This new volume in the Reproductive Medicine for Clinicians series focuses on the practical clinical impact of problems linked to infertility, discussing topics such as luteal support in ART cycles, ovulation induction using pulsatile administration of GnRH, how to deal with the metabolic changes in PCOS, treatment to restore fertility in endometriosis and how to improve implantation, which are common aspects of daily clinical practice. It also addresses significant novel areas like the biological clock in human reproduction, reproduction at advanced parental age and medical and social egg freezing, offering valuable insights for patients and their doctors. Further, the book covers various areas of growing importance, such as how to access the uterine cavity; the future of imaging in reproduction; non-invasive prenatal testing; ART and male infertility; as well as breast cancer and fertility preservation. Last but not least, it examines the medical, ethical and legal aspects of a number of challenges for current and future reproductive medicine, including uterine transplantation and human genetic modification. Bringing together updates on some of the most important problems in reproductive medicine and also covering ethical and legal bases, this book offers an overview of potential treatments for infertility. As such, it is a valuable resource for gynecologists, obstetricians, endocrinologists and all specialists dealing with reproductive health.

This volume surveys the state of knowledge and research on the determinants of human reproduction. It adopts an inter-disciplinary approach and integrates information from demographic, epidemiological and biological studies of fertility. The chapters provide a comprehensive overview of reproductive processes, including puberty and menopause, conception and fetal loss, and the effects of sexually transmitted diseases and lactation. The volume also considers the effects on fertility of nutrition and stress, environmental and occupational hazards, and social behaviour, and includes clinical papers on fertility following contraceptive use and treatment of infertility. Findings from original research on the determinants of human reproduction are also presented.

Neural tube defects, spina bifida, anencephalus, and encephalocoele, are among the commonest severe congenital abnormalities in most countries. The last decade has seen many advances, including the use of antenatal diagnosis by chemical and ultrasound methods, population screening, and many new findings in epidemiology, culminating in the demonstration of the protective effect of folic acid on recurrences. The progress in both antenatal diagnosis and in aetiological research on neural tube defects has been particularly dramatic, and may well anticipate developments in regard to other congenital abnormalities. Primary prevention now appears as an attainable goal. This book presents a critical review of the extensive findings of epidemiological studies, discusses several methodological issues of wider relevance such as ascertainment, seasonal variation, ethical and legal issues. As well as providing a unique resource in regard to neural tube defects, much of the material is relevant to those with wider interests in the prevention, antenatal diagnosis, and control of major diseases.

'Essential reading for anyone who has been through the sadness of a lost pregnancy' The Times 'Sensitive and insightful' Sunday Times Style 'This book will be a godsend to any woman going through the murky devastation that is called miscarriage but feels like something else entirely: the loss of a baby' Ariel Levy 'A compassionate, nuanced book that does this very complicated grief justice' Pandora Sykes 'This book will be the friend to hold your hand while you navigate your own pathway of grief. I'm so glad it's here' Elle Wright Beyond Grief also contains interviews with experts and other women who have experienced losses of their own, including Elizabeth Day, Leandra Medine Cohen, Melissa Odabash, Jools Oliver, Alexandra Stedman and Latham Thomas. Pippa Vosper tragically lost her son Axel in 2017, when she was five months pregnant, and has since written about miscarriage and baby loss online and in a series of pieces for Vogue. Beyond Grief: Navigating the Journey of Pregnancy and Baby Loss is the book she wishes had been available when her son died. It covers every aspect of pregnancy and baby loss at any stage, from the practical to the emotional, with advice from experts and stories from women who have been through it themselves. Beyond Grief offers both an inclusive perspective and a guiding hand to anyone who has experienced any kind of pregnancy loss, as well as those who are trying to support them through it.

Human embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science. Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.

An original graphic novel based on the IVF stories of its husband-and-wife authors and the 1-in-50 couples around the world like them. Conrad and Joanne met in their final year of university and have been virtually inseparable since then. For a while, it felt like they had all the time in the world. Yet now, when they are finally ready to have kids, they find that getting pregnant isn't always so easy. Ahead of them lies a difficult, expensive, and emotional journey into the world of assisted fertility, where each 'successful' implantation is followed by a two-week wait to see if the pregnancy takes. Join Joanne and Conrad, their friends, their family, their coworkers, and a stream of expert medical practitioners as they experience the highs and the lows, the tears and the laughter in this sensitive but unflinching portrayal of the hope and heartbreak offered to so many by modern medicine.

This book brings together the most up-to-date information about the physiology of progestogens. Addressing the bidirectional communication between hormones, fertility, tumors, and autoimmunity, it provides the basic science and clinical perspectives of progestogens which have not been previously available in one volume. In addition to estrogens, androgens, mineralocorticoids and glucocorticoids, progestogens are a major class of steroid hormone. While present in certain phases of estrous and menstrual cycles, progestogens are named for their function in maintaining pregnancy. This book is essentially practical in orientation, addressing the specific issues that confront the practitioner, and provides information to Obstetricians, Gynecologists, Reproductive endocrinologists, as well as Gynecological Oncologists and Rheumatologists. Contributions are from an international team of experts in the field, now completely updated in this new edition with new developments in primary dysmenorrhea and contraception.

This volume focuses on endometriosis from its pathogenesis and the importance of the early diagnosis to treatment, throughout all aspects of femininity that this disease affects, impacting health and quality of life. It also covers treatment strategies for the pain and for the disease management according to the age and needs of the patient, from adolescence to menopause, passing through the fertile age and the consequences that this disease can have on fertility and pregnancy. This book is a useful, clear and up-to-date tool for gynecologists, gynecological surgeons, reproductive medicine and general practitioners and is an important source of information to face this more and more frequent and devastating disease.

The fourth edition of this book updates and elaborates on the seven dimensions of maternal emotional health that have significant impact on delivery, postpartum adaptation, infant health, and early childhood development. Supported by the authors' original research and interviews, the book provides readers with an analysis of the role of these core functions throughout pregnancy, as well as practical materials for use with pregnant clients in the form of assessment instruments and evidence-based interventions for promoting positive development. The book provides a theoretical framework with rationales for the seven psychosocial dimensions, therapeutic and counseling intervention strategies to improve adaptive development in each of the seven psychosocial dimensions, findings specific to women in diverse cultural groups, a chapter devoted to women in the military and military spouses, and discussion of salient issues of pregnancy, including physical changes, body image, intimacy, trust, and ambivalence. The book focuses on the seven dimensions of maternal prenatal emotional health: Acceptance of the pregnancy. Motivation and preparation for motherhood. Relationship with husband/partner. Relationship with her own mother. Preparation for labor. Sense of control in labor Self-Esteem and Well-Being in labor. Psychosocial Adaptation to Pregnancy is a significant addition to the psychosocial assessment literature, a needed resource for clinical and health psychologists, clinical social workers, marriage and family therapists, professional counselors, midwives, and obstetrical nurses. It is also adaptable to undergraduate and graduate courses in maternal reproductive health and obstetrical nursing.

This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling readers to unambiguously interpret seminal cytologic images and compare reports for diagnostic, therapeutic and prognostic purposes. With its extensive collection of colored images, the book is intended as a reference resource for students and technicians in the field of andrology as well as practitioners and clinicians in andrology, urology, pathology, IVF and other ART programs

'Informative, powerful' VOGUE 'A fascinating and friendly guide for you to understand you better' MELISSA HEMSLEY 'Amy's book is everything I should have learned at school' EMMA GANNON Hormones were something Amy Thomson, founder and CEO of leading women's health app and tech service Moody, never paid attention to, until one day her periods stopped. When she discovered that her hormonal burnout was driven by stress, she quit her job and focused on trying to understand how our hormones can work for twenty-first-century survival. In this eye-opening guide, Thomson draws upon leading research from nutritionists, gynaecologists, endocrinologists, personal trainers and others to explain how understanding our systems and cycles can help you avoid burnouts, build better and healthier routines and optimise your life.

This comprehensive review of the factors that affect the harvesting and preparation of oocytes and the management of embryos will allow practitioners to make evidence-based decisions for successful IVF. The book reviews and re-considers the value of strategies and outcomes in the management of fertility and conception rates, centred on the production of oocytes, and successful development of the embryo. Authored by leading experts in the field, chapters engage with treatments and strategies that affect the production of oocytes and embryos, optimizing outcomes in the management of female fertility, conception rates, and live births. This vital guide covers controlled ovarian hyperstimulation, the role of AMH in determining ovarian reserve, and primary stimulation agents and the use of adjuncts. Integral for all clinicians and embryologists working in reproductive medicine units, readers are provided with evidence-based, comprehensive advice and review of all factors affecting the management of oocytes and the embryo that are vital for successful IVF cycles.

The Human Embryo in vitro explores the ways in which UK law engages with embryonic processes under the Human Fertilisation and Embryology Act 1990 (as amended), the intellectual basis of which has not been reconsidered for almost thirty years. McMillan argues that in regulating 'the embryo' - that is, a processual liminal entity in itself - the law is regulating for uncertainty. This book offers a fuller understanding of how complex biological processes of development and growth can be better aligned with a legal framework that purports to pay respect to the embryo while also allowing its destruction. To do so it employs an anthropological concept, liminality, which is itself concerned with revealing the dynamics of process. The implications of this for contemporary regulation of artificial reproduction are fully explored, and recommendations are offered for international regimes on how they can better align biological reality with social policy and law.

This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch's role in the development of the embryo to the Notch signaling pathway's role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch's role in senescence, the regulation of Notch signaling by microRNAs, Notch's role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books - Molecular Biology of Notch Signaling and Notch Signaling in Cancer - this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.

This important new book presents a comprehensive integration of psychoanalytic theories of human development from Freud to the present, showing their implications for the evaluation and treatment of children and adults. Phyllis Tyson and Robert L. Tyson not only review the literature on emotional growth but also provide a developmental theory of their own, one that examines psychosexual development in the context of a number of other simultaneously evolving systems-emotional, behavioral, cognitive, and social-all of which work in relation to one another in a dynamic way. The authors describe the developmental sequences of these systems and how they coalesce to form the human personality. The Tysons view development as it occurs rather than retrospectively from reconstructions of earlier life experience. They begin by tracing the history of this perspective, describing the developmental process, then critically reviewing psychoanalytic theories of development. The authors present developmental sequences for psychosexuality, object relations, the sense of self, affect, cognition, the superego, gender identity, and the ego. Throughout they maintain a central and orienting focus on the intrapsychic-on what happens in the mind as it evolves. In contrast to recent psychoanalytic emphases on interpersonal aspects of early development, they view perceived and felt interpersonal interactions as working in conjunction with innate factors to provide the basis for the internal world. According to the Tysons, it is the evolution and elaboration of this internal world that is the domain of psychoanalytic theory of development.

This second edition emphasizes the environmental impact on reproduction, with updated chapters throughout as well as complete new chapters on species such as sharks and rays. This is a wide-ranging book that will be of relevance to anyone involved in species conservation, and provides critical perspectives on the real utility of current and emerging reproductive sciences.Understanding reproductive biology is centrally important to the way many of the world's conservation problems should be tackled. Currently the extinction problem is huge, with up to 30% of the world's fauna being expected to disappear in the next 50 years. Nevertheless, it has been estimated that the global population of animals in zoos encompasses 12,000 - 15,000 species, and we anticipate that every effort will be made to preserve these species for as long as possible, minimizing inbreeding effects and providing the best welfare standards available. Even if the reproductive biology community cannot solve the global biodiversity crisis for all wild species, we should do our best to maintain important captive populations. Reproductive biology in this context is much more than the development of techniques for helping with too little or too much breeding. While some of the relevant techniques are useful for individual species that society might target for a variety of reasons, whether nationalistic, cultural or practical, technical developments have to be backed up by thorough biological understanding of the background behind the problems.

An authoritative account of the causes of infertility that fully explores the clinical assessment of patients and covers the decision-making behind treatment options. The content follows the MRCOG syllabus as well as delving deeper into subjects covered by the RCOG Advanced Training Skills Modules (ATSMs), leaving readers well prepared for their examinations. Written by nationally recognised leaders in the field, this volume concisely reviews contemporary clinical practice. Using an aetiology-based approach, chapters discuss ovulatory dysfunction, endometriosis, male infertility, uterine/tubal factors and unexplained infertility. The increasing use of third-party reproduction and surrogacy is explored, along with the psychosocial aspects of this type of treatment. Ethical dilemmas surrounding reproductive medicine and their management are covered in depth. With an emphasis on practical approaches to the delivery and organisation of clinical and laboratory services, readers learn how to ensure the support and care they offer is of the highest quality.

An account from the frontline of fertility treatment, giving a unique insight into not only the medical and scientific advances involved but the human cost and rewards behind this life-changing technology. Simon Fishel worked with Robert Edwards during his pioneering early IVF research and was part of the team in the world's first IVF clinic, with all the trials and tribulations that involved at the time, including a writ for murder! As the science developed over the decades so did his career, as he sought to do more for patients and taught the new technologies to doctors all over the world. He came up against regulatory and establishment barriers, including fighting a 3-year legal case in the High Court of Justice and a death threat from a doctor if he refused to work with him. The clinic he founded has grown into the largest IVF group in the UK, developing exciting new procedures, and he has helped establish clinics throughout the world, even being invited to introduce IVF to China.

In Quest for Conception, Marcia C. Inhorn portrays the poignant struggles of poor, urban Egyptian women and their attempts to overcome infertility. The author draws upon fifteen months of fieldwork in urban Egypt to present moving stories of infertile Muslim women whose tumultuous medical pilgrimages - or their "search for children," as they call their quests for conception - have yet to produce the desired pregnancies. Inhorn examines the devastating impact of infertility on the lives of these women, who are threatened with divorce by their husbands, harassed by their husbands' families, and ostracized by neighbors. Beliefs about procreation and infertility causation and cure among the Egyptian urban poor derive from a five-thousand-year history of shifting medical pluralism. Although colonially produced Western biomedicine is the dominant system in Egypt today, it represents only one of an array of therapeutic alternatives. Infertile women seek help from both "biogynecologists" (practitioners of Western biomedicine) and "ethnogynecologists" (practitioners of indigenous ethnomedicine), often using the remedies of both simultaneously. Quest for Conception examines in detail the variety of ethnomedical and biomedical treatments for infertility and concludes that treatments of both types are often ineffective and sometimes harmful. Given this untherapeutic setting, the future of infertile Egyptian women is explored in light of needed changes in reproductive health policy and the introduction of new reproductive technologies. Quest for Conception is the first comprehensive account of non-Western women's experiences of infertility and is a novel study within the literature on Middle Easternwomen.

Making a Good Life takes a timely look at the ideas and values that inform how people think about reproduction and assisted reproductive technologies. In an era of heightened scrutiny about parenting and reproduction, fears about environmental degradation, and the rise of the biotechnology industry, Katharine Dow delves into the reproductive ethics of those who do not have a personal stake in assisted reproductive technologies, but who are building lives inspired and influenced by environmentalism and concerns about the natural world's future. Moving away from experiences of infertility treatments tied to the clinic and laboratory, Dow instead explores reproduction and assisted reproductive technologies as topics of public concern and debate, and she examines how people living in a coastal village in rural Scotland make ethical decisions and judgments about these matters. In particular, Dow engages with people's ideas about nature and naturalness, and how these relate to views about parenting and building stable environments for future generations. Taking into account the ways daily responsibilities and commitments are balanced with moral values, Dow suggests there is still much to uncover about reproductive ethics. Analyzing how ideas about reproduction intersect with wider ethical struggles, Making a Good Life offers a new approach to researching, thinking, and writing about nature, ethics, and reproduction.

The over-arching goal of this volume is to help infertility practitioners evaluate and manage their patients with poor semen quality. The authors review the existing literature on the effects of medications on male fertility, and provide detailed information about what is known, giving the number of individuals and population characteristics for studies of medication effects on male fertility. Medications are designed to treat illness and reduce symptoms, but all have undesirable adverse effects such as headache or stomach upset. Some adverse reactions can even be life-threatening, so it is no surprise that some drugs have negative effects on male reproduction. Medical practitioners rarely consider a man's reproductive plans when prescribing medications. Men are routinely treated with drugs that can impair or abolish fertility. Although practitioners in the field of reproductive medicine generally realize that certain drugs impact negatively on reproductive health, there are limited resources providing evidence-based knowledge useful in counseling patients. Tables throughout this volume summarize the information for each drug, providing a handy reference for clinical use.

This second edition offers an expanded and updated history of the field of fetal and neonatal development, allowing readers to gain a comprehensive understanding of the biological aspects that contribute to the wellbeing or pathophysiology of newborns. In this concluding opus of a long and prominent career as a clinical scientist, Dr. Longo has invited new contributions from noted colleagues with expertise in various fields to provide a historical perspective on the impact of how modern concepts emerged in the field of fetal physiology and contributed to the current attention paid to the fetal origins of diseases in adults. In addition to new chapters on maternal physiology and complications during pregnancy, others trace the history of the Society for Reproductive Investigation, governmental funding of perinatal research, and major initiatives to support training in the new discipline of maternal fetal medicine, including the Reproductive Scientist Development program. The extensive survey provided by the author, who personally knew most of the pioneers in the field, offers a unique guide for all clinical and basic scientists interested in the history of - and future approaches to diagnosing and treating - pathologies that represent the leading causes of neonatal mortality and, far too often, life-long morbidity.