A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: * Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study * Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models * Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years * Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry

The textbook acquaints the reader with the architecture of receivers of analog and digital radio systems, helps to study the stages of designing a modern radio receiver and reveals the reasons and methods for its effective operation in networks for various purposes. Particular attention is paid to the methods of generating and processing signals in the receivers of digital systems with multiple access, which make it possible to provide data transfer rates close to the maximum possible (according to Shannon). As a textbook for students studying methods of optimal signal reception, the book will also be useful to specialists in the field of telecommunications involved in the development of radio receivers. The book shows how the development of theoretical, circuitry and integrated technologies led to the active introduction of algorithmic methods for signal processing changed both the design of receivers and the methods of forming the information flow in free space (MIMO, beamforming). The creation of a global 5G network based on heterogeneous networks puts forward new requirements for the architecture of receivers, which are determined by the requirements to achieve high data rates, low time delays or use in networks with coordinated multipoint transmission and reception (CoMP). To consolidate the knowledge gained, the book includes a complete set of materials for online classes, including questions and answers, a guide to solving problems for each chapter, and computer modeling units of receivers in the MicroCAP environment, based on preliminary calculations.