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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cell Signaling During Mammalian Early Embryo Development (Hardcover, 2015 ed.)
Loot Price: R3,371
Discovery Miles 33 710
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Cell Signaling During Mammalian Early Embryo Development (Hardcover, 2015 ed.)
Series: Advances in Experimental Medicine and Biology, 843
Expected to ship within 12 - 17 working days
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Total price: R3,391
Discovery Miles: 33 910
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The book considers signaling events from the zygote embryo through
to the blastocyst with relevant data from embryonic stem (ES)
cells, including dialogue with the extracellular environment and
with the maternal tract during the implantation process.
Application of the knowledge described to improve the success of
human and animal assisted conception is considered where
appropriate, but the focus is largely on fundamental rather than
applied cell/molecular biology, as this is the area that has
historically been neglected. While the general features of
metabolism during preimplantation development are well established,
especially in terms of nutrient requirements, uptake and fate,
remarkably little is known about early embryo signaling events,
intracellular or intercellular, between individual embryos in vitro
or with the female reproductive tract in vivo. This contrasts with
the wealth of information on cell signaling in somatic cells and
tissues, as a glance at any textbook of biochemistry illustrates.
This lack of information is such that our understanding of the
molecular cell biology of early embryos -- a prerequisite to
defining the mechanisms which regulate development at this critical
stage of the life cycle -- is seriously incomplete. This volume is
the first to address this issue by describing the current state of
knowledge on cell signaling during mammalian early embryo
development and highlighting priority areas for research.
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