This fascinating book describes the history, and epidemiology in both man and animals, and clinical features of this zoonosis. It reveals detailed information pertaining to the basic science aspects of the interaction of Coxiella burnetii, the etiologic agent of Q (Query) fever, with the host and the immune response of the host to this unique pathogen. This one-of-a-kind work uses the rules of epidemiological evidence to determine whether or not Coxiella burnetii is a perinatal pathogen for man. This interesting, easy-to-understand text concludes with chapters dealing with the antibiotic susceptibility of Coxiella burnetii and the studies that resulted in a vaccine that now can be used to prevent this infection. This volume is an absolute must for all microbiologists, respirologists, infectious disease physicians and veterinarians.

This publication is a collection of essays on the biology of intracellular parasitisms where both bacterial and protozoan parasites are discussed. The juxtaposition of authors representing fields of research emphasizes the many common problems facing intracellular parasites and the hosts that harbor them. In addition, numerous illustrations of how different parasites and host attempt to solve these problems in different ways are provided. The book includes one or more chapters on Bdellovibrio, Chlamydia, Rickettsia, Coxiella, Legionella, Shigellae, Mycobacterium, Microsporidium, Plasmodium, and Toxoplasma. The authors frequently speculate and generalize on the subject matter discussed.

Hygienic Design of Food Factories, Second Edition includes updates on existing chapters, along with new sections on cold storage, the control of air in food refrigeration facilities, and prevention of contamination when building during production and regulations in Asian countries (other than Japan). Sections cover the implications of hygiene and construction regulation in various countries on food factory design, describe site selection, factory layout and the associated issue of airflow, and address the hygienic design of essential parts of a food factory, including walls, ceilings, floors, selected utility and process support systems, entry and exit points, storage areas, and more. With its distinguished editors and international team of contributors, this book continues to be an essential reference for managers of food factories, food plant engineers, and all those with an academic research interest in the field.

Based on papers presented at the XI International Congress for Tropical Medicine and Malaria, this publication provides an authoritative evaluation of treatment and control of helminth parasite infections. A section on leprosy and a brief review of malaria vaccination are included. A comprehensive review of the history of schistosomiasis control programs presents information unavailable elsewhere. This book is of special interest to professionals concerned with health problems of less developed countries and in particular to public health officials, epidemiologists and clinicians dealing with patients in or returning from the tropics.

This informative text is divided into eight chapters, each of which presents a comprehensive review of natural and acquired host defense mechanisms in a major mycotic disease. The chapters are written by distinguished scientists whose studies have contributed significantly to the understanding of the immunology of the mycoses. This text should provide a valuable reference for researchers, practicing clinicians, and new investigators entering this expanding field.

Written expressly for the surgical pathologist, the pathology resi-dent and the urologic surgeon, this volume describes the histopathologic appearances of diseases affecting the prostate and the seminal vesicles. The introductory chapter includes a dis-cussion on the role and limitations of immunohistochemistry and fine needle aspiration in the diagnosis of prostatic carcinoma. In the pathologic descriptions the main emphasis is placed on microscopic differential diagnosis. Many conditions are discussed including pro-static calculi, benign nodular hyperplasia, tumors of prostatic urethra, therapy-induced changes, and rare carcinomas. Many dia-grams, charts, tables and 221 photomicrographs complement the text.

The first in a new series created to acknowledge the explosion of knowledge in fields related to infectious disesases and clinical microbiology. Thirteen contributions focus on organisms which are of major medical importance in this country or which have contributed to an understanding of pathology.

With a strong emphasis on hands-on learning, this highly practical text helps you develop the phlebotomy-related knowledge and skills you need to become a confident, competent health care professional. The Fifth Edition accelerates learning by following key topics immediately with relevant exercises, integrating workbook elements and textbook content to deliver a complete learning experience. The text covers the latest professional standards and competencies while thoughtfully connecting them to the realities of practice today. Step-by-step guidelines for more than 20 collection procedures are provided, along with real-life scenarios and prompts emphasizing the phlebotomist's legal and ethical role in patient care decisions. Full-color photographs highlight important steps and relevant equipment, while illustrations depict anatomical components critical to proper technique. In addition, the digital edition includes videos and interactive exercises ideal for today's learners.

This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.

This book is a collection of works that canvass many of the recent developments in various areas of connective tissue research. It focuses on the structure of the components, molecular organization and pathology of the extracellular matrix.

This guide to dermatopathology is a general overview helping readers review the histopathology of dermatological conditions. The book discusses superficial perivascular, interface, spongiotic, and psoriasis form dermatitis. It also examines lymphohistiocytic infiltrate, leukocytoclastic vasculitis, panniculitis, and folliculitis. Additional chapters cover nodular and diffuse dermatitis and bullous and vesicular dermatitis. The book describes the dermatopathology hierarchy infrastructure and provides a glossary of terms. Established practitioners as well as trainees will find this an ideal resource for revision and for recertification in the topic. Each entry follows a similar format with includes information on epidemiology, pathophysiology, clinical features, special studies, and clinical variants, histological features, histological differential and Good Things to Know.

The Essentials in Cytopathology book series fulfills the need for an easy-to-use and authoritative synopsis of site specific topics in cytopathology. These guide books fit into the lab coat pocket and are ideal for portability and quick reference. Each volume is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. This new edition of Pulmonary Cytopathology is fully updated and expanded providing more detailed discussion of the role of new techniques such as EUS needle biopsy and specific issues of adequacy assessment. The section on subclassification of poorly-differentiated non-small cell carcinomas has been expanded to include accuracy of diagnosis in small samples, the new classification of adenocarcinoma and NSCC, currently-used ancillary techniques; i.e., immunohistochemistry, molecular/genetic techniques and therapeutic applications. Molecular techniques have been added as needed for targeted therapy. The text and illustrations have been expanded throughout.

Nanotechnology Applications for Food Safety and Quality Monitoring brings together nanotechnology science-based research for food safety and quality monitoring. With the advancement in knowledge about behavior of nano-engineered materials in food and its toxicity, the application of nanotechnology is expected to reach unprecedented levels in achieving food safety. Currently, there is no practical resource of nanotechnology as a tool specifically for monitoring safety and quality. This is a practical, concise, applications-based reference that is essential for food industry researchers and scientists to monitor the safety and quality of food to ensure quality food supplies.

Significantly expanded, expertly and beautifully illustrated, The AJCC Cancer Staging Atlas, 2nd Edition, offers more than 600 illustrations created exclusively for this new edition and is fully updated to reflect the concepts discussed in the 7th Edition of both the AJCC Cancer Staging Manual and its companion Handbook. This Atlas illustrates the TNM classifications of all cancer sites and types included in the 7th Edition of the Manual and visually conceptualizes the TNM classifications and stage groupings. Specifically designed for simplicity and precision, the drawings have been verified through multi-disciplinary review to ensure accuracy and relevancy for clinical use. Every illustration provides detailed anatomic depictions to clarify critical structures and to allow the reader to instantly visualize the progressive extent of malignant disease. In addition, nodal maps are included for each site, appropriate labeling has been incorporated to identify significant anatomic structures, and each illustration is accompanied by an explanatory legend. The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.

Schistosomiasis is Africa's second most common parasitic disease. Less than 20 years ago, over 200 million were infected. In many high-risk areas the Schistosomiasis Control Initiative (SCI) has been helping to tackle the disease by offering treatments to millions of children. This book tells the story of a man, Alan Fenwick, who founded the SCI to control the worms and snails and so improve the lives of many burdened with the disease as well as reducing the numbers infected. Over this period SCI and the Ministries of Health and Education in 16 countries delivered over 220 million treatments. Treatment coverage of up to 75% has been achieved. Widely recognised as a cost-effective and successful intervention, SCI's knock-on effects include improving overall physical health, school attendance and future prospects for millions of people. The authors explore the work and experiences involved in forming, establishing and managing a health intervention system such as the SCI, while describing important lessons for anyone looking to replicate the success. This book covers: - Challenges faced and how the SCI overcame them to achieve its success; - Raising funds to deliver donated medicines; - Development of innovative partnerships; - Cultivation of working relationships and implementation across Africa; - A new model for other Neglected Tropical Disease programmes (NTDs); - Aspects of Alan's life in Africa told with memorable and often humorous anecdotes. A Tale of a Man, a Worm and a Snail is an essential resource for researchers, policymakers, health professionals and students of NTD control. The book is an enlightening, informative and enjoyable read for anyone interested in global health.

Pathophysiology and Pharmacology in Nursing has been carefully designed to provide an integrated introduction to both the biology of disease and the therapeutic agents that are used to manage them. It covers the basics of pharmacology, the core pathological concepts of inflammation, infection and cancer, as well as a systems based consideration of the pathophysiology and relevant pharmacology of common disorders. New to the second edition: All content updated and mapped to the 2018 NMC standards Two new chapters on 'Mental health conditions' and 'Renal conditions. The ideal starting point for student nurses to develop a robust, integrated knowledge of human disease and pharmacology, enabling them to provide care that is based on up-to-date knowledge of this important subject.

Neurovirology is an interdisciplinary field representing a melding of virology, clinical neuroscience, molecular pathogenesis, diagnostic virology, molecular biology, and immunology. Neuroviral Infections: RNA Viruses and Retroviruses presents an up-to-date overview of the general principles of infections and major neuroviral infections caused by RNA viruses and retroviruses. It is designed for virologists, specialists in infectious diseases, teachers of virology, and postgraduate students of medicine, virology, neurosciences, and immunology.

Key features: Succinct case studies presented in an easy-to-read format, listing patient history, examination and investigations Questions at the end of each case prompt readers to consider their options for diagnosis, investigation and management Answer pages then guide readers through the clinician's sequence of thoughts and actions Subsections include histopathology, laboratory medicine (chemical pathology and immunology), haematology and microbiology Illustrations, information boxes and key points summaries reinforce learning, ideal during exam revision A broad range of common conditions is covered, from acidosis to urinary tract infection, together with more unusual cases

The aim of the book was to produce the most comprehensive examination of a pandemic that has ever been attempted. By cataloging the full extent of the Zika pandemic, this book will be the most complete history and epistemic contextualization ever attempted to date. The work should function as the primary source for students, researchers, and scholars who need information about the Zika pandemic. This book examines the technical literature, digital and popular literature, and online materials to fully contextualize this event and provide a bona fide record of this event and its implications for the future. It is somewhat serendipitous that while this work was underway, we are going through another pandemic. One of the primary lessons we did not learn by Zika was pandemic events will return repeatedly, and we need to learn from each one of them to prepare the planet for the next one. Just because Zika seemed to have died out does not make it less important. We were lucky that the virus evolved into what seemed to be a less virulent version of itself, and the vector mosquitoes were concentrated elsewhere. Finally, this book represents a tour de force in scholarship involving nearly 4,000 sources of information and does not shy from a detailed examination of the controversies, conspiracies, and long-term consequences when we avoid learning from outbreaks, such as Zika.

Advances in Parasitology, Volume 116, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Landscape analysis of available diagnostic tests for STH: how far are we from the WHO TPPS? and Challenges and solutions for the diagnosis of animal and human Strongyloides stercoralis infection.

Please visit www.cancerstaging.org for information about content updates and staging forms. The AJCC Cancer Staging Manual is used by physicians and health care professionals throughout the world to facilitate the uniform description and reporting of neoplastic diseases. Proper classification and staging of cancer is essential for the physician to assign proper treatment, evaluate results of management and clinical trials, and to serve as the standard for local, regional and international reporting on cancer incidence and outcome. Significantly expanded and developed by international disease site expert panels, the Eighth Edition AJCC Cancer Staging Manual brings together all the currently available knowledge on staging of cancer at various anatomic sites. In this edition, evidence-based TNM staging is supplemented, as appropriate, by selected molecular markers and newly acquired insights into the molecular underpinnings of cancer. This edition features 12 entirely new staging systems, a wide range of changed or new staging definitions, and a refined emphasis on a personalized-medicine approach. To enhance the print and electronic usability of the cancer staging forms, they are now available exclusively for access and downloading at www.cancerstaging.org. The Eighth Edition AJCC Cancer Staging Manual remains the gold standard reference for oncologists, surgeons, pathologists, radiologists, cancer registrars and medical professionals world-wide to ensure that all those caring for cancer patients are fully versed in the language of cancer staging.

Offering rapid, portable access to key concepts and principles of pathology from Robbins and Cotran Pathologic Basis of Disease, 10th Edition, this up-to-date Pocket Companion makes it easy to locate essential information on the go. The condensed, at-a-glance format, organized to parallel the parent text, is ideal for quick review-anytime, anywhere. Features cutting-edge information on important topics such as novel therapies for hepatitis C, personalized medicine, the role of microbiome and metabolome in non-communicable disease, and much more. Includes new gross and microscopic figures for clarity of morphology and new artwork depicting the latest advances in molecular pathogenesis of cancers. Reflects updated page references and content changes found in to Robbins and Cotran Pathologic Basis of Disease, 10th Edition. Contains all the key data and principles needed for the USMLE Step 1, in-course exams, and rotations. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The large number of molecular protocols available creates a dilemma for those attempting to adopt the most appropriate for streamlined identification and detection of fungal pathogens of interest. Molecular Detection of Human Fungal Pathogens provides a reliable and comprehensive resource relating the molecular detection and identification of major human fungal pathogens. This volume contains expert contributions from international mycologists involved in fungal pathogen research and diagnosis. Following a similar format throughout, each chapter comprises: A brief review of the classification, epidemiology, clinical features, and diagnosis of one or a group of related fungal species An outline of clinical sample collection and preparation procedures A selection of representative stepwise molecular detection protocols A discussion on further research requirements for improving the diagnosis The book offers an indispensable tool for medical, veterinary, and industrial laboratory scientists working in the area of fungal determination. It also constitutes a convenient textbook for undergraduate and graduate students majoring in microbiology and is an essential guide for upcoming and experienced laboratory scientists wishing to acquire and polish their skills in molecular diagnosis of fungal diseases.

Quality refers to the amount of the unpriced attributes contained in each unit of the priced attribute. Leffler, 1982 Quality is neither mind nor matter, but a third entity independent of the two, even though Quality cannot be defined, you know what it is. Pirsig, 2000 The continuous formulation of good practices and procedures across fields reflects the importance of the recognition and maintenance of "quality" for nearly every profession. The widespread introduction of point-of-care testing, centralization of activities in large core laboratories, and the increase in number and complexity of diagnostic testing worldwide has driven changes in the organization of laboratory diagnostics over the past decades. As such, laboratory diagnostics, continuously catching up to updated techniques and complex procedures, need to stay vigilant about safety and good practices adjustments. Although widely defined and quantified, the concept of quality is an intrinsic feature of the human psyche and decision making. Written to improve laboratory work, Quality Assurance in the Pathology Laboratory examines: Quality assurance of quantifiable methods applied in laboratory medicine and toxicology Quality aspects of emerging disciplines including personalized therapy and virtopsy Regulatory and logistic instrumentation that ensure quality in laboratory methods Professional education at the graduate and postgraduate levels Laboratory diagnostics substantially contributes to clinical decision making by providing valuable information for the screening, diagnosis, therapeutic monitoring, and follow-up of most-if not all-human disorders. Providing general insights into the quality assurance aspects of pathology and laboratory medicine, this book aids in improving laboratory work and, at the same time, shows the possibilities and limits of all logistic and legal tools related to quality issues.

The Oxford Handbook of Tropical Medicine, fifth edition is the definitive resource for medical problems in tropical regions, and in low-resource settings. Comprehensive in scope, and concise in style, this portable guide ensures that you always have the vital information you need at your fingertips. Fully revised and updated for its fifth edition, it is now even better than ever. The chapter on HIV medicine has been significantly updated, and other revisions include up-to-date guidance on viruses such as COVID-19 and Ebola, improved vaccine regimens, and rabies prophylaxis. With the clear, easy-reference style of the trusted Oxford Handbook format, written and reviewed by an international team of clinical experts, this is a truly global handbook and an essential resource. Make sure you never leave home without it!