Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.

The book entitled "Schistosomiasis: Epidemiology, Diagnosis and Treatment", published by Nova Science Publishers Inc. presents a very interesting overview on this tropical parasitic disease in the post-genomic era. The book is a collection of 8 chapters written by world-renown health professionals and researchers, highly active in the field. The mainly targeted public is MDs specialising in Tropical Medicine as well as experienced Researchers and Professionals who are faced with the challenges of this ancient threat to human health. This book is conceptually divided into two sections: (1) a broad recollection of the up-to-date state of the comprehension of Schistosomiasis, including its interplay with the human host; (2) a focused survey on specific field studies, presenting the actual challenges of the disease. The first part, composed of 4 chapters, is preparatory to a better understanding of the case studies in the second part. Special attention has been put on three selected at risk categories of people: pre-school aged children, women, and travellers/migrants; the first two living in endemic areas, and the latter in non-endemic regions. In between these two sections is the chapter on zoonotic schistosomiasis, a neglected research area that shows the dangerous role of infected livestock in maintaining the disease in endemic countries.

Ticks are obligate blood sucking arthropods found in almost every region of the world. They are very important vectors of human and animal diseases. Tick-borne protozoan diseases such as Theileriasis and Babesiosis cause mortality and morbidity in domestic animals in many countries including India. An understanding of taxonomy, vector biology and ecology in the geographic regions of each country is essential so that a programme of control measures can be implemented. This book focuses on the ticks found in India and will be invaluable for health authorities, tick biologists and veterinary researchers. It covers taxonomic identification, medical importance and bionomics of haemaphysaline ticks.

Anaerobic parasitic protozoa cause medically and economically important diseases - such as dysentery, sexually transmitted infections, and gastroenteritis - that annually affect millions of people worldwide. Recently, the genomes of the three key anaerobic protozoa - Trichomonas, Giardia, and Entamoeba - have been determined. The availability of these genomic data and the use of post-genomic analyses have provided fascinating new insights into the biology of these important parasites. They will be important for the design of novel anti-protozoan drugs and the development of effective vaccines. In this book, internationally acclaimed researchers critically review the most important aspects of research on anaerobic parasitic protozoa, providing the first coherent picture of their genomics and molecular biology since the publication of the genomes. Chapters are written from a molecular and genomic perspective and contain speculative models upon which future research efforts can be based. Topics include: the genomes of Entamoeba histolytica, Trichomonas vaginalis, Giardia, and other diplomonads; the cytoskeletons of Entamoeba histolytica, Giardia lamblia, and Trichomonas vaginalis; genomic analyses and manipulation of gene expression in Entamoeba histolytica; nuclear and chromosomal structure and replication in Giardia; and the mitochondrion-like organelles of a fourth anaerobe, Blastocystis. The book is essential reading for all researchers working with these protozoa and related organisms and with eukaryotic model organisms. It is recommended for all parasitology laboratories.

The completion of the Plasmodium falciparum genome sequence in late 2002 heralded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renowned experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential to all researchers working in this highly topical field and is recom

As ravagers of crops and carriers of diseases affecting plants, humans and animals, insects present a challenge to a growing human population. In Pest and Vector Control, H.F. van Emden and Mike Service describe the available options for meeting this challenge, discussing their relative advantages, disadvantages and future potential. Methods such as chemical and biological control, host tolerance and resistance are discussed, intergrating--often for the first time--information and experience from the agricultural and medical/veterinary fields. Chemical control is seen as a major component of insect control, both now and in the future, but this is balanced with an extensive account of associated problems, especially the development of pesticide-tolerant populations. The authors are leading authorities in their respective fields and two of the best known entomologists of their generation.

"Reads like a murder mystery. . . . [Desowitz] writes with uncommon lucidity and verse, leaving the reader with a vivid understanding of malaria and other tropical diseases, and the ways in which culture, climate and politics have affected their spread and containment."—New York Times

Why, Robert S. Desowitz asks, has biotechnical research on malaria produced so little when it had promised so much? An expert in tropical diseases, Desowtiz searches for answers in this provocative book.

"Like such eminent science writers as Stephen Jay Gould and Lewis Thomas, Mr. Desowitz manages to make the basic principles of his subject immediately comprehensible to the general reader. He has also succeeded in giving us a profound appreciation of the ways in which scientific and medical knowledge advances, through hypothesis, error and experiment, through serendipity, dedication, and perseverance."—Michiko Kakutani, New York Times

"Like a novelist, [Desowitz] draws the reader into the human tragedy of disease. . . . Rich in historical-medical detective stories."—Betty Ann Kevles, Los Angeles Times

"A gripping account of how a one-celled protozoan has triumphed over modern science."—Wall Street Journal

"Just as it was not necessary to be an astrophysicist to feel the grandeur and scope of Stephen Hawking's A Brief History of Time, it is not necessary to be a parasitologist or specialist in tropical medicine to relate to the drama, tragedy and even romance of Desowitz's fascinating and provocative story. . . . Interesting and important."—New England Journal of Medicine

Increasing wisdom and ingenuity are required if we are to master our environment and cope with the myriad of organisms that affect our existence. Not the least of these organisms are the parasites and pathogens which can be found in all animals. The ecological implications of parasitism are obvious, and the interrelationships among different organisms within the same host are fascinating, but more knowledge and understanding are needed. The symposium are held to stimulate discussion of the significance of ecological problems presented by parasites and to develop means of attacking some of these problems. The diversity of parasitism from protozoa to anthropods was emphasized and the speakers and topics were selected to interest those in various biological disciplines and professions. Organized by the Department of Parasitology in the School of Hygiene of the University of Toronto, and held at Toronto in February 1970, the symposium was an unqualified success. The enthusiastic interest, indicated by the attendance of over three hundred people from seven countries, and numerous requests for copies of the proceedings led to the publication in this volume of the twelve papers presented at the symposium. The opening remarks of the leader of the discussion which follow each paper have been included and a complete bibliography is provided for each topic. The contributors are leading specialists in their fields; their papers present the results of the most recent research and assemble and review the scattered literature on each topic. The text is illustrated throughout with diagrams and photographs. Parasitism and associated phenomena are excellent examples of problems requiring the interdisciplinary approach taken by the symposium. The results of such an approach are useful in a wide variety of disciplines: microbiology, invertebrate zoology, entomology, and tropical medicine, as well as parasitology.

Friedrich Frischknecht gibt einen Einblick in die Malaria und die biologische Komplexitat der sie ausloesenden Parasiten. Der Autor nimmt den Leser mit auf eine Reise von der historischen Entdeckung der Erreger zu den modernen Methoden der Impfstoffentwicklung. Dabei erlautert er, wie genetische Manipulationen helfen, den Parasiten zu verstehen und neuartige Impfansatze zu entwickeln. Er erlautert die Schwierigkeiten, die zur Ausrottung von Malaria zu uberwinden sind. Der Autor: Prof. Dr. Friedrich Frischknecht hat nach dem Studium der Biochemie an der Freien Universitat Berlin am Europaischen Molekularbiologischen Laboratorium (EMBL) in Heidelberg uber Pockenviren promoviert. Nach einem Forschungsaufenthalt am Institut Pasteur in Paris leitet er seit 2005 eine Forschungsgruppe am Universitatsklinikum in Heidelberg und beschaftigt sich mit den molekularen Grundlagen der Bewegung von Malariaparasiten.

Alle der Lebensmittelgewinnung dienenden, lebenden und geschlachteten Tierarten sowie Primarerzeugnisse vom Tier wie Milch, Eier und Honig werden auf jahrlich vorgegebene Pflichtstoffe untersucht. Daruber hinaus konnen nach aktuellen Erfordernissen oder speziellen Gegebenheiten in den Landern weitere Stoffe frei ausgewahlt werden. Gemeinsam geben der Bund und die Lander die offizielle Veroffentlichung heraus, die fur landwirtschaftliche Betriebe, Handelsbetriebe, Futtermittelhersteller und importeure eine wichtige Informationsquelle bildet.

Questo volume rappresenta la versione italiana dell'ultima edizione di uno dei testi piu autorevoli e completi sulla microbiologia degli alimenti - Modern Food Microbiology - gia tradotto in varie lingue, tra le quali cinese e hindi. La trattazione introduce i fattori intrinseci ed estrinseci che influenzano la crescita microbica negli alimenti e quindi approfondisce il ruolo e la rilevanza dei diversi microrganismi prendendo in esame le principali categorie di prodotti alimentari, compresi quelli di quarta gamma e pronti al consumo. Una parte del volume e specificamente dedicata alle tecniche di ricerca dei microrganismi e dei loro metaboliti, dalle metodiche tradizionali a quelle piu avanzate. I diversi aspetti e le problematiche della conservazione degli alimenti sono trattati in relazione alle tecniche disponibili e ai fattori e alle forme di resistenza dei diversi gruppi microbici. Sono inoltre approfonditi i temi della valutazione e dell'analisi del rischio e degli indicatori di qualita e di sicurezza in tutte le fasi della produzione alimentare. Conclude il volume un'esaustiva rassegna delle principali malattie trasmesse da alimenti, dei patogeni responsabili e delle misure di controllo e prevenzione. L'opera e ricca di illustrazioni, tabelle e grafici e ogni capitolo e completato da un'ampia bibliografia. Un testo indispensabile per gli studenti e i ricercatori, ma anche un prezioso strumento di lavoro e di consultazione per tutti coloro che operano professionalmente nel settore alimentare o a stretto contatto con esso.

Human African trypanosomiasis or sleeping sickness is caused by infection with the morphologically indistinguishable subspecies Trypanosoma brucei rhodesiense (in East and Southern Africa) and Trypanosoma brucei gambiense (in West and Central Africa). The disease is presently almost under control and less than 4000 cases are currently reported. In both, T. b. rhodesiense and T. b. gambiense infection, after the injection of infective metacyclic trypanosomes with tsetse fly vector saliva, the parasites establish in the skin, differentiate to the bloodstream stage and spread via the local draining lymph node into the vascular system. In this book, Chapter One presents an overview of the current epidemiology, clinical features, diagnosis and treatment options. Chapter Two provides an in-depth review of diagnostic methods for African trypanosomiasis. Chapter Three discusses the use of aminoadamantane derivatives against Trypanosoma brucei.

This volume provides a reflective summary of research in parasitology in the late 20th Century combined with a vision of the major challenges and potential successes in the 21st Century. It has been compiled from selected papers presented at the Eighth International Congress of Parasitology. A wide variety of topics are covered including medical, veterinary, and plant parasitology, by contributors from many different countries. Chapters within the book consider current research on the biology of parasites, and new strategies in the transmission and control of parasitic diseases. This book represents an invaluable resource for all parasitologists. Not only is it an up- to-date summary of research, but it is also a thought provoking look at the future.

Human Parasitology, Fifth Edition emphasizes a medical perspective that also incorporates functional morphology, physiology, biochemistry and immunology to enhance appreciation of the diverse implications of parasitism. Bridging the gap between classical clinical parasitology texts and traditional encyclopedic treatises, the book will not only appeal to students interested in the medical aspects of parasitology, but also those who are interested in gaining a solid foundation in the biology of parasites. This updated edition has been fully revised to integrate the most recent molecular discoveries about mosquitoes, ticks and other arthropods as vectors, along with the most effective therapeutic regimens for each.

Nematodes are a highly assorted group of invertebrates occupying many terrestrial and aquatic habitats. Recent research has focused on the examination of nematode life history and biological traits to reflect the key functional attributes and infer the effects of environmental variables and human activities. In this book, the authors discuss the interaction between lectins and nematodes, biodiversity and distribution of nematodes belonging to the families Longidoridae and Trichodoridae in different habitats, analytical method for chemical characterisation of nematodes, and the use of plants as natural sources of nematicides.

Toxoplasma gondii is a parasite of the phylum Apicomplexa, Coccidia order, being an obligate intracellular protozoan that affects humans and diverse vertebrate hosts. In this book, the authors discuss its prevalence in humans and animals, genetic structure and role in disease distribution. Topics include the congenital transmission of toxoplasma gondii in ovine; the role of chickens in the transmission of toxoplasmosis to humans; updates on the serological and molecular diagnosis of toxoplasmosis; epidemiology and control of toxoplasmosis in dogs, cats, bovine, and in public health.

Parasitic Nematodes are amongst the most successful parasites on Earth. This fully-updated second edition constitutes a comprehensive volume that continues to discuss the molecular biology, biochemistry and immunology of nematode parasites of humans, domestic animals and plants. There is a strong focus on new advances including chapters on horizontal gene transfer, genetics of susceptibility in humans, nematode protein structures, role of bacterial symbionts, host immune system modulation, modulation of allergic and autoimmune diseases by parasitic nematodes and the use of these organisms or their products as therapeutics. This book will be of significant importance to advanced students and researchers in human and veterinary parasitology, plant nematology and pathogen immunology in general.

To date, parasite diseases still affect millions of people world-wide, mainly in developing countries. The recent sequencing of parasite genomes opened a new era in parasitology research since the acquisition of new genomic data, providing a useful tool to analyse and compare gene structure, location and characteristics from different species to study evolution and gene function. This book is a collection of the recent findings of international experts in modern parasitology, computational biology, evolutionary biology, and genetics. It includes specific data on the current knowledge and understanding of genome organisation, dynamic and function for Plasmodium falciparum, Trypanosoma spp., Leishmania spp., Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica and Microsporidium, which represent the main causes of parasitic infections in humans. This book will be an essential reference for all parasitologists and scientists, as well as researchers, postdoctoral fellows and graduate students in computational biology, evolutionary biology, and genetics.