Asiatic Liver Fluke - From Basic Science to Public Health, Volume 101, is a well-known and respected outlet for detailed and comprehensive reviews written by experts covering all aspects of parasitology. This latest release covers topics of interest, including the Taxonomy, ecology and population genetics of Opisthorchis viverrini and its intermediate hosts, the Epidemiology, geospatial analysis of Opisthorchis viverrini infection and climate change effects in the Mekong basin, Reservoir species and transmission of Opisthorchis viverrini, The draft genome of Opisthorchis viverrini, Functional genomics and genetic manipulation of Opisthorchis viverrini, Microbiomes and liver fluke infection, and more.

Modern Techniques for Food Authentication, Second Edition presents a comprehensive review of the novel techniques available to authenticate food products, including various spectroscopic technologies, methods based on isotopic analysis and chromatography, and other techniques based on DNA, enzymatic analysis and electrophoresis. This new edition pinpoints research and development trends for those working in research, development and operations in the food industry, giving them readily accessible information on modern food authentication techniques to ensure a safe and authentic food supply. It will also serve as an essential reference source to undergraduate and postgraduate students, and for researchers in universities and research institutions.

A study of mast cells and basophils, designed for the use of immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the context of the pathogenic mechanisms involved. The author provides a comprehensive review of the older and contemporary literature, considering both the common and much rarer complications of infection.
Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians.
Key Features
* Provides a comprehensive, worldwide perspective of viral disease pathology
* Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology
* Addresses topics from the perspective of the clinical pathologist
* Illustrates unique, viral induced pathological lesions
* Considers common and uncommon complications of infection

In May 1993, a cluster of cases of a lethal disease among healthy young people brought the attention of the world to the southwestern deserts. A previously unknown disease was killing up to 80% of the people it infected.
The reaction in the area and across the nation mixed fear, lack of information, and the struggles of doctors to save the victims of an unknown killer with hard science and the age old rhythmns of the desert. What came out was the story of a virus that had been killing since man arrived in the American continents, Hantavirus, with deadly relatives across the Americas and across the world. This book explains why and how the virus kills, and why it is still killing today. Why all of the science aimed at a virus identified back in 1993 has not brought a vaccine or a cure is part of the story, as is how that killer virus fits into the story of "new" diseases across the world.
The story of hantavirus disease, what has happened since that first outbreak, and what the real risks are is laid out by an experienced scientist and an award winning journalist living and working in the area of the 1993 outbreak.
Key Features
* Covers the full story of the recent hantavirus outbreak
* Includes interviews with survivors, and local reaction
* Presents the science in lay terms
* Places the event in the broader context of emerging diseases worldwide
* The only account which takes the reader beyond the initial outbreak in 1993-1994, bringing them up to late 1998
* Discusses hantavirus disease in the U.S., Argentina, and Canada

Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for "in vivo" efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections.
Key Features
* Discusses ethical and safety aspects in an introductory background section
* Covers principles of animal care and current techniques appropriate for the use of animal models of infection
* Details a wide range of animals including rodents, rabbits, cats, and primates
* Provides hands-on descriptions of how to set up the model
* Discusses the major advantages and limitations of each model
* Ensures full coverage of bacterial, fungal, viral, and parasitic infections

Zika Virus provides an authoritative account of one of most fascinating viruses of the 21st century, covering all the main points. It includes coverage of clinical manifestations, such as fever and fatigue, but also delves into neurological manifestations like acute demyelinating neuropathy. In addition, the book discusses new evidence that suggests that Zika fever in pregnant women can cause abnormal brain development in fetuses by mother-to-child transmission. The Zika virus infection has become one of the first where women are actively discouraged from getting pregnant. Readers will find this book to be a comprehensive resource on the topic.

Lippincott (R) Connect Featured Title Purchase of the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. Known for generations as the most comprehensive foundational text on medical microbiology, Schaechter's Mechanisms of Microbial Disease delivers a thorough understanding of microbial agents and the pathophysiology of microbial diseases. This trusted text is universally praised for "telling the story of a pathogen" in an engaging way, facilitating learning and recall by emphasizing unifying principles and paradigms. Content is uniquely organized by microbial class and by organ system, making it equally at home in traditional and systems-based curricula. This updated 6th Edition reflects the latest advances in the field, including significant enhancements to the coverage of serious threats to global health (including COVID-19), respiratory and childhood viruses, and sexually transmitted diseases. New illustrations and additional learning features further clarify concepts, reinforce understanding, and help users confidently prepare for board exams and beyond. Abundant full-color images clarify microbial concepts, structures, and processes in vivid detail. New Subject Review Tables broaden students' understanding of chapter content with additional context and detail. Paradigm boxes reinforce general principles through key examples. Case Studies with problem-solving questions, questions provide insight into clinical applications of microbiology, challenge students to apply what they've learned to common clinical scenarios. Key Concepts keep students focused on essential information. Suggested Readings guide students to relevant field research. Bolded Terms familiarize students with new or challenging terms. New content related to the COVID-19 pandemic concerning the virology, clinical features, treatment, and prevention of coronaviruses added to several relevant chapters prepares students for the clinical challenges ahead. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.

Immunofluorescence is a key diagnostic tool in dermatopathology, and essential in the diagnosis of connective tissue diseases, vasculitis and other cutaneous disorders. The need to interpret the results of immunofluorescence testing, and correlate these with histopathological results, is a key skill required not just of dermatopathologists but also, increasingly, of dermatologists who either read the slides themselves or use a pathology lab or academic referral centre. Handbook of Direct Immunofluorescence covers not only day-to-day findings but also less common patterns and rarities, and gives information on important diagnostic pitfalls. Each chapter is dedicated to a specific disease and is introduced by concise text that describes the clinical presentation and pathogenesis: then, multiple images show the range of histopathological and immunofluorescence findings associated with the disease in question. Key points Practical, clinically oriented coverage provides invaluable resource for dermato-, oral and general pathologists, as well as dermatologists Includes invaluable information on technical aspects (specimen procurement, transportation, etc) as well as guidance on interpreting histopathological and immunofluorescence findings Pattern-based approach serves as logical framework for reaching a diagnosis, as well as understanding when to order additional tests and how to recognise nonspecific findings

This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

Hazard Analysis and Risk-Based Preventive Controls: Improving Food Safety in Human Food Manufacturing for Food Businesses is a comprehensive, first of its kind resource for the retail food industry on the Hazard Analysis and Risk-based Preventive Controls (PCHF) regulations of the Food Safety Modernization Act (FSMA). This book covers all aspects of PCHF, including the legislation's intent, applications to ensure safe food production, and resources to keep up-to-date on new food safety hazards and regulatory guidance. Written for food safety professionals and food business leaders, its emphasis on what the retail food industry needs to know about PCHF make it an indispensable resource for organizations buying food from companies required to demonstrate compliance with PCHF. PCHF implementation is (or soon will be) required for human food companies along the supply chain in the United States, as well as all food companies that import ingredients and products for human consumption into the U.S.

Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine provides a comprehensive review of the natural anti-Gal antibody, which is the most abundant antibody in humans constituting ~1% of immunoglobulins and the carbohydrate antigen it recognizes, the a-gal epitope. It discusses the discovery of this antigen/antibody system, its evolution in mammals, the pathological effects of this antibody, and its possible use in various therapies in humans. Most significantly, the book discusses microbial and regenerative therapies in which an antibody present in all humans may be harnessed as an in vivo pharmaceutical agent that enables a wide variety of therapies. Some of these therapies are described as experimental studies that are compiled in this book, other already studied therapies in the area of cancer immunotherapy are also included in this book.

The 'golden age' for antibiotic discovery, from 1940 until the early 1970s, ushered in a new era in human- and animal-health and the associated dramatic increase in human life expectancies. Indeed the possibility of eradicating infectious disease seemed feasible. However it soon became apparent that microorganisms wouldn't be defeated so easily. Their weapon: antibiotic resistance. Today microbial antibiotic resistance is rapidly exhausting our supply of effective compounds and making the possibility of a global public health disaster seems likely. The urgency of this situation has spawned a plethora of new multi-disciplinary research initiatives looking for novel antibiotics and other antimicrobial agents. In this timely book respected international experts summarize the most important research to provide a timely overview of the field. Opening chapters define 'antibiotic', explain why we need new compounds, outline the applications of antibiotics, both old and new, and describe the producing microbes. These are followed by chapters that cover antibiotic resistance, toxicity, overuse, new antimicrobial sources, new targets, novel technologies for antibiotic discovery (e.g. silent gene clusters), lantibiotics, natural antivirals, new macrolide derivatives, and antibiotics in the pipeline. This books is essential reading for everyone working in antimicrobial research in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries.

This book covers both the molecular basics of fungal stress response strategies as well as biotechnological applications thereof. The complex regulatory mechanisms of stress response pathways are presented in a concise and well-readable manner. Also, light will be shed on the interconnection of pathways responding to different types of stress. Profound knowledge of stress responses in yeast and filamentous fungi is crucial for further optimization of industrial processes. Applications are manifold, for example in fungicide development, for improving the resistance of crop plants to fungal pathogens, but also in medicine to help curing fungal infections. The book targets researchers from academia and industry, as well as graduate students interested in microbiology, mycology and biomedicine.

Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.

This volume is composed of chapters that review important fundamental aspects of HCV biology and disease pathogenesis including, for example, the discovery and identification of the HCV genome, early virus-cell interactions including identification of various cellular receptors, HCV gene expression studied using the HCV replicon system, identification and characterization of HCV structural- and non-structural HCV proteins, HCV replication in cultured cells, and host factors involved in viral replication. This volume also contains chapters dealing with immunity to HCV infection and pathogenesis. This is particularly important in understanding hepatitis C because HCV infection alone is not cell lytic. Mechanisms underlying the persistent nature of HCV infection are also discussed in these chapters. Many of the authors published articles that were listed among the "top 10 papers" published in the 24 years since HCV was discovered in 1989. Their citations are above 1,000 (Web of Science). The authors describe the background and significance of their contributions to the field in the context of findings from other research groups.

Applications of High Resolution Mass Spectrometry: Food Safety and Pesticide Residue Analysis is the first book to offer complete coverage of all aspects of high resolution mass spectrometry (HRMS) used for the analysis of pesticide residue in food. Aimed at researchers and graduate students in food safety, toxicology, and analytical chemistry, the book equips readers with foundational knowledge of HRMS, including established and state-of-the-art principles and analysis strategies. Additionally, it provides a roadmap for implementation, including discussions of the latest instrumentation and software available. Detailed coverage is given to the application of HRMS coupled to ultra high-performance liquid chromatography (UHPLC-HRMS) in the analysis of pesticide residue in fruits and vegetables and food from animal origin. The book also discusses extraction procedures and the challenges of sample preparation, gas chromatography coupled to high resolution mass spectrometry, flow injection-HRMS, ambient ionization, and identification of pesticide transformation products in food. Responding to the fast development and application of these new procedures, this book is an essential resource in the food safety field.

Echinococcus and Echinococcosis, Part B, Volume 96 presents a complete synthesis on what is known about the parasitic cestode echinococcus and the disease it causes, echinococcosis (Hydatid Disease), demonstrating that, in addition to its medical, veterinary, and economic significance, it is also an intriguing biological phenomenon. Both parts build on the success of a previous volume-Echinococcus and Hydatid Disease, edited by R.C.A. Thompson and A.J. Lymbery, and published by CAB International-that details the major advances that have taken place since its release. The book remains the only comprehensive account embracing virtually all aspects of echinococcus and the disease it causes. The links between laboratory knowledge and field applications are emphasized throughout the volumes. Consequently, research workers, teachers, students of parasitology, clinicians, and field workers will find this work an indispensable source of information.

Ebola's Curse: 2013-2016 Outbreak in West Africa is about hemorrhagic fever viruses, especially Ebola, its initial origin in central Africa 1976, its unprecedented appearance in West Africa in 2013. The book records in sequence and detective style how the initial outbreak of Ebola from the index case in rural Guinea traveled to Sierra Leone, the work and fate of those working in the Kenema Government Hospital (KGH) isolation ward in Sierra Leone. The book provides vignettes of the three main players involved with Ebola at KGH, Sheik Khan, Pardis Sabeti, and Robert Garry. Khan was the head of the unit, declared a national hero by his Sierra Leone government. He died fighting Ebola and was/is recognized in the USA by American societies by awards created for his historic work and death. Pardis Sabeti, a geneticist from Harvard and Broad MIT Institute, who was honored as a "Scientist of the Year" by Time Magazine and the Smithsonian Institute. Robert Garry, head of the operation to fight hemorrhagic fevers and Ebola, shuttled between Tulane University, KGH, and The White House to make aware through the press and others the dilemma and tragedy that was unfolding, and the need to obtain additional medical and health care support and supplies. Sabeti and Garry currently work with Oldstone on Ebola at KGH and thus personal communication and knowledge was/is available to the author for the book.