Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of data across scales, and the prediction of tumor progression and treatment outcome (in silico oncology). Drawing on an interdisciplinary group of distinguished international experts, Multiscale Cancer Modeling discusses the scientific and technical expertise necessary to conduct innovative cancer modeling research across scales. It presents contributions from some of the top in silico modeling groups in the United States and Europe. The ultimate goal of multiscale modeling and simulation approaches is their use in clinical practice, such as supporting patient-specific treatment optimization. This volume covers state-of-the-art methods of multiscale cancer modeling and addresses the field's potential as well as future challenges. It encourages collaborations among researchers in various disciplines to achieve breakthroughs in cancer modeling.

This book describes how we can design and make efficient processors for high-performance computing, AI, and data science. Although there are many textbooks on the design of processors we do not have a widely accepted definition of the efficiency of a general-purpose computer architecture. Without a definition of the efficiency, it is difficult to make scientific approach to the processor design. In this book, a clear definition of efficiency is given and thus a scientific approach for processor design is made possible. In chapter 2, the history of the development of high-performance processor is overviewed, to discuss what quantity we can use to measure the efficiency of these processors. The proposed quantity is the ratio between the minimum possible energy consumption and the actual energy consumption for a given application using a given semiconductor technology. In chapter 3, whether or not this quantity can be used in practice is discussed, for many real-world applications. In chapter 4, general-purpose processors in the past and present are discussed from this viewpoint. In chapter 5, how we can actually design processors with near-optimal efficiencies is described, and in chapter 6 how we can program such processors. This book gives a new way to look at the field of the design of high-performance processors.

As a collection of ideas and methodologies, systems thinking has made an impact in organizations and in particular in the information systems field. However, this main emphasis on organizations limits the scope of systems thinking and practice. There is a need first to use systems thinking in addressing societal problems, and second to enable people involved in developing the information society to reflect on the impacts of systems and technologies in society as a whole. Thus, there are opportunities to review the scope and potential of systems thinking and practice to deal with information society-related issues.

Systems Practice in the Information Society provides students of information systems as well as practicing Inofrmation Systems managers with concepts and strategies to enable them to understand and use systems thinking methodologies and address challenges posed by the development of information-based societies. This book brings experiences, ideas, and applications of systemic thinking in designing and evaluating socio-technological initiatives. Using a number of cultural contexts, this book explores how organizations, including governments, can enable better access to information and communication technologies and improve the quality of life of individuals.

This book focuses on futuristic approaches and designs for real-time systems and applications, as well as the fundamental concepts of including advanced techniques and tools in models of data-driven blockchain ecosystems. The Data-Driven Blockchain Ecosystem: Fundamentals, Applications, and Emerging Technologies discusses how to implement and manage processes for releasing and delivering blockchain applications. It presents the core of blockchain technology, IoT-based and AI-based blockchain systems, and various manufacturing areas related to Industry 4.0. The book illustrates how to apply design principles to develop and manage blockchain networks, and also covers the role that cloud computing plays in blockchain applications. All major technologies involved in blockchain-embedded applications are included in this book, which makes it useful to engineering students, researchers, academicians, and professionals interested in the core of blockchain technology.

Maintaining compatibility among all affected network and application interfaces of modern enterprise systems can quickly become costly and overwhelming. This handbook presents the knowledge and practical experience of a global group of experts from varying disciplines to help you plan and implement enterprise integration projects that respond to business needs quickly and are seamless to business users. The Handbook of Enterprise Integration brings together the latest research and application results to provide infrastructure engineers, software engineers, software developers, system designers, and project managers with a clear and comprehensive understanding of systems integration technologies, architectures, applications, and project management techniques involved in enterprise system integration. The text includes coverage of mobile communications, standards for integrated manufacturing and e-commerce, RFID, Web-based systems, and complete service-oriented enterprise modeling and analysis. Practitioners will benefit from insights on managing virtual teams as well as techniques for introducing complex technology into businesses. Covering best practices in enterprise systems integration, the text highlights applications across various business enterprises to help you: Bring together existing systems for business processes improvement Design and implement systems that can be reconfigured quickly and easily in response to evolving operational needs Establish procedures for achieving smooth migrations from legacy systems-with minimal disruption to existing operations Complete with case studies, this book illustrates the current state of the art in the context of user requirements and integration and provides the up-to-date understanding required to manage today's complex and interconnected systems.

The art, craft, discipline, logic, practice and science of developing large-scale software products needs a professional base. The textbooks in this three-volume set combine informal, engineeringly sound approaches with the rigor of formal, mathematics-based approaches.

This volume covers the basic principles and techniques of specifying systems and languages. It deals with modelling the semiotics (pragmatics, semantics and syntax of systems and languages), modelling spatial and simple temporal phenomena, and such specialized topics as modularity (incl. UML class diagrams), Petri nets, live sequence charts, statecharts, and temporal logics, including the duration calculus. Finally, the book presents techniques for interpreter and compiler development of functional, imperative, modular and parallel programming languages.

This book is targeted at late undergraduate to early graduate university students, and researchers of programming methodologies. Vol. 1 of this series is a prerequisite text.

Since 1994, the European Conference on Product and Process Modelling (www.ecppm.org) has been providing a review of research, development and industrial implementation of product and process model technology in construction. The 7th European Conference on Product and Process Modelling (ECPPM 2008) provided a unique discussion platform for topics of key importance for the AEC/FM industry, with a focus on two main themes:

- Structuring of product and process information for enhanced collaborative teamwork and information sharing in this fragmented industry, and

- Advanced Computing, Information and Communication Technology addressing the resolution of challenges for the AEC/FM industry in the upcoming years.

Leading experts delivered up-to-date, comprehensive presentations on the broad achievements in research, development, standardisation and industrial implementation of product and process data technology. This book covers a large spectrum of topics, including process optimisation, extended products and future services for homes and buildings infrastructures, decision support systems for universal design of buildings, ICT-based applications for energy efficiency, environmental monitoring, the ageing population, assistive technologies for the built environment, policy, legal framework, and rules and regulations, and will be of interest to scientists and professionals working in these areas.

Comprehensive and self contained, this tutorial covers the design of a plethora of combinational and sequential logic circuits using conventional logic design and Verilog HDL. Number systems and number representations are presented along with various binary codes. Several advanced topics are covered, including functional decomposition and iterative networks. A variety of examples are provided for combinational and sequential logic, computer arithmetic, and advanced topics such as Hamming code error correction. Constructs supported by Verilog are described in detail. All designs are continued to completion. Each chapter includes numerous design issues of varying complexity to be resolved by the reader.

This book addresses reliability, maintenance, risk, and safety issues of industrial systems with applications of the latest decision-making techniques. Thus, this book presents chapters that apply advanced tools, techniques, and computing models for optimizing the performance of industrial and manufacturing systems, along with other complex engineering equipment. Computing techniques like data analytics, failure mode and effects analysis, fuzzy set theory, petri-net, multi-criteria decision-making (MCDM), and soft computing are used for solving problems of reliability, risk, and safety related issues.

This book constitutes the refereed proceedings of six International Workshops held as parallel events of the 17th IFIP WG 12.5 International Conference on Artificial Intelligence Applications and Innovations, AIAI 2021, virtually and in Hersonissos, Crete, Greece, in June 2021: the 6th Workshop on 5G-Putting Intelligence to the Network Edge, 5G-PINE 2021; Artificial Intelligence in Biomedical Engineering and Informatics Workshop, AI-BIO 2021; Workshop on Defense Applications of AI, DAAI 2021; Distributed AI for Resource-Constrained Platforms Workshop, DARE 2021; Energy Efficiency and Artificial Intelligence Workshop, EEAI 2021; and the 10th Mining Humanistic Data Workshop, MHDW 2021. The 24 full papers and 16 short papers presented at these workshops were carefully reviewed and selected from 72 submissions. The papers presented at 5G-PINE focus on the latest AI applications in the telecommunication industry and AI in modern 5G-oriented telecommunications infrastructures. The papers chosen for AI-BIO 2021 present research on the subject of AI, in its broadest sense, in biomedical engineering and health informatics. The DAAI 2021 papers aim at presenting recent evolutions in artificial intelligence applicable to defense and security applications. The papers selected for DARE 2021 address a variety of pertinent and challenging topics within the scope of distributed AI for resource-constrained platforms. The papers presented at EEAI 2021 aim to bring together interdisciplinary approaches that focus on the application of AI-driven solutions for increasing and improving energy efficiency of residential and tertiary buildings and of occupant behavior. The MHDW papers focus on topics such as recommendation systems, sentiment analysis, pattern recognition, data mining, and time series.

A must-have book for systems analysts, architects and managers interested in enhancing successful communication in their organisation.* Provides detailed examples of how to understand and implement 'fundamental modeling concepts' for IT-systems communication* Provides an already successfully implemented model that has been used at: Siemens, Alcatel, SAP and others* Benefits from extensive theoretical and practical research* Provides guidelines on how 'fundamental modeling concepts' can be used to support UML, OO, MDA and Architectural Patterns

Mechatronic design processes have become shorter and more parallelized, induced by growing time-to-market pressure. Methods that enable quantitative analysis in early design stages are required, should dependability analyses aim to influence the design. Due to the limited amount of data in this phase, the level of uncertainty is high and explicit modeling of these uncertainties becomes necessary.

This work introduces new uncertainty-preserving dependability methods for early design stages. These include the propagation of uncertainty through dependability models, the activation of data from similar components for analyses and the integration of uncertain dependability predictions into an optimization framework. It is shown that Dempster-Shafer theory can be an alternative to probability theory in early design stage dependability predictions. Expert estimates can be represented, input uncertainty is propagated through the system and prediction uncertainty can be measured and interpreted. The resulting coherent methodology can be applied to represent the uncertainty in dependability models.

With extraordinary clarity, the Systems Biology: Principles, Methods, and Concepts focuses on the technical practical aspects of modeling complex or organic general systems. It also provides in-depth coverage of modeling biochemical, thermodynamic, engineering, and ecological systems. Among other methods and concepts based in logic, computer science, and dynamical systems, it explores pragmatic techniques of General Systems Theory. This text presents biology as an autonomous science from the perspective of fundamental modeling techniques. A complete resource for anyone interested in biology as an exact science, it includes a comprehensive survey, review, and critique of concepts and methods in Systems Biology.

This book presents the proceedings of the 12th International Parallel Tools Workshop, held in Stuttgart, Germany, during September 17-18, 2018, and of the 13th International Parallel Tools Workshop, held in Dresden, Germany, during September 2-3, 2019. The workshops are a forum to discuss the latest advances in parallel tools for high-performance computing. High-performance computing plays an increasingly important role for numerical simulation and modeling in academic and industrial research. At the same time, using large-scale parallel systems efficiently is becoming more difficult. A number of tools addressing parallel program development and analysis has emerged from the high-performance computing community over the last decade, and what may have started as a collection of a small helper scripts has now matured into production-grade frameworks. Powerful user interfaces and an extensive body of documentation together create a user-friendly environment for parallel tools.

In two editions spanning more than a decade, The Electrical Engineering Handbook stands as the definitive reference to the multidisciplinary field of electrical engineering. Our knowledge continues to grow, and so does the Handbook. For the third edition, it has expanded into a set of six books carefully focused on a specialized area or field of study. Each book represents a concise yet definitive collection of key concepts, models, and equations in its respective domain, thoughtfully gathered for convenient access. Systems, Controls, Embedded Systems, Energy, and Machines explores in detail the fields of energy devices, machines, and systems as well as control systems. It provides all of the fundamental concepts needed for thorough, in-depth understanding of each area and devotes special attention to the emerging area of embedded systems. Each article includes defining terms, references, and sources of further information. Encompassing the work of the world's foremost experts in their respective specialties, Systems, Controls, Embedded Systems, Energy, and Machines features the latest developments, the broadest scope of coverage, and new material on human-computer interaction.

The volume contains latest research on software reliability assessment, testing, quality management, inventory management, mathematical modeling, analysis using soft computing techniques and management analytics. It links researcher and practitioner perspectives from different branches of engineering and management, and from around the world for a bird's eye view on the topics. The interdisciplinarity of engineering and management research is widely recognized and considered to be the most appropriate and significant in the fast changing dynamics of today's times. With insights from the volume, companies looking to drive decision making are provided actionable insight on each level and for every role using key indicators, to generate mobile-enabled scorecards, time-series based analysis using charts, and dashboards. At the same time, the book provides scholars with a platform to derive maximum utility in the area by subscribing to the idea of managing business through performance and business analytics.

With the diversification of Internet services and the increase in mobile users, efficient management of network resources has become an extremely important issue in the field of wireless communication networks (WCNs). Adaptive resource management is an effective tool for improving the economic efficiency of WCN systems as well as network design and construction, especially in view of the surge in mobile device demands. This book presents modelling methods based on queueing theory and Markov processes for a wide variety of WCN systems, as well as precise and approximate analytical solution methods for the numerical evaluation of the system performance. This is the first book to provide an overview of the numerical analyses that can be gleaned by applying queueing theory, traffic theory and other analytical methods to various WCN systems. It also discusses the recent advances in the resource management of WCNs, such as broadband wireless access networks, cognitive radio networks, and green cloud computing. It assumes a basic understanding of computer networks and queueing theory, and familiarity with stochastic processes is also recommended. The analysis methods presented in this book are useful for first-year-graduate or senior computer science and communication engineering students. Providing information on network design and management, performance evaluation, queueing theory, game theory, intelligent optimization, and operations research for researchers and engineers, the book is also a valuable reference resource for students, analysts, managers and anyone in the industry interested in WCN system modelling, performance analysis and numerical evaluation.

Highlights the broad field of AI applications in education, regarding any type of artificial intelligence that is correlated with education Discusses learning methodologies, intelligent tutoring systems, intelligent student guidance and assessments, intelligent educational chatbots, and artificial tutors Presents the practicality and applicability implications of AI in education Includes new and current research from research centers and higher education universities Offers case studies of AI techniques in educational activities

New insight in many scientific and engineering fields is unthinkable without the use of numerical simulations running efficiently on modern computers. The faster we get new results, the bigger and accurate are the problems that we can solve. It is the combination of mathematical ideas plus efficient programming that drives the progress in many disciplines. Future champions in the area thus will have to be qualified in their application domain, they will need a profound understanding of some mathematical ideas, and they need the skills to deliver fast code. The present textbook targets students which have programming skills already and do not shy away from mathematics, though they might be educated in computer science or an application domain. It introduces the basic concepts and ideas behind applied mathematics and parallel programming that we need to write numerical simulations for today's multicore workstations. Our intention is not to dive into one particular application domain or to introduce a new programming language - we lay the generic foundations for future courses and projects in the area. The text is written in an accessible style which is easy to digest for students without years and years of mathematics education. It values clarity and intuition over formalism, and uses a simple N-body simulation setup to illustrate basic ideas that are of relevance in various different subdomains of scientific computing. Its primary goal is to make theoretical and paradigmatic ideas accessible to undergraduate students and to bring the fascination of the field across.

This book will teach you how to take advantage of the JavaScript language to process data provided on the Internet. Much attention is given to the main JavaScript backbone: prototype based objects, and functional capabilities, while common features (loops, etc.) are summarized in a few cheat-sheets. Only operational features are detailed through the coding of several applications -the second and largest part of the book-, on free-access datasets (e.g. World Bank). It includes: cartography (SVG or API's based), data-sheets access (via Ajax or Jsonp), video data and post-synchronization, and animation examples.

Performance of Web Services provides innovative techniques to improve the performance of Web Services, as well as QoS (Quality of Service) requirements. This includes Qos performance, reliability and security. The author presents two levels of Web Services: the "kernel" (ithe SOAP engine which delivers messages from one point to another through various networks), and the "server side" (which processes heavy load / requests). The primary objective of this book is execution of applications delivered in a timely fashion. Case studies and examples are provided throughout this book.

Final year projects are an important feature of most undergraduate and postgraduate degrees in the fields of Business Information Technology, Information Systems, Software Engineering and Business Computing. These projects usually involve students in the practical application of theory together with a critical analysis or evaluation of the excecution of their project or of the theory applied. This book is the first to provide detailed guidance and support for students in preparing for, conducting and evaluating a system development project, independent of the development methodology or technical tools to be used.

This book constitutes the refereed post-conference proceedings of the 7th Russian Supercomputing Days, RuSCDays 2021, held in Moscow, Russia, in September 2021.The 37 revised full papers and 3 short papers presented were carefully reviewed and selected from 99 submissions. The papers are organized in the following topical sections: supercomputer simulation; HPC, BigData, AI: architectures, technologies, tools; and distributed and cloud computing.

This monograph is intended for researchers and professionals in the fields of computer science and cybernetics. Nowadays, the areas of computer science and cybernetics (mainly its artificial intelligence branches) are subject to an immense degree of study and are applied in a wide range of technical and industrial projects. The individual chapters of this monograph were developed from a series of invited lectures at the Brno University of Technology in the years 2018 and 2019. The main aim of these lectures was to create an opportunity for students, academics, and professionals to exchange ideas, novel research methods, and new industrial applications in the fields related to soft computing and cybernetics. The authors of these chapters come from around the world and their works cover both new theoretical and application-oriented results from areas such as automation, control, robotics, optimization, statistics, reinforcement learning, image processing, and evolutionary algorithms.