Malaria sickens hundreds of millions of people--and kills one to three million--each year. Despite massive efforts to eradicate the disease, it remains a major public health problem in poorer tropical regions. But malaria has not always been concentrated in tropical areas. How did other regions control malaria and why does the disease still flourish in some parts of the globe?

From Russia to Bengal to Palm Beach, Randall Packard's far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization--coupled with climate change and changes in the distribution and flow of water--create conditions in which malaria's carrier mosquitoes thrive. The combination of these forces, Packard contends, makes the tropical regions today a perfect home for the disease.

Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.

There are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas that remain highly neglected. All the major diseases such as malaria, trypanosomatids and TB are covered, with a review of each disease and established compounds, new mechanistic classes and new horizons. Each chapter highlights the key science that has led to breakthroughs, with detailed assessment of the key medicinal chemistry involved, and critical appraisal of new emerging approaches. Later chapters highlight under publicized disease areas where the medical needs are neglected and research is very limited, to raise awareness. The editors, acknowledged experts in the field, have a wealth of experience in successful drug discovery practice and tropical diseases.

This volume provides a reflective summary of research in parasitology in the late 20th Century combined with a vision of the major challenges and potential successes in the 21st Century. It has been compiled from selected papers presented at the Eighth International Congress of Parasitology. A wide variety of topics are covered including medical, veterinary, and plant parasitology, by contributors from many different countries. Chapters within the book consider current research on the biology of parasites, and new strategies in the transmission and control of parasitic diseases. This book represents an invaluable resource for all parasitologists. Not only is it an up- to-date summary of research, but it is also a thought provoking look at the future.

NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

The role of the Colonial Medical Service, the organisation responsible for healthcare in British overseas territories, goes to the heart of the British Colonial project. Practising Colonial Medicine is a unique study based on original sources and research into the work of doctors who served in East Africa. It shows the formulation of a distinct colonial identity based on factors of race, class, background, training and Colonial Service traditions, buttressed by professional skills and practice. Anna Crozier analyses all aspects of recruitment, qualifications, training as well as the vital personal factors that shaped the Service's character - religion, a sense of adventure, professional interest, ideas of imperial service, family traditions, professional ties, perceptions of service to humanity and the building up of a common service mentality among colonial medical staff. This is the first comprehensive history of the Colonial Medical Service and makes an important contribution to our understanding of the social and cultural aspects of medical history.

Sarah Thebarge, a Yale-trained physician assistant, nearly died of breast cancer at age twenty-seven, but that did not end her deeply felt spiritual calling to medical missions in Africa. Risking her own health, she moved to Togo, West Africa-ranked by the United Nations as the least happy country in the world-to care for sick and suffering patients. Serving without pay in a mission hospital, she pondered the intersection of faith and medicine in her quest to help make the world "well." In the hospital wards, she witnessed death over and over again. In the outpatient clinic, she daily diagnosed patients with deadly diseases, many of which had simple but unavailable cures. She lived in austere conditions and nearly succumbed herself in a harrowing bout with malaria. She describes her experiences in gripping detail and reflects courageously about difficult and deep human connections-across race, culture, material circumstances, and medical access. Her experience exemplifies the triumph of surviving in order to share the stories that often go untold. In the end, WELL is an invitation to ask what happens when, instead of asking why God allows suffering to happen in the world, we ask, "Why do we?"

Malaria is a disease caused by a parasite that lives part of its life in humans and part in mosquitoes. Malaria remains one of the major killers of humans world-wide, threatening the lives of more than one-third of the world's population. It thrives in the tropical areas of Asia, Africa, and Central and South America, where it strikes millions of people. In the early 1970's, a mysterious clustering of arthritis cases occurred among children in Lyme, Connecticut, and surrounding towns. While scientists were busy describing signs and symptoms of Lyme disease to help doctors diagnose patients, they discovered that antibiotics were effective in its treatment and that the bite of the deer tick was the key to the spread of the disease. This book presents the most current research on the diagnosis, treatment and prevention of both malaria and Lyme disease.

Malaria is the leading parasitic infectious disease in sub-Saharan Africa (SSA) in terms of morbidity, hospitalisation and mortality. Pregnant women and children under the age of five years, especially infants, are the most vulnerable. In SSA where 90% of the global burden of malaria is concentrated, at least one child dies of malaria every 40 seconds. Intermittent preventive treatment (IPT) describes the administration of a full course of anti-malarial drugs to the population at risk at specified time intervals, irrespective of whether or not one is infected. Drug resistance, especially multi-drug resistance, and difficulties in eradicating the mosquito vector have been the basis of malaria resurgence over the past 30 years. In addition, massive problems with logistics, planning, allocation of resources and a lack of operational research have contributed greatly to the failure of malaria eradication. This book gathers the latest research from around the globe in this field.

"Colonial Pathologies" is a groundbreaking history of the role of science and medicine in the American colonization of the Philippines from 1898 through the 1930s. Warwick Anderson describes how American colonizers sought to maintain their own health and stamina in a foreign environment while exerting control over and "civilizing" a population of seven million people spread out over seven thousand islands. In the process, he traces a significant transformation in the thinking of colonial doctors and scientists about what was most threatening to the health of white colonists. During the late nineteenth century, they understood the tropical environment as the greatest danger, and they sought to help their fellow colonizers to acclimate. Later, as their attention shifted to the role of microbial pathogens, colonial scientists came to view the Filipino people as a contaminated race, and they launched public health initiatives to reform Filipinos' personal hygiene practices and social conduct.

A vivid sense of a colonial culture characterized by an anxious and assertive white masculinity emerges from Anderson's description of American efforts to treat and discipline allegedly errant Filipinos. His narrative encompasses a colonial obsession with native excrement, a leper colony intended to transform those considered most unclean and least socialized, and the hookworm and malaria programs implemented by the Rockefeller Foundation in the 1920s and 1930s. Throughout, Anderson is attentive to the circulation of intertwined ideas about race, science, and medicine. He points to colonial public health in the Philippines as a key influence on the subsequent development of military medicine and industrial hygiene, U.S. urban health services, and racialized development regimes in other parts of the world.

Changes in the organization of health services in developing countries have led to the district level assuming more responsibility for the planning, delivery and quality of community health care. This fully up-dated new edition has been produced to help those working in the district laboratory, and those responsible for the organization and management of community laboratory services and the training of district laboratory personnel. Replacing the previous publication Medical Laboratory Manual for Tropical Countries, this book provides an up-to-date practical bench manual, taking a modern approach to the provision of a quality medical laboratory service. It includes practical accounts of: organization and staffing of district laboratory services; total quality management; health and safety; equipping district laboratories; parasitological tests, illustrated in colour; clinical chemistry tests; how to plan a training curriculum for district laboratory personnel. Volume 2, published in late 1999, covers microbiological tests, haematological tests and blood transfusion tests.

The Emergence of Tropical Medicine in France examines the turbulent history of the ideas, people, and institutions of French colonial and tropical medicine from their early modern origins through World War I. Until the 1890s colonial medicine was in essence naval medicine, taught almost exclusively in a system of provincial medical schools built by the navy in the port cities of Brest, Rochefort-sur-Mer, Toulon, and Bordeaux. Michael A. Osborne draws out this separate species of French medicine by examining the histories of these schools and other institutions in the regional and municipal contexts of port life. Each site was imbued with its own distinct sensibilities regarding diet, hygiene, ethnicity, and race, all of which shaped medical knowledge and practice in complex and heretofore unrecognized ways. Osborne argues that physicians formulated localized concepts of diseases according to specific climatic and meteorological conditions, and assessed, diagnosed, and treated patients according to their ethnic and cultural origins. He also demonstrates that regions, more so than a coherent nation, built the empire and specific medical concepts and practices. Thus, by considering tropical medicine's distinctive history, Osborne brings to light a more comprehensive and nuanced view of French medicine, medical geography, and race theory, all the while acknowledging the navy's crucial role in combating illness and investigating the racial dimensions of health.

This unique volume presents an up-to-date review of one of the world's major health problems diseases caused by the four dengue viruses. It begins with an insightful story of the origin of dengue disease outbreaks, including the emergence of severe and fatal dengue hemorrhagic fever. The nature, structure and biology of the four dengue viruses are described, and a major portion of the book is focused on the epidemiology of dengue as a mosquito-borne disease. This is complemented by critiques of existing mosquito control programs by three groups of outstanding authorities. The strongest element of the volume is its comprehensive description of the current understanding of dengue disease pathogenesis, followed by an analysis of the pros and cons of five of the most controversial areas in the field: the WHO DEF case definition, secondary dengue infections, virulent viruses, the role of abnormal T cells and autoimmunity.

Now in a revised and expanded second edition, this unique text discusses the opportunities and challenges to the practice of orthopedic surgery in resource-limited environments around the world. Sensibly divided into thematic sections, part I examines barriers to care, from the poorly recognized global burden of orthopedic conditions and the less than ideal equipment to the cultural considerations and ethical dilemmas inherent in such situations. General clinical topics are covered in part II, such as non-surgical approaches and anesthesia, while the remaining sections discuss adult and pediatric trauma, presented in an anatomical format for easy reference with a focus on the natural history and the best treatment methods within existing limitations, followed by musculoskeletal infections, non-infectious pediatric conditions, reconstruction, and amputations. Topics new to this edition include the management of non-unions by induced membrane techniques, autologous bone grafting, bone growth and burn charts, the management of neck and back pain, and principles of orthopedic rehabilitation. Written and edited by experts with years of experience working in austere settings, this second edition of Global Orthopedics is a seamless transition from the original and expands the range of possible management strategies in places desperate for orthopedic care, making it a must for all surgeons and practitioners planning to work in such challenging settings.

At the present time there are renewed global efforts to control the major tropical infections and to stem the tide of malnutrition, the two serious, often intertwined, problems that contribute to much of the morbidity and mortality in under- privileged populations. Many international organizations have joined hands with national governments and with the private sector to search for new approaches to problems that beset much of the developing world, including countries in the tropical region. This volume continues the tradition of the previous publication in the Series. A variety of fare is offered to readers: explanations of the activities and achievements of the UNDP/World Bank/WHO Special Programme for Re- search and Training in Tropical Diseases; and studies of infant mortality, schistosomiasis, trypanosomiasis, helminths, lactase deficiency, oral rehydration therapy, functional consequences of iron deficiency, and fertility control. Au- thoritative state-of-the-art reviews provide a critical analysis of recent data. I hope the Series will continue to prove useful to all those working in the tropics and to those in the industrialized countries whose awareness of physical health problems of the Third World is relatively limited. R. K. Chandra St. John's, Newfoundland VlI Contents Chapter 1. The Special Programme for Research and Training in Tropical Diseases . . . . . . . . . . . . . . . . . . . DAVID S. ROWE 1. Origins, Objectives, and Diseases. . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Modus Operandi of the Programme. . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Scientific Working Groups. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. Research Strengthening Group. . . . . . . . . . . . . . . . . . . . . . . . . 7 2. 3. The Scientific and Technical Advisory Committee. . . . . . . . . 7 2. 4. Joint Coordinating Board. . . . . . . . . . . . . . . . . . . . . . . . . . . . .