Brown-Sequard: An Improbable Genius Who Transformed Medicine traces the strange career of an eccentric, restless, widely admired, nineteenth-century physician-scientist who eventually came to be scorned by antivivisectionists for his work on animals, by churchgoers who believed that he encouraged licentious behavior, and by other scientists for his unorthodox views and for claims that, in fact, he never made. An improbable genius whose colorful life was characterized by dramatic reversals of fortune, he was a founder-physician of England's premier neurological hospital and held important professorships in America and France.
Brown-Sequard identified the sensory pathways in the spinal cord and emphasized functional processes in the integrative actions of the nervous system, thereby anticipating modern concepts of how the brain operates. He also discovered the function of the nerves that supply the blood vessels and thereby control their caliber, and the associated reflexes that adjust the circulation to bodily needs. He was the first to show that the adrenal glands are essential to life and suggested that other organs have internal secretions. He injected himself with ground-up animal testicles, claiming an invigorating effect, and this approach led to the development of modern hormone replacement therapy.
Charles-Edouard Brown-Sequard was reportedly "one of the greatest discover of facts that the world has ever seen." It has also been suggested that "if his reasoning power had equaled his power of observation he might have done for physiology what Newton did for physics." In fact, scientific advances in the years since his death have provided increasing support for many of his once-ridiculed beliefs."

Discovering the passions of Chris Woodhead Collected writings from a man who stimulated controversy and roused passions Best known as the Chief Inspector of Schools who demanded higher standards across the board, Woodhead was admired and condemned in equal measure for his determination to confront taboos and bring them into the national education debate. His final and greatest challenge was with Motor Neurone Disease, a condition he faced with strength and empathy until his death in 2015. While his education journalism stands at the core of this book, What Matters Most explores Woodhead's lesser known passions, literature and climbing, which he writes about with the precision and clarity that became his journalistic hallmark. In the final pages of the book Woodhead shares his personal views on assisted dying, advocating for individuals to be permitted to die with dignity at a time of their choosing. What Matters Most: A Collection of Pieces is a fascinating and poignant book which tracks the life and beliefs of a truly inspirational contemporary thinker.

Peter Byrne tells the story of Hugh Everett III (1930-1982), whose "many worlds" theory of multiple universes has had a profound impact on physics and philosophy. Using Everett's unpublished papers (recently discovered in his son's basement) and dozens of interviews with his friends, colleagues, and surviving family members, Byrne paints, for the general reader, a detailed portrait of the genius who invented an astonishing way of describing our complex universe from the inside. Everett's mathematical model (called the "universal wave function") treats all possible events as "equally real," and concludes that countless copies of every person and thing exist in all possible configurations spread over an infinity of universes: many worlds.
Afflicted by depression and addictions, Everett strove to bring rational order to the professional realms in which he played historically significant roles. In addition to his famous interpretation of quantum mechanics, Everett wrote a classic paper in game theory; created computer algorithms that revolutionized military operations research; and performed pioneering work in artificial intelligence for top secret government projects. He wrote the original software for targeting cities in a nuclear hot war; and he was one of the first scientists to recognize the danger of nuclear winter. As a Cold Warrior, he designed logical systems that modeled "rational" human and machine behaviors, and yet he was largely oblivious to the emotional damage his irrational personal behavior inflicted upon his family, lovers, and business partners.
He died young, but left behind a fascinating record of his life, including correspondence with such philosophically inclined physicists as Niels Bohr, Norbert Wiener, and John Wheeler. These remarkable letters illuminate the long and often bitter struggle to explain the paradox of measurement at the heart of quantum physics. In recent years, Everett's solution to this mysterious problem-the existence of a universe of universes-has gained considerable traction in scientific circles, not as science fiction, but as an explanation of physical reality.

CHOSEN AS A BOOK OF 2022 BY THE GUARDIAN AND THE NEW STATESMAN 'A STAND OUT' SUNDAY TIMES 'STARTLINGLY HONEST AND DEVASTATINGLY GOOD' RACHEL CLARKE, GUARDIAN 'BRILLIANT' OBSERVER 'POWERFUL AND EVOCATIVE' ADAM KAY 'YOU EMERGE KNOWING HOW LUCKY YOU ARE TO HAVE READ IT' ALI SMITH, NEW STATESMAN From the frontlines of the NHS, the story of a junior doctor's love, loss and grief through the Covid-19 crisis ------------------------------------------------------------------------------------------------------ In early 2020, junior doctor Roopa Farooki lost her sister to cancer. But just weeks later, she found herself plunged into another kind of crisis, fighting on the frontline of the battle taking place in her hospital, and in hospitals across the country. Everything is True is the story of Roopa's first forty days of the Covid-19 crisis from the frontlines of A&E and the acute medical wards, as struggling through her grief, she battles for her patients' and colleagues' survival. Working thirteen-hour shifts, she returns home each evening to write through her exhaustion, chronicling the devastating losses and slowly eroding dehumanisation happening in real time on the ward.

This biography of the famous Soviet physicist Leonid Isaakovich Mandelstam (1889-1944), who became a Professor at Moscow State University in 1925 and an Academician (the highest scientific title in the USSR) in 1929, describes his contributions to both physics and technology. It also discusses the scientific community that formed around him, commonly known as the Mandelstam School. By doing so, it places Mandelstam's life story in its cultural context: the context of German University (until 1914), the First World War, the Civil War, and the development of the Socialist Revolution (until 1925) and the young socialist country. The book considers various general issues, such as the impact of German scientific culture on Russian science; the problems and fates of Russian intellectuals during the revolutionary and post-revolutionary years; the formation of the Soviet Academy of Science, the State Academy; and the transformation of the system of higher education in the USSR during the 1920s and 1930s. Further, it reconstructs Mandelstam's philosophy of science and his approach to the social and ethical function of science and science education based on his fundamental writings and lecture notes. This reconstruction is enhanced by extensive use of previously unpublished archive material as well as the transcripts of personal interviews conducted by the author. The book also discusses the biographies of Mandelstam's friends and collaborators: German mathematician and philosopher Richard von Mises, Soviet Communist Party official and philosopher B.M.Hessen, Russian specialist in radio engineering N.D.Papalexy, the specialists in non-linear dynamics A.A.Andronov, S.E. Chaikin, A.A.Vitt and the plasma physicist M.A.Leontovich. This second, extended edition reconstructs the social and economic backgrounds of Mandelstam and his colleagues, describing their positions at the universities and the institutes belonging to the Academy of Science. Additionally, Mandelstam's philosophy of science is investigated in connection with the ideological attacks that occurred after Mandelstam's death, particularly the great mathematician A.D.Alexandrov's criticism of Mandelstam's operationalism.

'I think you have something here' I said, 'This could lead to a whole new way of understanding criminal behaviour. As far as I know no one's ever tried to figure out why serial killers kill. The implications are profound.' Haunting, heartfelt, and deeply human, Dr Ann Burgess's remarkable memoir combines a riveting personal narrative of fearless feminism and ambition, bone-chilling encounters with real-life monsters, and a revealing portrait of the ever-evolving US criminal justice system. A Killer By Design will inspire, terrify, and enlighten you in equal measure. It forces us to confront the age-old question 'What drives someone to kill, and how can we stop them?' 'Of all the colleagues I've worked with, Ann is one of the sharpest - and one of the toughest ... She taught us how to harness the chaos of serial killers' minds and helped us decipher the undecipherable. I'd recommend that everyone read A Killer By Design; not only is it a great page-turner, but it's about time Ann's story was heard' - JOHN E. DOUGLAS, former FBI criminal profiler and bestselling author of Mindhunter.

What if you could peer into the minds of an entire population? What if you could target the weakest with rumours that only they saw?

In 2016, an obscure British military contractor turned the world upside down. Funded by a billionaire on a crusade to start his own far-right insurgency, Cambridge Analytica combined psychological research with private Facebook data to make an invisible weapon with the power to change what voters perceived as real.

The firm was created to launch the then unknown Steve Bannon's ideological assault on America. But as it honed its dark arts in elections from Trinidad to Nigeria, 24-year-old research director Christopher Wylie began to see what he and his colleagues were unleashing.

He had heard the disturbing visions of the investors. He saw what CEO Alexander Nix did behind closed doors. When Britain shocked the world by voting to leave the EU, Wylie realised it was time to expose his old associates. The political crime of the century had just taken place - the weapon had been tested - and nobody knew.

"American Prometheus is the first full-scale biography of J. Robert Oppenheimer, "father of the atomic bomb," the brilliant, charismatic physicist who led the effort to capture the awesome fire of the sun for his country in time of war. Immediately after Hiroshima, he became the most famous scientist of his generation-one of the iconic figures of the twentieth century, the embodiment of modern man confronting the consequences of scientific progress.
He was the author of a radical proposal to place international controls over atomic materials-an idea that is still relevant today. He opposed the development of the hydrogen bomb and criticized the Air Force's plans to fight an infinitely dangerous nuclear war. In the now almost-forgotten hysteria of the early 1950s, his ideas were anathema to powerful advocates of a massive nuclear buildup, and, in response, Atomic Energy Commission chairman Lewis Strauss, Superbomb advocate Edward Teller and FBI director J. Edgar Hoover worked behind the scenes to have a hearing board find that Oppenheimer could not be trusted with America's nuclear secrets.
"American Prometheus sets forth Oppenheimer's life and times in revealing and unprecedented detail. Exhaustively researched, it is based on thousands of records and letters gathered from archives in America and abroad, on massive FBI files and on close to a hundred interviews with Oppenheimer's friends, relatives and colleagues.
We follow him from his earliest education at the turn of the twentieth century at New York City's Ethical Culture School, through personal crises at Harvard and Cambridge universities. Then to Germany, where he studied quantum physics with the world's mostaccomplished theorists; and to Berkeley, California, where he established, during the 1930s, the leading American school of theoretical physics, and where he became deeply involved with social justice causes and their advocates, many of whom were communists. Then to Los Alamos, New Mexico, where he transformed a bleak mesa into the world's most potent nuclear weapons laboratory-and where he himself was transformed. And finally, to the Institute for Advanced Study in Princeton, which he directed from 1947 to 1966.
"American Prometheus is a rich evocation of America at midcentury, a new and compelling portrait of a brilliant, ambitious, complex and flawed man profoundly connected to its major events-the Depression, World War II and the Cold War. It is at once biography and history, and essential to our understanding of our recent past-and of our choices for the future.

This book (hardcover) is part of the TREDITION CLASSICS. It contains classical literature works from over two thousand years. Most of these titles have been out of print and off the bookstore shelves for decades. The book series is intended to preserve the cultural legacy and to promote the timeless works of classical literature. Readers of a TREDITION CLASSICS book support the mission to save many of the amazing works of world literature from oblivion. With this series, tredition intends to make thousands of international literature classics available in printed format again - worldwide.

Explorer-naturalists Robert Brown and Mungo Park played a pivotal role in the development of natural history and exploration in the late eighteenth and early nineteenth centuries. This work is a fresh examination of the lives and careers of Brown and Park and their impact on natural history and exploration. Brown and Park were part of a group of intrepid naturalists who brought back some of the flora and fauna they encountered, drawings of what they observed, and most importantly, their ideas. The educated public back home was able to gain an understanding of the diversity in nature. This eventually led to the development of new ways of regarding the natural world and the eventual development of a coherent theory of organic evolution. This book considers these naturalists, Brown, Park, and their contemporaries, from the perspective of the Scottish Enlightenment. Brown's investigations in natural history created a fertile environment for breakthroughs in taxonomy, cytology, and eventually evolution. Brown's pioneering work in plant taxonomy allowed biologists to look at the animal and plant kingdoms differently. Park's adventures stimulated significant discoveries in exploration. Brown and Park's adventures formed a bridge to such journeys as Charles Darwin's voyage on H.M.S. Beagle, which led to a revolution in biology and full explication of the theory of evolution.

"Jonathan Friedlaender has devoted much of his professional life to studies of human population variation in Pacific Islanders.. His collaborator on this memoir of his life and experiences in the Pacific is Joanna Radin, a young but remarkably knowledgeable historian of science currently conducting graduate studies at the University of Pennsylvania. These two professionals weave a fascinating fabric of complex texture that incorporates the educational, political, governmental, and research climate of the 1960s, 1970s, and 1980s with the trials and tribulations of a young researcher and academic trying to make his way in a highly competitive arena. The book is much more than a series of recollections about one man's life; rather, it is a history of an important era in the development of anthropological genetics and the dramatic transition in this science that took place in the early 1980s.

Friedlaender's book should have appeal to a number of audiences - students, professional anthropologists, and lay readers, alike... Jonathan Friedlaender's Reflections is a valuable addition to the historical record of this important science. This is a worthwhile book to read for anyone with interests in the history of science or the history of a science."

From the Foreword by Professor Michael A. Little, Binghamton University

'If you want to read a book that moves you both at the level of sentence and the quality of language and with the emotional depth of its subject matter, then A Fortunate Woman is definitely the book you should be reading' Samanth Subramanian, Baillie Gifford Judge When Polly Morland is clearing out her mother's house she finds a book that will lead her to a remarkable figure living on her own doorstep: the country doctor who works in the same remote, wooded valley she has lived in for many years. This doctor is a rarity in contemporary medicine, she knows her patients inside out, and their stories are deeply entwined with her own. In A Fortunate Woman, with its beautiful photographs by Richard Baker, Polly Morland has written a profoundly moving love letter to a landscape, a community and, above all, to what it means to be a good doctor. 'Morland writes about nature and the changing landscape with such lyrical precision that her prose sometimes seems close to poetry' Christina Patterson, The Sunday Times 'Timely . . . compelling . . . a delicately drawn miniature' The Financial Times 'This book deepens our understanding of the life and thoughts of a modern doctor, and the modern NHS, and it expands movingly to chronicle a community and a landscape' Kathleen Jamie, The New Statesman

Like the "funny, brilliant, bawdy" (The New Yorker) "Surely You're Joking, Mr. Feynman!" this book's many stories-some funny, others intensely moving-display Richard P. Feynman's unquenchable thirst for adventure and unparalleled ability to recount important moments from his life. Here we meet Feynman's first wife, Arlene, who taught him of love's irreducible mystery as she lay dying in a hospital bed while he worked on the atomic bomb at nearby Los Alamos. We listen to the fascinating narrative of the investigation into the space shuttle Challenger's explosion in 1986 and relive the moment when Feynman revealed the disaster's cause through an elegant experiment: dropping a ring of rubber into a glass of cold water and pulling it out, misshapen. In "What Do You Care What Other People Think?" one of the greatest physicists of the twentieth century lets us see the man behind the genius.

Triumph over Tragedy by Jay Fox, a popular entertainer known both in his home, Bermuda, as well as in the USA and internationally, is the personal story of his journey from a beginning as a mixed-blood child of a single mother of limited means in a prejudicial and insular society to a highly popular singer, songwriter, performer, and respected hotel manager. How he handled this challenging double life and how it affected his growing need for meaning in his life leads to a stormy personal situation and his relocation to Crossville, a small town in Tennessee. When all was going well personally, with a family and a horse-training ranch, and professionally, with a busy schedule of performances and an enthusiastic following of loyal fans, tragedy struck when a wasp sting turned into an infectious disease, diagnosed as group-A streptococcal toxic shock syndrome, which cost him his leg and threatened his very life. His faith in God and the support of his family, friends, and fans have led him to a future he could never have anticipated.

Discover the exhilarating true story of Ernest Shackleton's legendary Antarctic expedition Told through the words of the world's greatest living explorer, Sir Ranulph Fiennes - one of the only men to understand his experience first-hand . . . 'For anyone with a passion for polar exploration, this is a must read' NEW YORK TIMES 'THE definitive book on Shackleton and no one could have done it better . . . an authentic account by one of the few men who truly knows what it's like to challenge Antarctica' LORRAINE KELLY _________ In 1915, Sir Ernest Shackleton's attempt to be the first to traverse the Antarctic was cut short when his ship, Endurance, became trapped in ice. He and his crew should have died. Instead, through a long, dark winter, Shackleton fought back: enduring sub-zero temperatures, a perilous lifeboat journey across icy seas, and a murderous march over glaciers to seek help. Shackleton's epic trek is one of history's most enthralling adventures. But who was he? How did previous Antarctic expeditions and his rivalry with Captain Scott forge him? And what happened afterwards to the man many believed was invincible? In this astonishing account, Fiennes brings the story vividly to life in a book that is part celebration, part vindication and all adventure. _________ 'Fiennes makes a fine guide on voyage into Shackleton's world . . . What makes this book so engaging is the author's own storytelling skills' Irish Independent 'Fiennes relates these tales of exploration and survival, adding insight to Shackleton's journeys unlike any other biographer' Radio Times Praise for Sir Ranulph Fiennes: 'The World's Greatest Living Explorer' Guinness Book of Records 'Full of awe-inspiring details of hardship, resolve and weather that defies belief, told by someone of unique authority. No one is more tailor-made to tell [this] story than Sir Ranulph Fiennes' Newsday 'Fiennes' own experiences certainly allow him to write vividly and with empathy of the hell that the men went through' Sunday Times 'Fiennes brings the promised perspective of one who has been there, illuminating Shackleton's actions by comparing them with his own. Beginners to the Heroic Age will enjoy this volume, as will serious polar adventurers seeking advice. For all readers, it's a tremendous story' Sara Wheeler, The Wall Street Journal

In a world of viral ideas and emotion, who gets to control the narrative, who gets to be heard, and what does power really cost?

This is the story of the showdown between Elon Musk and Twitter and how the richest man on earth suddenly came to control one of the most powerful media platforms in the world. In Character Limit, award-winning reporters Kate Conger and Ryan Mac draw on exclusive interviews, unreported documents and internal Twitter recordings to provide a revelatory, three-dimensional, and definitive account of what really happened when Musk showed up to takeover Twitter, spoiling for a brawl and intent on revolution, with his merciless, sycophantic cadre of lawyers, investors, and bankers.

In part, this is the story of Twitter's founder, Jack Dorsey, who idealistically dreamed of building a 'digital town square' but detested Wall Street and never built a profitable business, and Musk, one of the site's most influential users with over 70 million followers. To Musk, Twitter—once known for its almost absolute commitment to free speech—had utterly lost its way. Blaming it for the proliferation of what he called the “woke mind virus”, he claimed that the survival of humanity itself depended on the future of the site.

In January 2022, Musk began secretly accumulating Twitter stock. By April, he was its largest shareholder, and, soon after, he made an unsolicited offer to purchase the company for the unimaginable sum of $44 billion. Backed into a corner, Twitter’s board accepted his offer—only for Musk to change his mind, forcing Twitter to sue him.

Drawing on unparalleled sources, this is the defining story of our time told in vivid, cinematic detail.

Carol's gripping story begins 29 years ago when, as a teenager, she asks to have her nose surgically altered. But before plastic surgery can be performed, her world comes crashing down around her when she receives shocking news-she has a rare disease, Wegener's granulomatosis.

Though the treatments take their toll on her body, and the disease ironically changes the shape of her nose, Carol refuses to let it destroy her spirit. Meanwhile, her mother's persistent efforts to find information and support for herself led to today's international Vasculitis Foundation.

Learn how to make the healthcare system work for you. Find out the value of second opinions and how a positive attitude can save your sanity. See how compassionate relationships are vital to this patient's recovery.

Told through the eyes of her mother, Myrna, this moving and personal story, which details their journey from darkness to hope, is not only inspiring but a valuable source of information for anyone touched by a serious chronic illness.