In this issue of Clinics in Laboratory Medicine, guest editor Dr. Gregory Tsongalis brings his considerable expertise to Current Topics in Molecular Diagnostics and Precision Medicine. Top experts in the field cover key topics such as syndromic and point-of-care molecular testing; building evidence for clinical use of pharmacogenomics and reimbursement for testing; precision medicine using pharmacogenomic panel-testing; and more. Contains 12 relevant, practice-oriented topics including next-generation sequencing approaches to predicting antimicrobial susceptibility testing results; the role of the human gutome on chronic disease: a review of the microbiome and nutrigenomics; blood group genotyping; review of SARS-CoV-2 antigen and antibody testing in diagnosis and community surveillance; and more. Provides in-depth clinical reviews on current topics in molecular diagnostics and precision medicine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Liquid Biopsy: New Challenges in the era of Immunotherapy and Precision Oncology aims to describe links between cancer, precision oncology, and liquid biopsy, focusing on their participation to immunotherapy management. The book provides updated information on the main applications of liquid biopsy and immunotherapy as well as interesting aspects useful for planning basic and translational research activities. It helps readers understand the central aspects of precision medicine in oncology, including the use of new generation technologies for translational and diagnostic settings and the main clinical trials in this area that may be useful during their research. The book is a valuable source for cancer researchers, oncologists and other members of the medical and biomedical field who are interested in learning more about recent developments in liquid biopsy and its relationship with precision medicine and immunotherapy.

In this issue of Surgical Pathology Clinics, guest editor Dr. Ming Zhou brings his considerable expertise to the topic of Genitourinary Pathology. Top experts in the field cover key topics such as prostate cancer: update on grading and reporting; cribriform lesions of the prostate; urothelial carcinoma: divergent differentiation and variants; kidney tumors: new developments in existing WHO kidney tumor entities; and more. Contains 13 relevant, practice-oriented topics including testicular tumors: new developments in germ cell tumors and sex cord stromal tumors; computational pathology in genitourinary pathology; molecular genetics of prostate cancer and role of genomic testing; evolving role of multiparametric MRI in prostate cancer diagnosis and reporting; and more. Provides in-depth clinical reviews on current topics in genitourinary pathology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Advances in Molecular Pathology reviews the year's most important findings and updates within the field in order to provide molecular pathologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Gregory Tsongalis, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in molecular pathology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care. Provides in-depth, clinical reviews in molecular pathology, providing actionable insights for clinical practice. Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies highlight diverse types of infections, including viral, bacterial, parasitic, fungal, and the therapeutic efficacy of antibiotics, antivirals, antifungals and other medications, nutraceuticals, and phytotherapeutics. This book addresses the molecular, pathophysiological, and cellular pathways involved in the process of infection. It also examines the host defense mechanisms modulated by innate and adaptive immunity. The book starts off with an introduction, which includes etiology, pathophysiology, and diagnosis of infections. It then goes on to cover a wide spectrum of salient features involved in viral, bacterial, parasitic, and fungal infections and effective therapeutic strategies. In addition, there is a complete section of eight chapters elaborating the detailed aspects of COVID-19 infections, Mucormycosis, Omicron, and strategic vaccines and therapeutics. The book further goes on to discuss novel antibiotics, vaccines, bromhexine, boron compounds, phytotherapeutics, and aspects on boosting immune competence. Contributed by experts in the fields of viral, parasitic, bacterial, and fungal infections, the book comprehensively details the various types of infections such as herpes and COVID-19, their molecular mechanisms, and treatment strategies for those engaged in the research of infectious diseases.

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care. Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more. Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Microbial Resources: From Functional Existence in Nature to Applications provides an exciting interdisciplinary journey through the rapidly developing field of microbial resources, including relationships to aspects of microbiology. Covers the functional existence of microorganisms in nature, as well as the transfer of this knowledge for industrial and other applications. Examines the economic perspective of revealing the potential value of microbial material and figuring it into socio-economic value; legal perspectives; and how to organize a fair allotment of socio-economic benefits to all stakeholders who have effectively contributed to the preservation, study, and exploitation of microbiological material.

American Trypanosomiasis, Chagas Disease: One Hundred Years of Research, Second Edition, provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease, the host, the insect vectors, and the causative parasite. In addition, new insights on the molecular biology and diagnostics of Chagas diseases, the persistence of infections in the host, and the interaction of the parasite and host metabolism are now included in this new and updated edition.

Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.

Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects uses a metabolic and nutritional theme to explain the complex interrelationships between obesity and metabolic profiles before and after bariatric surgery. The book is sectioned into seven distinct areas, Features of Obesity, Surgical Procedures, Nutritional Aspects, Metabolic Aspects, Diabetes, Insulin Resistance and Glucose Control, Cardiovascular and Physiological Effects, and Psychological and Behavioral Effects. Included is coverage on the various types of bariatric surgery, including Roux-en-Y gastric bypass, gastric banding, sleeve gastrectomy, biliopancreatic diversion, and jejunoileal bypass, as well as the variations upon these procedures.

Electron Spin Resonance in Food Science covers, in detail, the ESR identification of the irradiation history of food products and beverages to investigate changes that occur during storage, with an aim of improving hygienic quality and extending shelf-life with minimal tempering in nutritional profile. The book also includes ESR studies on the interaction of food items and packaging materials, along with a section on new approaches in ESR identification of irradiated foods that is followed by a chapter on international legislation relevant to irradiated food. A section on ESR applications in characterizing ROS/antioxidants in food items and lipid oxidation, including spin labeling, spin trapping and imaging applications is also covered, as are ESR applications in nutrition and pharmaceutics.

The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research.

Recent advances in array-based detectors and imaging technologies have provided high throughput systems that can operate within a substantially reduced timeframe and other techniques that can detect multiple contaminants at one time. These technologies are revolutionary in terms of food safety assessment in manufacturing, and will also have a significant impact on areas such as public health and food defence. This book summarizes the latest research and applications of sensor technologies for online and high throughput screening of food. The book first introduces high throughput screening strategies and technology platforms, and discusses key issues in sample collection and preparation. The subsequent chapters are then grouped into four sections: Part I reviews biorecognition techniques; Part II covers the use of optical biosensors and hyperspectral imaging in food safety assessment; Part III focuses on electrochemical and mass-based transducers; and finally Part IV deals with the application of these safety assessment technologies in specific food products, including meat and poultry, seafood, fruits and vegetables.

Consumers demand quality milk with a reasonable shelf-life, a requirement that can be met more successfully by the milk industry through use of improved processes and technologies. Guaranteeing the production of safe milk also remains of paramount importance. Improving the safety and quality of milk provides a comprehensive and timely reference to best practice and research advances in these areas. Volume 1 focuses on milk production and processing. Volume 2 covers the sensory and nutritional quality of cow's milk and addresses quality improvement of a range of other milk-based products. The health aspects of milk, its role in the diet and milk-based functional foods are the focus of the opening section of Volume 2. Part two reviews essential aspects of milk quality, including milk microbial spoilage and chemical deterioration, sensory evaluation, factors affecting milk vitamin and mineral content and the impact of packaging on quality. Chapters in part three look at improving particular products, such as organic milk, goat milk and sheep milk. The impact of milk on the quality of yoghurt and cheese is also covered. With its distinguished editor and international team of contributors, volume 2 of Improving the safety and quality of milk is an essential reference for researchers and those in industry responsible for milk safety and quality.

Food safety is vital for consumer confidence, and the hygienic design of food processing facilities is central to the manufacture of safe products. Hygienic design of food factories provides an authoritative overview of hygiene control in the design, construction and renovation of food factories. The business case for a new or refurbished food factory, its equipment needs and the impacts on factory design and construction are considered in two introductory chapters. Part one then reviews the implications of hygiene and construction regulation in various countries on food factory design. Retailer requirements are also discussed. Part two describes site selection, factory layout and the associated issue of airflow. Parts three, four and five then address the hygienic design of essential parts of a food factory. These include walls, ceilings, floors, selected utility and process support systems, entry and exit points, storage areas and changing rooms. Lastly part six covers the management of building work and factory inspection when commissioning the plant. With its distinguished editors and international team of contributors, Hygienic design of food factories is an essential reference for managers of food factories, food plant engineers and all those with an academic research interest in the field.

Eggs are economical and of high nutritional value, yet can also be a source of foodborne disease. Understanding of the factors influencing egg quality has increased in recent years and new technologies to assure egg safety have been developed. Improving the safety and quality of eggs and egg products reviews recent research in these areas Volume 2 focuses on egg safety and nutritional quality. Part one provides an overview of egg contaminants, covering both microbial pathogens and chemical residues. Salmonella control in laying hens is the focus of part two. Chapters cover essential topics such as monitoring and control procedures in laying flocks and egg decontamination methods. Finally, part three looks at the role of eggs in nutrition and other health applications. Chapters cover dietary cholesterol, egg allergy, egg enrichment and bioactive fractions of eggs, among other topics. With its distinguished editors and international team of contributors, Volume 2 of Improving the safety and quality of eggs and egg products is an essential reference for managers in the egg industry, professionals in the food industry using eggs as ingredients and all those with a research interest in the subject.

The Microbiology of Respiratory System Infections reviews modern approaches in the diagnosis, treatment, and prophylaxis of respiratory system infections. The book is very useful for researchers, scientists, academics, medical practitioners, graduate and postgraduate students, and specialists from pharmaceutical and laboratory diagnostic companies. The book has been divided into three sections according to the types of respiratory pathogens. The first section contains reviews on the most common and epidemiologically important respiratory viruses, such as influenza virus, severe acute respiratory system coronavirus, and recently discovered Middle East respiratory syndrome coronavirus. The second section is devoted to bacterial and fungal pathogens, which discusses etiology and pathogenesis including infections in patients with compromised immune system, and infections caused by fungal pathogens, such as Aspergillus and Pneumocystis. The third section incorporates treatment approaches against different types of bacterial infections of the lower respiratory tract. This section reviews classical antimicrobial and phytomedical approaches as well as the application of nanotechnology against respiratory pathogens.

The Advances in Applied Microbiology series, first published in 1959, continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology, and includes recent research on the roles of fungal communities in soil nutrient recycling, the microbial nitrogen cycle in soil, and the inter-kingdom associations between soil bacteria, fungi, and mycorrhizal fungi.

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.