This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities. Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasms for all disease entities. Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms. It will provide a practical and concise yet comprehensive review.

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

It is not the presence of microorganisms, but their interaction with patients that determines their influence on wound healing. Documenting this critical but often ignored aspect of the treatment process, Microbiology of Wounds discusses the microbiology and biology of human wounds in relation to infection and non-healing. Gain the necessary scientific and clinical knowledge pertaining to chronic and acute wounds. The practice of wound healing is dynamic, infinitely complex, nonlinear, and prodigiously individualized to the patient. When one considers the myriad host variables that contribute to the disease state, understanding the intricacies of chronic wounds becomes even more difficult. This book presents the necessary scientific and clinical data pertaining to chronic and acute wounds, and discusses inflammation, epithelialization, granulation tissue, and tissue remodeling. It details techniques for treating chronic and acute wounds and covers the mode of action and efficacy of anti-infectives used in treating wounds. Microbiology of Wounds answers the call for a definitive reference on chronic and acute wounds.

This is a thorough revision and update of the highly successful first edition, which which achieved sales in excess of 4,500. The text serves as a comprehensive introduction to parasitology for both undergraduate and beginning graduate students. In this edition, particular emphasis is placed on parasites of human and veterinary importance. The first three chapters in the text are concerned with how parasites 'work, ' their biochemistry, molecular and cell biology and physiology. The remaining chapters cover ecology and epidemiology, immunology and chemotherapy, with the final chapter covering integrated control. This new edition contains new material on cell and molecular biology, vectors and control, which is in contrast to the general biological approach of the first edition. The second edition will succeed the first as the major text on parasitology for students in biology, zoology, microbiology, medicine, veterinary medicine, tropical medicine and public health

How does it feel to confront a pandemic from the inside, one patient at a time? To bridge the gulf between a perilously unwell patient in quarantine and their distraught family outside? To be uncertain whether the protective equipment you wear fits the science or the size of the government stockpile? To strive your utmost to maintain your humanity even while barricaded behind visors and masks? Rachel is a palliative care doctor who looked after the most gravely unwell patients on the Covid-19 wards of her hospital. Amid the tensions, fatigue and rising death toll, she witnessed the courage of patients and NHS staff alike in conditions of unprecedented adversity. For all the bleakness and fear, she found that moments that could stop you in your tracks abounded. People who rose to their best, upon facing the worst, as a microbe laid waste to the population. Her new book, Breathtaking, is an unflinching insider's account of medicine in the time of coronavirus. Drawing on testimony from nursing, acute and intensive care colleagues - as well as, crucially, her patients - Clarke argue that this age of contagion has inspired a profound attentiveness to - and gratitude for - what matters most in life.

Vector-borne diseases have increasingly emerged as significant causes of human illnesses worldwide, largely due to environmental changes (deforestation), population movements (migration and travelling), international trades, and buildup of drug resistance. These are presenting major challenge to the efficacy and use of conventional tools for controlling vector-borne diseases. Therefore, use of microbial approach for the control of vector-borne diseases is gaining importance. This book comprehensively reviews vector-borne diseases and their microbial control, emphasizing majorly on ecofriendly ways of microbial control.

Selected as a Doody's Core Title for 2022! Widely recognized as the gold standard reference in the field, Rosen's Breast Pathology provides comprehensive, up-to-date information on diseases of the breast from renowned experts at four leading medical centers, masterfully edited by Dr. Paul P. Rosen. The revised fifth edition covers the latest advances in immunohistochemical, pathobiological, and molecular aspects of benign and malignant breast diseases, helping you reach an accurate diagnosis with confidence. It's an ideal reference for all physicians and medical personnel who require a thorough knowledge of breast pathology, including pathologists, surgeons, oncologists, radiologists, and radiation oncologists. Covers clinical and radiological presentation, epidemiology, gross pathology, microscopic pathology, treatment, and prognosis (when relevant) for each disease entity. Addresses surgical and oncological aspects of various diseases wherever appropriate. Thoroughly updated throughout to reflect the latest advances in this dynamic area of practice. Features more than 2,000 high-quality images that highlight key diagnostic features, including hundreds of new illustrations. Stresses the role of pathology in the multidisciplinary management of breast diseases. Emphasizes histopathological features of breast diseases. Recommends appropriate management for specific breast diseases. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques: Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node provides a thoroughly illustrated review of the tissue damage and reparative changes associated with standardized irradiation doses in rhesus macaques. In addition to time-sequenced, routinely stained histologic sections, the book presents results of numerous histochemical, immunohistochemical and chromogenic in-situ stains that provide insights into the pathogenesis of radiation-associated tissue injury and repair. This book is compiled and written by a board-certified veterinary pathologist with more than 40 years of experience in the interpretation of experimentally induced tissue alterations in laboratory animals. This is an important resource for researchers in the field of animal science radiation injury, including radiation oncologists and individuals involved in disaster preparedness related to accidental or deliberate radiation exposure in large populations.

Liquid Biopsy: New Challenges in the era of Immunotherapy and Precision Oncology aims to describe links between cancer, precision oncology, and liquid biopsy, focusing on their participation to immunotherapy management. The book provides updated information on the main applications of liquid biopsy and immunotherapy as well as interesting aspects useful for planning basic and translational research activities. It helps readers understand the central aspects of precision medicine in oncology, including the use of new generation technologies for translational and diagnostic settings and the main clinical trials in this area that may be useful during their research. The book is a valuable source for cancer researchers, oncologists and other members of the medical and biomedical field who are interested in learning more about recent developments in liquid biopsy and its relationship with precision medicine and immunotherapy.

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri

Genetically Modified and Irradiated Food: Controversial Issues: Facts versus Perceptions explains the technologies used in these processes so they can be understood by those in general public health, scientific organizations, politicians and opinion makers/policymakers. The facts presented include a massive amount of scientific evidence that these technologies are safe and can be beneficial. Because the world is facing a future with an increasing number of people, new technologies are needed to ensure enough safe and healthy food, thus technologies that have the potential to dramatically increase the availability of safe and healthy food should be welcomed by everybody.

"Medical Mycology: cellular and Molecular" techniques is a clear and concise overview of the subject that details the techniques essential for ongoing research in the area. Drawing together contributions from both scientists and clinicians working in the field, the text will provide a valuable perspective on the applicability of specific techniques to patient care.

A wide range of molecular, immunological and cytological techniques are discussed throughout, with the inclusion of protocol section in each chapter designed to provide both a background a up-to-date account of the applications of each procedure. Every technique is fully referenced and illustrations are provided where required to enhance student understanding. comprehensive introduction to the key techniques critical to the study of medical mycology clear explanation of how each technique is applied in the lab contributions from internationally recognised experts in the field outlines the background to many techniques required for the successful completion of a research project

An invaluable reference for students of microbiology, biochemistry and molecular biology as well as postgraduates and researchers in the field of medical mycology looking for an up-to-date overview of the latest laboratory techniques.

The Stereotaxic Brain Atlas of the Egyptian Fruit Bat provides the first stereotaxic atlas of the brain of the Egyptian fruit bat (Rousettus aegyptiacus), an emerging model in neuroscience. This atlas contains coronal brain sections stained with cresyl violet (Nissl), AChE, and Parvalbumin - all stereotaxically calibrated. It will serve the needs of any neuroscientist who wishes to work with these bats - allowing to precisely target specific brain areas for electrophysiology, optogenetics, pharmacology, and lesioning. More broadly, this atlas will be useful to all neuroscientists working with bats, as it delineates many brain regions that were not delineated so far in any bat species. Finally, this atlas will provide a useful resource for researchers interested in comparative neuroanatomy of the mammalian brain.

Widely used by residents, fellows, and practicing pathologists around the world, Gattuso's Differential Diagnosis in Surgical Pathology provides a user-friendly road map to the main criteria to consider in order to differentiate between a variety of potential diagnoses that all have a very similar appearance. This comprehensive guide helps you make informed decisions for even your most complex and challenging cases, presenting a comprehensive differential diagnosis list and comparisons for every entity discussed. The 4th Edition brings you fully up to date with updated diagnostic techniques, new classifications, and new content throughout-perfect for quick reference at every microscope in the sign-out room. Provides brief descriptions of both common and uncommon disorders, with an emphasis on differential diagnosis, along with excellent illustrative examples of the pathology and carefully selected references. Streamlines the differential diagnosis process by offering a series of bullet point checklists that detail the respective features of the entities being considered. Discusses a complete range of tumors and tumor-like conditions in all organ systems. Contains updated information on personalized/precision medicine especially as it pertains to the immunotherapies; for example, PDL-1 targeted therapies in many cancers. Includes new classification of neuroendocrine tumors, new classification and updates of follicular variant of papillary thyroid carcinoma, and a new section on the most common metastatic tumors and utilization of ancillary techniques for diagnosis and molecular studies. Uses a reader friendly, outline format for each diagnosis that details clinical information, epidemiology, gross and microscopic findings, ancillary stains and tests, differential diagnoses, and pearls of wisdom. Features 1,400 full-color macro- and micrographs that provide a realistic basis for comparison of what you see under the microscope. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development.

This book aims to facilitate readers to understand the origin, growth pattern and relationship between tumor and adherent structure of craniopharyngioma, so as to improve the cure rate and safety of surgery. It's contributed by Neurosurgery Department of Nanfang Hospital, Southern Medical University, China, which focuses on the management of craniopharyngioma. This book covers histoembryology of craniopharyngioma, together with anatomical morphology and abundant clinical data, systematically showing an innovative classification method, i.e. QST classification. This classification method can better reflect the different origin and growth pattern of craniopharyngioma,the relationship between tumors and surrounding structure of the tumor growth pattern, and clinical significance in surgery. The 70 clinical cases with different classification and treatment history are discussed as an important reference for surgical treatment of craniopharyngioma. The anatomy, morphology and pathology of sellar region also have great reference value for researchers in the field of neural science. The underlying intention of this book is to help bring a change in the concept that "craniopharyngioma is an incurable benign tumor only due to its anatomical location".

SUITABLE FOR KINDLE AND OTHER EBOOK DEVICES Switch off the news and mute your tense WhatsApp chats - here are 101 family-friendly, fun, smart, silly, useful, good-to-know things to do and learn that will take your mind off what's going on outside the comfort of your own home, providing you with plenty of much needed moments of positivity and calm. Including (but not limited to!): * Quizzes * Anagrams * Poems * Riddles * Jokes * Word games * Fun facts * And other ways to occupy your time in a fulfilling way. Suitable for those aged 7 to 107, with the quizzes requiring some grown-up knowledge. And whilst you #StayHome, don't miss these other great titles from Sphere Books: ** The Bumper Book of Would You Rather? Over 350 hilarious hypothetical questions for ages 6 to 106 ** ** Home Sweet Home: The Little Book of Natural Cleaning ** ** Shelf Respect: A Book Lovers' Guide to Curating Book Shelves at Home **

The aim of this atlas is to guide pathologists and radiologists in the accurate triage and diagnosis of deep seated mass lesions biopsied under ultrasound, CT Scan or fluoroscopic guidance. Fine needle aspiration cytology has become the foremost diagnostic modality in recent years for the diagnosis of mass lesions, including primary and recurrent neoplasms and masses of non-neoplastic and infectious etiology. An essential requirement in the accurate diagnosis of these masses is the correlation of cytomorphology with the radiological findings and adequate triage of acquired material during the biopsy procedure. The cytologic appearance (fine needle aspiration smears, touch preparations, cell blocks and core biopsy), gross surgical resected specimen (where available on follow-up) and imaging findings will be illustrated to provide a complete pathologic-radiologic correlation of the entities discussed. Collection methods and correlation with ancillary studies such as flow cytometry, microbiologic cultures, cytogenetics and immunohistochemistry will be described. The importance of specimen type and cytologic and radiologic techniques will be emphasized.

This updated volume on clinical forensic medicine covers the topics required for forensic healthcare professionals working in general forensic medicine and sexual offence medicine. All chapters have been reviewed and revised to reflect how the provision of forensic medical services has changed since the previous edition with multidisciplinary teams working in the custodial environment, comprising doctors, nurses, and paramedics and those practitioners providing sexual offence examinations. New and updated topics include: the increasing importance of photo documentation by health care professionals; updated information on strangulation, torture; a review of bite mark injuries; the explosion of Novel Psychoactive Substances worldwide; the changing patterns of deaths in custody and deaths following police contact; and the introduction in various jurisdictions of legal limits for drugs based on zero tolerance or a risk based approach. Written by a team of experts, the new edition of this book is a valuable resource for forensic healthcare professionals including doctors, nurses and paramedics working in general forensic medicine and sexual offence medicine, as well as emergency physicians, pediatricians and gynaecologists.

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems

"Infection: Microbiology and Management" provides a core resource for the understanding of medical microbiology and infectious diseases. Content covers microbiological and clinical diagnosis, through to clinical management, epidemiology and the control of infectious conditions as they occur both in the hospital and community setting.

With a concise, systems-based approach, the third edition has been revised and restructured and now covers wider epidemiological and public concerns. Key feature boxes, self assessment and case studies assist learning in each chapter.

Designed to be used either as a basic learning text, or as a practical textbook in the clinical setting, "Infection: Microbiology and Management, previously" titled "Infectious Disease," will continue to appeal to students at all stages of their career, candidates for higher examinations, the general physician and surgeon, epidemiologists and experts in public health.

Highly acclaimed and considered the leading reference in the field, "Pathology of Melanocytic Nevi and Malignant Melanoma" has once again been fully revised and updated to reflect the most recent advances and techniques in the field of melanoma pathology. The successful focus and format of the previous editions have been preserved. Each lesion and diagnosis is clearly illustrated withthe aid of a wealth of digitally enhanced full-color photomicrographs. A concise description of the clinical features, histopathology, differential diagnosis, andthe most importantcharacteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. "Pathology of Melanocytic Nevi and Malignant Melanoma" is the essential reference for every practicing dermatopathologist, pathologist, dermatologist, and cancer research scientist today."

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of breast pathology, it incorporates the most recent clinical, pathological, radiological, staging, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Breast is a one-stop reference for accurate, complete surgical pathology evaluation-ideal as a day-to-day reference or as a reliable training resource. Includes a wide range of new information on breast pathology, including material specific to core needle biopsies, to help you identify, diagnose, and manage disease Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer Features new chapters covering gene expression profiling; immunotherapy; the differential diagnosis for common histologic patterns; solid papillary carcinoma; acinic cell carcinoma; and intraoperative consultations, including a video showing how to process specimens with radioactive seeds Offers expert guidance on evaluation of postneoadjuvant resection specimens, sentinel lymph nodes, and extent of disease and multifocality Contains thousands of extensively annotated images, including gross pathology photographs, histopathology photomicrographs with a wide range of immunohistochemical stains, fluorescent in situ hybridization, and full-color illustrations Features a templated, highly formatted design; concise, bulleted text; diagnostic pearls; key facts in each chapter; and an extensive index for easy reference Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Green Products in Food Safety explores the potential of green chemicals in the sustainable management of food biodeterioration agents while also addressing existing limitations of green products for their sustainable application. The book summarizes food loss by biodeterioration agent (bacteria, fungi, mycotoxin and insect pest), novel detection methods for hazardous food contaminants, different sources of green chemicals, their origin, extraction and characterization methods, and bioactivity of green products against biodeterioration agent with their molecular sites of action. The contents of the book cover the basic and translational aspects that will prove to be beneficial for food scientists, researchers, students and young professionals. In addition, the pharmacological properties, metabolic engineering of green chemical biosynthesis, role of mathematical modeling to design the novel synergistic formulation (Additive, adjuvant and synergistic effect), nanocarrier applications in the food system, elucidation of novel site of action, and toxicity prediction and ecological perception are also included to overcome the existing limitations.