This book brings together current thought on several aspects of the use of pesticides in and around homes, schools and workplaces. The book addresses several parts of the process, from the discovery and development of new active ingredients, their formulation, use, longevity, environmental fate and human exposure.

This reference handbook provides fully updated chemical, regulatory, health, and safety information on nearly 800 pesticides and other agricultural chemicals. The clear, consistent and comprehensive presentation of information makes Sittig's an essential reference for a wide audience including first responders, environmental and industrial health/safety professionals, the food industry, the agricultural sector and toxicologists. Detailed profiles are provided for each substance listed, including: usage; crop-specific residue limits; hazard ratings for long-term human toxicity; and endocrine disruptor and reproductive toxicity information. Every chemical profile contains references and web links to source information from the EPA, OSHA, the World Health Organization (WHO), and other important advisory and lawmaking bodies. This work is focused on regulated chemicals. The substances covered include pesticides, insecticides, herbicides, fungicides, rodenticides and related agricultural chemicals used on foods grown and produced for both human and animal consumption. These products are organized with common names, chemical synonyms, trade names, chemical formulae, US EPA pesticide codes, EU regulations including Hazard Symbol and Risk Phrases, EINECS, RTECS, CAS, and other unique identifiers so that all who may have contact with, or interest in them can find needed information quickly.

"Biotransformation of Pesticides" is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides anin depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans.
Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment

Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides

Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations "

This book focuses on the microbial degradation of endosulfan, lindane, chlorophenols, organochlorine, aldrin, dieldrin, isoproturon and atrazine, etc. which are commonly used in crop fields to kill the pests. Further, it illustrates the role of degradative enzymes, metabolic pathways of degradation, toxicity of metabolites, and the factors regulating the pesticide degradation. In view of persistence of synthetic pesticides, scientists have discovered suitable microbes, such as bacteria, fungi and algae (naturally occurring or genetically engineered) over the years. After successful trials under laboratory and field conditions, these microbes are being used to degrade chemical pesticides in agriculture. As of now 2.56 billion kg of chemical pesticides is used every year to protect agricultural fields against pest attack. These technologies have been found to be highly effective, eco-friendly and cost-effective without disturbing the agro-ecosystems. As this book contains review articles contributed by various researchers from different countries whose work demonstrates recent advances in microbial degradation of pesticides, it will serve as a ready reckoner and also a valuable quick reference guide for scientists, academicians, cultivators and industrialists alike.

The book covers a critical compilation of analytical methods used for the monitoring of pesticides and their degradation products in water. It contains up-to-date material and is the direct result of the authors' experience in the field of pesticide analysis. The book is structured in six chapters, starting from general aspects of pesticides like usage, physicochemical parameters and occurrence in the environment. A second chapter is devoted to sampling from water matrices, stability methods of pesticides in water and quality assurance issues. The general chromatographic methods for pesticides are reported, including the newly developed electrophoresis methods and GC-MS and LC-MS confirmatory analytical methods. Sample preparation methodologies, including off-line and on-line techniques are described in the next two chapters, with a comprehensive list of examples of pesticides and many metabolites, including the use of different GC-methods and LC-methods. The final chapter is devoted to the development of biological techniques, immunoassays and biosensors, for the trace determination of pesticides in water samples.

The book answers one of the key problems in pesticide analysis: the diversity of chemical functional groups, with varying polarity and physicochemical properties. Pesticides and their metabolites have received particular attention during the last few years in environmental trace-organic analysis. For instance, in the case of groundwater, the use of pesticides has become a cause for concern. Under the right conditions, pesticides, such as fertilizer nitrogen, can move through the soil into groundwater, a phenomenon once thought improbable. The movement of agrochemicals in surface water flow can be, in some instances, a major problem, specially in the case of water soluble pesticides that are generally transported to estuarine and coastal waters. Estuarine waters feature gradients of both pollutant concentrations and physicochemical characteristics such as salinity, turbidity and pH, and all these parameters must be carefully considered when developing methods of analysis for trace organics in estuarine waters.

One of the key parameters in analytical determination is the environmental sampling. Different protocols and devices are needed for sampling sea-water samples - usually using large sample volumes of more than 50 litres either with LLE or SPE, with the problems encountered due to dissolved and particulate matter - which is different from drinking water and well water sampling. The representativeness of the sampling is also of concern.

The sample preparation of organic compounds from water matrices has been recognized to be a bottleneck and it has been traditionally neglected in the literature. We should comment following R.W. Frie's ideas - that the most sophisticated hardware is useless if the chemistry in the protocol does not work. During the last few years new adsorbents have appeared - carbon type, polymeric sorbents with high capacity and immunosorbents - which can more efficiently trap the more polar compounds.

The development of advanced automation methods based, usually on solid phase extraction techniques - PROSPEKT, OSP-2 and ASPEC XL - are examples of commercially available equipment that are of growing importance. These systems are generally coupled to LC and GC techniques.

Sampling and sample handling can not be regarded as separate techniques in the analytical process and both should be integrated into the whole analytical determination. For this reason, validation and confirmation methods, such as mass spectrometry, either GC-MS and/or LC-MS, are needed. These serve to check the quality assurance of the developed method. The discussion between multiscreening versus specific methods of analysis and the influence of the matrix (ground-, surface- and estuarine-water), is also a point of concern due to the diversity of chemical classes within the compounds of study.

Finally the use of rapid methods of analysis, which refer basically to biological techniques, biosensors and immunoassays are also of growing interest for the determination of pesticides in environmental matrices. The rapid development of these techniques, being more sensitive and that can work at different pH and drastic environmental conditions, like very different pH and salinity values, makes that these methods are very useful and complementary to conventional GC and/or LC techniques for the determination of pesticides.

This new volume brings together scientists from a variety of disciplines to present, summarize, review, and update information related to bioherbicides. Among the topics covered are pathogens with potential as bioherbicides, phylloplane-pathogen interactions, aspects of soil microorganisms, formulation and commercialization of microbes as bioherbicides, genetic aspects of pathogens for weed control, and chemistry and biochemistry of microbial-plant interactions. A valuable source of information for researchers involved in both biological weed control and herbicide development.

The future of insect control looked very bright in the 1950s and 1960s with new insecticides constantly coming onto the market. Today, however, whole classes of pesticide chemistry have fallen by the wayside due to misuse which generated resistance problems reaching crisis proportions, severe adverse effects on the environment, and public outcry that has led to increasingly stricter regulation and legislation. It is with this background, demanding the need for safer, environmentally friendly pesticides and new strategies to reduce resistance problems, that this book was written. The authors of the various chapters have a wealth of experience in pesticide chemistry, biochemical modes of action, mechanism of resistance and application, and have presented concise reviews. Each is actively involved in thedevelopment of new groups of pesticide chemistry which led to the development of novel insecticides with special impact in controlling agricultural pests. Emphasis has been given to insecticides with selective properties, such as insect growth regulators hormone mimics, ecdysone agonists), (chitin synthesis inhibitors, juvenile chloronicotinyl insecticides (imidacloprid, acetamiprid), botanical insecticides (neem, plant oils), pymetrozine, diafenthiuron, pyrrole insecticides, and others. The importance of these compounds, as components in integrated pest management programs and in insecticide resistance management strategies, is discussed. The data presented are essential in establishing new technologies and developing novel groups of compounds which will have impact on our future agricultural practices.

This book presents the progress made in the study of the mode of action of phytotoxic compounds that have been developed as herbicides in the recent past. The 13 chapters are written by experts in herbicide research and development, chemists, biochemists, and plant physiologists. The biochemistry of the target enzymes is described together with model assays, molecular genetics and special reference to transgenic herbicide-resistant crops. Additional chapters deal with new synthetic chemical pathways, chirality effects found in certain herbicide classes, and transcuticular pesticide penetration.

Pesticide Profiles: Toxicity, Environmental Impact, and Fate is like three books in one-it is a profile containing specific information about 137 pesticides, a primer of environmental toxicology, and an extensive trade name index. Profiles of each pesticide contain regulatory information, toxicity assessments, environmental fate data, physical properties, and acceptable exposure limit values. What these values and data mean in terms of human toxicity is clearly interpreted as well. The book also describes the meaning of carcinogenicity and how it is assessed in non-technical terms the non-expert can understand. Readers with a technical background are provided with the data to make their own judgments.
In addition to information about specific pesticides, there are sections on general classes of pesticides, such as organophosphates. This information allows readers to make inferences about any pesticide in a class, even if a profile is not provided. Pesticide Profiles: Toxicity, Environmental Impact, and Fate goes beyond the usual listings of toxicity values or environmental half-lives to offer a broad understanding to readers of various backgrounds and interests.

This work highlights the physical chemistry of surfactant solutions, detailing a fundamental method of selecting surfactants for agrochemical formulations and delineating how surfactants enhance the biological efficacy of agrochemicals. The unique properties of surfactants that have a major influence on the performance of an agrochemical are summarized.;The book is intended for physical, surface and colloid chemists; biochemists; microbiologists; agronomists; research and development personnel in the pesticide and fertilizer industries; and upper-level undergraduate and graduate students taking chemistry and chemical engineering courses.;College and university bookstores may order five or more copies at a special price which is available on request from Marcel Dekker Inc.

Basic Guide to Pesticides covers the physical properties of about 700 pesticides and their contaminants and related health hazards. It is important in dealing with environmental problems in general and individual cases.

A comprehensive collection of robust methods for the detection of pesticide compounds or their metabolites useful in food, environmental, and biological monitoring, and in studies of exposure via food, water, air, and the skin or lungs. The readily reproducible methods range from gas and liquid chromatography coupled to mass spectrometry detection and other classic detectors, to capillary electrophoresis and immunochemical or radioimmunoassay methods. The authors have focused on extraction and cleanup procedures, in order to develop and optimize more fullyautomated and miniaturized methods, including solid-phase extraction, solid-phase microextraction, microwave-assisted extraction, and on-line tandem liquid chromatography (LC/LC) trace enrichment, among others. The protocols offer step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

This book presents detailed information on the imidazolinone herbicides, provided in chapters contributed by scientists and product development managers who work for American Cyanamid, categorized in sections covering chemistry, biology, metabolism and residues, environmental fate and product performance. Each chapter has its own bibliography, and appendices give (a) details of the chemical and physical properties, formulations and trade names of imazapyr, imazamethabenz-methyl, imazethapyr and imazaquin, and (b) the scientific and common names of species used in the text. There is a general bibliography of references for each of the above imidazolinone herbicides and a useful subject index. The individual chapters are abstracted separately.

With increasing population and industrialization, our negative impact on our environment is no longer limited to coastal and surface waters or to urban air; it is necessary to examine the movement of chemical pollutants over vastly greater areas. Oceans, deep groundwater aquifers, and even the stratosphere are significantly affected. The mechanisms by which pollutants reach these areas, how they migrate and are transformed through physical and biochemical processes, and their ultimate effects are the topics at the forefront of environmental science. This volume addresses the fate of chemical pollutants in our air, water, and soil. The result of a historic collaboration between eminent Russian and American scientists, Fate of Pesticides and Chemicals in the Environment contains new predictive models of transport and transformation from many of the leading scientists in this area of research. Numerous informative chapters analyze the biotransformation of organic chemicals and pesticides, atmospheric deposition of toxic pollutants in the Great Lakes and elsewhere, the transport of volatile organic compounds and pesticide residues through surface soil, and many other important problems in the field. The sources and pathways of pollutants into all areas of the environment are thoroughly explored; the role of free radicals in chemical transformations, surface and bottom sediment redox reactions in water, the contribution of microbial degradation, and considerations for in situ biorestoration are just a few of the complex issues addressed. The book also contains comprehensive information on pesticide labeling laws and groundwater protection which will be of interest to all soil and waterchemists and environmental engineers.

This book presents the current approaches for insect pest control as a "green" alternative to classical and more toxaic agrochemicals. An overview of the recent advances in insecticide chemistry is also included, which will be of interest to a vast group of researchers - agrochemists, biochemists, chemists and toxicologists. The combination of both chemical and toxicological aspects of insecticides is unique and the book includes contributions from synthetic chemists, entomologists, environmentalists and toxicologists giving it wide appeal. Throughout the book, the different approaches that involve "greener chemicals" are emphasized. The book is divided into 9 chapters, each considering the state of art of each family of insecticides, together with future expectations. Each chapter gives a description of useful biorational insecticides, highlighting environmentally-friendly processes and then the mode of action is fully-described, emphasizing selectivity towards targeted species. Finally, for every family of compounds, their environmental effects (toxicity, bioaccumulation and metabolism) is considered, comparing them to classical insecticides, including human and environmental risk assessments. In addition the formulation, dispersal and persistence in the environment are covered as key aspects in developing greener agrochemicals. The book also includes a general introduction to entomology, with special emphasis on those insects that act as vectors in the spread of diseases. Insects that may be potential pests against humans and livestock are included, focusing on their life cycles, and physiology, as a logical comprehension of mode of action of insecticides. In addition there is a chapter on classical insecticides (covering both, approaches prior to the chemical era, and classical chemical insecticides, organochlorinated, organophosphorus, and carbamates) for comparison with current trends in pest control. The negative environmental effects that such insecticides have caused in nature, such as poisonings, bioaccumulation or toxic effects are highlighted. It is hoped that the use of more specific agrochemicals and approaches may avoid, or at least considerably reduce such severe and irreversible effects in nature. The insecticides covered are considered from numerous points of views: chemistry, toxicological profile, risk assessment, legal status, environmental behaviour and selectivity. The most important families of currently used insecticides are covered and critical discussions about future perspectives are included with frequent comparisons to classical insecticides. The following topics are covered in the book, as greener alternatives to classical insecticides: " Pyrethrins and pyrethroids " Neonicotinoids " Spynosins " Insect growth regulators " Botanical insecticides " Microbial insecticides " Integrated Pest Management Programs (IPM)

This handbook provides a systematic description of the principles, procedures, and technology of the modern analytical techniques used in the detection, extraction, clean up, and determination of pesticide residues present in the environment. This book provides the historical background of pesticides and emerging trends in pesticide regulation. The text discusses various techniques for analysis, including supercritical fluid extraction, disposable electrochemical biosensors, matrix solid-phase dispersion, volatmetric methods, and liquid chromatography. The authors also address the scope and limitation of NEEM products in plant protection as well as the analysis of medicinal plants.

The authors of this book report up-to-date methodologies relating to isolation, identification and use of various enzymes and receptor systems that serve as targets for insecticide action or as sites for resistance development. Thus, this book serves as an indispensable tool for scientists in academia and industry research, investigating or developing new insecticides with selective properties for the benefit of the environment. Possible countermeasures for resistance to novel insecticides are discussed.

Piperonyl Butoxide contains 20 chapters contributed by world experts in the field on the properties, uses, plant metabolism, and mammalian and environmental toxicology of piperonyl butoxide. The mode of action of piperonyl butoxide is discussed as well as many other specialist topics, including the measurement of synergism in the laboratory, and the potential use of this chemical alone for the control of whiteflies, as well as with insect growth regulators.
This book will prove to be a valuable reference for all concerned with the designing of safe and cost-effective insecticide formulations, particularly those used in the home, industry, or on or near animals and food.

Worldwide, there are a vast array of agricultural pesticides and chemicals used to eliminate pests and to protect health, food, and fiber. The safe handling, usage, and disposal of these chemicals and pesticides is of vital importance. The Agrochemical and Pesticides Safety Handbook serves as a field resource on the hazards of these pesticides and chemicals.
Providing information on more than 500 pesticides and 100 agricultural chemicals, this informative handbook guides the reader in selecting proper respiratory protection, chemical protective clothing, and storage methods. The text also instructs users on proper response procedures for fires, spills, and other incidents involving these chemicals.

This book presents a collection of known information on the insecticidal properties of constituents of higher plants, microorganisms, animals, and marine flora and fauna in order to assist researchers in selecting leads for further development.

Pesticide Formulation and Adjuvant Technology brings together experts from industry, academia, regulatory offices, and the legal profession to provide a complete and international reference on agrichemical formulations and modern adjuvant technology.
Global specialists discuss key topics, from scientific and technical issues to regulatory and legal aspects, including:

Emphasizing the need for more integrated pest management programmes, this work presents the development and state-of-the-art technology of genetically-engineered microbes, viruses, bacterial toxins and plants. Throughout, both environmental and regulatory concerns are addressed.

This quick-reference guide contains over 400 Fourier-transform infrared (FTIR) spectra of commonly used pesticides and related metabolites. Systematically arranged for easy referral, the book: supplies relevant chemical, physical and structural data, in addition to the spectra; compares the improved quality of spectra performed on Fourier transform instruments, in terms of signal-to-noise ratio and optical resolution, to those recorded on dispersive spectrometers; and promotes Good Laborotory Practices (GLP) and Good Manufacturing Practices (GMP) by applying infrared spectroscopy to identify control of standards prior to performing qualitative and quantitative analyses.

Reference to the design of new insecticides nontoxic to the environment and the public emphasizing optimal food production with greater safety. Some 30 international experts examine topics including new types of active molecules among natural products and animal toxins; insect metabolic and organ sy

The incidence of fungal infections increases with the increase in antibiotic usage and increasing immunosuppressed populations. There is no longer only one antifungal agent and the response of fungi to various agents is not always predictable. The need for standardized antifungal susceptibility testing, and standardized interpretation of results in conjunction with studies that describe clinical outcomes based on those tools is ever important. Interactions of Yeasts, Moulds, and Antifungal Agents: How to Detect Resistance covers the available antifungal agents, how to perform in vitro testing and how those results should be interpreted for the most common fungal pathogens.