Species of aspergilli are common in man's environment and are responsible for a wide spectrum of human and animal disease, ranging in animals from mycotic abortion to aflatoxicosis and in humans from localized colonization of the ear or skin to life-threatening systemic infection of neutropenic patients. In recent times, invasive aspergillosis has become increasingly important as a cause of morbidity and death, initially in patients receiving immunosuppression prior to organ transplantation, and latterly in haematologic patients rendered neutropenic by underlying disease or chemotherapy. In some centres, the condition has been recorded in more than 40% of patients dying with acute leukaemia. Laboratory diagnostic procedures are not always helpful and the diagnosis depends largely on clinical parameters. The clinician is faced with yet another problem, that of management. At present, antifungal therapy of invasive aspergillosis can be largely ineffectual, and the mortality rate remains unacceptably high. Since Aspergillus fumigatus was first described almost 125 years ago, several other pathogenic species have been recognized. The marked biosynthetic abilities and varied mechanisms of gene recombination of aspergilli have long commanded attention in food technology and genetics. Their equally varied abilities to cause disease have attracted the interest of toxicologists, allergists and physicians concerned with infectious diseases.

This book targets new advances in areas of treatment and drug delivery sciences for Malaria. This is the only published book which compiles the complete road map of malarial drug delivery systems along with an overview on the pathology, current state of malaria across the globe, new clinical trials, emerging drugs and evolving novel drug delivery platforms. A wide variety of novel micro-and nano-formulations using promising technologies are being explored to deliver the malarial drug via different administration routes. This book addresses the gap between new approaches and old treatment modalities and how the former is superior in pharmacological performance when tested in in-vitro and in-vivo. Audience from wide range group like from researchers to regulatory bodies can benefit from the compiled information to find out patient needs and addresses a much-needed update to the existing malaria drug delivery research.

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.

With the exception of a few tropical medicine schools worldwide, current medical education programs include almost zero discussion of the interface between infectious diseases and entomology. That is why this book was initially published in the first edition almost 17 years ago. The third edition of this valuable infectious disease entomology book updates all existing chapters with the newest scientific developments described in the medical and entomological literature in addition to covering 10 entirely new topics not addressed in previous editions, which include: * arthropod identification controversies * early beginnings of public health and disease control * red-meat allergy * updates on vaccine development for dengue and malaria * discussion of Chikungunya and Zika viruses * American Boutonnneuse Fever * the newest controversies in Lyme disease * recent findings of viruses in ticks * bed bug bite reactions * Morgellons disease (an imaginary infectious disease)

Originally published in 1980, this book focusses attention on various aspects of disease ecology. A series of contrasts appear, between urban and rural, temperate and tropical, and affluent and poor communities. These socio-geographical contrasts are related to a further dichotomy between infectious (usually acute) diseases, and non-infectious (usually chronic) ones. The first part of the book is largely concerned with infectious disease, such as malaria and gastroenteritis, in rural/tropical/poor communities. The second discusses the often-antithetical combination of chronic disease in urban/temperate/affluent populations.

Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Focusing on yellow fever, cholera, and plague epidemics as well as on sanitation in the context of urban growth in Saint-Louis-du-Senegal between 1867 and 1920, this book explores how the French colonial and medical authorities responded to the emergence and re-emergence of deadly epidemic diseases and environmental contamination. Official reactions ranged from blaming the Africans and the tropical climate to the imposition of urban residential segregation and strictly enforced furloughs of civil servants and European troops. Drastic and disruptive sanitary measures led to a conflict between the interests of competing conceptions of public health and those of commerce, civil liberties, and popular culture. This book also examines the effort undertaken by the colonizer to make Senegal a healthy colony and Saint-Louis the healthiest port-city/capital through better hygiene, building codes, vector control, and the construction of waterworks and a sewerage system. The author offers insight into the urban processes and daily life in a colonial city during the formative years of the French empire in West Africa.

The emergence of Zika virus in 2015 challenged conventional ideas of mosquito-borne diseases, tested the resilience of health systems and embedded itself within local sociocultural worlds, with major implications for environmental, sexual, reproductive and paediatric health. This book explores this complex viral epidemic and situates it within its broader social, epidemiological and historical context in Latin America and the Caribbean. The chapters include a diverse set of case studies from scholars and health practitioners working across the region, from Brazil, Venezuela, Ecuador, Mexico, Colombia, the United States and Haiti. The book explores how mosquito-borne disease epidemics (not only Zika but also chikungunya, dengue and malaria) intersect with social change and health governance. By doing so, the authors reflect on the ways in which situated knowledge and social science approaches can contribute to more effective health policy and practice for mosquito-borne disease threats in a changing world. The Open Access version of this book, available at http://www.tandfebooks.com , has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.

This book documents and presents new developments in the study of amebiasis, one of the neglected tropical diseases. Nearly 50 million people worldwide are infected with the pathogen Entamoeba histolytica, causing large-scale morbidity and mortality particularly in developing countries. This book will help clinicians for better diagnosis and management of the disease, researchers for initiating research projects on some of the poorly understood aspects of the disease and the pathogen, and students for updating their knowledge. The subjects covered range from genomics and molecular and cell biology to drug resistance and new drug development, highlighting major advances in recent years in our understanding due to rapid progress in genomic and other biomedical technologies, such as visualization of molecular processes. Most of the chapters provide recent information based on latest publications. A few chapters describe some of the critical methodological issues that will be helpful for students and researchers interested in getting into the field. The contributing authors include almost all the active researchers and clinicians from around the world. This book will be a useful primary material and a valuable source of information for anyone interested in understanding amebiasis, its diagnosis, and treatment. It will also be useful to those who are interested in learning about the biology of early branching eukaryotes and protist pathogens.

1. A guide to managing paediatric surgical patients in a remote and rural setting 2. Includes guidance on differences in presentation and problems relating to the Tropical environment 3. A key resource in understanding paediatric surgical patients needs when being managed remotely

This practical book covers all aspects of the biology of malaria vectors, with notes on the vectors of dengue. It is the first work in this field to concentrate on mosquitoes, rather than covering all disease vectors. Authored by renowned field entomologist Jacques Derek Charlwood, it disseminates his vast experience working on mosquito biology, ecology and the evaluation of new vector control tools across five continents over the past 40 years. Covering all aspects from classification and systematics, population dynamics, vector control, to surveillance and sampling, epidemics, and a selection of case histories, the book also considers genetics and resistance, Aedes biology, and malaria and dengue models. It is designed to fill the gap between very specialized texts and undergraduate books on general disease vectors, and is ideal as a textbook for postgraduate courses in entomology and mosquito vectors of disease.

This book covers current aspects of important infectious diseases affecting human and animal health in Latin American countries. Readers are equipped with details on arthropod vectors as well as on neglected health problems. Diseases covered include Neglected Tropical Diseases such as Chagas Disease, schistosomiasis, tungiasis, myiasis and leishmaniasis, but also Zika and Chikungunya viral infections, plague and yellow fever. One focus is given on parasitic transmission routes. In addition, the authors describe current therapeutic options and sustainable control measures, considering both human and animal health. By highlighting options within the interdisciplinary One Health approach, they round off this work into a cutting-edge reference for diverse expert readers. Scientists and clinicians concerned on public health, entomology, tropical medicine and parasitology not only in Latin America will find this collection particularly valuable. Finally, these contributions are essential in the framework of the Sustainable Development Goals and the targets of SDG 3 (Good Health and Well-being) in order to combat and end epidemics of Neglected Tropical Diseases.

This fully updated third edition of a classic book, widely cited as the most important and useful volume for health engineering and disease prevention, describes infectious diseases in tropical and developing countries, and the measures that may be used effectively against them. The infections described include the diarrheal diseases, the common gut worms, guinea worm, schistosomiasis, malaria, bancroftian filariasis, and other mosquito borne infections. The environmental interventions that receive most attention are domestic water supplies and improved excreta disposal. Appropriate technology for these interventions, and also their impact on infectious diseases are documented in detail.This edition includes new sections on arsenic in groundwater supplies and arsenic removal technologies as well as new material in most chapters, including information on water supplies in developing countries and surface water drainage.

Produced amidst the still rippling effects of a pandemic and as the world experiences the increasing burden of global warming and a rapidly changing biosphere, the second edition of Parasitology: A Conceptual Approach offers a timely overview of the eukaryotic parasites affecting human health and the health of domestic and wild animals and plants. The book offers a broadly encompassing, integrative view of the phenomenon of parasitism and of the remarkable diversity of the world's parasites. This second edition has been thoroughly updated on all aspects of parasitism, including expanded sections on parasite biodiversity, parasite genomes, the interface between parasitology and disease ecology, and applications of new techniques like CRISPR and gene drives for parasite control. Key selling features: Emphasis on a distinctive integrative and conceptual approach rather than the taxon-by-taxon approach used in most parasitology books A concise, handy Rogues Gallery section that summarizes the basic biology for the most important eukaryotic parasites of humans and domestic animals, one a reader is repeatedly directed to throughout the chapters Outstanding full-color illustrations and photographs to reinforce key points The use of text boxes to set apart important topics or ideas that deserve special emphasis Provision of end-of-chapter summaries, questions to test understanding and key references for those wishing to seek further information Reference to particular URLs to highlight recent developments that often pose new and distinctive problems awaiting solution Parasitology: A Conceptual Approach is designed for an upper-level undergraduate audience, but its readability and careful explanation of underlying scientific concepts and terminology makes it appropriate for anyone seeking a broader understanding of the impact of infectious organisms on our well-being and the changes underway in the modern world.

The role of the Colonial Medical Service - the organisation responsible for healthcare in British overseas territories - goes to the heart of the British Colonial project. "Practising Colonial Medicine" is a unique study based on original sources and research into the work of doctors who served in East Africa. It shows the formulation of a distinct colonial identity based on factors of race, class, background, training and Colonial Service traditions, buttressed by professional skills and practice. Anna Crozier analyses all aspects of recruitment, qualifications, training as well as the vital personal factors that shaped the Service's character - religion, a sense of adventure, professional interest, ideas of imperial service, family traditions, professional ties, perceptions of service to humanity and the building up of a common service mentality among colonial medical staff. This is the first comprehensive history of the Colonial Medical Service and makes an important contribution to our understanding of the social and cultural aspects of medical history.

1. A guide to managing paediatric surgical patients in a remote and rural setting 2. Includes guidance on differences in presentation and problems relating to the Tropical environment 3. A key resource in understanding paediatric surgical patients needs when being managed remotely

This new pocket guide provides rapid facts for everyday use in clinical practice and is an ideal resource for exam preparation.

"Rapid Infectious Diseases & Tropical Medicine "is the fourth title in the new Rapid series and is the ideal companion for medical students and junior doctors working on a wide range of clinical attachments, as well as general practitioners and emergency medical staff treating patients in primary care situations. It provides quick access to information on the common infectious diseases, their signs, symptoms, and aetiological agents. Arranged in A-Z format, each disease is covered using the same headings - Definition, Aetiology, Associations/Risk Factors, Epidemiology, History, Examination, Pathology, Investigations, Management, Complications, and Prognosis. There are also further sections on immunisations, malaria prophylaxis and antibiotics.

Key symptoms and signs of infectious diseases
Information on aetiological agents
A-Z organization of over 100 common infectious diseases
Concise entries following the Rapid series mnemonic to aid revision and recall
Provides additional information on immunisations, Malaria prophylaxis, and recommended antibiotics therapy

"Rapid Infectious Diseases & Tropical Medicine "is authored by Rachel Isba, a recent medical graduate from Oxford University. Dr Brian Angus, a senior clinician and Clinical Tutor in Medicine at Oxford University has provided support and advice as the Editorial Advisor.

Produced amidst the still rippling effects of a pandemic and as the world experiences the increasing burden of global warming and a rapidly changing biosphere, the second edition of Parasitology: A Conceptual Approach offers a timely overview of the eukaryotic parasites affecting human health and the health of domestic and wild animals and plants. The book offers a broadly encompassing, integrative view of the phenomenon of parasitism and of the remarkable diversity of the world's parasites. This second edition has been thoroughly updated on all aspects of parasitism, including expanded sections on parasite biodiversity, parasite genomes, the interface between parasitology and disease ecology, and applications of new techniques like CRISPR and gene drives for parasite control. Key selling features: Emphasis on a distinctive integrative and conceptual approach rather than the taxon-by-taxon approach used in most parasitology books A concise, handy Rogues Gallery section that summarizes the basic biology for the most important eukaryotic parasites of humans and domestic animals, one a reader is repeatedly directed to throughout the chapters Outstanding full-color illustrations and photographs to reinforce key points The use of text boxes to set apart important topics or ideas that deserve special emphasis Provision of end-of-chapter summaries, questions to test understanding and key references for those wishing to seek further information Reference to particular URLs to highlight recent developments that often pose new and distinctive problems awaiting solution Parasitology: A Conceptual Approach is designed for an upper-level undergraduate audience, but its readability and careful explanation of underlying scientific concepts and terminology makes it appropriate for anyone seeking a broader understanding of the impact of infectious organisms on our well-being and the changes underway in the modern world.

This is a thorough revision and update of the highly successful first edition, which which achieved sales in excess of 4,500. The text serves as a comprehensive introduction to parasitology for both undergraduate and beginning graduate students. In this edition, particular emphasis is placed on parasites of human and veterinary importance. The first three chapters in the text are concerned with how parasites 'work, ' their biochemistry, molecular and cell biology and physiology. The remaining chapters cover ecology and epidemiology, immunology and chemotherapy, with the final chapter covering integrated control. This new edition contains new material on cell and molecular biology, vectors and control, which is in contrast to the general biological approach of the first edition. The second edition will succeed the first as the major text on parasitology for students in biology, zoology, microbiology, medicine, veterinary medicine, tropical medicine and public health