine clinician who may not see a large number of cancer patients.
This book provides andrologists and other practitioners with reliable, up-to-date information on all aspects of male infertility and is designed to assist in the clinical management of patients. Clear guidance is offered on classification of infertility, sperm analysis interpretation and diagnosis. The full range of types and causes of male infertility are then discussed in depth. Particular attention is devoted to poorly understood conditions such as unexplained couple infertility and idiopathic male infertility, but the roles of diverse disorders, health and lifestyle factors and environmental pollution are also fully explored. Research considered stimulating for the reader is highlighted, reflecting the fascinating and controversial nature of the field. International treatment guidelines are presented and the role of diet and dietary supplements is discussed in view of their increasing importance. Clinicians will find that the book's straightforward approach ensures that it can be easily and rapidly consulted.
This contributed volume regenerates the significance of and respect for natural phenomenon in the background of the risks and complications seen in ART such as ovarian hyperstimulation and multiple pregnancies. Balancing the clinical practice between the beneficial natural physiology and the prolific use of stimulation drugs for ART may help eliminate risks that may prove clinically, financially and psychologically expensive. It underscores the fact that 'greater' is not always synonymous with 'better' with regard to the oocyte yield. While highlighting the risks involved with the use of high-dose gonadotropins, the book presents a stratification of patients who might benefit from the 'soft' minimal and natural cycle IVF stimulation protocols that may be used. Additionally, clinicians can understand the significance of cryopreservation technology, now a useful adjunct to minimal stimulation protocols, with its manifold future advantages. Written by an international team of experts, this handbook emphasizes how minimal stimulation and natural cycle IVF can lead to a milder, safer and more effective approach to ART.
Non-Invasive Sperm Selection for In Vitro Fertilization summarizes and discusses the relevant literature on the various advanced sperm selection methods used in modern Assisted Reproductive Technologies (ART). Chapters review some of the major unresolved issues in the field, the feasibility and success of the various sperm selection methods, their safety and the effects they have on sperm quality and ART outcomes. The book makes recommendations on clinical applications and future research, while helping to elucidate the benefits and promise of non-invasive sperm selection techniques. A distinguished team of scientists, embryologists, and urologists, with expertise in male infertility and ART, contributes to this original and valuable reference guide meant for academics, researchers, and professionals in the field of reproductive medicine who need an update on the current status of the study and practice of non-invasive sperm selection techniques.
The age-friendly community movement is a global phenomenon, currently growing with the support of the WHO and multiple international and national organizations in the field of aging. Drawing on an extensive collection of international case studies, this volume provides an introduction to the movement. The contributors - both researchers and practitioners - touch on a number of current tensions and issues in the movement and offer a wide-ranging set of recommendations for advancing age-friendly community development. The book concludes with a call for a radical transformation of a medical and lifestyle model of aging into a relational model of health and social/individual wellbeing. |
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