Congenital hip disease (CHD) is the main cause of secondary osteoarthritis (OA) of the hip in young adults, which accounts for almost 40% of all cases of hip OA. Total hip replacement (THR) performed using optimal techniques can achieve a radical improvement in the quality of life of adult patients. This book offers in-depth coverage of all aspects of CHD in adults and its treatment. Relevant information is first provided on the basic anatomy of the hip and OA of the hip and on the classification, epidemiology, and natural history of CHD. The now limited role of femoral and pelvic osteotomies is carefully evaluated, and the use of THR is then considered in detail. Indications and preoperative planning are discussed, and the available operative techniques, analyzed. Clear guidance is provided on overcoming major technical difficulties, and the benefits of particular approaches and techniques are highlighted. More than 180 images and numerous case studies complement this reader-friendly text. The book will be an invaluable tool for orthopedic surgeons, rheumatologists and radiologists.

Total joint arthroplasty is an effective surgical procedure for end-stage osteoarthritis of major joints with satisfactory long term clinical outcome. A large and growing number of arthroplasties are performed annually worldwide and a great number of orthopaedic surgeons are practicing arthroplasty surgery as their main surgical activity. The biological behavior of the bone-implant interface is crucial for the long term survival of the artificial joint. All factors which have a positive or negative effect on the interface are of great interest for those practicing arthroplasty surgery. Basic scientists and the industry are continuously searching for new implant fixation mechanisms and improved materials. There is an accumulation of a great amount of basic science data (both biological, material and mechanical) related to the incorporation or loosening of the bone-implant interface. However, basic science data does not always translate to satisfactory clinical application, and orthopaedic practitioners often wonder which piece of information is clinically useful. A further problem is that basic scientists often speak their own scientific language and may not fully appreciate common clinical practice needs. In this textbook the biological and mechanical mechanisms of implant incorporation and loosening will be presented. All new data concerning materials and methods for incorporation enhancement will be critically analyzed. Data useful for clinical application will be stressed. Orthopaedic Surgeons will find information which will improve their clinical practice and basic scientists will be helped to understand and appreciate clinical needs.

Recent research indicates that gender differences in anatomy and physiology, endocrinology, hand eye co-ordination and motor development have an effect on the kinds of injuries incurred as a result of sporting activities. Since men and women have different responses to exercise; strength and conditioning programs should be modified for these differences. Musculoskeletal Health in Women was born out of a need to provide fitness advice tailored to women. For example, research has focused on correcting neuromuscular imbalances in women to prevent injuries. Increased abduction moment at the knee and balance problems have been found to be predictors of ACL injury. Muscle strengthening with special emphasis on the terminal knee extensors and hip abductors can improve these neuromuscular imbalances. Additionally, taping and bracing at the ankle may be helpful, particularly in women prone to certain injuries. Any discussion of women's sports injuries is only complete if it includes the Female Athlete Triad: energy availability (which is affected by eating disorders), osteoporosis, and menstrual function. Musculoskeletal Health in Women provides a fully-illustrated and comprehensive overview of all of these aspects and its multidisciplinary approach ensures that expertise is provided from disciplines such as psychiatry, physiatry, endocrinology, nutrition, rheumatology, orthopedics, physical therapy and radiology. These authors have worked with women athletes of all ilks and are well equipped to address a full spectrum of issues related to the musculoskeletal health of women. Musculoskeletal Health in Women will be of primary interest to women athletes and women embarking on a fitness regimen. Health professionals working in this area would also invariably benefit from the advice and guidance provided within these pages.

Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves - such as bisphosphonates, antiresorptives and anabolic agents - within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.

This volume describes the most recent medical guidelines for perioperative management in arthroplasty with the aim of facilitating excellent control of bleeding/thrombosis, pain and infection. For each area – hemostasis control, pain control and infection control – hot topics of key practical importance are discussed and contrasting perspectives are presented on controversial issues, covering the views of different practitioners and specialties. Using the information contained in this book, the practitioner will be in an excellent position to meet the principal goals of perioperative medical management. The information provided will assist in the choice of a multimodal guideline that minimizes the complication rate regarding bleeding and thromboembolism while not interfering with the patient’s recovery. Similarly, effective means of pain control and an optimized pain control protocol are discussed with a view to shortening hospital stay and achieving functional milestones that meet the patient’s expectations. Finally, host, wound and environmental factors relevant to infection and its prevention are explained, with discussion of the best means of prophylaxis, treatment and imaging. Surgeons, anesthesiologists and all medical practitioners and staff involved in the field of total hip and knee arthroplasty will find this book to be of value in their daily clinical practice. It will assist in the provision of enhanced medical management that ensures quicker recovery of the patient with fewer complications.

Neglected finger injuries may lead to chronic lesions that often have detrimental consequences for the practice of a ball sport, whether at a recreational level or at the top athlete level. The initial injury management is crucial. Depending on the type and the severity of the lesions, different people may get involved: the players themselves or their entourage, physiotherapists, club doctors, emergency physicians, family doctors, sports doctors or hand surgeons. Treatment is usually conservative: the long fingers require rapid mobilization to prevent stiffness and contrary to that, the thumb requires stability. Surgery may be necessary to reach these goals especially for athletes, because of the demands of their sport. Chronic lesions are also in part related to repeated trauma, requiring specialized long-term multidisciplinary treatment. They can often lead to the end of a sporting career, but also may limit the functionality of the fingers at the time of conversion. Dr Chick is Consultant Hand Surgeon in Hopital de la Tour (Geneva) and Clinique de Genolier, Switzerland, and Visiting Surgeon in Aspetar, Orthopaedic and Sports Medicine Hospital, Doha, Qatar.

In Osteoporosis and Osteoarthritis expert investigators detail modern tools to enhance discovery in bone and cartilage biology and promote translational research in osteoporosis and osteoarthritis. New chapters describe methods to generate induced pluripotent stem cells, perform high-throughput chromatin analysis, assess loads on bone cells in vivo and in vitro, use state-of-the art imaging techniques to measure articular cartilage thickness and biochemical properties, and establish animal models of osteoarthritis and bone healing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Osteoporosis and Osteoarthritis shares successful techniques that can be applied to the study of either disease.

Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.

This book creates a unique platform that covers main ankle pathologies specifically related with football. Experiences from professional players have been combined with evidence-based medical content from renowned experts in the field to present a comprehensive picture on ankle injuries in football. Worldwide, ankle injuries present a high burden for sports medicine physicians, physiotherapists, players and coaches in and around the football pitch. This book contains updated content for both medical and nonmedical individuals involved with football.

Hip Magnetic Resonance Imaging presents a basic yet comprehensive discussion of the role and use of MRI in the diagnosis and treatment of injuries and diseases of the hip, highlighting common concerns and procedures. Beginning with the principles of MRI and dGEMRIC and moving on to normal and abnormal hip anatomy, the focus shifts to the MRI techniques used in the detection of disease conditions of the hip, including labral disease, osteonecrosis, extra-articular conditions and cartilage damage. Chapters on the utilization of biochemical imaging biomarkers in the treatment of hip disorders round out the text. Written by experts in radiology and orthopedics and generously illustrated with MRI radiographs, this book will be an important reference work for clinicians in those fields, as well as practitioners of sports medicine and primary care physicians.

This book addresses the background and significance of the factors potentially influencing the clinical and biological outcomes of metal-on-metal hip implants. Metal-on-metal bearings were introduced and evaluated as an alternative to other bearing couples, particularly metal-on-polyethylene, due to their enhanced wear resistance as determined in laboratory testing. Initially, reports of short-term clinical outcomes were favorable and an increasing number of metal-on-metal prostheses were implanted. Subsequently, isolated case findings describing adverse tissue responses around the articulation became the harbinger of an increasing number of reports describing pseudotumors and other significant lymphocytic-based responses associated with metal-on-metal prostheses. Questions have been raised as to whether this is an implant, design, or patient-specific response. The reasons why some patients have a negative biological response and pathology while others do not remain to be determined, but tens of thousands of patients in the US, the UK, and around the world are considered to be at risk. Leading researchers and clinicians describe the issues related to the nature of the biological and pathological responses and the protocols that should be followed to determine if an adverse response is occurring. This book is essential reading for researchers, engineers, and orthopaedic surgeons who are involved in the design, evaluation, and implantation of metal-on-metal prostheses.

Molecular and Cell Biology of Muscular Dystrophy gives a series of accounts of various aspects of the remarkable breakthrough which has been achieved in our understanding of the Duchenne/Becker muscular dystrophies and of the consequences and ramifications of this breakthrough.

Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener's granulomatosis, systemic sclerosis, Sjoegren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.

Arthritis Research: Methods and Protocols, Second Edition expands upon the first edition to present new and current techniques for the research of arthritis and related conditions. A compendium of leaders in the field contribute chapters that cover practical research methods such as the intravital multiphoton microscopy technique, techniques for evaluating exhausted CD8 T cell and for studying nucleic acid sensors and their effects, methods for in vivo tetracycline-controlled transgenic mice and T cell receptor transgenic mice, protocols to detect V(D)J recombination products and microRNA, and the technique to make bleomycin-induced dermal fibrosis. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Arthritis Research: Methods and Protocols, Second Edition will serve both professionals and novices with state-of-the-art techniques pertaining to this fascinating research field.

This third edition expands upon the role of anticoagulants in clinical practice. In addition, it summarizes new developments in the field and provides evidence-based guidelines for the use of anticoagulants in routine day-to-day practice. The Handbook of Thromboprophylaxis Third Edition is a key resource for all physicians with an interest in thromboprophylaxis.

This text provides a comprehensive overview of orthopaedic oncology – the field of orthopaedic surgery that specializes in the evaluation and treatment of bone and soft tissue tumors of the musculoskeletal system. The opening chapters cover musculoskeletal imaging interpretation and the principles of musculoskeletal biopsy. Assessment and treatment of the full range of tumors are then described in a series of well-illustrated chapters. Detailed consideration is given to benign tumors, osteosarcomas, Ewing sarcomas, chondrosarcomas, metastatic bone disease of the axial and appendicular skeleton, and soft tissue sarcomas. This book will be invaluable for both orthopaedic surgeons and medical oncologists, providing a framework for understanding the fundamentals of these tumors and a sound basis for their treatment.

A number of books and research papers have been published on trauma and biomechanics.Theyhavesofarnotbeenrealisticallyintegrated.Thebasicaim ofthisbookistopresentauni?edapproachbetweentheengineeringandm- ical professions. The available engineering analyses and mathematical models can be interlinked and glued together with the medical ?ndings by means of surgeries and X-rays/scans. They can be translated into vastly developed computer programs predicting e?ects of plasticity, temperature, cracking, and crushing with and without muscles and other interlocking phenomenon. The available mathematical-cum-engineering model on trauma and bone mechanics are then linked to the ?nite element analysis and to a computer programinwhichprovisionsaremadetocaterforallpossibleeventualitiesand medicalparameters.Theproblemencounteredbysurgeriescanbeeasilybe- corporated into hybrid ?nite element computer programs such as PROGRAM ISOPARusedinthisbook.Inallcasestudiesthesurgicalin?uenceshavebeen considered together with the bone material data for both the operational, nonoperational and overloading behaviour of the human body structure. In all circumstances the human body structure and its important elements were treated as composite. The bone-blood interaction has been incorporated in ordertoobtainrealisticsolutions.Materialpropertiesinthree-dimensionhave always been considered in throughout in various investigations. Engineering analysis of trauma is being continuously developed taking into consideration the ever increasing changes in analytical, design, safety, and manufacturing techniques. The engineering advances in that direction are steadily gaining international acceptance in the wide sense of the medical profession.

Presenting a logical, comprehensive approach to the patient with a massive rotator cuff tear, this book begins with the pathoanatomy and diagnostic work-up for this common injury, including imaging. Both non-operative and operative treatment options for massive tears follow, including arthroscopy, the use of biologics and patches, tendon transfers, and hemiarthroplasty and reverse total shoulder arthroplasty. A practical treatment algorithm for clinicians treating patients with massive rotator cuff tears is also included. Each chapter opens with pearls and pitfalls covering the main key points for quick reference. The overarching theme of this book is that patients with similar imaging findings may demonstrate very different clinical presentations, and the final treatment recommendation should be made based on their complaints and expectations. As such, it will be an excellent resource for orthopedic surgeons, sports medicine and shoulder physicians, physiatrists, physical medicine and rehab specialists, and occupational therapists.

This book provides clear instruction on the surgical treatment of joint problems in adult hemophilia patients. The procedures applicable to specific joints, including the shoulder, elbow, hip, knee and ankle, are carefully reviewed with the aid of high-quality illustrations. The surgical treatment of articular hemophilic pseudotumors and bone cysts is also considered. In addition, clinically relevant information is provided on a range of topics, such as the treatment of hemophilic hemarthrosis, the imaging of hemophilic joints, hematological perioperative management, anesthesia, rehabilitation and pharmacoeconomics. Finally, the controversial issues of postoperative thromboembolic prophylaxis and the role of COX-2 inhibitors in hemophiliacs are reviewed. The guidance provided draws on both the authors' extensive personal experience and an in-depth review of the pertinent literature. The book offers an excellent, up-to-date account of knowledge on musculoskeletal problems and approaches to joint surgery in adults with hemophilia. It will be of value to orthopedic surgeons, rehabilitation physicians, hematologists, radiologists and pharmacy researchers.

Spinal Injuries and Conditions in Young Athletes provides a comprehensive, in-depth review of the mechanisms and management of back injuries and problems occurring in this ever-growing and active population. Led by Dr. Lyle Micheli and his co-editors, an award-winning group of orthopedists discusses and explores common adolescent spine injuries and procedures, in addition to breakthroughs in gene therapy, tissue engineering, and complex operations. As spine surgery is among the most complex and challenging procedures performed in orthopedics, special considerations and procedures are required in pediatric populations. Since many corrective surgeries run the risk of arthritis later in life, particular efforts must be made in young populations to prevent future injury in a child's adolescence and young adulthood while maximizing return-to-play potential. Chapters cover acute spinal injuries, concussions, overuse injuries, spinal malformations, tumors, infections and inflammatory diseases across the range of athletics, including swimming and combat sports. Spinal Injuries and Conditions in Young Athletes provides an immeasurable guide for back surgery in pediatric populations and will be a go-to resource for practitioners and residents in pediatric orthopedics and sports medicine.

Thoroughly discussing the varied elements of meniscal damage and repair, Meniscal Injuries: Management and Surgical Techniques includes the insights and expertise of over 20 leading surgeons and researchers on topics ranging from meniscal anatomy, physical examination, innovative resection and repair techniques, gene therapy, and tissue regeneration. This treatise offers wisdom aimed at assessing true surgical candidates, exploring the intricacies of meniscal composition and function, an overview of meniscal scaffolds and replacements, and patient examination pearls. Also discussed in depth is cutting edge research concerning meniscal repair enhancement, nanofiber technology as a means of meniscal replacement, and biologic agents directed toward chondral protection. All the science presented will direct the sports medicine practitioner to state-of-the-art treatment aimed at knee preservation. Meniscal repair and regeneration is a rapidly evolving science - early attempts at meniscal restoration or repair resulted in short-term gains which often sacrificed long-term joint integrity. Now, the practitioner is afforded numerous means of retaining or restoring meniscal tissue. Breakthroughs in scaffold and allograft replacement, as featured herein, offer the promise of articular cartilage preservation like never before. In addition, tissue regeneration and gene therapy techniques, featured throughout, offer a glimpse into emerging technologies aimed at preserving or replacing meniscal tissue in previously considered "hopeless" cases. As such, Meniscal Injuries will be an indispensible resource to orthopedic surgeons and sports medicine practitioners interested in providing the absolute most contemporary and evidence-based care to their patients.

Accurate assessment of hand function is critical to any treatment regimen of the hand compromised patient. Hand Function is a practical, clinical book which provides the knowledge needed to distinguish the different dimensions of hand function, particularly impairment, disability and handicap. Beginning with an overview of basic principles and examination, subsequent chapters evaluate the hand function in specific afflicted populations, including the rheumatoid patient, the stroke patient, the trauma patient, the geriatric patient and the pediatric patient, as well as special populations such as diabetes mellitus patients and musicians. An appendix containing hand function scales essential to the assessment of disability is also included. Rheumatologists, physiatrists, hand surgeons, orthopedists, occupational therapists and physical therapists will all find Hand Function a useful and valuable addition to their clinical references.

Selected as a Doody's Core Title for 2022! For nearly 40 years, Surgical Exposures in Orthopaedics: The Anatomic Approach has helped orthopaedic surgeons enhance their anatomic knowledge, increase safety, and improve patient outcomes. The fully revised sixth edition carries on the legacy of Dr. Stanley Hoppenfeld (1934-2020), whose ideas have influenced orthopaedic surgical care worldwide. Coauthored by Piet de Boer and Dr. Richard Buckley, this bestselling reference provides a clear view of orthopaedic anatomy from the surgeon's perspective using easy-to-follow descriptions and hundreds of superb full-color illustrations. Brings you up to date with recent changes in the field, using a highly relevant anatomic approach that has become increasingly important as approaches become smaller. Details the techniques and pitfalls of each surgical approach, gives a clear preview of anatomic landmarks and incisions, and highlights potential dangers of superficial and deep dissection. Contains 21 new surgical approaches, including fixation of rib fractures, the suprapatellar approach for tibial nail insertion, a minimally invasive approach to the clavicle, the posterior triceps-on approach to the distal humerus, three new approaches to the distal femur, as well as several others. Includes expanded content on the anteromedial approach to the elbow and new surgical approaches to the talus, cuboid, navicular, and Lisfranc's joint. Features fully revised content throughout, including changes to the trochanteric osteotomy required to perform surgical hip dislocation, updated content on external fixation, and new references where appropriate. Provides access to numerous high-quality procedural videos from every relevant angle, including a split screen with diagrams. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Comprised exclusively of clinical cases covering scaphoid fractures and nonunions, this concise, practical casebook will provide clinicians in orthopedic, plastic and hand surgery with the best real-world strategies to properly diagnose and treat the various forms of the condition they may encounter. After a brief introduction covering scaphoid anatomy, each chapter is in the form of a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Cases included illustrate different injuries and management strategies from acute scaphoid fractures and nonunions to advanced collapse, covering non-operative and arthroscopic techniques as well as autograft procedures and salvage options. Pragmatic and reader-friendly, Scaphoid Fractures and Nonunions: A Clinical Casebook will be an excellent resource for seasoned as well as those training to be orthopedic surgeons, plastic surgeons, hand surgeons and emergency medicine physicians alike.

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.