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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
Basic science and clinical immunology are demystified for the medical and other health sciences student. The basic immunological processes are described first, with a level of detail restricted to what is appropriate for medical and other similar curricula. In the second part of the book immunological mechanisms behind major diseases of the various body systems are explained. Throughout the text clinical details are highlighted and more in-depth material is differentiated from the main text. Covers both basic science and clinical immunology in one volume Specifically aimed at medical students and appropriate for integrated system-based curricula Main text supported by 'in depth', key point and clinical boxes Now full-colour throughout Specialised material removed and replaced with clearer introductory explanations Clearer illustrations, thanks to rewritten captions
Drs. Glen Furuta and Dan Atkins have assembled an in-depth look at Eosinophilic Gastrointestinal Diseases as related to allergy with topics such as "Basic pathogenetic mechanisms of Eosinophilic Esophagitis," "Nutritional management of patients with food allergies and EGIDs," "Chemotactic factors role in EGIDs," "Biomarkers associated with allergic diseases," "Association of other allergic diseases with EGIDs" and much more!
Pocket Guide to Gene Level Diagnostics in Clinical Practice is an abbreviated, pocket-size, quick-reference guide that provides a point-by-point synopsis of the vast wealth of information contained in CRC Handbook of Gene Level Diagnostics in Clinical Practice. All sections and subsections in the Pocket Guide are cross-referenced to corresponding pages in the Handbook. The book works well on its own as a quick reference, but also can be used in conjunction with the larger Handbook for detailed coverage and references to specific information. Pocket Guide to Gene Level Diagnostics in Clinical Practice also includes extensive supplements featuring material not included in the Handbook. These are intended to provide an up-dated, practical source of information useful to anyone involved in molecular diagnostic research and/or service. Supplements are cross-referenced to the main text of the Pocket Guide, that complement and enhance the material covered. Pocket Guide to Gene Level Diagnostics in Clinical Practice will be a handy reference for professionals and students in pathology, biotechnology, biology, and medicine.
In 1772 in Uppsala the Swedish chemist Karl Wilhelm Scheele discovered the element Oxygen. Two hundred and one years later, in 1973, the International Society on Oxygen Transport to Tissue (ISOTT) was founded. Since then there has been an annual ISOTT meeting. After 24 years of international ISOTT meetings it was decided, at the 2005 summit in Bary, Italy, that the 2007 meeting was to be held in Uppsala, Sweden. Thus, after the Louisville meeting we, in the Uppsala group, withdrew to the Edgewater Resort at Taylorsville Lake outside Louisville and prepared the Uppsala ISOTT meeting by tasting Kentucky Bourbons, smoking cigars while bathing in a jacuzzi in the hot dark Kentucky night full of fire flies and a sky full of stars. The ISOTT program should include different aspects of oxygen - however, it is accepted that each meeting has its own local "touch". We decided to focus the Uppsala ISOTT meeting on the theme of "Imaging and measuring oxygen changes". With this in mind we invited scientists within and outside the ISOTT society. We then also received lots of good abstracts from ISOTT members that were included in the program. Lars-Olof Sundeloef introduction speech "AIR AND FIRE" concerned how oxygen was discovered in Uppsala in 1772 by Karl Wilhelm Scheele. After the introduction speech a get together event took place in the magnificent and spacious foyer of Uppsala University main building. The vice chancellor Ulf Pettersson welcomed all delegates to Sweden and Uppsala.
This unique textbook provides information on the dramatic advances taking place in the field of inflammatory (autoimmune) diseases and their therapies. Experts in many different medical fields - allergology, dermatology, gastroenterology, pulmonology, rheumatology etc. - will describe the advances in our understanding of the most important inflammatory diseases linking basic science discoveries to the advances in therapeutics that have taken place over the past years and foreshadow even more dramatic changes which will occur in the years to come. This is a truly multi-specialty bench-to-bedside textbook that will enable readers to gain a wide-ranging but also solidly built understanding of the therapeutic areas of inflammatory diseases.
The hypothalamic-pituitary-adrenal axis controls reactions to
stress and regulates various body processes such as digestion, the
immune system, mood and sexuality, and energy usage.
This book is one of the first to evaluate the role of Steroids in
autoimmune rheumatic diseases from the basic mechanisms to the
clinical involvements and focuses on the importance of steroidal
hormones in the pathogenesis and therapeutic management of the
autoimmune rheumatic diseases. In particular, the chapters analyze
the mechanisms of action and the involvement of adrenal steroids
(glucocorticoids) in the neuroendocrine immune system, including
effects on the elderly.
More than two decades into the global HIV epidemic, many HIV positive patients who have access to antiretroviral medications are graying. These patients and their clinicians now face another set of complex health issues related to aging. HIV and Aging examines the known effects of HIV and HIV medications on older patients and on their immune systems. The book explores the coalescence of aging and HIV on neurologic, psychiatric, cardiovascular, endocrine, renal, and pulmonary systems and oncology. Written by some of today 's top experts, HIV and Aging answers questions like:
This book opens a new page of neuroimmunebiology providing
substantive experimental and clinical data to support current
understanding in the field, and potential applications of this
knowledge in the treatment of disease. The volume is a collection
of complex, new data drawn from multiple areas of investigation in
the field. The contents summarize current understanding on the
presence and function of CNS cytokines and their receptors in a
variety of central nervous system cells during health and disease.
The chapters are a collection of complex, new data demonstrating
the presence and synthesis of cytokines in brain cells, as well as
their receptors on cell membranes in health and disease. The
strength of the volume are the descriptions of the authors own
investigations, together with those of others in the field
pertaining to a large number of cytokines in brain function, as
well as mechanisms involved in the development of CNS disorders,
including multiple sclerosis and Alzheimer's disease. Also included
are novel approaches to the treatment of CNS disorders based on new
experimental data. The contributors to this volume are
internationally known scientists and clinical researchers in their
respective fields of investigation and treatment.
A continuously evolving technique, immunotherapy for the treatment of cancers now incorporates the use of immune cells infused during bone marrow transplants as well as approaches like cell and gene therapy, while stem cell-based therapies, tissue engineering, and targeting have also contributed to the latest successes in pre-clinical immunotherapy studies. In Immunotherapy of Cancer: Methods and Protocols, expert researchers in the field describe detailed procedures for trainees and experts in the area of basic, clinical science who wish to undertake their own cutting-edge immunotherapy studies. In addition to the protocols, the volume also contains two general overviews providing useful updates in each area as well as summaries of recent pre-clinical and clinical trials. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Immunotherapy of Cancer: Methods and Protocols seeks to guide scientists along the path to a further developed system of immunotherapeutic treatments in order to reduce and hopefully eradicate this terrible disease.
This volume brings together an international group of clinicians and clinical scientists to contribute to a state-of the-art review of the underlying pathogenic mechanisms, methods of clinical assessment, classification and diagnosis of renal disease, combined with a detailed overview of treatment strategies. An essential reference source for all those involved with the care of patients with renal involvement in systemic autoimmune disease, and for those contributing to research into the underlying pathogenic mechanisms in these disorders.
One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.
This volume is dedicated to multidisciplinary research at the interface between basic biomedicine and clinical practice. This book guides best practice in the diagnosis and therapy while dealing with difficult-to-treat disorders of yet unclear etiology. Chapters address such disorders as granulomatosis with polyangiitis causing autoimmune-related multiorgan inflammation of blood vessels, increasingly widespread allergy to peanuts, occupational exposure to zinc oxide, and immunogenic responses to pneumococcal and influenza vaccination underlying their preventive effectiveness. Other hot issues deal with the proper use of fluid therapy in the perioperative period and a cognitive decline in lung transplant patients. A new physiotherapeutic approach of treating key myofascial trigger points in low-back pain appears highly beneficial in reducing patients' disability, advancing physiotherapy of this overwhelming condition. Finally, other chapters consider ways to streamline medical management to increase the number of physicians and their availability for patients, a particularly sensitive issue in the current COVID-19 pandemic. The dissemination of clinical knowledge about high-risk and hardly controllable conditions is an inalienable part of progress in medical practice. The book is a resource for clinical specialists, general practitioners, and allied healthcare professionals.
Reflects the current state of scholarship in Buddhist Studies, its entries being written by specialists in many areas, presenting an accurate overview of Buddhist history, thought and practices, most entries having cross-referencing to others and bibliographical references. Contain around 1000 pages and 500,000 words, totalling around 1200 entries.
Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular virology, and pathogenesis of henipavirus infections. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. The first section introduces the epidemiology and ecology of Nipah and Hendra viruses in their respective endemic areas, including a first-hand account of the discovery of Nipah virus during its initial outbreak in Malaysia; the next section documents the molecular virology of henipaviruses, and the substantial advances made towards understanding the unique features of henipavirus entry and tropism; and this is followed by accounts of the clinical and pathologic features of henipavirus infections in their human and naturally infected animal hosts. The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. The final sections describe our current and future capabilities for diagnosis and control, including an account of potentially effective immunization strategies that are currently being tested. This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.
New Concepts in the Pathogenesis of HIV1 Encephalopathy: HIV Encephalopathy: Clinical and Diagnostic Considerations (J.R. Berger, R. Kaderman). Models of HIV1 Infection and Neurotoxicity in the Human Fetal Nervous System: Overview: Models of HIV1 Infection and Neurotoxicity in the Human Fetal Nervous System (L.G. Epstein). Model Cell Cultures from Adult Brain and Glioma Cell Lines: Molecular Interaction of HIV1 in Glioma Cells (V. Erfle et al.). Neurotropism of HIV1 Strains: Contribution of V3 and Reverse Transcriptase Sequence Analysis to Understanding the Concept of HIV1 Neurotropism (F. Chiordi et al.). Molecular Technology for the Detection and Analysis of HIV1 in Nervous System Tissue: Detection of HIV1 Gene Sequences in Brain Tissue by in situ Polymerase Chain Reaction (O. Bagasra et al.). Development of New Techniques and Methods Applied to AIDS: Technology in PCR and PCR Evaluation Technology and Its Application to the Study of Cerebrospinal Fluid in HIV Disease (P. Schmid). Focus on AIDS and the Nervous System: Challenges During the Decade of the Brain: Treatment of the Neurological Complications in AIDS: The AIDS Clinical Trials Group in the 1990s (D.B. Clifford). 18 additional articles. Index.
In HaemophilusiInfluenzae Protocols, leading research scientists and infectious disease specialists detail in a readily reproducible format the major molecular and immunological techniques for exploring the pathogenicity of H. influenzae. Described with step-by-instructions to ensure robust and successful experimental results, the techniques cover plasmid analysis, proteomics, genomics, DNA array technology, gene expression, mutagenesis (transposon and nontransposon), and structural analysis. These methods illuminate how the bacterium causes disease, as well as how best to develop novel vaccines and antibiotics against the organism.
"Natural Immunity" is a broadly-based account of the activities of
the evolutionarily conserved molecules, cells and processes of the
natural immune system. This encompasses the early host protection
against microbes (bacteria and viruses) and tumours, prior to the
generation of the adaptive immune response, diverse major current
pathologies including inflammatory and autoimmune diseases, and key
roles in essential physiological processes such as reproduction and
wound healing.
This book describes, in detail, tested techniques for the produc-tion and use of monoclonal antibodies. It covers those aspects of interest to all scientists working with monoclonal antibodies and presents methods in a step-by-step format for easy refer-ence. The text serves as a laboratory manual; and discusses rationale behind each method, and the choices between methods. It also provides a rational basis where several alternative methods are available.
Monoclonal antibodies have had their impact on biomedical research for more than a decade. Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle. With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway. The book reviews the status of technological development and brings this into the perspective of clinical results. A rapidly growing amount of clinical data is collected in an expanding number of indications. Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation. This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.
Most of the diseases of modern mankind involve either acute or
chronic inflammation. Measuring Immunity integrates the current
information available on biomarkers and surrogate assays into a
single handbook. It highlights the principles behind various
applications, gives a brief summary on how they are conducted and
provides detailed and critical analyses of murine models of
immunity, clinical trials, and tests to predict utility and
benefit. Measuring Immunity is indispensable for scientists and
clinicians interested in the clinical applications of modern
immunobiology.
Unlike any other source on the subject, Antiviral Agents, Vaccines, and Immunotherapies analyzes the benefits and limitations of every available drug, vaccine, and immunotherapy utilized in the prevention and control of viral diseases. This reference provides in-depth reviews of more than 50 drugs and antiviral agents for HIV, human herpesviruses, human papillomaviruses (HPV), influenza, respiratory syncytial virus, hepatitis B, and analyzes their mechanisms of action, dosage, side effects, and drug resistance. The book also provides an overview of the use of immunoglobulins and monoclonal antibodies for antiviral use and supplies extensive references, tables, and figures throughout the text.
Systemic autoimmune diseases can affect both the central and
peripheral nervous systems in a myriad of ways and through a
heterogeneous number of mechanisms leading to many different
clinical manifestations. As a result, neurological complications of
these disorders can result in significant morbidity and mortality.
Advances in the diagnosis, laboratory investigations, and
management of these conditions has placed an increasing burden on
the practicing clinician to correctly assess and treat these
patients.
The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the "world of naked gene vaccines", namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing "burning questions". |
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