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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology

Basic and Clinical Immunology - with STUDENT CONSULT access (Paperback, 2nd edition): Mark Peakman, Diego Vergani Basic and Clinical Immunology - with STUDENT CONSULT access (Paperback, 2nd edition)
Mark Peakman, Diego Vergani
R1,358 Discovery Miles 13 580 Ships in 12 - 19 working days

Basic science and clinical immunology are demystified for the medical and other health sciences student. The basic immunological processes are described first, with a level of detail restricted to what is appropriate for medical and other similar curricula. In the second part of the book immunological mechanisms behind major diseases of the various body systems are explained. Throughout the text clinical details are highlighted and more in-depth material is differentiated from the main text. Covers both basic science and clinical immunology in one volume Specifically aimed at medical students and appropriate for integrated system-based curricula Main text supported by 'in depth', key point and clinical boxes Now full-colour throughout Specialised material removed and replaced with clearer introductory explanations Clearer illustrations, thanks to rewritten captions

Eosinophilic Gastrointestinal Diseases, An Issue of Immunology and Allergy Clinics, Volume 29-1 (Hardcover): Glen Furuta, Dan... Eosinophilic Gastrointestinal Diseases, An Issue of Immunology and Allergy Clinics, Volume 29-1 (Hardcover)
Glen Furuta, Dan Atkins
R1,816 Discovery Miles 18 160 Ships in 12 - 19 working days

Drs. Glen Furuta and Dan Atkins have assembled an in-depth look at Eosinophilic Gastrointestinal Diseases as related to allergy with topics such as "Basic pathogenetic mechanisms of Eosinophilic Esophagitis," "Nutritional management of patients with food allergies and EGIDs," "Chemotactic factors role in EGIDs," "Biomarkers associated with allergic diseases," "Association of other allergic diseases with EGIDs" and much more!

Pocket Guide to Gene Level Diagnostics in Clinical Practice (Hardcover): Victor A. Bernstam Pocket Guide to Gene Level Diagnostics in Clinical Practice (Hardcover)
Victor A. Bernstam
R1,767 Discovery Miles 17 670 Ships in 12 - 19 working days

Pocket Guide to Gene Level Diagnostics in Clinical Practice is an abbreviated, pocket-size, quick-reference guide that provides a point-by-point synopsis of the vast wealth of information contained in CRC Handbook of Gene Level Diagnostics in Clinical Practice. All sections and subsections in the Pocket Guide are cross-referenced to corresponding pages in the Handbook. The book works well on its own as a quick reference, but also can be used in conjunction with the larger Handbook for detailed coverage and references to specific information. Pocket Guide to Gene Level Diagnostics in Clinical Practice also includes extensive supplements featuring material not included in the Handbook. These are intended to provide an up-dated, practical source of information useful to anyone involved in molecular diagnostic research and/or service. Supplements are cross-referenced to the main text of the Pocket Guide, that complement and enhance the material covered. Pocket Guide to Gene Level Diagnostics in Clinical Practice will be a handy reference for professionals and students in pathology, biotechnology, biology, and medicine.

Oxygen Transport to Tissue XXX (Hardcover, 2009 ed.): Per Liss, Peter Hansell, Duane F. Bruley Oxygen Transport to Tissue XXX (Hardcover, 2009 ed.)
Per Liss, Peter Hansell, Duane F. Bruley
R5,638 Discovery Miles 56 380 Ships in 10 - 15 working days

In 1772 in Uppsala the Swedish chemist Karl Wilhelm Scheele discovered the element Oxygen. Two hundred and one years later, in 1973, the International Society on Oxygen Transport to Tissue (ISOTT) was founded. Since then there has been an annual ISOTT meeting. After 24 years of international ISOTT meetings it was decided, at the 2005 summit in Bary, Italy, that the 2007 meeting was to be held in Uppsala, Sweden. Thus, after the Louisville meeting we, in the Uppsala group, withdrew to the Edgewater Resort at Taylorsville Lake outside Louisville and prepared the Uppsala ISOTT meeting by tasting Kentucky Bourbons, smoking cigars while bathing in a jacuzzi in the hot dark Kentucky night full of fire flies and a sky full of stars. The ISOTT program should include different aspects of oxygen - however, it is accepted that each meeting has its own local "touch". We decided to focus the Uppsala ISOTT meeting on the theme of "Imaging and measuring oxygen changes". With this in mind we invited scientists within and outside the ISOTT society. We then also received lots of good abstracts from ISOTT members that were included in the program. Lars-Olof Sundeloef introduction speech "AIR AND FIRE" concerned how oxygen was discovered in Uppsala in 1772 by Karl Wilhelm Scheele. After the introduction speech a get together event took place in the magnificent and spacious foyer of Uppsala University main building. The vice chancellor Ulf Pettersson welcomed all delegates to Sweden and Uppsala.

Clinical Therapy Research In The Inflammatory Diseases (Hardcover): Ronald F van  Vollenhoven Clinical Therapy Research In The Inflammatory Diseases (Hardcover)
Ronald F van Vollenhoven
R2,273 Discovery Miles 22 730 Ships in 12 - 19 working days

This unique textbook provides information on the dramatic advances taking place in the field of inflammatory (autoimmune) diseases and their therapies. Experts in many different medical fields - allergology, dermatology, gastroenterology, pulmonology, rheumatology etc. - will describe the advances in our understanding of the most important inflammatory diseases linking basic science discoveries to the advances in therapeutics that have taken place over the past years and foreshadow even more dramatic changes which will occur in the years to come. This is a truly multi-specialty bench-to-bedside textbook that will enable readers to gain a wide-ranging but also solidly built understanding of the therapeutic areas of inflammatory diseases.

The Hypothalamus-Pituitary-Adrenal Axis, Volume 7 (Hardcover): Adriana Del Rey, George Chrousos, Hugo Besedovsky The Hypothalamus-Pituitary-Adrenal Axis, Volume 7 (Hardcover)
Adriana Del Rey, George Chrousos, Hugo Besedovsky
R3,682 Discovery Miles 36 820 Ships in 12 - 19 working days

The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage.
This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease.
* Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle.
* Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later.

Endocrine Manifestations of Systemic Autoimmune Diseases, Volume 9 (Hardcover): Ronald Asherson Endocrine Manifestations of Systemic Autoimmune Diseases, Volume 9 (Hardcover)
Ronald Asherson; Volume editing by Sara Walker, Luis J. Jara
R4,320 Discovery Miles 43 200 Ships in 12 - 19 working days

This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly.
The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics.
*The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements
*Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy
*The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis

HIV and Aging (Paperback): Sharon Dian Lee HIV and Aging (Paperback)
Sharon Dian Lee
R2,565 Discovery Miles 25 650 Ships in 12 - 19 working days

More than two decades into the global HIV epidemic, many HIV positive patients who have access to antiretroviral medications are graying. These patients and their clinicians now face another set of complex health issues related to aging. HIV and Aging examines the known effects of HIV and HIV medications on older patients and on their immune systems. The book explores the coalescence of aging and HIV on neurologic, psychiatric, cardiovascular, endocrine, renal, and pulmonary systems and oncology.

Written by some of today 's top experts, HIV and Aging answers questions like:

  • What are the similarities with immune system changes that occur with aging and those associated with HIV?
  • What effects do HIV and HIV medications have on cardiovascular health?
  • What do we know about drug interactions between antiretrovirals and medicines used to treat diseases of aging?
Cytokines and the Brain, Volume 6 (Hardcover): Christopher P Phelps, Elena A. Korneva Cytokines and the Brain, Volume 6 (Hardcover)
Christopher P Phelps, Elena A. Korneva
R4,444 Discovery Miles 44 440 Ships in 12 - 19 working days

This book opens a new page of neuroimmunebiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of central nervous system cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer's disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment.
* Opens a new page of neuroimmunebiology and provides substantive evidence for the promise of this field in the treatment of disease
* Summarizes current understanding on the presence and function of CNS cytokines and their receptors in a variety of central nervous system cells during health and disease
* Includes novel approaches to the treatment of CNS disorders based on new experimental data
* Offers new insight into triggers forthe development of autoimmune diseases in the brain and the possibilities for treatment

Immunotherapy of Cancer - Methods and Protocols (Hardcover, Edition.): Patricia Yotnda Immunotherapy of Cancer - Methods and Protocols (Hardcover, Edition.)
Patricia Yotnda
R3,156 Discovery Miles 31 560 Ships in 10 - 15 working days

A continuously evolving technique, immunotherapy for the treatment of cancers now incorporates the use of immune cells infused during bone marrow transplants as well as approaches like cell and gene therapy, while stem cell-based therapies, tissue engineering, and targeting have also contributed to the latest successes in pre-clinical immunotherapy studies. In Immunotherapy of Cancer: Methods and Protocols, expert researchers in the field describe detailed procedures for trainees and experts in the area of basic, clinical science who wish to undertake their own cutting-edge immunotherapy studies. In addition to the protocols, the volume also contains two general overviews providing useful updates in each area as well as summaries of recent pre-clinical and clinical trials. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Immunotherapy of Cancer: Methods and Protocols seeks to guide scientists along the path to a further developed system of immunotherapeutic treatments in order to reduce and hopefully eradicate this terrible disease.

The Kidney in Systemic Autoimmune Diseases, Volume 7 (Hardcover): Justin Mason, Charles Pusey The Kidney in Systemic Autoimmune Diseases, Volume 7 (Hardcover)
Justin Mason, Charles Pusey; Series edited by Ronald Asherson
R4,148 Discovery Miles 41 480 Ships in 12 - 19 working days

This volume brings together an international group of clinicians and clinical scientists to contribute to a state-of the-art review of the underlying pathogenic mechanisms, methods of clinical assessment, classification and diagnosis of renal disease, combined with a detailed overview of treatment strategies. An essential reference source for all those involved with the care of patients with renal involvement in systemic autoimmune disease, and for those contributing to research into the underlying pathogenic mechanisms in these disorders.

Microbicides for Prevention of HIV Infection (Hardcover, 2014 ed.): Jeremy Nuttall Microbicides for Prevention of HIV Infection (Hardcover, 2014 ed.)
Jeremy Nuttall
R4,347 R3,490 Discovery Miles 34 900 Save R857 (20%) Ships in 12 - 19 working days

One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.

Medical Research and Innovation (Hardcover, 1st ed. 2021): Mieczyslaw Pokorski Medical Research and Innovation (Hardcover, 1st ed. 2021)
Mieczyslaw Pokorski
R3,611 Discovery Miles 36 110 Ships in 10 - 15 working days

This volume is dedicated to multidisciplinary research at the interface between basic biomedicine and clinical practice. This book guides best practice in the diagnosis and therapy while dealing with difficult-to-treat disorders of yet unclear etiology. Chapters address such disorders as granulomatosis with polyangiitis causing autoimmune-related multiorgan inflammation of blood vessels, increasingly widespread allergy to peanuts, occupational exposure to zinc oxide, and immunogenic responses to pneumococcal and influenza vaccination underlying their preventive effectiveness. Other hot issues deal with the proper use of fluid therapy in the perioperative period and a cognitive decline in lung transplant patients. A new physiotherapeutic approach of treating key myofascial trigger points in low-back pain appears highly beneficial in reducing patients' disability, advancing physiotherapy of this overwhelming condition. Finally, other chapters consider ways to streamline medical management to increase the number of physicians and their availability for patients, a particularly sensitive issue in the current COVID-19 pandemic. The dissemination of clinical knowledge about high-risk and hardly controllable conditions is an inalienable part of progress in medical practice. The book is a resource for clinical specialists, general practitioners, and allied healthcare professionals.

Encyclopedia of Buddhism (Hardcover): Damien Keown, Charles S. Prebish Encyclopedia of Buddhism (Hardcover)
Damien Keown, Charles S. Prebish
R9,991 Discovery Miles 99 910 Ships in 12 - 19 working days

Reflects the current state of scholarship in Buddhist Studies, its entries being written by specialists in many areas, presenting an accurate overview of Buddhist history, thought and practices, most entries having cross-referencing to others and bibliographical references. Contain around 1000 pages and 500,000 words, totalling around 1200 entries.

Henipavirus - Ecology, Molecular Virology, and Pathogenesis (Hardcover, 2012 ed.): Benhur Lee, Paul A. Rota Henipavirus - Ecology, Molecular Virology, and Pathogenesis (Hardcover, 2012 ed.)
Benhur Lee, Paul A. Rota
R5,101 Discovery Miles 51 010 Ships in 10 - 15 working days

Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular virology, and pathogenesis of henipavirus infections. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. The first section introduces the epidemiology and ecology of Nipah and Hendra viruses in their respective endemic areas, including a first-hand account of the discovery of Nipah virus during its initial outbreak in Malaysia; the next section documents the molecular virology of henipaviruses, and the substantial advances made towards understanding the unique features of henipavirus entry and tropism; and this is followed by accounts of the clinical and pathologic features of henipavirus infections in their human and naturally infected animal hosts. The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. The final sections describe our current and future capabilities for diagnosis and control, including an account of potentially effective immunization strategies that are currently being tested. This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.

Technical Advances in AIDS Research in the Human Nervous System - Proceedings of a NIH Workshop Held in Washington D.C.,... Technical Advances in AIDS Research in the Human Nervous System - Proceedings of a NIH Workshop Held in Washington D.C., October 4-5, 1993 (Hardcover, New)
Eugene O. Major, Etc
R2,616 Discovery Miles 26 160 Ships in 12 - 19 working days

New Concepts in the Pathogenesis of HIV1 Encephalopathy: HIV Encephalopathy: Clinical and Diagnostic Considerations (J.R. Berger, R. Kaderman). Models of HIV1 Infection and Neurotoxicity in the Human Fetal Nervous System: Overview: Models of HIV1 Infection and Neurotoxicity in the Human Fetal Nervous System (L.G. Epstein). Model Cell Cultures from Adult Brain and Glioma Cell Lines: Molecular Interaction of HIV1 in Glioma Cells (V. Erfle et al.). Neurotropism of HIV1 Strains: Contribution of V3 and Reverse Transcriptase Sequence Analysis to Understanding the Concept of HIV1 Neurotropism (F. Chiordi et al.). Molecular Technology for the Detection and Analysis of HIV1 in Nervous System Tissue: Detection of HIV1 Gene Sequences in Brain Tissue by in situ Polymerase Chain Reaction (O. Bagasra et al.). Development of New Techniques and Methods Applied to AIDS: Technology in PCR and PCR Evaluation Technology and Its Application to the Study of Cerebrospinal Fluid in HIV Disease (P. Schmid). Focus on AIDS and the Nervous System: Challenges During the Decade of the Brain: Treatment of the Neurological Complications in AIDS: The AIDS Clinical Trials Group in the 1990s (D.B. Clifford). 18 additional articles. Index.

Haemophilus influenzae Protocols (Hardcover, 2003 ed.): Mark A Herbert, Derek W Hood, E. Richard Moxon Haemophilus influenzae Protocols (Hardcover, 2003 ed.)
Mark A Herbert, Derek W Hood, E. Richard Moxon
R2,915 Discovery Miles 29 150 Ships in 10 - 15 working days

In HaemophilusiInfluenzae Protocols, leading research scientists and infectious disease specialists detail in a readily reproducible format the major molecular and immunological techniques for exploring the pathogenicity of H. influenzae. Described with step-by-instructions to ensure robust and successful experimental results, the techniques cover plasmid analysis, proteomics, genomics, DNA array technology, gene expression, mutagenesis (transposon and nontransposon), and structural analysis. These methods illuminate how the bacterium causes disease, as well as how best to develop novel vaccines and antibiotics against the organism.

Natural Immunity, Volume 5 (Hardcover): Lorand Bertok, Donna Chow Natural Immunity, Volume 5 (Hardcover)
Lorand Bertok, Donna Chow
R3,288 Discovery Miles 32 880 Ships in 12 - 19 working days

"Natural Immunity" is a broadly-based account of the activities of the evolutionarily conserved molecules, cells and processes of the natural immune system. This encompasses the early host protection against microbes (bacteria and viruses) and tumours, prior to the generation of the adaptive immune response, diverse major current pathologies including inflammatory and autoimmune diseases, and key roles in essential physiological processes such as reproduction and wound healing.
* The first comprehensive book on natural immunity
* Reviews new topics, effects of behaviour, aging, and exercise, and diet on natural immunity
* Highlights the physiological role of natural immunity
* Focuses on the relationship of the neuroendocrine system with natural immunity
* Brings together the diversity and complexity of natural immune system activity

Monoclonal Antibodies - A Manual of Techniques (Paperback): Heddy Zola Monoclonal Antibodies - A Manual of Techniques (Paperback)
Heddy Zola
R1,977 Discovery Miles 19 770 Ships in 12 - 19 working days

This book describes, in detail, tested techniques for the produc-tion and use of monoclonal antibodies. It covers those aspects of interest to all scientists working with monoclonal antibodies and presents methods in a step-by-step format for easy refer-ence. The text serves as a laboratory manual; and discusses rationale behind each method, and the choices between methods. It also provides a rational basis where several alternative methods are available.

Antibodies in Diagnosis and Therapy - Technologies, Mechanisms and Clinical Data (Paperback): Matzku Antibodies in Diagnosis and Therapy - Technologies, Mechanisms and Clinical Data (Paperback)
Matzku
R1,898 Discovery Miles 18 980 Ships in 12 - 19 working days

Monoclonal antibodies have had their impact on biomedical research for more than a decade. Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle. With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway. The book reviews the status of technological development and brings this into the perspective of clinical results. A rapidly growing amount of clinical data is collected in an expanding number of indications. Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation. This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.

The Hashimoto's Cookbook and Action Plan - 31 Days to Eliminate Toxins and Restore Thyroid Health Through Diet... The Hashimoto's Cookbook and Action Plan - 31 Days to Eliminate Toxins and Restore Thyroid Health Through Diet (Paperback)
Karen Frazier 2
R522 Discovery Miles 5 220 Ships in 10 - 15 working days
Measuring Immunity - Basic Science and Clinical Practice (Hardcover): Michael T. Lotze, Angus W. Thomson Measuring Immunity - Basic Science and Clinical Practice (Hardcover)
Michael T. Lotze, Angus W. Thomson
R4,979 Discovery Miles 49 790 Ships in 12 - 19 working days

Most of the diseases of modern mankind involve either acute or chronic inflammation. Measuring Immunity integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit. Measuring Immunity is indispensable for scientists and clinicians interested in the clinical applications of modern immunobiology.
* Defines which assays of immune function are helpful in the assessment of clinical disorders involving inflammation and immunity
* Assesses the dynamics of cellular and soluble factors in the peripheral blood using modern techniques
* Includes basic science foundations as well as the approaches currently applied

Antiviral Agents, Vaccines, and Immunotherapies (Hardcover, New): Stephen Tyring Antiviral Agents, Vaccines, and Immunotherapies (Hardcover, New)
Stephen Tyring
R5,560 Discovery Miles 55 600 Ships in 12 - 19 working days

Unlike any other source on the subject, Antiviral Agents, Vaccines, and Immunotherapies analyzes the benefits and limitations of every available drug, vaccine, and immunotherapy utilized in the prevention and control of viral diseases. This reference provides in-depth reviews of more than 50 drugs and antiviral agents for HIV, human herpesviruses, human papillomaviruses (HPV), influenza, respiratory syncytial virus, hepatitis B, and analyzes their mechanisms of action, dosage, side effects, and drug resistance. The book also provides an overview of the use of immunoglobulins and monoclonal antibodies for antiviral use and supplies extensive references, tables, and figures throughout the text.

The Neurologic Involvement in Systemic Autoimmune Diseases, Volume 3 (Hardcover): Ronald Asherson The Neurologic Involvement in Systemic Autoimmune Diseases, Volume 3 (Hardcover)
Ronald Asherson; Volume editing by Doruk Erkan, Steven R. Levine
R4,857 Discovery Miles 48 570 Ships in 12 - 19 working days

Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. Advances in the diagnosis, laboratory investigations, and management of these conditions has placed an increasing burden on the practicing clinician to correctly assess and treat these patients.
This volume of the Handbook of the Systemic Autoimmune Diseases will help the clinician and researcher better understand the current concepts of nervous system involvement from systemic autoimmune disorders, recognize current approaches to diagnosis and treatment, current controversies, and areas that need significant research efforts. It is believed that providing this approach in a single volume will facilitate its use as a frequent resource for all those caring for or investigating these patients and their diseases.
Each chapter follows a consistent outline to provide the reader with important and useful information in an easy-to-navigate manner and is also liberally referenced to provide more primary source material for further consideration. The standardized approach to each chapter will allow the reader to be able to compare and contrast more efficiently the neurological complications of the autoimmune diseases discussed.

Gene Vaccines (Hardcover, 2012 ed.): Josef Thalhamer, Richard Weiss, Sandra Scheiblhofer Gene Vaccines (Hardcover, 2012 ed.)
Josef Thalhamer, Richard Weiss, Sandra Scheiblhofer
R4,422 Discovery Miles 44 220 Ships in 10 - 15 working days

The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the "world of naked gene vaccines", namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing "burning questions".

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