Late aging associated changes in alcohol sensitivity, neurobehavioral function, and neuroinflammation, Volume 148, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

Infertility affects an estimated 50 million women worldwide and has a wide range of causes including eating disorders, smoking, chemotherapy, diseases such as STIs, as well as genetic factors and malformations. The preliminary assessment and diagnosis involves a potentially broad array of lab and imaging tests, physical examination and potentially genetic tests, after which a management plan is selected depending on the woman’s age, the cause(s) and duration of the infertility. Female Infertility: Core Principles and Clinical Management provides clinicians with a comprehensive understanding of how best to overcome infertility using the various treatment options now available. The book opens with an introduction to the anatomy and physiology of the female reproductive system before describing the assessment and investigative tools used in primary and secondary healthcare settings. Subsequent chapters describe how to secure optimum functionality of the ovaries, the measurement of ovarian reserves, stimulation protocols and the process of oogenesis and oocyte collection. Given their potential adverse impact on the quality of oocytes and implantation, dedicated chapters focus on the treatment of polycystic ovarian syndrome and endometriosis. Concluding chapters address fast moving and future technologies, including the use of pluripotent stem cells for treating different medical conditions; the management of mitochondrial disease and the transplantation of cryopreserved ovaries. Highly illustrated and written by a team of international experts in the field, Female Infertility: Core Principles and Clinical Management serves as an essential resource for all clinicians, nurses and clinical scientists who specialise in reproductive medicine, gynecology, oncology, infertility and embryology.

This volume explores the latest clinical and basic science advances in the field of reproductive sciences. Contributions from leading experts in the field cover a wide breadth of topics from in vitro fertilization to stem cell biology.Special focus is given to discussion of major obstacles in making clinical progress in the fields of in vitro fertilization, endometriois, uterine and ovarian transplantation, recurrent pregnancy loss, and preterm delivery. Novel evidence-based approaches to advance the field are discussed, including in vitro molecular approaches, translational studies, as well as those that may immediately be considered for use at the bedside to improve reproductive outcomes.

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As an objective of human security, it is important to understand the social system and to make more appropriate policies for people based on the bio-psycho-social viewpoint of health advocated by the World Health Organization (WHO). For countries with increasingly large populations of older adults, aging-related disorders cause many social handicaps. A comprehensive approach for integrating not only medical, but also psychosocial and spiritual viewpoints is needed for better health policy planning.During a risky situation such as a major disaster, which can critically affect peoples lives, people should utilize their brains more fully in order to survive; i.e., to understand the situation around them, to make a proper judgment call, and to choose their behaviors. All of these approaches are associated with brain functions. Understanding the situation primarily requires the posterior part of the brain, especially the parietal lobe.Briefly, the occipital, temporal, parietal, and frontal lobes are related to visual, auditory, other sensory, and motor functions, respectively. Each lobe has primary and secondary areas: The former is associated with primary function, whereas the latter is related to association functions, which add meaning to the primary information. In particular, visual and auditory information should be fully integrated to understand the situation and make a judgment call, which is the function of the parietal lobe.Human Security: Social Support for the Health of an Aging Population Based on Geriatric Behavioral Neurology is meant to help readers understand the bio-psycho-social viewpoint and bioethics of social support for elderly people. The second aim is to understand the social support system and Quality of Life (QOL) for handicapped and elderly people. Especially, the long-term care insurance system for elderly people in Japan, which is a well-organized system to support well-being in the elderly, needs to be understood. Also, dementia is one of the important age-related disorders that can affect not only patients themselves, but also their families, community residents, and society. The third objective is to understand dementia and dementing diseases, not only from a medical perspective, but in terms of psychosocial and spiritual aspects. Following the Great East Japan Earthquake of 2011, various cases of weakness due to the disaster were analyzed. Most of them were previously assessed as a borderline condition between healthy and dementia. Therefore, it is important to routinely screen community residents for security.All risky situations such as a disaster should be treated internationally. The author recalls that one student told them that the Indonesian government faces difficulties in preparing for a disaster with a unified language. Indeed, more than 700 regional languages are spoken in Indonesias numerous islands. However, disasters do not select a language. The author is certain that there are some lessons from their history that have not been recorded in a common language. It is important to establish a network based not only on local culture and language, but also a global proposal based on a common language.The author hopes that young scientists in the next generation will have an integrated perspective and will apply science to human security worldwide.