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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology

Revival: Rat Hybridomas and Rat Monoclonal Antibodies (1990) (Hardcover): Herve Bazin Revival: Rat Hybridomas and Rat Monoclonal Antibodies (1990) (Hardcover)
Herve Bazin
R5,574 Discovery Miles 55 740 Ships in 12 - 19 working days

The purpose of this book is to provide information which supports the fact that rat hybridomas are no more difficult to develop than mouse hybridomas. This is the first book devoted to the development of rat hybridomas. It includes theories, step-by-step techniques, ingredients and apparatus. The focus of this work is on the antibody repertoire, the unique biological properties of rat immunoglobulins, the one-step purification procedure by immunoaffinity chromatography, the absence of C-type particles, and the easy production of large amounts of ascitic fluid containing rat MAb. This rare publication is an absolute must for all scientists using MAbs and those interested in the fields of immunology, biotechnology, and biochemistry.

The Best Guide to Allergy (Hardcover, 3rd ed. 1994): Nathan D. Schultz, Allan V. Giannini, Terrance T. Chang, Diane C. Wong The Best Guide to Allergy (Hardcover, 3rd ed. 1994)
Nathan D. Schultz, Allan V. Giannini, Terrance T. Chang, Diane C. Wong
R1,471 Discovery Miles 14 710 Ships in 12 - 19 working days

In The Best Guide to Allergy, medical experts answer all your personal concerns and questions about allergy and asthma in easily understood language. Drawing on their extensive experience in treating both children and adults, as well as on the latest research findings, they offer up-to-date, explanations of the causes, care, treatment, remedies, and prevention of these uncomfortable, often debilitating, and sometimes even life-threatening ailments.

The Neuroimmunological Basis of Behavior and Mental Disorders (Hardcover, 2009 ed.): Allan Siegel, Steven S. Zalcman The Neuroimmunological Basis of Behavior and Mental Disorders (Hardcover, 2009 ed.)
Allan Siegel, Steven S. Zalcman
R4,611 Discovery Miles 46 110 Ships in 10 - 15 working days

For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were those whose efforts were directed at establishing neuroimmune connections as well as others whose research focused upon the relationship between immunity, cytokines, and behavior. This book brings together outstanding scientists and clinicians who have made major contributions to the rapidly developing eld investigating the relationship between immunity and behavior. The book is divided into three parts. The rst part describes pathways by which the brain and immune systems communicate and int- act with each other. In the chapter "Cytokines and the Blood-Brain Barrier" p- vides insight into interactions between the blood-brain barrier and cytokines. Such interactions underlie basic communication between the immune system and brain that are present in normal as well as in disease conditions. In the chapter "Neu- chemical and Endocrine Responses to Immune Activation: The Role of Cytokines," the neurochemical and endocrine consequences of immune challenge and cytokine administration on central neurotransmitter activity are discussed.

Interaction of Immune and Cancer Cells (Hardcover, 2nd ed. 2022): Magdalena Klink, Izabela Szulc-Kielbik Interaction of Immune and Cancer Cells (Hardcover, 2nd ed. 2022)
Magdalena Klink, Izabela Szulc-Kielbik
R5,136 Discovery Miles 51 360 Ships in 10 - 15 working days

Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.

Revival: Hepatocyte and Kupffer Cell Interactions (1992) (Hardcover): Timothy R. Billiar, Ronald D. Curran Revival: Hepatocyte and Kupffer Cell Interactions (1992) (Hardcover)
Timothy R. Billiar, Ronald D. Curran
R5,842 Discovery Miles 58 420 Ships in 12 - 19 working days

Hepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. Microanatomy and methods of experimental study are covered as well. In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states. Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.

Handbook of Eicosanoids (1987) - Volume I, Part A (Hardcover): A.L. Willis Handbook of Eicosanoids (1987) - Volume I, Part A (Hardcover)
A.L. Willis
R6,744 Discovery Miles 67 440 Ships in 12 - 19 working days

Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text.

Immunology - Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy (Paperback): M. A. Hayat Immunology - Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy (Paperback)
M. A. Hayat
R4,283 R3,982 Discovery Miles 39 820 Save R301 (7%) Ships in 12 - 19 working days

Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an improved understanding of the immune system, avoidance of unhealthy habits (e.g., smoking, intake of alcohol, perpetual stress, and lack of exercise) and early detection (using biomarkers) are the only three friends we have to at least delay the onset of serious diseases.

Immunoepidemiology (Hardcover, 1st ed. 2019): Peter J. Krause, Paula B. Kavathas, Nancy H. Ruddle Immunoepidemiology (Hardcover, 1st ed. 2019)
Peter J. Krause, Paula B. Kavathas, Nancy H. Ruddle
R3,126 Discovery Miles 31 260 Ships in 9 - 17 working days

This textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled "Immunology for Epidemiologists" at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.

Dermatopathology, An Issue of Clinics in Laboratory Medicine, Volume 37-3 (Hardcover): Steven D. Billings Dermatopathology, An Issue of Clinics in Laboratory Medicine, Volume 37-3 (Hardcover)
Steven D. Billings
R2,177 R2,065 Discovery Miles 20 650 Save R112 (5%) Ships in 12 - 19 working days

This issue of Clinics in Laboratory Medicine, edited by Dr. Steven Billings, will cover Dermatopathology. Topics covered in this issue include Blue nevi and related lesions, sentinel lymph node biopsies in melanoma, Spitzoid melanocytic neoplasms, Tumor immunology related to melanoma, Molecular aspects of melanoma, Merkel cell carcinoma, Cutaneous Squamous Cell Carcinoma, Cutaneous T-cell lymphomas, Cutaneous B-cell lymphomas, Myeloid neoplasms, among others.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 12 (Hardcover): M. A. Hayat Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 12 (Hardcover)
M. A. Hayat
R4,153 R3,873 Discovery Miles 38 730 Save R280 (7%) Ships in 12 - 19 working days

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating 'toxic assets' and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms.

Drug Allergy Testing (Hardcover): David Khan, Aleena Banerji Drug Allergy Testing (Hardcover)
David Khan, Aleena Banerji
R2,154 Discovery Miles 21 540 Ships in 12 - 19 working days

With a focus on improving diagnosis and treatment, Drug Allergy Testing is your new go-to resource for understanding various drug allergies and testing methods, the epidemiology of and economic impact of drug allergies, and new drug and allergy developments. Features a wealth of up-to-date information for allergists, immunologists, and primary care physicians who diagnose and treat patients with drug allergies and hypersensitivity. Covers the basics of drug allergy evaluation and management as well as specific drugs including antibiotics, ASA/NSAIDs, chemotherapeutic agents and monoclonal antibodies.

Advances in Immunology, Volume 135 (Hardcover): Frederick Alt Advances in Immunology, Volume 135 (Hardcover)
Frederick Alt
R4,621 Discovery Miles 46 210 Ships in 12 - 19 working days

Advances in Immunology, Volume 135, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this latest update including chapters on GPCR Biology, the Role of Caveolin-1 in BCR and TCR Receptors, New Developments in the Chemokine Field, and The Complement System in Developmental Neurobiology and Neurodegeneration. Readers will find comprehensive information on molecular and cellular activation mechanisms, phylogeny and molecular evolution and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Nanomedicine for Inflammatory Diseases (Hardcover): Lara Scheherazade Milane, Mansoor M. Amiji Nanomedicine for Inflammatory Diseases (Hardcover)
Lara Scheherazade Milane, Mansoor M. Amiji
R5,859 Discovery Miles 58 590 Ships in 12 - 19 working days

Nanomedicine for Inflammatory Diseases is a cutting-edge resource for clinicians and scientists alike, working at the intersection of development and clinical therapeutics. This text is ideal for graduate level courses in nanomedicine, translational medicine, or inflammatory disease. This book is a progressive hallmark in translational medicine as it unites clinicians treating inflammatory disease with scientists developing experimental nanomedicine therapeutics. The commonality is made through a translational nanomedicine expert - bridging the gap between the laboratory benchtop and the clinical bedside.

Advances in Applied Microbiology, Volume 100 (Hardcover): Geoffrey Michael Gadd, Sima Sariaslani Advances in Applied Microbiology, Volume 100 (Hardcover)
Geoffrey Michael Gadd, Sima Sariaslani
R3,288 Discovery Miles 32 880 Ships in 12 - 19 working days

Advances in Applied Microbiology, Volume 100 continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. This latest release includes specific chapters on a variety of topics, most notably, Current interventions for controlling pathogenic Escherichia coli, Microbial ecology and process technology of sourdough fermentation, Diversity, Application, and Synthetic Biology of Industrially Important Aspergillus Fungi, and Advances in the Microbial Ecology of Biohydrometallurgy. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

Biologic Therapies of Immunologic Diseases, An Issue of Immunology and Allergy Clinics of North America, Volume 37-2... Biologic Therapies of Immunologic Diseases, An Issue of Immunology and Allergy Clinics of North America, Volume 37-2 (Hardcover)
Bradley E. Chipps, Stephen P. Peters
R2,070 Discovery Miles 20 700 Ships in 12 - 19 working days

This issue of Immunology and Allergy Clinics, guest edited by Drs. Bradley Chipps and Stephen Peters, is devoted to Biologic Therapies of Immunologic Diseases. Articles in this issue include: Immunologic Mechanisms and Potential Targets; Strategies for Immunologic Interventions; Patient Characteristics and Individualization of Therapy; Biologic Therapies for Autoimmune and Connective Tissue Diseases; Biologic Therapies for Skin Disease including Urticaria; Biologic Therapies for Asthma; Biologic Therapies for Rhinitis and Sinusitis; Biologic Therapies for Chronic Obstructive Pulmonary Disease; Biologic Therapies for Food Allergies and Eosinophilic Esophagitis; Future Prospects for Biologic Therapies of Immunologic Diseases; Pharmacoeconomics of Biologic Therapy; and Adverse Reaction to Biologic Therapy.

Milestones in Immunology - Based on Collected Papers (Paperback): Domenico Ribatti Milestones in Immunology - Based on Collected Papers (Paperback)
Domenico Ribatti
R1,753 Discovery Miles 17 530 Ships in 12 - 19 working days

Milestones in Immunology: Based on Collected Papers contains scientific milestones relating to the history of medicine over the past two centuries. The book highlights the contributions of pioneering scientists whose discoveries have paved the way for researchers working in the field of immunology. As the science of immunology grew from knowledge that survivors of common infectious diseases rarely contracted them again, the book uses this as a central thesis, helping readers understand how the adaptive immune system aids in defense against pathogens. In addition, the book covers special fields, such as immunohistochemistry, immunogenetics and immunopathology. For the past century, immunology has fascinated and inspired some of the greatest scientists of our time. Numerous Nobel Prizes have been awarded for fundamental discoveries in immunology, from Paul Ehrlich' work on antibodies (1908) to the studies of Zinkernagel and Doherty (1986) elucidating mechanisms of cell-mediated immunity.

Glycoimmunology - Proceedings of the Third Jenner International Glycoimmunology Meeting Held in Il Ciocco, Tuscany, Italy,... Glycoimmunology - Proceedings of the Third Jenner International Glycoimmunology Meeting Held in Il Ciocco, Tuscany, Italy, October 11-14, 1994 (Hardcover)
A. Alavi, J.S. Alford, John S. Axford
R2,609 Discovery Miles 26 090 Ships in 12 - 19 working days

Glycoprotein Analysis: A Review of the Biological Significance of Carbohydrates on Glycoproteins and Methods for Their Analysis; R. Dennis The Different FACES of Diseases; J. Klock, C.M. Starr The Glycosyltransferases: Control and Function of Complextype Oligosaccharide Synthesis: Novel Variants of the LAcNAc Pathway; D.H. van den Eijnden, et al. The Regulation of Cell and Tissuespecific Expression of Glycans by Glycosyltransferases; A. Dinter, E.G. Berger Oligosaccharides and Biological Function: Olinked Nacetylglucosamine: The 'YinYang' of Ser/Thr Phosphorylation? G.W. Hart, et al. Heparan Sulphate and Protein Recognition: Binding Specificies and Activation Mechanisms; J.T. Gallagher Glycosylation and Disease: An Introduction to Glycosylation and Rheumatic Disease: What Is the Current State of Play? J.S. Axford, A. Alavi Abnormalities in the Glycosylation of IgG-Its Clinical Utility; D.A. Isenberg Carbohydrates and Therapeutics: Synthesis and Biological Activity of Oligosaccharide Libraries; Y. Ding, et al. In vivo Targeting Function of Nlinked Oligosaccharides; K.G. Rice, et al. 23 additional articles. Index.

Autoimmunity - Basic Principles and New Diagnostic  Tools Pt A (Paperback, New): M.E. Gershwin Autoimmunity - Basic Principles and New Diagnostic Tools Pt A (Paperback, New)
M.E. Gershwin
R3,345 Discovery Miles 33 450 Ships in 12 - 19 working days

The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results.

This volume contains the first section of the proceedings of a large, comprehensive meeting held in Sorrento, Italy. Because the meeting focused on such an important area of human health, four volumes have been dedicated to it: Part A presents new principles in autoimmunity, including the roles of key players such as designed ankyrin repeat proteins, SLAM-associated protein, interleukin-12, human proteinase 3, the complement system, IgG, disturbances in cytokine synthesis, and IFN-γ blockers. The second section of the volume takes a look at new diagnostic tools, including screening of endothelial expression libraries, electrical skin impedance, and IgA anti-tissue transglutaminase antibody assays.

"Autoimmunity, Part B" continues the presentation of basic research and its applications with a focus on genetics. Parts C and D present the clinical research in various manifestations of autoimmune disease and its treatments.

"NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit ""www.blackwellpublishing.com/nyas,"" "

"ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (""www.nyas.org""). Members of the New York Academy of Science receive full-text access to the Annals online anddiscounts on print volumes. Please visit ""www.nyas.org/membership/main.asp"" for more information about becoming a member.
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Allergic Hypersensitivities Induced by Chemicals - Recommendations for Prevention (Hardcover): Regional Office WHO/Europe Allergic Hypersensitivities Induced by Chemicals - Recommendations for Prevention (Hardcover)
Regional Office WHO/Europe; Contributions by Janos Gergely, Torkil Menne, Johannes Ring, Ian Kimber, …
R7,799 Discovery Miles 77 990 Ships in 9 - 17 working days

This book, commissioned by the World Health Organization (WHO) and written by international experts, provides consensus views on the most important issues related to allergic hypersensitivities. The text details predictive testing, diagnosis, epidemiological monitoring of intervention measures, sources of sensitizing agents, and mechanisms of action.
Contributors extensively cover allergic hypersensitivity reactions of the skin and the respiratory system. They present the current knowledge on hypersensitivity reactions of the gastrointestinal tract and kidneys. Major gaps in existing information about allergic hypersensitivities are highlighted and recommendations for future research are given. Practical methods are provided for establishing preventive programs.
Allergic Hypersensitivities Induced by Chemicals offers valuable information to both scientists and public health officials. This is a useful reference for health professionals in their work with allergies, allergens, and allergy sufferers.

Hepatitis Prevention and Treatment (Hardcover, 2004 ed.): Joseph M. Colacino, Beverly A. Heinz Hepatitis Prevention and Treatment (Hardcover, 2004 ed.)
Joseph M. Colacino, Beverly A. Heinz
R4,405 Discovery Miles 44 050 Ships in 10 - 15 working days

Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system for HCV replication and a readily accessible small-animal model of HCV infection have hampered the development of antiviral agents for HCV. Neverthe-less, new antiviral agents targeting HCV are now in preclinical and clinical development.

This monograph, providing an up-to-date overview of the field of Hepatitis Prevention and Treatment, includes contributions from internationally recognized experts in the field of viral hepatitis, and covers the current state of knowledge and practice regarding the molecular biology, immunology, biochemistry, pharmacology and clinical aspects of chronic HBV and HCV infection. The volume includes salient topics such as: the history and epidemiology of HBV and HCV; recent insights into the molecular mechanisms of viral replication; the host immune response to infection and a discussion of the use (HBV) or potential development (HCV) of vaccines; the current standard of care for chronically-infected patients; and emerging therapies and issues associated with current antiviral treatments. The latest information to researchers and clinicians actively engaged in viral hepatitis research is provided, but also sufficient background and discussion of the literature to benefit the newcomer to the field.

Advances in Applied Microbiology, Volume 99 (Hardcover): Geoffrey Michael Gadd, Sima Sariaslani Advances in Applied Microbiology, Volume 99 (Hardcover)
Geoffrey Michael Gadd, Sima Sariaslani
R3,277 Discovery Miles 32 770 Ships in 12 - 19 working days

Advances in Applied Microbiology, Volume 99 continues is one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. This volume presents comprehensive information on a variety of topics, including the Physiological Role of Two-Component Signal Transduction Systems in Food-Associated Lactic Acid Bacteria, Fungal Bio recovery of Gold from E-Waste, Stone-Eating Fungi: Mechanisms in Bio weathering and the Potential Role of Laccases in Black Slate Degradation with the Basidiomycete Schizophyllum commune, and the Arsenic Detoxification System in Corynebacteria: Basis and Application for Bioremediation and Redox Control. This serial's eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation.

Advances in Immunology, Volume 134 (Hardcover): Frederick Alt Advances in Immunology, Volume 134 (Hardcover)
Frederick Alt
R4,645 Discovery Miles 46 450 Ships in 12 - 19 working days

Advances in Immunology, Volume 134, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Topics covered in this new volume include ?d T Cells and B Cells, A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes. Tissue Specific Regulation of Dendritic Cell Development and Function, and the Regulation of Innate and Adaptive Immunity by Transforming Growth Factor Beta (TGFss). Articles in this long running series address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Immunotoxicology Of Environmental And Occupational Metals (Hardcover): Judith T. Zelicoff, Peter Thomas Immunotoxicology Of Environmental And Occupational Metals (Hardcover)
Judith T. Zelicoff, Peter Thomas
R7,115 Discovery Miles 71 150 Ships in 10 - 15 working days

Provides an overview of the effects of environmentally and occupationally important metals on the immune system and host defence. The fist ten chapters in the text focus on particular metals or groups of metals, including arsenic, beryllium, cadmiun, chronium, lead, mercury, nickel and vanadium. Subsequent chapters examine the immunotoxicological effects of trace metals such as indium and platinum and essential metals such as iron, zinc and copper. The main emphasis is on the "in vivo" and "in vitro" effects of these metals on host immune responses in a variety of mammalian species including humans. Each chapter also briefly reviews the history, use, occurance, biology and toxicology of the metals.

Gene Therapy for HIV and Chronic Infections (Hardcover, 2015 ed.): Ben Berkhout, Hildegund C. J. Ertl, Marc S. Weinberg Gene Therapy for HIV and Chronic Infections (Hardcover, 2015 ed.)
Ben Berkhout, Hildegund C. J. Ertl, Marc S. Weinberg
R4,164 R3,594 Discovery Miles 35 940 Save R570 (14%) Ships in 12 - 19 working days

This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990's. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.

Aspirin-Exacerbated Respiratory Disease, An Issue of Immunology and Allergy Clinics of North America, Volume 36-4 (Hardcover):... Aspirin-Exacerbated Respiratory Disease, An Issue of Immunology and Allergy Clinics of North America, Volume 36-4 (Hardcover)
Andrew A White
R2,048 Discovery Miles 20 480 Ships in 12 - 19 working days

This issue of Immunology and Allergy Clinics, guest edited by Dr. Andrew A. White, is devoted to Aspirin-Exacerbated Respiratory Disease. Articles in this issue include: An Overview of Non-Steroidal Anti-inflammatory Drug Reactions; The Clinical Presentation of Aspirin-Exacerbated Respiratory Disease; Diagnostic Evaluation in Aspirin-Exacerbated Respiratory Disease; Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis; Pathogenesis of Aspirin Reactions in Aspirin-Exacerbated Respiratory Disease; Performing Aspirin Desensitization; Clinical Trials in Aspirin-Exacerbated Respiratory Disease Treatment; Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease; Mechanisms of Benefit with Aspirin Therapy; Lipid Mediators in Aspirin-Exacerbated Respiratory Disease; and Epigenetic and Genetic Components of Aspirin-Exacerbated Respiratory Disease.

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