"Original, important, moving, witty and exquisitely-written. WHAT a feat." - BERNARDINE EVARISTO "Incredible... beautiful and funny and humane." - EMILIE PINE "Pristine poetry and prose." KATHERINE MAY, AUTHOR OF WINTERING "Babies who are this small, he says, have a good chance of survival. Small is not good for babies. It is not whimsical or cute or the cause of admiration. It is the first time it occurs to us that they might not survive. Babies die from smallness." Claire Lynch knew that having children with her wife would be complicated but she could never have anticipated the extent to which her life would be redrawn by the process. This dazzling debut begins with the smallest of life's substances, the microscopic cells subdividing in a petri dish in a fertility treatment centre. She moves through her story in incremental yet ever growing steps, from the fingernail-sized pregnancy test result screen which bears two affirmative lines to the premature arrival of her children who have to wear scale-model oxygen masks in their life-saving incubators. Devastatingly poignant and profoundly observant - and funny against the odds - Claire considers whether it is our smallness that makes our lives so big.

This important new volume in the series Cambridge Reviews in Human Reproduction provides a wide-ranging and authoritative account of the uterus and its physiological role in fertility, normal pregnancy and delivery. Acknowledged authorities from around the world provide a detailed and timely account of uterine physiology. The volume encompasses a wealth of material including cell and developmental biology, structure, function, anatomy and endocrinology, and then goes on to cover clinically important issues such as the cervix during pregnancy, measurement of uterine contractions and initiation of labour. It will prove of particular value to those involved in the management of women with pre-term labour, as well as those concerned with the development of new procedures for the prevention or amelioration of this condition.

In this second edition of Disorders of Thrombosis and Hemostasis in Pregnancy - A Guide to Management the content has been thoroughly updated, with a particular focus on strengthening the management sections to ensure that advice on management represents state of the art.

Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood. This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known. The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function. Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.

Infertility can have devastating physical, emotional and financial effects on people affected. It is a common problem, but can be hard to talk about, and hard to understand. In this concise book, Dr Kovacs, a reproductive gynaecologist who has spent the past 40 years working with patients facing fertility problems, focuses on and unpicks key misconceptions. In his clear explanations, he covers the basic physiology of conceiving, and describes the areas that have to be explored for those who have not yet been able to conceive. Specific chapters cover the three major problem areas: lack of releasing eggs, sperm problems, and abnormalities of the female passages. Treatment options are discussed for each of these areas, including technical details and a brief readable overview of their history. The many ways of parenting which are now available are also detailed. This is a recommended read for couples wanting to conceive, their friends and families, and anyone who wants to understand fertility.

Each of the 6 units of PROLOG addresses a major area in obstetrics and gynecology and consists of two parts - an assessment book and a critique book. Put your knowledge to the test and earn 25 CME credits for this volume!On completion, users of this unit should be able to:Identify epidemiologic factors that contribute to the risks of various malignancies and determine appropriate screening tests. Analyze the pathophysiology and evaluate the histopathology of various malignancies. Associate symptoms with early onset of specific malignancies, determine appropriate diagnostic tests, and select diagnosis. Identify physical and surgical findings related to specific stages of malignant disease. Determine appropriate surgical and nonsurgical management for various types of cancer and identify common complication of therapy. Determine approaches for preoperative assessment, select surgical techniques for gynecologic disorders, and identify common complications of surgery. Apply knowledge of anatomy, wound management, and appropriate surgical techniques in the surgical therapy of gynecologic disease. Determine the appropriate management of the critical care patient.

In the mid-1990s, the international community pronounced prenatal sex selection via abortion an "act of violence against women" and "unethical." At the same time, new developments in reproductive technology in the United States led to a method of sex selection before conception; its US inventor marketed the practice as "family balancing" and defended it with the rhetoric of freedom of choice. In Gender before Birth, Rajani Bhatia takes on the double standard of how similar practices in the West and non-West are divergently named and framed. Bhatia's extensive fieldwork includes interviews with clinicians, scientists, biomedical service providers, and feminist activists, and her resulting analysis extends both feminist theory on reproduction and feminist science and technology studies. She argues that we are at the beginning of a changing transnational terrain that presents new challenges to theorized inequality in reproduction, demonstrating how the technosciences often get embroiled in colonial gender and racial politics.

Reproduction is a fundamental feature of life, it is the way life persists across the ages. This book offers new, wider vistas on this fundamental biological phenomenon, exploring how it works through the whole tree of life. It explores facets such as asexual reproduction, parthenogenesis, sex determination and reproductive investment, with a taxonomic coverage extended over all the main groups - animals, plants including 'algae', fungi, protists and bacteria. It collates into one volume perspectives from varied disciplines - including zoology, botany, microbiology, genetics, cell biology, developmental biology, evolutionary biology, animal and plant physiology, and ethology - integrating information into a common language. Crucially, the book aims to identify the commonalties among reproductive phenomena, while demonstrating the diversity even amongst closely related taxa. Its integrated approach makes this a valuable reference book for students and researchers, as well as an effective entry point for deeper study on specific topics.

No one wants to think about getting older. It's true. At any age, when things are moving along normally day to day and everyone seems fit and well, there seems no reason to think about future problems that your friends and relatives might (and probably will) come across as they age. In fact, it might even seem a little morbid to think such thoughts, or possibly even tempting fate? Yet there will come a time when you must raise these issues and, ideally, this should be before any problems arise. The Essential Family Guide to Caring for Older People is the ultimate source of information and help for families with care responsibilities. Deborah Stone draws on her extensive experience working in elder care to offer practical advice on every aspect of the field indepth. Topics range from how to get help immediately, legal information, care funding options, a guide to useful technology and advice on the main physical and mental health issues that affect older people. Plus guidance is given on dealing with social services and ensuring you choose the right care for your situations. Crucially, the book also offers help on how to cope as a carer with practical advice on juggling family, work and your caring responsibilities while looking after yourself.

This book analyzes the basic science and treatment of male factor infertility with Dr. Silber's characteristic honesty and clear thinking. It describes finally what works and what doesn't work. It will inspire everyone in reproductive medicine (Gynecologists, Urologists, Embryologists and Endocrinologists) who wish to better understand male infertility.

The Physiological Effects of Ageing is a comprehensive resource for student nurses, qualified nurses and allied professionals working with older people in a variety of contexts, enabling them to apply their knowledge of the ageing process and in doing so enhance care delivery. This book emphasizes the normal ageing changes before considering possible effects of ageing on body systems. Although problems associated with ageing are identified, nursing assessment and interventions are considered which can help reduce the impact these changes have on a person's functional ability. This is a highly accessible text which encourages holistic patient-centred care.

Special Features:

- Explores current theories of ageing

- Makes use of reflective points and points of practice

- Looks at key topics of maintaining a safe environment and communication

- Discusses error theory, free radical theory and the immune theory

This authoritative reference work contains more than 300 entries covering all aspects of the multi-disciplinary field of adult development and aging Brings together concise, accurate summaries of classic topics as well as the most recent thinking and research in new areas Covers a broad range of issues, from biological and physiological changes in the body to changes in cognition, personality, and social roles to applied areas such as psychotherapy, long-term care, and end-of-life issues Includes contributions from major researchers in the academic and clinical realms 3 Volumes www.encyclopediaadulthoodandaging.com

This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

The Female Reproductive System chart presents an overview of the structure and function of female reproductive anatomy. The primary image illustrates the overall structure, including the ovary, uterine tube and uterus. Diagrams show the process of the menstrual cycle and ovulation. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

This book is the second collection of essays on reproductive ethics from Drs. Campo-Engelstein and Burcher. This volume is unique in that it is both timely and includes several essays on new technologies, while also being a comprehensive review of most of the major questions in the field, from racial disparities in reproductive healthcare to gene editing and the possibility of the creation of a transhuman species. The scholars writing these essays are pre-eminent in their fields, and their backgrounds are quite varied, including philosophers, anthropologists, physicians, and professors of law. Reproductive ethics remains an underdeveloped area of bioethics despite the recent technological breakthroughs that carry both great promise and potential threats. Building on the first volume of work from a conference held just over one year ago, this new collection of essays from a conference held April 2017 continues this discussion as well as provides ethical insights and reviews of these emerging technologies. The ethical questions swirling around human reproduction are both old and new, but the conference presentations, and the essays derived from them, focus on new ways of appreciating old arguments such as the ethics of abortion, as well as new ways of seeing new technologies such as CRISPR and mitochondrial transfer.

This book summarizes the contributions at an April 2016 conference held at Albany Medical College, Reproductive Ethics: New Challenges and Conversations. Reproductive ethics does not suffer from a lack of challenging issues, yet a few "hot button" issues such as abortion and surrogacy seem to attract most of the attention, while other issues and dilemmas remain relatively underdeveloped in bioethics literature. The goal of this book is to explore and expand the range of topics addressed in reproductive ethics. This is a multi-disciplinary book bringing together philosophers, clinicians, sociologists, anthropologists, and other scholars whose research or clinical interests touch reproductive issues. The results of this compilation are a comprehensive and unique discussion of the evolving issues in the rapidly changing field. The majority of the popular reproductive ethics anthologies were published at least 10 years ago. The field of reproductive ethics would benefit from a new anthology that addresses some of the perennial dilemmas in reproductive ethics (e.g. abortion, sex selection) from updated perspectives and that also covers new technologies that have emerged only in the last few years, such as social egg freezing.

An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM. Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.

"In 1968, a popular writer ranked the pill's importance with the discovery of fire and the developments of tool-making, hunting, agriculture, urbanism, scientific medicine, and nuclear energy. Twenty-five years later, the leading British weekly, the "Economist," listed the pill as one of the seven wonders of the modern world. The image of the oral contraceptive as revolutionary persists in popular culture, yet the nature of the changes it supposedly brought about has not been fully investigated. After more than thirty-five years on the market, the role of the pill is due for a thorough examination."--from the Introduction

In this fresh look at the pill's cultural and medical history, Elizabeth Siegel Watkins re-examines the scientific and ideological forces that led to its development, the part women played in debates over its application, and the role of the media, medical profession, and pharmaceutical industry in deciding issues of its safety and meaning. Her study helps us not only to understand the contraceptive revolution as such but also to appreciate the misinterpretations that surround it.

This unique book is a comprehensive guide for healthcare providers who treat patients with complex medical conditions but lack the resources to address fertility and sexuality concerns and help patients navigate their fertility decision-making process. It presents up-to-date information concerning fertility preservation and restoration for patients with hereditary cancer syndromes, disorders of sex development, hematologic diseases, genetic disorders of gonadal dysfunction, immunologic diseases, gynecologic diseases, endocrine disorders, and autoimmune and inflammatory diseases. Utilizing a practical, user-friendly format, each chapter discusses the epidemiology, classification, risk factors and/or clinical manifestations, and diagnosis and treatment modalities specific to each condition, as well as the effect of it or its treatment on fertility and unique options that may exist. Complex medical conditions are inherently difficult to manage, and reproductive interventions are often not part of the conversation. As such, Fertility Preservation and Restoration for Patients with Complex Medical Conditions will be an excellent resource for primary care physicians, obstetrician/gynecologists, endocrinologists, oncologists, and other health professionals working with patients with fertility concerns. This book, together with Oncofertility: Fertility Preservation for Cancer Survivors; Oncofertility: Ethical, Legal, Social, and Medical Perspectives; Oncofertility Medical Practice: Clinical Issues and Implementation; Oncofertility Communication: Sharing Information and Building Relationships across Disciplines; and Pediatric and Adolescent Oncofertility: Best Practices and Emerging Technologies, provides scientific and medically relevant information on fertility preservation from all vantage points and is an indispensable series for those interested in fertility management in cancer or complex settings.

Reflecting the increasing interest in fertility management for pediatric and adolescent patients and fulfilling an urgent need to have a comprehensive guide to the management of these individuals, this is the first book of its kind to present a comprehensive discussion of pediatric and adolescent oncofertility. It carefully examines the impact of pediatric cancer and cancer therapy on fertility and presents both current and emerging fertility preservation techniques for both males and females, such as cryopreservation. Fertility concerns beyond cancer are also discussed, including disorders of sexual differentiation, gender dysphoria and thalassemia. Practical chapters on pediatric oncofertility in the clinic round out the book, covering setting up a practice, counseling and consent, disclosure and insurance considerations. Concluding chapters document fertility preservation techniques and outcomes internationally, with contributions from Portuguese, Brazilian and Japanese authors. Timely and wide-ranging, Pediatric and Adolescent Oncofertility is an ideal resource for reproductive medicine specialists, pediatric oncologists, and primary care physicians treating pediatric and adolescent cancer patients looking to protect fertility options.

Fertility preservation has become one of the most important and fast growing fields of reproductive medicine. Although there are several strategies for fertility preservation in female, most of them are still considered experimental. It is important to perfect the existing technologies, but also developing new strategies should be actively sought. The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles. One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms. To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level. Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation. The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics. "

This book describes the life cycle of a unique endocrine gland that is absolutely essential for the establishment and maintenance of pregnancy in all mammalian species. The corpus luteum is unique because it is formed and destroyed every (non-fertile) reproductive cycle. When fertilization occurs, the corpus luteum is rescued or maintained. The processes that control corpus luteum formation, demise (luteolysis), or maintenance are just beginning to be unraveled in recent years; they involve diverse cell types and mechanisms. Some of these processes resemble tumor development-angiogenesis, for instance-but interestingly enough, this resemblance is only up to a point. The corpus luteum uses mechanisms that allow its normal, physiological growth and disappearance. Pulling together key research on the corpus luteum, this volume is of interest to both reproductive endocrinologists and comparative physiologists, with clinical relevance spanning comparative animal studies to women's health.

This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system. This volume covers various clinical pathologies related to the reproductive system that arise from or produce oxidative stress, both in the male and female. The use of antioxidants as a therapeutic measure to keep ROS levels in check are highlighted, describing the outcome of various clinical studies involving antioxidant supplementation in infertile patients. Infertility is a global disease that affects 15-25% of all couples, and oxidative stress arising from a multitude of sources has been implicated as one of the major contributing factors to the decline in human fertility. As such, this book provides an up-to-date review on the significance of ROS in human reproduction.

Bringing together the latest knowledge on the growth and development of children and the most important abnormalities of puberty, this comprehensive text presents the current views on the pathogenesis, diagnostic possibilities and therapeutic options of the main deviations from the normal course of puberty (e.g., precocious and delayed puberty). The chain of physical and hormonal changes in the transitional years is carefully followed, including the regulation of the hypothalamic pulse generator as well as the timing of puberty. Further topics include growth disturbances, adolescent varicocele, adolescent gynecomastia, polycystic ovary syndrome, pubertal acne, and the psychosocial development of adolescents with pubertal abnormalities. Written and edited by internationally noted experts, Puberty will be an excellent resource for pediatricians, endocrinologists, gynecologists, andrologists, urologists, family practitioners, child psychologists and public health specialists - all those who will be challenged in their everyday practice with the problems of puberty.