Gene Vaccines (Hardcover, 2012 ed.)

The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the "world of naked gene vaccines", namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing "burning questions".

General

Imprint:	Springer-Verlag
Country of origin:	Austria
Release date:	September 2011
First published:	2012
Editors:	Josef Thalhamer • Richard Weiss • Sandra Scheiblhofer
Dimensions:	235 x 155 x 18mm (L x W x T)
Format:	Hardcover
Pages:	330
Edition:	2012 ed.
ISBN-13:	978-3-7091-0438-5
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	3-7091-0438-6
Barcode:	9783709104385

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