This concise, truncated version of Nagy, Varghese and Agarwal's Practical Manual of In Vitro Fertilization is comprised of select practical chapters for a portable, affordable and up-to-date resource. Building and Managing an IVF Laboratory covers a variety of topics, including: - Setting up and running an IVF laboratory - IVF laboratory equipment and culture systems - Organization of the IVF unit - Licensing and regulation in the ART laboratory - Quality control and troubleshooting Practical for both clinicians and researchers alike, Building and Managing an IVF Laboratory brings together all of the need-to-know information about these important topics in reproductive medicine.

This concise, truncated version of Zini and Agarwal's Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction offers select, clinical chapters for a handy, more affordable, state-of-the-art resource. Sperm Chromatin for the Clinician addresses such vital issues as: -Male subfertility and sperm chromatin damage -Aging and sperm DNA damage -Cancer and implications for sperm quality -Environmental factors -Cryopreservation and sperm DNA integrity -Postnatal effects of sperm chromatin damage Practical for clinicians and researchers alike, Sperm Chromatin for the Clinician contains all of the need-to-know information about this cutting-edge topic in reproductive medicine. "

This concise, truncated version of Parekattil and Agarwal's" Male Infertility: Contemporary Clinical Approaches, Andrology, ART & Antioxidants" is the first resource dedicated solely to clinicalissues of infertility. With select chapters that will prove invaluable to the reproductive medicine clinician, "Male Infertility for the Clinician"addresses issues like:

- Diagnosis and management of male infertility conditions such as varicocele, ejaculatory duct obstruction and congenital epididymal obstruction

- New approaches to Klinefelter's syndrome

- A concise structured approach to the genetics of male infertility

- Management of cancer patients (oncofertility) and ethical considerations in special male infertility circumstances

-New advances in biomaterials for reconstruction and new robotic-assisted microsurgical techniques

Practical for clinicians and researchers alike, "Male Infertility for the Clinician"contains all of the need-to-know information about these cutting-edge topics in reproductive medicine.

This book is a point-of-care resource for effective sexual and reproductive healthcare for patients of all ages, sexual orientations, gender identities and medical backgrounds in the primary care setting. This useful guide is divided into three parts, and other than part three, which deals exclusively with transgender and gender diverse patients, all content will relate to patients of all gender identities. Part one presents sexual and reproductive health (SRH) using a lifespan approach, including chapters on pediatrics, adolescents and young adults, adults, and older adult patients. Part two presents an approach to common SRH issues that span multiple age groups, including contraception and family planning, sexually transmitted infections and cancer screenings as well as sexual and reproductive health in the setting of common medical conditions. Part three is dedicated to sexual and reproductive health for transgender and gender non-binary patients, including psychosocial, medical, surgical and legal aspects of health. This book provides primary care clinicians with a framework for providing effective sexual and reproductive healthcare to patients of all ages, sexual orientations and gender identities in a way that is inclusive, focuses on health, and addresses the needs unique to specific populations.

Historically, sperm have been seen as simply a mechanism of transferring a haploid set of chromosomes to the oocyte. However, data from assisted reproduction therapies (ART) have demonstrated that in many couples the sperm appears to be responsible for abnormal embryogenesis. Recent advances in genetic and epigenetic techniques have identified key mechanisms by which the sperm, and the DNA carried by the sperm, can affect early embryonic development. Paternal Influences on Human Reproductive Success examines the genetic and epigenetic influences on embryogenesis, as well as practical clinical factors related to the male contribution to reproductive success. It also provides 'cutting edge' data and analysis of recent evaluations of the role of advanced paternal age, environmental influences and lifestyle factors on male reproductive fitness, making this an invaluable text for physicians treating patients for infertility, recurrent pregnancy loss, and developmental anomalies, as well as basic scientists studying embryogenesis and spermatogenesis.

Biology of Menopause presents the proceedings of an international symposium held from September 10-13, 1998 in Newport Beach, CA. The proceedings review current knowledge and explores future research directions on the biologic changes of the hypothalamic-pituitary-ovarian axis across the menopausal transition and the associated changes in physiologic systems outside of the HPO axis, including the brain, the musculoskeletal and cardiovascular systems. Additionally, chapters present new methods of study and emerging areas of research.

Founded in 1914, the Department of Embryology of the Carnegie Institution of Washington has made an unparalleled contribution to the biological understanding of embryos and their development. Originally much of the research was carried out through experimental embryology, but by the second half of the twentieth century, tissue and cell cultures were providing histological information about development, and biochemistry and molecular genetics have taken center stage. This final volume in a series of five histories of the Carnegie Institution of Washington provides a history of embryology and reproductive biology spanning a hundred years. It provides important insights into the evolution of both scientific ideas and the public perception of embryo research, concluding with a reflection on current debates.

This practical 2003 handbook provides an extremely comprehensive and highly illustrated guide to micromanipulation techniques in assisted conception in a clinical setting. It includes detailed, illustrated descriptions of all the common micromanipulation systems currently in use in IVF laboratories around the world and clearly explains how to optimise their successful use. The volume covers state-of-the-art techniques including intracytoplasmic sperm injection (ICSI), and procedures such as assisted hatching and the blastomere biopsy (for preimplantation genetic diagnosis PGD). Valuable information on troubleshooting the potential mechanical and technical difficulties that can arise is provided to help all the practitioners of these techniques, including trainee embryologists and consultant obstetricians, and technicians and scientists involved in animal transgenesis and cloning. It will undoubtedly be of immense value to all doctors and scientists working with assisted reproductive technologies.

How and to what extent have Islamic legal scholars and Middle Eastern lawmakers, as well as Middle Eastern Muslim physicians and patients, grappled with the complex bioethical, legal and social issues that are raised in the process of attempting to conceive life in the face of infertility? This path-breaking volume explores the influence of Islamic attitudes on assisted reproductive technologies (ARTs) and reveals the variations in both the Islamic jurisprudence and the cultural responses to ARTs.

The phenomenon of bleeding has been shown to appear in up to 22% of all pregnancies and is associated with significant maternal and fetal morbidities, and even mortality. Although vaginal bleeding occurs mainly during the first trimester, it can appear at any stage of pregnancy and in the postpartum period. This sometimes life-threatening event requires an extensive work-up in order to recognize its cause and establish a rapid and effective therapeutic approach. This book is a comprehensive appraisal of this critical condition. It draws on evidence-based data and brings together, in a single volume, updated information on all aspects of pregnancy-related bleeding. A global group of interdisciplinary experts contributed chapters on: bleeding during early pregnancy (early pregnancy loss, ectopic pregnancy, gestational trophoblastic disease, and cancer of the reproductive tract during pregnancy); bleeding in late pregnancy (preterm delivery, placental abruption, placenta previa, vasa previa and uterine rupture); and postpartum hemorrhage.

Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.

Making a Good Life takes a timely look at the ideas and values that inform how people think about reproduction and assisted reproductive technologies. In an era of heightened scrutiny about parenting and reproduction, fears about environmental degradation, and the rise of the biotechnology industry, Katharine Dow delves into the reproductive ethics of those who do not have a personal stake in assisted reproductive technologies, but who are building lives inspired and influenced by environmentalism and concerns about the natural world's future. Moving away from experiences of infertility treatments tied to the clinic and laboratory, Dow instead explores reproduction and assisted reproductive technologies as topics of public concern and debate, and she examines how people living in a coastal village in rural Scotland make ethical decisions and judgments about these matters. In particular, Dow engages with people's ideas about nature and naturalness, and how these relate to views about parenting and building stable environments for future generations. Taking into account the ways daily responsibilities and commitments are balanced with moral values, Dow suggests there is still much to uncover about reproductive ethics. Analyzing how ideas about reproduction intersect with wider ethical struggles, Making a Good Life offers a new approach to researching, thinking, and writing about nature, ethics, and reproduction.

IVF is now established worldwide as a clinical service. Units are striving to improve their success rates, and many treatments are being advocated as 'yet another breakthrough'. The purpose of this book is to help clinicians to evaluate each of these new treatments. Each chapter is written by a recognized international expert in the field and the chapters are short and succinct, summarizing the latest evidence-based information for each topic and treatment. Sections cover patient selection and preparation, the role of AIH before IVF, stimulation, monitoring, laboratory techniques, embryo transfer, ancillary treatments and assessment of results. How to Improve your ART Success Rates: An Evidence-Based Review of Adjuncts to IVF is essential reading for all clinicians working with infertility and assisted reproduction, and is also a valuable addition to any medical library.

An Introduction to Male Reproductive Medicine is written specifically for readers seeking entry into this fast-moving, complex specialty with a solid understanding of the subject. The first chapters cover the anatomy and physiology, clinical evaluation, surgery, medicine, genetics and laboratory testing involved in the current evaluation and treatment of the infertile male, and the final chapter describes the interaction of the field with female reproductive medicine. Throughout the book, references are directly made to the fourth edition of the major text in the specialty, Infertility in the Male, edited by Larry Lipshultz, Stuart Howards and Craig Niederberger, allowing readers to expand their understanding of specific areas where desired. Each chapter is written by a well-renowned expert in an easy to follow, informal style, making the text ideal for students, residents and general physicians who are seeking to increase their general knowledge of the field.

ART treatment is vulnerable to the hazard of potential infection from many different sources: patients, samples, staff and the environment. Culture of gametes and embryos in vitro provides multiple targets for transmission of potential infection, including the developing embryo, neighbouring gametes and embryos, the couple undergoing treatment and other couples being treated during the same period. This unique situation, with multifaceted opportunities for microbial growth and transmission, makes infection and contamination control absolutely crucial in the practice of assisted reproduction, and in the laboratory in particular. Originally published in 2004, this practical book provides a basic overview of microbiology in the context of ART, providing a guide to infections in reproductive medicine. The relevant facets of the complex and vast field of microbiology are condensed and focused, highlighting information that is crucial for safe practice in both clinical and laboratory aspects of ART.

This insightful and thought-provoking 2002 collection of chapters describes the rapid advances that had revolutionised reproductive medicine in the years leading up to its publication. This transformation was the result of converging and overlapping developments in reproductive biology, molecular biology and genetics. These advances allied with remarkable technical developments pushed the boundaries of this discipline ever faster forward. This volume surveys this rapid expansion as it stood in 2002 and looks ahead at exciting prospects for the future that stand at the watershed between basic science and clinical application. From oogeneis and spermatogenesis, through to fertilisation, embryogenesis and cloning, this volume looks at scientific advances. Subsequent chapters focus on infertility and its diagnosis and treatment using the full armory of assisted reproductive technologies. A concluding section surveys the impact of these developments on the provision, regulation and financing of reproductive health care in the global community.

Introduced in Phnom Penh around 1990, at the twilight of socialism and after two decades of conflict and upheaval, ultrasound took root in humanitarian and then privatized medicine. Services have since multiplied, promising diagnostic information and better prenatal and general health care. In Fixing the Image Jenna Grant draws on years of ethnographic and archival research to theorize the force and appeal of medical imaging in the urban landscape of Phnom Penh. Set within long genealogies of technology as tool of postcolonial modernity, and vision as central to skilled diagnosis in medicine and Theravada Buddhism, ultrasound offers stabilizing knowledge and elicits desire and pleasure, particularly for pregnant women. Grant offers the concept of "fixing"-which invokes repair, stabilization, and a dose of something to which one is addicted-to illuminate how ultrasound is entangled with practices of care and neglect across different domains. Fixing the Image thus provides a method for studying technological practice in terms of specific materialities and capacities of technologies-in this case, image production and the permeability of the body-illuminating how images are a material form of engagement between patients, between patients and their doctors, and between patients and their bodies.

Pre-eclampsia is one of the leading causes of death and disability in mothers and babies. Over four million women worldwide will develop the disorder every year. This book, written by an international team of experts, focuses on both the scientific basis of pre-eclampsia and its management. The basic science section contains reviews of the most exciting research developments in pre-eclampsia. The clinical chapters provide a comprehensive review of the pertinent literature, highlighting data and ideas or developments in management. There is a section in each chapter (where relevant) that deals with practical management, giving clinicians a formulated treatment plan that they can implement directly. The book was originally published in 2007, and will have continuing relevance for all professionals interested in the reproductive sciences, and to obstetricians and physicians with an interest in pre-eclampsia.

Ume Eder Bat (A beautiful child) (popular song from Basque folklore) The aim of this monograph is to introduce the postnatal development of morphological features that are relevant to readers interested in the neurobiology and pathology of the hippocampal formation in terms of the complex phenomena that underlie the progressive anatomical and functional maturation of this brain region. This review focuses on the morphological aspects, while more detailed basic phenomena associated with neuronal maturation-which are undoubtedly also of great interest-are only marginally referred to, although a selection of behavioral and clinical aspects will also be briefly addressed in an attempt to illustrate real situations in different clinical specialties. The creation of this monograph is justified by the increasing importance and growing awareness shown in recent years of neurodevelopmental disorders in children. This awareness is leading to increasing refinement in clinical exami- tions of patients that may suffer from different neurodevelopment-related diseases, such as autism, epilepsy, memory disorders, etc. To the best of our knowledge, this work is the first comprehensive description of the postnatal changes in the hip- campal formation in its different constituent fields. Given the growing sensitivity and accuracy of neuroradiological examinations, particularly MRI, we also sought to offer a glimpse at the MRI aspects related to the development of the hippocampal formation in the human infant.

How the fear of malpractice affects mothers and reproductive choices Giving birth is a monumental event, not only in the personal life of the woman giving birth, but as a medical process and procedure. In The Business of Birth, Louise Marie Roth explores the process of giving birth, and the ways in which medicine and law interact to shape maternity care. Focusing on the United States, Roth explores how the law creates an environment where medical providers, malpractice attorneys, and others limit women’s rights and choices during birth. She shows how a fear of liability risk often drives the decision-making process of medical providers, who prioritize hospital efficiency over patient safety, to the detriment of mothers themselves. Ultimately, Roth advocates for an approach that protects the reproductive rights of mothers. A comprehensive overview, The Business of Birth provides valuable insight into the impact of the law on mothers, medical providers, maternity care practices, and others in the United States.

Many reproductive and developmental health problems are caused by exposure to chemicals that are widely dispersed in our environment. These problems include infertility, miscarriage, poor pregnancy outcomes, abnormal fetal development, early puberty, endometriosis, and diseases and cancers of reproductive organs. The compelling nature of the collective science has resulted in recognition of a new field of environmental reproductive health. Focusing on exposures to environmental contaminants, particularly during critical periods in development and their potential effects on all aspects of future reproductive life-course, this book provides the first comprehensive source of information bringing together the arguments that are spread out among various scientific disciplines in environmental health, clinical and public health fields. It provides a review of the science in key areas of the relationship between environmental contaminants and reproductive health outcomes, and recommendations on efforts toward prevention in clinical care and public policy.

Public attention on embryo research has never been greater. Modern reproductive medicine technology and the use of embryos to generate stem cells ensure that this will continue to be a topic of debate and research across many disciplines. This multidisciplinary book explores the concept of a 'healthy' embryo, its implications on the health of children and adults, and how perceptions of what constitutes child and adult health influence the concept of embryo 'health'. The concept of human embryo health is considered from preconception to pre-implantation genetic diagnosis to recent foetal surgical approaches. Burgeoning capacities in both genetic and reproductive science and their clinical implications have catalysed the necessity to explore the concept of a 'healthy' embryo. The authors are from five countries and 13 disciplines in the social sciences, humanities, biological sciences and medicine, ensuring that the book has a broad coverage and approach.

Reproductive ageing affects both individuals and wider society, and obstetricians and gynaecologists are witness to the impact of reproductive ageing and to some of the fears and misapprehensions of the general public. This book raises awareness of societal trends and their implications. The wider importance of the subject to the whole of society is emphasized by contributions from outside the world of obstetrics and gynaecology, both within and outside medicine. The 56th RCOG Study Group brought together a range of experts to examine reproductive ageing. This book presents the findings of the Study Group, with sections covering: background to ageing and demographics basic science of reproductive ageing pregnancy: the ageing mother and medical needs the outcomes: children and mothers future fertility insurance: screening, cryopreservation or egg donors? sex beyond and after fertility fertility treatment: science and reality - the NHS and the market the future: dreams and waking up."

There are many haematological complications associated with obstetrics, pregnancy and gynaecology, and unfortunately, they often lead to significant morbidity or mortality for both mother and child. As the first comprehensive reference on all aspects of haematological complications of obstetrics, pregnancy and gynaecology this book will be a valuable resource to haematologists, obstetricians, gynaecologists, reproductive medicine specialists, internists, anaesthesiologists and others. The chapters are written by acknowledged experts in the field, and for each condition covered the etiology, pathophysiology, clinical and laboratory diagnosis and management are discussed where appropriate.