Cloning, genetic screening, embryo freezing, in vitro fertilization, Norplant, RU486--these are the technologies revolutionizing our reproductive landscape. Through the lens of procreative liberty--meaning both the freedom to decide whether or not to have children as well as the freedom to control one's reproductive capacity--John Robertson, a leading legal bioethicist, analyzes the ethical, legal, and social controversies surrounding each major technology and opens up a multitude of fascinating questions: Do frozen embryos have the right to be born? Should parents be allowed to select offspring traits? May a government force welfare recipients to take contraceptives? Robertson's arguments examine the broad range of consequences of each reproductive technology and offers a timely, multifaceted analysis of the competing interests at stake for patients, couples, doctors, policymakers, lawyers, and ethicists.

The Fourth Edition of Knobil & Neill will continue to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. This new edition will seek to synthesize all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context.
*The leading comprehensive work on the physiology of reproduction
*Edited and authored by the world's leading scientists in the field
*Is a synthesis of the molecular, cellular, and organismic levels of organization
*Bibliogrpahics of chapters are extensive and cover all the relevant literature

Nowhere has the impact of ultrasonography been more dramatic than in reproductive medicine, particularly in the diagnosis of female and male infertility, the management of assisted reproductive procedures and the monitoring of early pregnancy. This authoritative textbook encompasses the complete role of ultrasonography in the evaluation of infertility and assisted reproduction. Covering every indication for ultrasonography in assisted reproductive technology, this will prove an invaluable resource in the evaluation of the infertile patient and optimization of the outcome of treatment. The interpretation of images to improve fertility and reproductive success is emphasized throughout. Ultrasonography in Reproductive Medicine and Infertility is essential reading for clinicians working both in IVF clinics and in office practice. It will be particularly useful to gynecologists, infertility specialists, ultrasonographers and radiologists working in reproductive endocrinology and infertility, assisted reproductive technology, ultrasonography and radiology.

Helping the Stork The sourcebook for all the information parents-to-be need to know about the choices and challenges of donor insemination Each year donor insemination (DI) offers a pathway to parenthood for the hundreds of thousands who turn to family-building alternatives. Although DI is considered as often as adoption, couples facing male infertility, as well as single women and lesbian couples, have had few places to turn for information about this method, which has been shrouded in secrecy. In Helping the Stork, parents-to-be, as well as friends and family, doctors, and counselors, can explore the choices and challenges raised by this alternative to overcoming childlessness. This comprehensive handbook moves through each step of the process: reaching a solid decision about whether donor insemination is the best choice for a family's future; handling the difficult issue of privacy; selecting a donor and getting started; and learning to thrive as a family meeting DI's added challenges. Full of wisdom from medical and mental health experts, Helping the Stork is also enriched with stories from many families who share their insights and experiences. This book is a reassuring, supportive, and helpful guide that no one considering or going through the process of donor insemination should be without. Visit us online at http: //www.mcp.com/mgr

Now in a completely revised and expanded fourth edition, including two new chapters, this user-friendly textbook offers a succinct overview of both the medical and surgical management of reproductive disorders, as well as coverage of associated imaging modalities. Included here are updated chapters on major reproductive endocrinology and infertility issues, such as polycystic ovary syndrome (PCOS), pubertal disorders, amenorrhea, menopause, management of endometriosis and fibroids (including interventional radiology), laboratory and clinical aspects of assisted reproductive technologies (ART), imaging modalities such as ultrasonography and sonohysterography, hysteroscopic and laparoscopic techniques, an expansion of female infertility and fertility, preimplantation diagnosis and screening, osteoporosis, and contraception and sterilization. Chapters new to this edition discuss third-party reproduction and uterine transplantation. In addition, chapters opens with a list of bulleted key points and end with multiple choice review questions, and most include vibrant clinical case material to illustrate important concepts. Residents, fellows, and new clinicians in obstetrics and gynecology interested in reproductive endocrinology and infertility will find this fourth edition of Clinical Reproductive Medicine and Surgery: A Practical Guide a valuable and focused reference.

Scientists and philosophers have long struggled to answer the questions of when human life begins and when human life has inherent value. The phenomenon of identical (monozygotic) twinning presents a significant challenge to the view that human life and human personhood begin at conception. The fact that a single embryo can split to generate two (or more) genetically identical embryos seems to defy the notion that prior to splitting an embryo can be a single human individual. In Untangling Twinning, Maureen Condic looks at the questions raised by human twinning based on a unique synthesis of molecular developmental biology and Aristotelian philosophy. She begins with a brief historical analysis of the current scientific perspective on the embryo and proceeds to address the major philosophic and scientific concerns regarding human twinning and embryo fusion: Is the embryo one human or two (or even more)? Does the original embryo die, and if not, which of the twins is the original? Who are the parents of the twins? What do twins, chimeras, cloning, and asexual reproduction in humans mean? And what does the science of human embryology say about human ensoulment, human individuality, and human value? Condic's original approach makes a unique contribution to the discussion of human value and human individuality, and offers a clear, evidence-based resolution to questions raised by human twinning. The book is written for students and scholars of bioethics, scientists, theologians, and attorneys who are involved in questions surrounding the human embryo.

Winner of the NCTE George Orwell Award for Distinguished Contribution to Honesty and Clarity in Public Language Although Roe v. Wade identified abortion as a constitutional right 45 years ago, it still bears stigma-a proverbial scarlet A. Millions of Americans have participated in or benefited from an abortion, but few want to reveal that they have done so. Approximately one in five pregnancies in the US ends in abortion. Why is something so common, which has been legal so long, still a source of shame and secrecy? Why is it so regularly debated by politicians, and so seldom divulged from friend to friend? This book explores the personal stigma that prevents many from sharing their abortion experiences with friends and family in private conversation, and the structural stigma that keeps it that way. In public discussion, both proponents and opponents of abortion's legality tend to focus on extraordinary cases. This tendency keeps the national debate polarized and contentious, and keeps our focus on the cases that occur the least. Professor Katie Watson focuses instead on the cases that happen the most, which she calls "ordinary abortion." Scarlet A gives the reflective reader a more accurate impression of what the majority of American abortion practice really looks like. It explains how our silence around private experience has distorted public opinion, and how including both ordinary abortion and abortion ethics could make our public exchanges more fruitful. In Scarlet A, Watson wisely and respectfully navigates one of the most divisive topics in contemporary life. This book explains the law of abortion, challenges the toxic politics that make it a public football and private secret, offers tools for more productive private exchanges, and leads the way to a more robust public discussion of abortion ethics. Scarlet A combines storytelling and statistics to bring the story of ordinary abortion out of the shadows, painting a rich, rarely seen picture of how patients and doctors currently think and act, and ultimately inviting readers to tell their own stories and draw their own conclusions.

Intrauterine insemination (IUI), also known as artificial insemination, is a fertility treatment that uses a catheter to place washed sperm directly into the uterus. Its aim is to increase the number of sperm reaching the fallopian tubes and subsequently increase the chances of fertilisation (American Pregnancy Association). This book is the first in a new series, Handbook on Infertility. Beginning with an overview of Intrauterine Insemination, the following chapters guide readers step by step through the process, from basic science to clinical application. Ethical, psychosocial and medicolegal aspects are also covered. Written by an internationally recognised author and editor team, this useful manual serves as a quick reference guide and includes photographs, illustrations and tables to enhance learning. Key points First title in new series Handbook on Infertility Presents complete overview of intrauterine insemination Includes chapters on ethical, psychosocial and medicolegal aspects Internationally recognised author and editor team

This book comprehensively addresses female and male fertility preservation. It discusses in detail all major aspects of fertility preservation in both sexes, explains the basis of fertility preservation, and highlights the currently available techniques; further chapters are dedicated to specific diseases. The book offers an essential reference guide for all physicians, specialists or not, seeking to improve their grasp of female and male fertility preservation.

"Original, important, moving, witty and exquisitely-written. WHAT a feat." - BERNARDINE EVARISTO "Incredible... beautiful and funny and humane." - EMILIE PINE "Pristine poetry and prose." KATHERINE MAY, AUTHOR OF WINTERING "Babies who are this small, he says, have a good chance of survival. Small is not good for babies. It is not whimsical or cute or the cause of admiration. It is the first time it occurs to us that they might not survive. Babies die from smallness." Claire Lynch knew that having children with her wife would be complicated but she could never have anticipated the extent to which her life would be redrawn by the process. This dazzling debut begins with the smallest of life's substances, the microscopic cells subdividing in a petri dish in a fertility treatment centre. She moves through her story in incremental yet ever growing steps, from the fingernail-sized pregnancy test result screen which bears two affirmative lines to the premature arrival of her children who have to wear scale-model oxygen masks in their life-saving incubators. Devastatingly poignant and profoundly observant - and funny against the odds - Claire considers whether it is our smallness that makes our lives so big.

Humans and flies look nothing alike, yet their genetic circuits are remarkably similar. Here, Lewis I. Held, Jr compares the genetics and development of the two to review the evidence for deep homology, the biggest discovery from the emerging field of evolutionary developmental biology. Remnants of the operating system of our hypothetical common ancestor 600 million years ago are compared in chapters arranged by region of the body, from the nervous system, limbs and heart, to vision, hearing and smell. Concept maps provide a clear understanding of the complex subjects addressed, while encyclopaedic tables offer comprehensive inventories of genetic information. Written in an engaging style with a reference section listing thousands of relevant publications, this is a vital resource for scientific researchers, and graduate and undergraduate students.

Why do American couples differ in the number of children they have? To answer this question the first major longitudinal study in American fertility was begun in 1957 with a series of interviews with parents of two children. Family Growth in Metropolitan America (1961) and The Third Child (1963) reported the results of the first two phases of this research project. In this book, in addition to evaluating the longitudinal design of the study, the authors report the results of the third and final interviews, a decade after the first, and attempt to answer such questions as: How well are couples able to predict their own fertility over the years? To what extent does the number of children desired affect the spacing of births? How is fertility affected by peer group relations, by the wife's participation in the labor force, by religion? Originally published in 1971. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Has the college experience of women been an influence on the number of children desired and the number and spacing of their children? Do women come to college with their attitudes and values in this regard already formed? This study of 15,000 women, freshmen and seniors in 45 American colleges and universities, both secular and nonsecular, attempts to answer this question and to determine how such characteristics as religious preference, career intentions, and the number of children in her own family influence a woman's fertility values. Attention is paid to an earlier finding that Catholic college graduates have higher fertility than Catholic high school graduates, although higher education is usually associated with lower fertility. Originally published in 1967. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Node.js, MongoDB and Angular Web Development The definitive guide to using the MEAN stack to build web applications Node.js is a leading server-side programming environment, MongoDB is the most popular NoSQL database, and Angular is the leading framework for MVC-based front-end development. Together, they provide an easy-to-implement, fully integrated web development stack that allows web programmers to create high-performance sites and applications built completely in JavaScript, from server to client. Updated for Angular 2, Angular 4, and subsequent versions, this new edition of Node.js, MongoDB and Angular Web Development shows you how to integrate these three technologies into complete working solutions. It begins with concise, crystal-clear tutorials on each technology and then quickly moves on to building common web applications. You'll learn how to use Node.js and MongoDB to build more scalable, high-performance sites, how to leverage Angular's innovative MVC approach to structure more effective pages and applications, and how to use all three together to deliver outstanding next-generation Web solutions. Implement a highly scalable and dynamic web server using Node.js and Express Implement a MongoDB data store for your web applications Access and interact with MongoDB from Node.js JavaScript code Learn the basics of TypeScript Define custom Angular directives that extend the HTML language Build server-side web services in JavaScript Implement client-side services that can interact with the Node.js web server Build dynamic browser views that provide rich user interaction Add authenticated user accounts and nested comment components to your web applications and pages Contents at a Glance Part I: Getting Started 1 Introducing the Node.js-to-Angular Stack 2 JavaScript Primer Part II: Learning Node.js 3 Getting Started with Node.js 4 Using Events, Listeners, Timers, and Callbacks in Node.js 5 Handling Data I/O in Node.js 6 Accessing the File System from Node.js 7 Implementing HTTP Services in Node.js 8 Implementing Socket Services in Node.js 9 Scaling Applications Using Multiple Processors in Node.js 10 Using Additional Node.js Modules Part III: Learning MongoDB 11 Understanding NoSQL and MongoDB 12 Getting Started with MongoDB 13 Getting Started with MongoDB and Node.js 14 Manipulating MongoDB Documents from Node.js 15 Accessing MongoDB from Node.js 16 Using Mongoose for Structured Schema and Validation 17 Advanced MongoDB Concepts Part IV: Using Express to Make Life Easier 18 Implementing Express in Node.js 19 Implementing Express Middleware Part V: Learning Angular 20 Jumping into TypeScript 21 Getting Started with Angular 22 Angular Components 23 Expressions 24 Data Binding 25 Built-in Directives Part VI: Advanced Angular 26 Custom Directives 27 Events and Change Detection 28 Implementing Angular Services in Web Applications 29 Creating Your Own Custom Angular Services 30 Having Fun with Angular

Frank Nawroth thematisiert das Social Freezing und die zugehoerige Beratung, die nicht nur Chancen, sondern auch denkbare Komplikationen und Grenzen der Methode aufzeigen muss. Zum Beispiel haben die gesellschaftspolitisch nicht optimal geloeste Problematik des moeglichen Karriere-Nachteils einer berufstatigen Mutter oder die haufig bestehende Schwierigkeit, den geeigneten Partner zu finden, bei gleichzeitig verbesserten Kryokonservierungsmethoden dazu gefuhrt, dass Frauen ohne medizinische Indikation uber das Einfrieren ihrer Eizellen nachdenken. Die Technologie selbst ist seit Langerem Routine vor fertilitatsbeeintrachtigenden Therapien onkologischer Erkrankungen (Operation, Strahlen- und/oder Chemotherapie) im reproduktiven Alter.

Maintaining consistent and reliably high success rates is a daily challenge for every IVF laboratory. This step-by-step guide is an essential aid in navigating the complex maze of physical, chemical, biological, and logistic parameters that underpin successful gamete and embryo culture: temperature, pH, osmolality, gas supplies, air quality, light exposure, infections, managing supplies, personnel, as well as overall quality control. Numerous real-life troubleshooting case reports are presented, identifying all aspects necessary for troubleshooting. Process maps and flow charts accompanying each chapter offer a logical and systematic approach to problem solving in the laboratory. This is an essential resource for scientists in assisted reproductive technology and specialists in reproductive biology and medicine, helping IVF clinics to achieve the dream of every infertile couple: the birth of a healthy child.

Millions of Americans rely on the likes of birth control, IVF, and genetic testing to make plans as intimate and farreaching as any over a lifetime. This is no less than the medicine of miracles. It fills empty cradles, frees families from terrible disease, and empowers them to fashion their lives on their own terms. But accidents happen. Pharmacists mix up pills. Lab techs misread tests. Obstetricians tell women their healthy fetuses would be stillborn. Political and economic forces conspire against regulation. And judges throw up their hands when professionals foist parenthood on people who didn't want it, or childlessness on those who did. Failed abortions, switched donors, and lost embryos may be first-world problems. But these aren't innocent lapses or harmless errors. They're wrongs in need of rights. This book lifts the curtain on reproductive negligence, gives voice to the lives it upends, and vindicates the interests that advances in medicine and technology bring to full expression. It charts the legal universe of errors that: (1) deprive pregnancy or parenthood of people who set out to pursue them; (2) impose pregnancy or parenthood on those who tried to avoid these roles; or (3) confound efforts to have a child with or without certain genetic traits. This novel architecture forces citizens and courts to rethink the reproductive controversies of our time, and equips us to meet the new challenges-from womb transplants to gene editing-that lie just over the horizon.

'Quite simply the best book about science and life that I have ever read' - Alice Roberts How does life begin? What drives a newly fertilized egg to keep dividing and growing until it becomes 40 trillion cells, a greater number than stars in the galaxy? How do these cells know how to make a human, from lips to heart to toes? How does your body build itself? Magdalena Zernicka-Goetz was pregnant at 42 when a routine genetic test came back with that dreaded word: abnormal. A quarter of sampled cells contained abnormalities and she was warned her baby had an increased risk of being miscarried or born with birth defects. Six months later she gave birth to a healthy baby boy and her research on mice embryos went on to prove that - as she had suspected - the embryo has an amazing and previously unknown ability to correct abnormal cells at an early stage of its development. The Dance of Life will take you inside the incredible world of life just as it begins and reveal the wonder of the earliest and most profound moments in how we become human. Through Magda's trailblazing research as a professor at Cambridge - where she has doubled the survival time of human embryos in the laboratory, and made the first artificial embryo-like structures from stem cells - you'll discover how early life is programmed to repair and organise itself, what this means for the future of pregnancy, and how we might one day solve IVF disorders, prevent miscarriages and learn more about the dance of life as it starts to take shape. The Dance of Life is a moving celebration of the balletic beauty of life's beginnings.

IVF can seem like a daunting prospect. An often expensive emotional and physical rollercoaster, and one that is filled with new and strange jargon. How do you choose a clinic or decide which treatment options are right for you? And how do you avoid getting sucked into a black hole of late night googling, searching for answers? This fully up to date handbook contains everything you need to know about the ever evolving world of IVF, with professional insights from top level consultants and counsellors. Science journalist Jheni Osman holds your hand through the process, taking you step by step through each stage, and cuts through the confusing terminology and information overload. Find out exactly how IVF and ICSI work, what the different medications involved do, and the costs involved. Learn about why some of us struggle to conceive, how to handle the ups and downs, and what can be done to improve your chances of conception via IVF.

This concise, truncated version of Zini and Agarwal's Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction offers select, research-oriented chapters for a handy, more affordable, state-of-the-art resource. Sperm Chromatin for the Researcher addresses such vital issues as: - Structure and function of human sperm chromatin - Biological determinants of sperm chromatin damage - Laboratory evaluation of sperm chromatin - Protocols to measure sperm chromatin damage Ideal for novice and experienced researchers alike, Sperm Chromatin for the Researcher contains all of the need-to-know information about these cutting-edge topics in reproductive medicine.

The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook - inspired by the postgraduate degree program at the University of Oxford - guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.

This book presents the latest insights into all the critical aspects of Klinefelter's Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more "evidence-based" support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.

In Taking Baby Steps, Jody Lynee Madeira takes readers inside the infertility experience, from dealing with infertility-related emotions through forming treatment relationships with medical professionals to confronting difficult medical decisions. Based on hundreds of interviews, this book investigates how women, men, and medical professionals negotiate infertility's rocky terrain to create life and build families-a journey across personal, medical, legal, and ethical minefields that can test mental and physical health, friendships and marriages, spirituality, and financial security.