Microscopy is at the forefront of multidisciplinary research. It was developed by physicists, made specific by chemists, and applied by biologists and doctors to better understand how the human body works. For this very reason, the field has been revolutionized in past decades. The objective of Optical Nanoscopy and Novel Microscopy Techniques is to choose some of those revolutionary ideas and serve a general audience from broad disciplines to achieve a fundamental understanding of these technologies and to better apply them in their daily research. The book begins with coverage of super-resolution optical microscopy, which discusses targeted modulation such as STED and SIM or localization methods such as PALM. It then discusses novel development of fluorescent probes, such as organic small-molecule probes, fluorescent proteins, and inorganic labels such as quantum dots. Finally, it describes advanced optical microscopy, such as fluorescence lifetime imaging, fiber optic microscopy, scanning ion conductance microscopy, and the joining of optics and acoustics-photoacoustic microscopy. Following each chapter, a detailed list of references is provided. Problems at the end of each chapter are also included.

Recent developments in atomic force microscopy (AFM) have been accomplished through various technical and instrumental innovations, including high-resolution and recognition imaging technology under physiological conditions, fast-scanning AFM, and general methods for cantilever modification and force measurement. All these techniques are now highly powerful not only in material sciences but also in basic biological sciences. There are many nanotechnology books that focus on materials, instruments, and applications in engineering and medicine, but only a few of them are directed toward basic biological sciences. This book tries to bridge this gap.

Edited by a prominent researcher, this volume provides an overview of modern AFM technologies: the basic AFM protocols in Part I, newly developed technologies in Part II, and the most recent applications of AFM technologies in biological sciences in Parts III and IV. The chapters are contributed by some of the leading scientists in the field of nanobiology.

Provides an account of some of the key developments in the field since the 1992 publication of the monograph Acoustic Microscopy by Oxford U. Press. Among the topics in eight contributed chapters are acoustic microscopy analysis of microelectronic interconnection and packaging technologies; measurin

Drug performance is a vital part of drug development, drawing on expertise from both pharmaceutics and pharmacokinetics disciplines. This book offers readers step-wise information to develop quality pharmaceuticals. It consists of sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality.

The European Federation of Corrosion s Working Party on Surface Science and the Mechanisms of Corrosion and Protection (EFC WP6) has defined, as one of its objectives, the development of a reference material and reference guidelines for the application of electrochemical scanning tunnelling microscopy (EC-STM) in corrosion science. The use of EC-STM to study the relationship between surface structure and surface reactivity in situ on electrodes in contact with an electrolyte is of major importance in corrosion research. This report describes the reference material and procedural guidelines required to use this technique effectively. STM-users are instructed how to obtain high resolution data on a carefully prepared copper single-crystal surface.
Describes the reference material and procedural guidelines required to use this technique effectivelyDiscusses an area of major importance in corrosion research"

Stereology is the science that relates three-dimensional structure to the two-dimensional images that can be measured. The most common field of application is in microscopy, both of man-made materials (metals, ceramics, composites, etc.) and of biological tissue samples. This book covers the applications and terminology of both fields. Recent emphasis in stereology is concerned with sampling strategies to avoid bias due to directionality and non-uniformity, and these methods are fully covered. So are the classic techniques that measure size distributions, surface curvature, etc., which are widely useful but not discussed in other recent texts. Finally, most stereology is taught as manual procedures using counting and grids, but this text also covers the use of modern desktop computers for image analysis and processing to obtain and interpret the stereological data.