Measurements and experiments are made each and every day, in fields as disparate as particle physics, chemistry, economics and medicine, but have you ever wondered why it is that a particular experiment has been designed to be the way it is. Indeed, how do you design an experiment to measure something whose value is unknown, and what should your considerations be on deciding whether an experiment has yielded the sought after, or indeed any useful result? These are old questions, and they are the reason behind this volume. We will explore the origins of the methods of data analysis that are today routinely applied to all measurements, but which were unknown before the mid-19th Century. Anyone who is interested in the relationship between the precision and accuracy of measurements will find this volume useful. Whether you are a physicist, a chemist, a social scientist, or a student studying one of these subjects, you will discover that the basis of measurement is the struggle to identify the needle of useful data hidden in the haystack of obscuring background noise.

The International Linear Collider (ILC) is a mega-scale, technically complex project, requiring large financial resources and cooperation of thousands of scientists and engineers from all over the world. Such a big and expensive project has to be discussed publicly, and the planned goals have to be clearly formulated. This book advocates for the demand for the project, motivated by the current situation in particle physics. The natural and most powerful way of obtaining new knowledge in particle physics is to build a new collider with a larger energy. In this approach, the Large Hadron Collider (LHC) was created and is now operating at the world record center of-mass energy of 13 TeV. Although the design of colliders with a larger energy of 50-100 TeV has been discussed, the practical realization of such a project is not possible for another 20-30 years. Of course, many new results are expected from LHC over the next decade. However, we must also think about other opportunities, and in particular, about the construction of more dedicated experiments. There are many potentially promising projects, however, the most obvious possibility to achieve significant progress in particle physics in the near future is the construction of a linear e+e- collider with energies in the range (250-1000) GeV. Such a project, the ILC, is proposed to be built in Kitakami, Japan. This book will discuss why this project is important and which new discoveries can be expected with this collider.

Time-resolved optical stimulation of luminescence has become established as an important method for measurement of optically stimulated luminescence. Its enduring appeal is easy to see with the number of materials studied growing from the initial focus on natural minerals such as quartz and feldspar to synthetic dosimeters such as i !-Al2O3:C, BeO and YAlO3:Mn2+. The aim of time-resolved optical stimulation is to separate in time the stimulation and emission of luminescence. The luminescence is stimulated from a sample using a brief light pulse. The ensuing luminescence can be monitored either during stimulation in the presence of scattered stimulating light or after the light-pulse. The time-resolved luminescence spectrum measured in this way can be resolved into components each with a distinct lifetime. The lifetimes are linked to physical processes of luminescence and thus provide a means to study dynamics involving charge transfer between point-defects in materials. This book is devoted to time-resolved optically stimulated luminescence and is suitable for researchers with an interest in the study of point-defects using luminescence methods. The book first sets the method within the context of luminescence field at large and then provides an overview of the instrumentation used. There is much attention on models for time-resolved optically stimulated luminescence, two of which are analytical and the third of which is based on computational simulation of experimental results. To bring relevance to the discussion, the book draws on examples from studies on quartz and a-Al2O3:C, two materials widely investigated using this method. The book shows how kinetic analysis for various thermal effects such as thermal quenching and thermal assistance can be investigated using time-resolved luminescence. Although use of light sums is an obvious choice for this, contemporary work is discussed to show the versatility of using other alternative methods such the dynamic throughput.

Data integrity is the hottest topic in the pharmaceutical industry. Global regulatory agencies have issued guidance, after guidance after guidance in the past few years, most of which does not offer practical advice on how to implement policies, procedures and processes to ensure integrity. These guidances state what but not how. Additionally, key stages of analysis that impact data integrity are omitted entirely. The aim of this book is to provide practical and detailed help on how to implement data integrity and data governance for regulated analytical laboratories working in or for the pharmaceutical industry. It provides clarification of the regulatory issues and trends, and gives practical methods for meeting regulatory requirements and guidance. Using a data integrity model as a basis, the principles of data integrity and data governance are expanded into practical steps for regulated laboratories to implement. The author uses case study examples to illustrate his points and provides instructions for applying the principles of data integrity and data governance to individual laboratory needs. This book is a useful reference for analytical chemists and scientists, management and senior management working in regulated laboratories requiring either an understanding about data integrity or help in implementing practical solutions. Consultants will also benefit from the practical guidance provided.

Dawn is the first mission to orbit a main belt asteroid and the first scientific mission to use ion propulsion. Major objectives of this mission include mapping of the surfaces of 4 Vesta and 1 Ceres, determining its topography from stereo measurements, determining its mineralogy, measuring its elemental composition and obtaining gravity data. This book describes the Dawn mission, its exploration and scientific objectives, the instruments that accomplish those objectives, the operations plan and the education and outreach plan. It is directed to those studying asteroids and the evolution of the solar system. This volume will be a valuable reference for anyone who uses data from the instruments of the DAWN mission. Previously published in Space Science Reviews, Vol. 163/1-4, 2012.

Since the turn of the century, the increasing availability of photoelectron imaging experiments, along with the increasing sophistication of experimental techniques, and the availability of computational resources for analysis and numerics, has allowed for significant developments in such photoelectron metrology. Quantum Metrology with Photoelectrons, Volume 2: Applications and Advances discusses the fundamental concepts along with recent and emerging applications. Volume 2 explores the applications and development of quantum metrology schemes based on photoelectron measurements. The author begins with a brief historical background on ""complete"" photoionization experiments, followed by the details of state reconstruction methodologies from experimental measurements. Three specific applications of quantum metrology schemes are discussed in detail. In addition, the book provides advances, future directions, and an outlook including (ongoing) work to generalise these schemes and extend them to dynamical many-body systems. Volume 2 will be of interest to readers wishing to see the (sometimes messy) details of state reconstruction from photoelectron measurements as well as explore the future prospects for this class of metrology.

Since the turn of the century, the increasing availability of photoelectron imaging experiments, along with the increasing sophistication of experimental techniques, and the availability of computational resources for analysis and numerics, has allowed for significant developments in such photoelectron metrology. Quantum Metrology with Photoelectrons, Volume 1: Foundations discusses the fundamental concepts along with recent and emerging applications. The core physics is that of photoionization, and Volume 1 addresses this topic. The foundational material is presented in part as a tutorial with extensive numerical examples and also in part as a collected reference to the relevant theoretical treatments from the literature for a range of cases. Topics are discussed with an eye to developing general quantum metrology schemes, in which full quantum state reconstruction of the photoelectron wavefunction is the goal. In many cases, code and/or additional resources are available online. Consequently, it is hoped that readers at all levels will find something of interest and that the material provides something rather different from existing textbooks.

The Transmission Electron Microscope (TEM) is the ultimate tool to see and measure structures on the nanoscale and to probe their elemental composition and electronic structure with sub-nanometer spatial resolution. Recent technological breakthroughs have revolutionized our understanding of materials via use of the TEM, and it promises to become a significant tool in understanding biological and biomolecular systems such as viruses and DNA molecules. This book is a practical guide for scientists who need to use the TEM as a tool to answer questions about physical and chemical phenomena on the nanoscale.

This book describes modern focused ion beam microscopes and techniques and how they can be used to aid materials metrology and as tools for the fabrication of devices that in turn are used in many other aspects of fundamental metrology. Beginning with a description of the currently available instruments including the new addition to the field of plasma-based sources, it then gives an overview of ion solid interactions and how the different types of instrument can be applied. Chapters then describe how these machines can be applied to the field of materials science and device fabrication giving examples of recent and current activity in both these areas.

Photoemission (also known as photoelectron) spectroscopy refers to the process in which an electron is removed from a specimen after the atomic absorption of a photon. The first evidence of this phenomenon dates back to 1887 but it was not until 1905 that Einstein offered an explanation of this effect, which is now referred to as ""the photoelectric effect"".Quantitative Core Level Photoelectron Spectroscopy: A Primer tackles the pragmatic aspects of the photoemission process with the aim of introducing the reader to the concepts and instrumentation that emerge from an experimental approach. The basic elements implemented for the technique are discussed and the geometry of the instrumentation is explained. The book covers each of the features that have been observed in the X-ray photoemission spectra and provides the tools necessary for their understanding and correct identification. Charging effects are covered in the penultimate chapter with the final chapter bringing closure to the basic uses of the X-ray photoemission process, as well as guiding the reader through some of the most popular applications used in current research.