For around half of the couples who have trouble conceiving the cause of infertility is sperm-related. Intracytoplasmic sperm injection (ICSI) is the most common and successful treatment for male infertility. Here, the pioneers for the technique, along with authorities in the field, describe the underlying science of ICSI and other micromanipulation techniques. Practical advice for performing the techniques is covered in depth, including sperm selection, laser-assisted ICSI, and the use of piezo in ICSI. Examining the safety of ICSI in animal models as well as the impact of ICSI on the health and well-being of the children conceived through the procedure is discussed. This manual is an essential resource for clinical embryologists and laboratory personnel wishing to refine or develop techniques and improve outcomes.

A powerful, personal reflection on miscarriage from an acclaimed health and science journalist, drawing on original interviews and ground-breaking research to offer fresh insight into this underacknowledged subject. After losing four pregnancies with no obvious cause, Jennie Agg set out to understand why miscarriage remains such a profoundly misunderstood, under-researched and under-acknowledged experience. Part-memoir, part-scientific investigation, Life, Almost documents Agg's path to motherhood and her search for answers. Tracing each tentative step of her fifth pregnancy - as her body becomes a creature she does not wish to spook - Agg dismantles the myths that we unquestioningly accept about our reproductive lives- Why are we told miscarriage can't be prevented when half of all miscarriages are of perfectly healthy embryos? Why is it normal not to tell anyone you're pregnant for the first three months? Why don't we know why labour starts? Drawing on pioneering research and interviews with world-leading experts, Life, Almost is a ground-breaking book that will change how you think about miscarriage, and a moving reflection on grief and love at the edge of life as we understand it.

Cloning, genetic screening, embryo freezing, in vitro fertilization, Norplant, RU486--these are the technologies revolutionizing our reproductive landscape. Through the lens of procreative liberty--meaning both the freedom to decide whether or not to have children as well as the freedom to control one's reproductive capacity--John Robertson, a leading legal bioethicist, analyzes the ethical, legal, and social controversies surrounding each major technology and opens up a multitude of fascinating questions: Do frozen embryos have the right to be born? Should parents be allowed to select offspring traits? May a government force welfare recipients to take contraceptives? Robertson's arguments examine the broad range of consequences of each reproductive technology and offers a timely, multifaceted analysis of the competing interests at stake for patients, couples, doctors, policymakers, lawyers, and ethicists.

Nowhere has the impact of ultrasonography been more dramatic than in reproductive medicine, particularly in the diagnosis of female and male infertility, the management of assisted reproductive procedures and the monitoring of early pregnancy. This authoritative textbook encompasses the complete role of ultrasonography in the evaluation of infertility and assisted reproduction. Covering every indication for ultrasonography in assisted reproductive technology, this will prove an invaluable resource in the evaluation of the infertile patient and optimization of the outcome of treatment. The interpretation of images to improve fertility and reproductive success is emphasized throughout. Ultrasonography in Reproductive Medicine and Infertility is essential reading for clinicians working both in IVF clinics and in office practice. It will be particularly useful to gynecologists, infertility specialists, ultrasonographers and radiologists working in reproductive endocrinology and infertility, assisted reproductive technology, ultrasonography and radiology.

Helping the Stork The sourcebook for all the information parents-to-be need to know about the choices and challenges of donor insemination Each year donor insemination (DI) offers a pathway to parenthood for the hundreds of thousands who turn to family-building alternatives. Although DI is considered as often as adoption, couples facing male infertility, as well as single women and lesbian couples, have had few places to turn for information about this method, which has been shrouded in secrecy. In Helping the Stork, parents-to-be, as well as friends and family, doctors, and counselors, can explore the choices and challenges raised by this alternative to overcoming childlessness. This comprehensive handbook moves through each step of the process: reaching a solid decision about whether donor insemination is the best choice for a family's future; handling the difficult issue of privacy; selecting a donor and getting started; and learning to thrive as a family meeting DI's added challenges. Full of wisdom from medical and mental health experts, Helping the Stork is also enriched with stories from many families who share their insights and experiences. This book is a reassuring, supportive, and helpful guide that no one considering or going through the process of donor insemination should be without. Visit us online at http: //www.mcp.com/mgr

This is an up-to-date evidence-based textbook for junior obstetricians and gynaecologists. It contains all the material relevant to everyday practice and the new RCOG curriculum. It has been written and edited by inspiring teams that combine juniors, new and established consultants working in a range of settings and many of the UK's top experts in obstetrics and gynaecology.
Step-by-step descriptions and pictures of practical procedures help trainees integrate their clinical and drills-and-skills teaching with the theoritical basis of the vital, life-saving and emergency aspects of this specialty. The text covers the basic knowledge, skills, and attitudes required before taking advanced modules or training in the subspecialty areas of obstetrics and gynaecology. Full reference is made to grades and levels of evidence, to specialty, and RCOG, and NICE guidance.
A novel section on professional skills covers a wide range of issues that other textbooks skim over, but will add quality to practice: breaking bad news, clinical errors and negligence, the Confidential Enquiries, law and ethics, and what to do when things go wrong.
The book manages to combine both a freshness and enthusiasm for the specialty along with wisdom rooted in reflective clinical practice. The text is laid out with excellent instructions, diagrams, clinical tips, landmark studies, key references and useful websites, all encouraging understanding and enjoyable learning.

The definitive week-by-week diet and lifestyle plan to support IVF treatment and help you become pregnant from the one of the UK's foremost experts on fertility and conception, Zita West. 'The IVF process is so out of your control and this was a really helpful tool to bring me back in control and nurture my body' -- ***** Reader review 'Excellent book, a great way to feel like you have some control over this crazy process!' -- ***** Reader review 'Terrific and informative - worth every penny' -- ***** Reader review 'Easy to read and easy to understand' -- ***** Reader review 'Brilliant' -- ***** Reader review **************************************************************************************************** More and more couples are turning to IVF each year to help them conceive, and yet there are still many questions to be answered. "What makes IVF successful?" and "what else can we do to support our treatment?" are two of the most important queries couples can have, and here, Zita West offers solutions. Nutrition and lifestyle advice, psychological and emotional support and a positive mindset all play an important part in helping couples conceive, and can even make the difference between a successful and unsuccessful outcome. This book not only advises how to prepare for IVF, but why it's so important to prepare, and with a step-by-step diet and lifestyle plan and over 60 recipes for meals designed for optimum fertility heath, this is a clear way to actively support your treatment.

Forms of embodied labor, such as surrogacy and participation in clinical trials, are central to biomedical innovation, but they are rarely considered as labor. Melinda Cooper and Catherine Waldby take on that project, analyzing what they call "clinical labor," and asking what such an analysis might indicate about the organization of the bioeconomy and the broader organization of labor and value today. At the same time, they reflect on the challenges that clinical labor might pose to some of the founding assumptions of classical, Marxist, and post-Fordist theories of labor.
Cooper and Waldby examine the rapidly expanding transnational labor markets surrounding assisted reproduction and experimental drug trials. As they discuss, the pharmaceutical industry demands ever greater numbers of trial subjects to meet its innovation imperatives. The assisted reproductive market grows as more and more households look to third-party providers for fertility services and sectors of the biomedical industry seek reproductive tissues rich in stem cells. Cooper and Waldby trace the historical conditions, political economy, and contemporary trajectory of clinical labor. Ultimately, they reveal clinical labor to be emblematic of labor in twenty-first-century neoliberal economies.

The last step in the IVF treatment cycle, embryo transfer, is also the process with the highest failure rate. No matter how good the laboratory technique is, a successful pregnancy will not be achieved without meticulous preparation of the uterus to accept the embryo. This book reviews the scientific evidence on endometrial receptivity, including histological, hormonal, biochemical, and immunological factors. Practical and concise, it supports gynecologists and embryologists to make evidence-based decisions that can influence the success rates of implantation and live births. Part of a series of books offering treatments and strategies for fertility and conception to optimize IVF outcomes, this volume is for all clinicians and embryologists working in reproductive medicine.

Scientists and philosophers have long struggled to answer the questions of when human life begins and when human life has inherent value. The phenomenon of identical (monozygotic) twinning presents a significant challenge to the view that human life and human personhood begin at conception. The fact that a single embryo can split to generate two (or more) genetically identical embryos seems to defy the notion that prior to splitting an embryo can be a single human individual. In Untangling Twinning, Maureen Condic looks at the questions raised by human twinning based on a unique synthesis of molecular developmental biology and Aristotelian philosophy. She begins with a brief historical analysis of the current scientific perspective on the embryo and proceeds to address the major philosophic and scientific concerns regarding human twinning and embryo fusion: Is the embryo one human or two (or even more)? Does the original embryo die, and if not, which of the twins is the original? Who are the parents of the twins? What do twins, chimeras, cloning, and asexual reproduction in humans mean? And what does the science of human embryology say about human ensoulment, human individuality, and human value? Condic's original approach makes a unique contribution to the discussion of human value and human individuality, and offers a clear, evidence-based resolution to questions raised by human twinning. The book is written for students and scholars of bioethics, scientists, theologians, and attorneys who are involved in questions surrounding the human embryo.

Biopolitics and posthumanism have been passe theories in the academy for a while now, standing on the unfashionable side of the fault line between biology and liberal thought. These days, if people invoke them, they do so a bit apologetically. But, as Ruth Miller argues, we should not be so quick to relegate these terms to the scholarly dustbin. This is because they can help to explain an increasingly important (and contested) influence in modern democratic politicsthat of nostalgia. Nostalgia is another somewhat embarrassing concept for the academy. It is that wistful sense of longing for an imaginary and unitary past that leads to an impossible future. And, moreover for this book, it is ordinarily considered bad for democracy. But, again, Miller says, not so fast. As she argues in this book, nostalgia is the mode of engagement with the world that allows thought and life to coexist, productively, within democratic politics. Miller demonstrates her theory by looking at nostalgia as a nonhuman mode of thought, embedded in biopolitical reproduction. To put this another way, she looks at mass democracy as a classically nonhuman affair and nostalgic, nonhuman reproduction as the political activity that makes this democracy happen. To illustrate, Miller draws on the politics surrounding embryos and the modernization of the Turkish alphabet. Situating this argument in feminist theories of biopolitics, this unusual and erudite book demonstrates that nostalgia is not as detrimental to democratic engagement as scholars have claimed.

Why do American couples differ in the number of children they have? To answer this question the first major longitudinal study in American fertility was begun in 1957 with a series of interviews with parents of two children. Family Growth in Metropolitan America (1961) and The Third Child (1963) reported the results of the first two phases of this research project. In this book, in addition to evaluating the longitudinal design of the study, the authors report the results of the third and final interviews, a decade after the first, and attempt to answer such questions as: How well are couples able to predict their own fertility over the years? To what extent does the number of children desired affect the spacing of births? How is fertility affected by peer group relations, by the wife's participation in the labor force, by religion? Originally published in 1971. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Has the college experience of women been an influence on the number of children desired and the number and spacing of their children? Do women come to college with their attitudes and values in this regard already formed? This study of 15,000 women, freshmen and seniors in 45 American colleges and universities, both secular and nonsecular, attempts to answer this question and to determine how such characteristics as religious preference, career intentions, and the number of children in her own family influence a woman's fertility values. Attention is paid to an earlier finding that Catholic college graduates have higher fertility than Catholic high school graduates, although higher education is usually associated with lower fertility. Originally published in 1967. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

This book comprehensively addresses female and male fertility preservation. It discusses in detail all major aspects of fertility preservation in both sexes, explains the basis of fertility preservation, and highlights the currently available techniques; further chapters are dedicated to specific diseases. The book offers an essential reference guide for all physicians, specialists or not, seeking to improve their grasp of female and male fertility preservation.

Maintaining consistent and reliably high success rates is a daily challenge for every IVF laboratory. This step-by-step guide is an essential aid in navigating the complex maze of physical, chemical, biological, and logistic parameters that underpin successful gamete and embryo culture: temperature, pH, osmolality, gas supplies, air quality, light exposure, infections, managing supplies, personnel, as well as overall quality control. Numerous real-life troubleshooting case reports are presented, identifying all aspects necessary for troubleshooting. Process maps and flow charts accompanying each chapter offer a logical and systematic approach to problem solving in the laboratory. This is an essential resource for scientists in assisted reproductive technology and specialists in reproductive biology and medicine, helping IVF clinics to achieve the dream of every infertile couple: the birth of a healthy child.

As a biological, cultural, and social entity, the human fetus is a multifaceted subject which calls for equally diverse perspectives to fully understand. Anthropology of the Fetus seeks to achieve this by bringing together specialists in biological anthropology, archaeology, and cultural anthropology. Contributors draw on research in prehistoric, historic, and contemporary sites in Europe, Asia, North Africa, and North America to explore the biological and cultural phenomenon of the fetus, raising methodological and theoretical concerns with the ultimate goal of developing a holistic anthropology of the fetus.

Intimate and medicalized, natural and technological, reproduction poses some of the most challenging ethical dilemmas of our time. Reproduction presses the boundaries of humanity and ethical respect, the permissible limits of technology, conscientious objection by health care professionals, and social justice. This volume brings together scholars from multiple perspectives to address both traditional and novel questions about the rights and responsibilities of human reproducers, their caregivers, and the societies in which they live. Among issues treated in the volume are what it is to be a parent, the responsibilities of parents, and the role of society in facilitating or discouraging parenting. May gamete donors be anonymous? Is surrogacy in which a woman gestates a child for others ethically permissible when efforts are made to prevent coercion or exploitation? Should it be mandatory to screen newborns for potentially serious conditions, or permissible to sequence their genomes? Are both parties to a reproductive act equally responsible to support the child, even if one deceived the other? Are there ethical asymmetries between male and female parents, and is the lack of available contraceptives for men unjust? Should the costs of infertility treatment be socially shared, as they are for other forms of health care? Do parents have a duty to try to conceive children under the best circumstances they can - or to avoid conception if the child will suffer? What is the status of the fetus and what ethical limits constrain the use of fetal tissue? Reproduction is a rapidly changing medical field, with novel developments such as mitochondrial transfer or uterine transplantation occurring regularly. And there are emerging natural challenges, too, like the Zika virus. The volume gives readers tools not only to address the problems we now know, but ones that may emerge in the future as well.

Millions of Americans rely on the likes of birth control, IVF, and genetic testing to make plans as intimate and farreaching as any over a lifetime. This is no less than the medicine of miracles. It fills empty cradles, frees families from terrible disease, and empowers them to fashion their lives on their own terms. But accidents happen. Pharmacists mix up pills. Lab techs misread tests. Obstetricians tell women their healthy fetuses would be stillborn. Political and economic forces conspire against regulation. And judges throw up their hands when professionals foist parenthood on people who didn't want it, or childlessness on those who did. Failed abortions, switched donors, and lost embryos may be first-world problems. But these aren't innocent lapses or harmless errors. They're wrongs in need of rights. This book lifts the curtain on reproductive negligence, gives voice to the lives it upends, and vindicates the interests that advances in medicine and technology bring to full expression. It charts the legal universe of errors that: (1) deprive pregnancy or parenthood of people who set out to pursue them; (2) impose pregnancy or parenthood on those who tried to avoid these roles; or (3) confound efforts to have a child with or without certain genetic traits. This novel architecture forces citizens and courts to rethink the reproductive controversies of our time, and equips us to meet the new challenges-from womb transplants to gene editing-that lie just over the horizon.

The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook - inspired by the postgraduate degree program at the University of Oxford - guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.

In Taking Baby Steps, Jody Lynee Madeira takes readers inside the infertility experience, from dealing with infertility-related emotions through forming treatment relationships with medical professionals to confronting difficult medical decisions. Based on hundreds of interviews, this book investigates how women, men, and medical professionals negotiate infertility's rocky terrain to create life and build families-a journey across personal, medical, legal, and ethical minefields that can test mental and physical health, friendships and marriages, spirituality, and financial security.

Men with cancer rendered infertile by surgery, chemotherapy, radiation and hormone therapy that are needed to control or cure their disease are increasingly being offered the chance to preserve their reproductive potential through artificial reproductive technologies. Cryopreservation of sperm and testicular tissue have increasingly helped boys and men preserve their fertility. There is a growing subspecialty within reproductive medicine aimed at fertility preservation in this population. Furthermore, strategies are being developed that may in the future revolutionize the approach to such patients. Written by international authorities in the field of fertility preservation, this comprehensive book is aimed at clinicians dealing with male cancer patients, in particular, urologists, andrologists, oncologists, pediatricians and nursing staff as well as clinicians in reproductive endocrinology. The text reviews the impact of cancers and their treatment on male fertility, the available fertility preservation strategies and post-treatment management.

In the mid-1990s, the international community pronounced prenatal sex selection via abortion an "act of violence against women" and "unethical." At the same time, new developments in reproductive technology in the United States led to a method of sex selection before conception; its US inventor marketed the practice as "family balancing" and defended it with the rhetoric of freedom of choice. In Gender before Birth, Rajani Bhatia takes on the double standard of how similar practices in the West and non-West are divergently named and framed. Bhatia's extensive fieldwork includes interviews with clinicians, scientists, biomedical service providers, and feminist activists, and her resulting analysis extends both feminist theory on reproduction and feminist science and technology studies. She argues that we are at the beginning of a changing transnational terrain that presents new challenges to theorized inequality in reproduction, demonstrating how the technosciences often get embroiled in colonial gender and racial politics.

"Extremely well-written, innovative, and timely, "Infertility Around the Globe is a definitive work. Together, the authors use infertility as the lens to examine numerous compelling social issues, generating a powerful argument that infertility is a globally significant phenomenon. This volume will attract anthropologists and other social scientists interested in the study of reproduction, as well as anyone interested in gender studies, women's studies, and international health."--Carolyn Sargent, co-editor of "Childbirth and Authoritative Knowledge: Cross-Cultural Perspectives

"This groundbreaking, interdisciplinary book will change how infertility is theorized and how intervention programs are designed. It will become the primary sourcebook for international and comparative research in a variety of cultural settings. Reading this book was a distinct pleasure."--Lynn Morgan, co-editor of "Fetal Subjects, Feminist Positions

"A stunning achievement. Through its richly textured ethnographic accounts, this book beautifully explicates the universals and particularities of involuntary childlessness in disparate world regions. It challenges the myopic view that the heartbreak is limited to advanced industrial societies. This book is a much-needed antidote in a field mostly characterized by polemic and untested assumptions."--C. H. Browner, UCLA School of Medicine

"Scholarship on infertility too often has been culture-bound, focusing on Western versions of biosocial reproductive problems and on technological solutions. This innovative volume decenters that perspective, with studies on the ostracism of elder childless men in Kenya, political suspicions of vaccination campaigns in theCameroons, new reproductive technologies for ultraorthodox use in Israel, and China's emergent eugenics. It enlarges the 'public' in public health."--Rayna Rapp, co-editor of "Conceiving the New World Order: The Global Politics of Reproduction

Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.

Intrauterine insemination and ovulation induction is effective first-line treatment for infertility in many straightforward cases and is preferred by many clinicians because they are less invasive than in-vitro fertilization and its variants. This is a comprehensive account of how to set up and run a successful IUI program. The book addresses the practical aspects of treatments that will produce optimum results in terms of pregnancy outcome and safety, as well as the pharmacological and physiological reasons for their use. Chapters on how to prevent complications of ovulation induction such as multiple births and ovarian hyperstimulation syndrome are included, as well as how to diagnose infertility in both sexes. Laboratory procedures for sperm preparation are described in detail. Worldwide resources for obtaining donor sperm and legal issues that surround the management of patients are included. This 2009 manual is of interest to reproductive medicine specialists, general practitioners and general obstetrician gynecologists.