Offering an example for transnational cooperation and successful reduction of a neglected tropical disease, this volume shows how Chinese scientists and local physicians controlled schistosomiasis in Zanzibar. Over a four-year study, local medical specialists and the population of Zanzibar were taught how to diagnose the parasitosis caused by flukes (trematode worms) of the genus Schistosoma. Furthermore, methods to eliminate the disease and prevent new infections were established. The developed control system will avoid repeated increase of human schistosomiasis, which is still prevalent in the tropics and subtropics. Rural populations and poor communities lacking access to clean drinking water and adequate sanitation are most affected. This book is a blueprint of activities urgently needed to combat schistosomiasis in countries with low medical impact. The strategies outlined are particularly relevant to parasitologists and professionals in public health, physicians, medical personnel and also governmental, healthcare and pharmaceutical institutions.

This thematic collection focuses on key parasites and their vectors in Southeast Asia. Up-to-date essays invite readers to discover parasite and vector morphology, genetic diversity as well as dynamic parasite communities linked to human land-use and climate change. The authors shed light on transmission pathways and explore tick-borne diseases, intestinal protozoa, cestodes, nematodes and the multiplicity of cryptic trematode species. Particular attention is given to mosquito vectors in changing environments and the dynamic biodiversity of vertebrate hosts, including mammals, birds and fish. The richly illustrated chapters are completed by new approaches in diagnostic methods, treatment and prevention to protect humans and animals from tropical parasite infections. Not only parasitologists and experts in tropical medicine but also public health officials and travelers will find this volume highly informative.

Much acclaimed, this book is now available in paperback. It provides an analytical framework for evaluating public health measures aimed at eradicating or controlling communicable diseases. The authors are leaders in the field. Their distinctive contribution has been to show the practice and far-reaching power of mathematical modelling in epidemiology, fully set out here for the first time.

This volume of the Neglected Tropical Diseases (NTD) series covers the most prevalent NTDs in North America. This book discusses in detail pathology, diagnostics and control approaches of selected NTDs in the sub-tropical regions of the United States of America. There are disproportionate numbers of children and adults living in poverty within the United States that are at risk of infections caused by helminths, protozoa, viruses and bacteria which commonly lead to chronic, debilitating and stigmatizing diseases. Each chapter focuses on one specific disease or series of related diseases, and provides in-depth insights into the topic.

This book provides an up-to-date review of fasciolosis, a disease caused by Fasciola hepatica and Fasciola gigantica, including its biology, transmission, epidemiology, host distribution, economic impact, and novel approaches for its diagnosis, treatment and prevention. It first offers a brief overview of the history of the disease, the genetic diversity of the parasite and its distribution, and the ecology of the vector snail, which belongs to the Lymnaeidae/Planorbidae family. It also examines the current strategies and novel approaches for controlling the parasite, diagnosing infections and vaccine development. Importantly, it highlights issues relating to the control of fasciolosis, including drug resistance, lack of effective diagnostics, and the parasite's long-term survival strategies based on regulation and modulation of the host immune system. Lastly, it discusses the novel control snail vectors using bait formulations, and synergetic and phototherapy treatment with chlorophyllin, which does not kill the vector.

This book covers all details for a successful control and elimination strategy against propagation of deadly liver and intestinal flukes of the genus Schistosoma in China. Cancer due to schistosomiasis is still common in subtropical countries and affords hundred thousands of human and animal deaths per year. Expert authors play close attention to the biology and morphologic aspects of Schistosoma species as well as the history and status quo of schistosomiasis epidemiology. In a unique way, the present work illustrates the need to involve strategic measurements, and to control both adult worms and larval parasite stages. With a special focus on Jiangxi Province, the authors present an effective management plan, ranging from intermediate host snail control to diagnostic tools, medical aid, as well as public health education. This approach from China can be used as blueprint in other countries hit by the same worm infections. The contents of this book will thus be meaningful for academics and practitioners in the fields of parasitology, public health, as well as human and veterinary medicine.

This book summarizes the recent advancements in identifying the mosquito vectors and discusses various strategies for their control. The book describes various molecular taxonomic methods, including DNA barcoding and single nucleotide polymorphism-based machine learning approach, which are used for the identification of mosquito vectors. It also presents the various mosquito control methods, namely, phytochemicals, Bacillus thuringiensis toxins, nanotechnology, biological control agents, and environmental management strategies. It also highlights the importance of various repellents that are used for protection from different kinds of mosquito vectors. Finally, the book offers a comprehensive yet representative description of challenges associated with mosquito vector-borne diseases. The book is a useful resource for medical entomologists, health workers, and researchers working in mosquito-control and vector-borne diseases.

Written for nonspecialists, this useful manual provides sufficient detail to allow inexperienced clinicians and medical students to give an anesthetic in an unexpected or emergency situation. The author covers the use of ether with air as a carrier gas; ketamine, epidural, and subarachnoid anesthesia; various methods of local and regional anesthesia; intubation; and the use of relaxants. There is also a chapter on primary intensive care, and an appendix featuring a detailed list of equipment.

The Tropics are home to the greatest biodiversity in the world, but tropical species are at risk due to anthropogenic activities, mainly land use change, habitat loss, invasive species, and pathogens. Over the past 20 years, the avian malaria and related parasites (Order: Haemosporida) systems have received increased attention in the tropical regions from a diverse array of research perspectives. However, to date no attempts have been made to synthesize the available information and to propose new lines of research. This book provides such a synthesis by not only focusing on the antagonistic interactions, but also by providing conceptual chapters on topics going from avian haemosporidians life cycles and study techniques, to chapters addressing current concepts on ecology and evolution. For example, a chapter synthesizing basic biogeography and ecological niche model concepts is presented, followed by one on the island biogeography of avian haemosporidians. Accordingly, researchers and professionals interested in these antagonistic interaction systems will find both an overview of the field with special emphasis on the tropics, and access to the necessary conceptual framework for various topics in ecology, evolution and systematics. Given its conceptual perspective, the book will appeal not only to readers interested in avian haemosporidians, but also to those more generally interested in the ecology, evolution and systematics of host-parasite interactions.

This book presents the latest information on canine parasites with zoonotic potential, to help avoid human infections. Compiled by international specialists, it covers protozoa, ectoparasites and helminth species of clinical importance in dogs, as well as the state of the art in diagnosis, preventive measures and potentially necessary treatment schemes. Dogs are commonly kept in families around the world and can predispose their human companions to disease. Updating and deepening insights from other specialist literature, the book is intended for practitioners and scientists alike. It also offers practical guidance for veterinary and human physicians and highlights unexplored research areas, making it a valuable resource for students and educated non-experts with an interest in parasitology, infectiology and zoonotic pet diseases.

This book is the second volume in the series Livestock Diseases and Management, and reviews the importance and implications of animal origin viral zoonoses. It also highlights the specific etiology and epidemiology of these viral infections and discusses their various biological and mechanical transmission mechanisms. Further, the book reviews various measures for controlling viral zoonoses and examines novel therapeutic and prophylactic strategies. Discussing recent studies on the pathogenesis and host immune response to these infections, it underscores the importance of using vaccines against these viral diseases to reduce the risk of them being transmitted to humans.Lastly, it describes in detail the challenges posed by these viral infections and our readiness to face them.

The book comprehensively discusses the mechanisms of pathogenesis and drug resistance; current diagnostics landscape of four key human pathogens; bacterial, fungal, protozoans and viral which are the causes of major infectious diseases. It also assesses the emerging technologies for the detection and quantification of these pathogens. Further, it discusses the novel opportunities to fight against these infectious diseases and to identify pertinent drug targets with novel methodologies. It also reviews the current and future insights into the control, elimination, and eradication of these infectious diseases. Importantly, the book discusses the epidemiological characteristics and various challenges in combating Ebola and Influenza diseases. Finally, the book highlights the growing role of nanotechnology and bioinformatics resources for combating the infectious diseases. In summary, the book provides the mechanistic insight of the pathogenicity, drug-resistance, therapeutic strategies and identification of the novel drug targets of Mycobacterium tuberculosis, Plasmodium, Candida, Hepatitis C and emerging viral infections.

Multiple demographic or economic parameters contribute to the origin of emerging infections, for example: poverty, urbanization, climate change, conflicts and population migrations. All these factors are a challenge to assess the impact (present and future) of parasitic diseases on public health. The intestine is a major target of these infections; it is a nutrient-rich environment harbouring a complex and dynamic population of 100 trillion microbes: the microbiome. Most researches on the microbiome focus on bacteria, which share the gut ecosystem with a population of uni- and multi cellular eukaryotic organisms that may prey on them. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called "intestinal eukaryome", that include fungi, protists and helminths. Knowledge on the reciprocal influence between the microbiome and the eukaryome, and on their combined impact on homeostasis and intestinal diseases is scanty and can be considered as an important emerging field. Furthermore, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. This book presents an overview of the science presented and discussed in the First Eukaryome Congress held from October 16th to 18th, 2019 at the Pasteur Institute in Paris. This book covers the following topics: Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes; and their (still enigmatic) historical evolution and potential contributions to mucosal immune homeostasis. Integrative biology to study the molecular cell biology of parasite-host interactions and the multiple parameters underlining the infectious process. The exploitation of tissue engineering and microfluidics to establish three-dimensional (3D) systems that help to understand homeostasis and pathological processes in the human intestine.

This volume is a republication in one volume of the 10-part "CIH Keys to the Nematode Parasites of Vertebrates," first published between 1974 and 1983. For many years the "Keys" have provided a working tool to those within the field and laboratory needing to know "what is this worm?"Now due to popular demand and to coincide with the long awaited publication of the supplement volume, the "Keys" will be presented as one volume, refreshed and reformatted with the additional convenience of reordering into superfamily. As an indispensable guide the "Keys" shall continue to be an essential resource to those working within medical, veterinary and biological departments worldwide for many more years to come.

This book provides a comprehensive overview of recent novel coronavirus (SARS-CoV-2) infection, their biology and associated challenges for their treatment and prevention of novel Coronavirus Disease 2019 (COVID-19). Discussing various aspects of COVID-19 infection, including global epidemiology, genome organization, immunopathogenesis, transmission cycle, diagnosis, treatment, prevention, and control strategies, it highlights host-pathogen interactions, host immune response, and pathogen immune invasion strategies toward developing an immune intervention or preventive vaccine for COVID-19. An understanding of the topics covered in the book is imperative in the context of designing strategies to protect the human race from further losses and harm due to SARS-CoV-2 infection causing COVID-19.

This book focuses on waterborne pathogens and significant diseases occurring along major rivers around the globe, including key examples like the Amazonas, Mekong River and Nile. Written by leading international experts, it offers unique insights into local riverine infection risks in times of global warming, and addressing these through advances in diagnosis, health management and the development of simple but effective control measures. It also sheds light on why former societies collapsed due to transmitted diseases during periods of climate change, droughts and floods, to help establish effective preventive measures for the future. The book appeals to a wide readership, from scientists in the field of parasitology, infectious diseases and epidemiology, to healthcare managers and general readers with an interest in pathogen spread along the largest rivers on earth. It particularly highlights past and current control mechanisms in times of global warming and assesses potential future health hazards.

This is the first English-language book dedicated to Brazilian sand flies and their medical importance. No other country has so many species of these haematophagous insects as Brazil and their diversity has reached an astonishing level. The book contains comprehensive chapters, written by Brazilian experts on their regional distribution, their ecology and their importance as vectors of pathogens and parasites. Methods for sampling, processing and preserving phlebotomines are reviewed as are perspectives on surveillance and leishmaniasis vector control. A novel classification is presented whose aim is to help investigators identify the species that they are working with more efficiently.

Spirochetes comprise a fascinating group of bacteria. Although diverse in terms of their habitat, ecology and infectivity for vertebrate and non-vertebrate hosts, they are often considered together because of their similar cellular morphologies. This volume brings together an international group of experts to provide essential insights into spirochete biology, with an emphasis on recent advances made possible by the availability of genome sequences. As such, it offers a valuable resource for microbiologists and other scientists with an interest in spirochete biology.

This book is the first to explore in detail the systematics and taxonomy of the digenean fauna of fish in Indian marine waters. It includes morphological descriptions of 648 species in 190 genera and 30 families. The figures from the original publications are enhanced and made more attractive. Each description is accompanied by information on hosts and distribution. Digenetic trematodes, usually known as Digeneans, are the most diverse group of metazoan parasites of marine fishes. They are parasitic flatworms (Phylum Platyhelminthes) with a complex life-cycle and as adults inhabit mainly the alimentary system and associated organs, but also occur in the blood, under the scales, in the body cavity and in the gall and urinary bladders. Keys to families, genera and species are provided, except for a few large and controversial genera, where morphological characters are insufficient for identification. Although there is extensive literature on Digeneans, it is scattered and largely in obscure local journals. Bringing together most of the primary literature on the subject, this book provides a primer for further study and a starting point for the use of modern molecular methods for the fauna of this region. Unique in its scope, it is a valuable resource for students, professional parasitologists and ecologists as well as fishery and wildlife biologists.

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

Early diagnosis of parasitic diseases, especially of the opportunistic infections, is gaining importance daily and pathologists now have the chance to make rapid diagnoses of these disorders by examining tissues and body fluids. Though parasitic infections and infestations occur mainly in subtropical and tropical areas, they are increasingly imported into other areas, where the pathologist must be able to recognize them. This new full-colour atlas, containing over 500 photographs, many diagrams and tables, with extensive references and index, concentrates on histology, differential diagnosis and on the structure of parasitic elements such as eggs, larvae and adult worms, in and outside tissues. The atlas will be invaluable as a bench manual for the practising pathologists to keep by the microscope, as well as for physicians, surgeons, dermatologists and pathologists in training, and all those who are concerned with parasitic infections.

This second edition of the popular advanced student textbook (previously published as "Worms and Disease: A Manual of Medical Helminthology") has been thoroughly updated and revised since it was first published in 1975. It includes contributions and a chapter by Prof. Derek Wakelin, University of Nottingham, UK. * An authoritative handbook covering all human helminth infections with particular emphasis on diagnosis, treatment, clinical manifestations, pathogenesis, epidemiology and control * Practical guidelines are given for estimating the clinical and public significance of helminthiases, vital in areas where the majority of inhabitants are infected with many helminths but only a few are sick.

This book illustrates the importance and significance of the systems approach in deciphering diverse aspects of host-parasite interactions in infection dynamics. It describes the complex issues and state-of-the-art progress in the infection biology of parasitic protozoa. The book explores the current concepts and paradigms of gene expression, metabolome, and immune remodeling in these diseases. The chapters encompass updates on the parasitic tropism, co-evolution, systemic responses in hosts, and translational approaches. It provides an overview of the parasite's efficient ways of exploiting host molecules and describes pathways for their survival, differentiation, and replication within the host cells. The book also delineates the role of inflammasomes and their activation in response to the protozoan parasite. The book discusses technological progress and machine learning-based modeling approaches to revisit parasitic infection from a non-conventional perspective. Collectively this book offers a comprehensive purview of concepts and paradigms in parasitic infection in the form of an updated yet discernible elucidation.

Over the past ten years, many powerful new techniques have been developed that have dramatically changed malaria research. The second edition of Malaria: Methods and Protocols expands upon the previous edition with current, detailed techniques for laboratory research. With new chapters on parasite culture techniques, genome manipulation methods, 'omic' approaches, and techniques for studying the biology of the red blood cell and pre-erythrocytic stages of Plasmodium. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Malaria: Methods and Protocols, Second Edition, offers a comprehensive set of standard techniques for laboratory researchers.